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ID: oai:openaccess.sgul.ac.uk:107353
Date: 2015-03-05

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107353</identifier>
      <datestamp>2015-03-05T13:24:42Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8). This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107353/1/No_evidence_genome_wide_interactions_plasma_fibrinogen_smoking_alcohol_consumption.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1932-6203</dc:source><dc:title>No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.</dc:title><rioxxterms:author>Baumert, J</rioxxterms:author><rioxxterms:author>Huang, J</rioxxterms:author><rioxxterms:author>McKnight, B</rioxxterms:author><rioxxterms:author>Sabater-Lleal, M</rioxxterms:author><rioxxterms:author>Steri, M</rioxxterms:author><rioxxterms:author>Chu, AY</rioxxterms:author><rioxxterms:author>Trompet, S</rioxxterms:author><rioxxterms:author>Lopez, LM</rioxxterms:author><rioxxterms:author>Fornage, M</rioxxterms:author><rioxxterms:author>Teumer, A</rioxxterms:author><rioxxterms:author>Tang, W</rioxxterms:author><rioxxterms:author>Rudnicka, AR</rioxxterms:author><rioxxterms:author>Mälarstig, A</rioxxterms:author><rioxxterms:author>Hottenga, JJ</rioxxterms:author><rioxxterms:author>Kavousi, M</rioxxterms:author><rioxxterms:author>Lahti, J</rioxxterms:author><rioxxterms:author>Tanaka, T</rioxxterms:author><rioxxterms:author>Hayward, C</rioxxterms:author><rioxxterms:author>Huffman, JE</rioxxterms:author><rioxxterms:author>Morange, PE</rioxxterms:author><rioxxterms:author>Rose, LM</rioxxterms:author><rioxxterms:author>Basu, S</rioxxterms:author><rioxxterms:author>Rumley, A</rioxxterms:author><rioxxterms:author>Stott, DJ</rioxxterms:author><rioxxterms:author>Buckley, BM</rioxxterms:author><rioxxterms:author>de Craen, AJ</rioxxterms:author><rioxxterms:author>Sanna, S</rioxxterms:author><rioxxterms:author>Masala, M</rioxxterms:author><rioxxterms:author>Biffar, R</rioxxterms:author><rioxxterms:author>Homuth, G</rioxxterms:author><rioxxterms:author>Silveira, A</rioxxterms:author><rioxxterms:author>Sennblad, B</rioxxterms:author><rioxxterms:author>Goel, A</rioxxterms:author><rioxxterms:author>Watkins, H</rioxxterms:author><rioxxterms:author>Müller-Nurasyid, M</rioxxterms:author><rioxxterms:author>Rückerl, R</rioxxterms:author><rioxxterms:author>Taylor, K</rioxxterms:author><rioxxterms:author>Chen, MH</rioxxterms:author><rioxxterms:author>de Geus, EJ</rioxxterms:author><rioxxterms:author>Hofman, A</rioxxterms:author><rioxxterms:author>Witteman, JC</rioxxterms:author><rioxxterms:author>de Maat, MP</rioxxterms:author><rioxxterms:author>Palotie, A</rioxxterms:author><rioxxterms:author>Davies, G</rioxxterms:author><rioxxterms:author>Siscovick, DS</rioxxterms:author><rioxxterms:author>Kolcic, I</rioxxterms:author><rioxxterms:author>Wild, SH</rioxxterms:author><rioxxterms:author>Song, J</rioxxterms:author><rioxxterms:author>McArdle, WL</rioxxterms:author><rioxxterms:author>Ford, I</rioxxterms:author><rioxxterms:author>Sattar, N</rioxxterms:author><rioxxterms:author>Schlessinger, D</rioxxterms:author><rioxxterms:author>Grotevendt, A</rioxxterms:author><rioxxterms:author>Franzosi, MG</rioxxterms:author><rioxxterms:author>Illig, T</rioxxterms:author><rioxxterms:author>Waldenberger, M</rioxxterms:author><rioxxterms:author>Lumley, T</rioxxterms:author><rioxxterms:author>Tofler, GH</rioxxterms:author><rioxxterms:author>Willemsen, G</rioxxterms:author><rioxxterms:author>Uitterlinden, AG</rioxxterms:author><rioxxterms:author>Rivadeneira, F</rioxxterms:author><rioxxterms:author>Räikkönen, K</rioxxterms:author><rioxxterms:author>Chasman, DI</rioxxterms:author><rioxxterms:author>Folsom, AR</rioxxterms:author><rioxxterms:author>Lowe, GD</rioxxterms:author><rioxxterms:author>Westendorp, RG</rioxxterms:author><rioxxterms:author>Slagboom, PE</rioxxterms:author><rioxxterms:author>Cucca, F</rioxxterms:author><rioxxterms:author>Wallaschofski, H</rioxxterms:author><rioxxterms:author>Strawbridge, RJ</rioxxterms:author><rioxxterms:author>Seedorf, U</rioxxterms:author><rioxxterms:author>Koenig, W</rioxxterms:author><rioxxterms:author>Bis, JC</rioxxterms:author><rioxxterms:author>Mukamal, KJ</rioxxterms:author><rioxxterms:author>van Dongen, J</rioxxterms:author><rioxxterms:author>Widen, E</rioxxterms:author><rioxxterms:author>Franco, OH</rioxxterms:author><rioxxterms:author>Starr, JM</rioxxterms:author><rioxxterms:author>Liu, K</rioxxterms:author><rioxxterms:author>Ferrucci, L</rioxxterms:author><rioxxterms:author>Polasek, O</rioxxterms:author><rioxxterms:author>Wilson, JF</rioxxterms:author><rioxxterms:author>Oudot-Mellakh, T</rioxxterms:author><rioxxterms:author>Campbell, H</rioxxterms:author><rioxxterms:author>Navarro, P</rioxxterms:author><rioxxterms:author>Bandinelli, S</rioxxterms:author><rioxxterms:author>Eriksson, J</rioxxterms:author><rioxxterms:author>Boomsma, DI</rioxxterms:author><rioxxterms:author>Dehghan, A</rioxxterms:author><rioxxterms:author>Clarke, R</rioxxterms:author><rioxxterms:author>Hamsten, A</rioxxterms:author><rioxxterms:author>Boerwinkle, E</rioxxterms:author><rioxxterms:author>Jukema, JW</rioxxterms:author><rioxxterms:author>Naitza, S</rioxxterms:author><rioxxterms:author>Ridker, PM</rioxxterms:author><rioxxterms:author>Völzke, H</rioxxterms:author><rioxxterms:author>Deary, IJ</rioxxterms:author><rioxxterms:author>Reiner, AP</rioxxterms:author><rioxxterms:author>Trégouët, DA</rioxxterms:author><rioxxterms:author>O'Donnell, CJ</rioxxterms:author><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Peters, A</rioxxterms:author><rioxxterms:author>Smith, NL</rioxxterms:author><rioxxterms:project funder_name="NHLBI NIH HHS">N01-HC-25195</rioxxterms:project><rioxxterms:project funder_name="NHLBI NIH HHS">N02-HL-6-4278</rioxxterms:project><rioxxterms:project funder_name="NHLBI NIH HHS">R01 HL059367</rioxxterms:project><rioxxterms:publication_date>2014-12-31</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0111156</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107352
Date: 2015-03-04

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is a valid RIOXX record

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107352</identifier>
      <datestamp>2015-03-04T16:51:40Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated.&#13;
&#13;
METHODS: Cross-sectional studies of stratified random samples of 8-12-year-old children (n = 10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated.&#13;
&#13;
RESULTS: Overweight (odds ratio = 1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio = 1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, -0.90, 95%-confidence interval: -1.33%; -0.47%, for overweight and -2.46%, 95%-confidence interval: -3.84%; -1.07%, for obesity) whereas the results for the other objective markers, including atopy, were null.&#13;
&#13;
CONCLUSIONS: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107352/1/Overweight_obesity_respiratory_allergic_disease_in_children_ISAAC_Phase_Two.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1932-6203</dc:source><dc:title>Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two.</dc:title><rioxxterms:author>Weinmayr, G</rioxxterms:author><rioxxterms:author>Forastiere, F</rioxxterms:author><rioxxterms:author>Büchele, G</rioxxterms:author><rioxxterms:author>Jaensch, A</rioxxterms:author><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Nagel, G</rioxxterms:author><rioxxterms:author>ISAAC Phase Two Study Group, </rioxxterms:author><rioxxterms:publication_date>2014-12-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0113996</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107351
Date: 2015-03-04

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is a valid RIOXX record

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107351</identifier>
      <datestamp>2015-03-04T16:25:30Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells. &#13;
&#13;
METHODOLOGY/PRINCIPAL FINDINGS: Here we show that human inducible regulatory T cells (iTregs) also express IL-9. IL-4+TGF-beta induced higher levels of IL-9 expression in plate bound-anti-CD3 mAb (pbCD3)/soluble-anti-CD28 mAb (sCD28) activated human resting memory CD4(+)CD25(-)CD45RO(+) T cells as compared to naïve CD4(+)CD25(-)CD45RA(+) T cells. In addition, as compared to pbCD3/sCD28 plus TGF-beta stimulation, IL-4+TGF-beta stimulated memory CD4(+)CD25(-)CD45RO(+) T cells expressed reduced FOXP3 protein. As analyzed by pre-amplification boosted single-cell real-time PCR, human CD4(+)IL-9(+) T cells expressed GATA3 and RORC, but not IL-10, IL-13, IFNgamma or IL-17A/F. Attempts to optimize IL-9 production by pbCD3/sCD28 and IL-4+TGF-beta stimulated resting memory CD4(+) T cells demonstrated that the addition of IL-1beta, IL-12, and IL-21 further enhance IL-9 production. &#13;
&#13;
CONCLUSIONS/SIGNIFICANCE: Taken together these data show both the differences and similarities between mouse and human CD4(+)IL9(+) T cells and reaffirm the powerful influence of inflammatory cytokines to shape the response of activated CD4(+) T cells to antigen. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107351/1/Human_CD4_memory_T_cells_can_become_CD4_IL_9_T_cells.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1932-6203</dc:source><dc:title>Human CD4 memory T cells can become CD4+IL-9+ T cells.</dc:title><rioxxterms:author>Putheti, P</rioxxterms:author><rioxxterms:author>Awasthi, A</rioxxterms:author><rioxxterms:author>Popoola, J</rioxxterms:author><rioxxterms:author>Gao, W</rioxxterms:author><rioxxterms:author>Strom, TB</rioxxterms:author><rioxxterms:project funder_name="PHS HHS">5P01 A1041521-1</rioxxterms:project><rioxxterms:publication_date>2010-01-14</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0008706</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107350
Date: 2015-03-04

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is a valid RIOXX record

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107350</identifier>
      <datestamp>2015-03-04T16:06:43Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: The Quality Indicator for Rehabilitative Care (QuIRC) is a staff rated, international toolkit that assesses care in longer term hospital and community based mental health facilities. The QuIRC was developed from review of the international literature, an international Delphi exercise with over 400 service users, practitioners, carers and advocates from ten European countries at different stages of deinstitutionalisation, and review of the care standards in these countries. It can be completed in under an hour by the facility manager and has robust content validity, acceptability and inter-rater reliability. In this study, we investigated the internal validity of the QuIRC. Our aim was to identify the QuIRC domains of care that independently predicted better service user experiences of care.&#13;
&#13;
METHOD: At least 20 units providing longer term care for adults with severe mental illness were recruited in each of ten European countries. Service users completed standardised measures of their experiences of care, quality of life, autonomy and the unit's therapeutic milieu. Unit managers completed the QuIRC. Multilevel modelling allowed analysis of associations between service user ratings as dependent variables with unit QuIRC domain ratings as independent variables. &#13;
&#13;
RESULTS: 1750/2495 (70%) users and the managers of 213 units from across ten European countries participated. QuIRC ratings were positively associated with service users' autonomy and experiences of care. Associations between QuIRC ratings and service users' ratings of their quality of life and the unit's therapeutic milieu were explained by service user characteristics (age, diagnosis and functioning). A hypothetical 10% increase in QuIRC rating resulted in a clinically meaningful improvement in autonomy.&#13;
&#13;
CONCLUSIONS: Ratings of the quality of longer term mental health facilities made by service managers were positively associated with service users' autonomy and experiences of care. Interventions that improve quality of care in these settings may promote service users' autonomy. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107350/1/Quality_longer_term_mental_health_facilities_Europe_validation_quality_indicator.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1932-6203</dc:source><dc:title>Quality of longer term mental health facilities in Europe: validation of the quality indicator for rehabilitative care against service users' views.</dc:title><rioxxterms:author>Killaspy, H</rioxxterms:author><rioxxterms:author>White, S</rioxxterms:author><rioxxterms:author>Wright, C</rioxxterms:author><rioxxterms:author>Taylor, TL</rioxxterms:author><rioxxterms:author>Turton, P</rioxxterms:author><rioxxterms:author>Kallert, T</rioxxterms:author><rioxxterms:author>Schuster, M</rioxxterms:author><rioxxterms:author>Cervilla, JA</rioxxterms:author><rioxxterms:author>Brangier, P</rioxxterms:author><rioxxterms:author>Raboch, J</rioxxterms:author><rioxxterms:author>Kalisova, L</rioxxterms:author><rioxxterms:author>Onchev, G</rioxxterms:author><rioxxterms:author>Alexiev, S</rioxxterms:author><rioxxterms:author>Mezzina, R</rioxxterms:author><rioxxterms:author>Ridente, P</rioxxterms:author><rioxxterms:author>Wiersma, D</rioxxterms:author><rioxxterms:author>Visser, E</rioxxterms:author><rioxxterms:author>Kiejna, A</rioxxterms:author><rioxxterms:author>Piotrowski, P</rioxxterms:author><rioxxterms:author>Ploumpidis, D</rioxxterms:author><rioxxterms:author>Gonidakis, F</rioxxterms:author><rioxxterms:author>Caldas-de-Almeida, JM</rioxxterms:author><rioxxterms:author>Cardoso, G</rioxxterms:author><rioxxterms:author>King, M</rioxxterms:author><rioxxterms:publication_date>2012-06-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0038070</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107349
Date: 2015-03-04

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is a valid RIOXX record

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107349</identifier>
      <datestamp>2015-03-04T15:40:37Z</datestamp>
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      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Emerging pathogens undermine initiatives to control the global health impact of infectious diseases. Zoonotic malaria is no exception. Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, has entered the human population. P. knowlesi, like Plasmodium falciparum, can reach high parasitaemia in human infections, and the World Health Organization guidelines for severe malaria list hyperparasitaemia among the measures of severe malaria in both infections. Not all patients with P. knowlesi infections develop hyperparasitaemia, and it is important to determine why. Between isolate variability in erythrocyte invasion, efficiency seems key. Here we investigate the idea that particular alleles of two P. knowlesi erythrocyte invasion genes, P. knowlesi normocyte binding protein Pknbpxa and Pknbpxb, influence parasitaemia and human disease progression. Pknbpxa and Pknbpxb reference DNA sequences were generated from five geographically and temporally distinct P. knowlesi patient isolates. Polymorphic regions of each gene (approximately 800 bp) were identified by haplotyping 147 patient isolates at each locus. Parasitaemia in the study cohort was associated with markers of disease severity including liver and renal dysfunction, haemoglobin, platelets and lactate, (r = ≥ 0.34, p =  &lt;0.0001 for all). Seventy-five and 51 Pknbpxa and Pknbpxb haplotypes were resolved in 138 (94%) and 134 (92%) patient isolates respectively. The haplotypes formed twelve Pknbpxa and two Pknbpxb allelic groups. Patients infected with parasites with particular Pknbpxa and Pknbpxb alleles within the groups had significantly higher parasitaemia and other markers of disease severity. Our study strongly suggests that P. knowlesi invasion gene variants contribute to parasite virulence. We focused on two invasion genes, and we anticipate that additional virulent loci will be identified in pathogen genome-wide studies. The multiple sustained entries of this diverse pathogen into the human population must give cause for concern to malaria elimination strategists in the Southeast Asian region.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107349/1/Disease_progression_Plasmodium_knowlesi_malaria_linked_variation_invasion_gene_family.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1935-2735</dc:source><dc:title>Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members.</dc:title><rioxxterms:author>Ahmed, AM</rioxxterms:author><rioxxterms:author>Pinheiro, MM</rioxxterms:author><rioxxterms:author>Divis, PC</rioxxterms:author><rioxxterms:author>Siner, A</rioxxterms:author><rioxxterms:author>Zainudin, R</rioxxterms:author><rioxxterms:author>Wong, IT</rioxxterms:author><rioxxterms:author>Lu, CW</rioxxterms:author><rioxxterms:author>Singh-Khaira, SK</rioxxterms:author><rioxxterms:author>Millar, SB</rioxxterms:author><rioxxterms:author>Lynch, S</rioxxterms:author><rioxxterms:author>Willmann, M</rioxxterms:author><rioxxterms:author>Singh, B</rioxxterms:author><rioxxterms:author>Krishna, S</rioxxterms:author><rioxxterms:author>Cox-Singh, J</rioxxterms:author><rioxxterms:project funder_name="Medical Research Council">G0801971</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust">ISSF 097831/Z/11/Z</rioxxterms:project><rioxxterms:publication_date>2014-08-14</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pntd.0003086</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107348
Date: 2015-03-04

RIOXX

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This is a valid RIOXX record

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107348</identifier>
      <datestamp>2015-03-04T15:06:30Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00 × 10(-10)), but also unexpectedly found that it was associated with 0.35% higher BMI in never smokers (95% CI +0.18 to +0.52, P = 6.38 × 10(-5)). An interaction test confirmed that these estimates differed from each other (P = 4.95 × 10(-13)). This difference in effects suggests the variant influences BMI both via pathways unrelated to smoking, and via the weight-reducing effects of smoking. It would therefore be essentially undetectable in an unstratified genome-wide association study of BMI, given the opposite association with BMI in never and current smokers. This demonstrates that novel associations may be obscured by hidden population sub-structure. Stratification on well-characterized environmental factors known to impact on health outcomes may therefore reveal novel genetic associations.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107348/1/Stratification_by_smoking_status_reveals_association_of_CHRNA5_A3_B4_genotype.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1553-7404</dc:source><dc:title>Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.</dc:title><rioxxterms:author>Taylor, AE</rioxxterms:author><rioxxterms:author>Morris, RW</rioxxterms:author><rioxxterms:author>Fluharty, ME</rioxxterms:author><rioxxterms:author>Bjorngaard, JH</rioxxterms:author><rioxxterms:author>Åsvold, BO</rioxxterms:author><rioxxterms:author>Gabrielsen, ME</rioxxterms:author><rioxxterms:author>Campbell, A</rioxxterms:author><rioxxterms:author>Marioni, R</rioxxterms:author><rioxxterms:author>Kumari, M</rioxxterms:author><rioxxterms:author>Hällfors, J</rioxxterms:author><rioxxterms:author>Männistö, S</rioxxterms:author><rioxxterms:author>Marques-Vidal, P</rioxxterms:author><rioxxterms:author>Kaakinen, M</rioxxterms:author><rioxxterms:author>Cavadino, A</rioxxterms:author><rioxxterms:author>Postmus, I</rioxxterms:author><rioxxterms:author>Husemoen, LL</rioxxterms:author><rioxxterms:author>Skaaby, T</rioxxterms:author><rioxxterms:author>Ahluwalia, TS</rioxxterms:author><rioxxterms:author>Treur, JL</rioxxterms:author><rioxxterms:author>Willemsen, G</rioxxterms:author><rioxxterms:author>Dale, C</rioxxterms:author><rioxxterms:author>Wannamethee, SG</rioxxterms:author><rioxxterms:author>Lahti, J</rioxxterms:author><rioxxterms:author>Palotie, A</rioxxterms:author><rioxxterms:author>Räikkönen, K</rioxxterms:author><rioxxterms:author>Kisialiou, A</rioxxterms:author><rioxxterms:author>McConnachie, A</rioxxterms:author><rioxxterms:author>Padmanabhan, S</rioxxterms:author><rioxxterms:author>Wong, A</rioxxterms:author><rioxxterms:author>Dalgård, C</rioxxterms:author><rioxxterms:author>Paternoster, L</rioxxterms:author><rioxxterms:author>Ben-Shlomo, Y</rioxxterms:author><rioxxterms:author>Tyrrell, J</rioxxterms:author><rioxxterms:author>Horwood, J</rioxxterms:author><rioxxterms:author>Fergusson, DM</rioxxterms:author><rioxxterms:author>Kennedy, MA</rioxxterms:author><rioxxterms:author>Frayling, T</rioxxterms:author><rioxxterms:author>Nohr, EA</rioxxterms:author><rioxxterms:author>Christiansen, L</rioxxterms:author><rioxxterms:author>Ohm Kyvik, K</rioxxterms:author><rioxxterms:author>Kuh, D</rioxxterms:author><rioxxterms:author>Watt, G</rioxxterms:author><rioxxterms:author>Eriksson, J</rioxxterms:author><rioxxterms:author>Whincup, PH</rioxxterms:author><rioxxterms:author>Vink, JM</rioxxterms:author><rioxxterms:author>Boomsma, DI</rioxxterms:author><rioxxterms:author>Davey Smith, G</rioxxterms:author><rioxxterms:author>Lawlor, D</rioxxterms:author><rioxxterms:author>Linneberg, A</rioxxterms:author><rioxxterms:author>Ford, I</rioxxterms:author><rioxxterms:author>Jukema, JW</rioxxterms:author><rioxxterms:author>Power, C</rioxxterms:author><rioxxterms:author>Hyppönen, E</rioxxterms:author><rioxxterms:author>Jarvelin, MR</rioxxterms:author><rioxxterms:author>Preisig, M</rioxxterms:author><rioxxterms:author>Borodulin, K</rioxxterms:author><rioxxterms:author>Kaprio, J</rioxxterms:author><rioxxterms:author>Kivimaki, M</rioxxterms:author><rioxxterms:author>Smith, BH</rioxxterms:author><rioxxterms:author>Hayward, C</rioxxterms:author><rioxxterms:author>Romundstad, PR</rioxxterms:author><rioxxterms:author>Sørensen, TI</rioxxterms:author><rioxxterms:author>Munafò, MR</rioxxterms:author><rioxxterms:author>Sattar, N</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">102215</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">MC_UU_12013/1</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">MR/J01351X/1</rioxxterms:project><rioxxterms:publication_date>2014-12-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pgen.1004799</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107347
Date: 2015-03-04

RIOXX

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This is a valid RIOXX record

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107347</identifier>
      <datestamp>2015-03-04T14:21:13Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Transplantation has made a considerable difference to the lives of many patients. However, feedback from patients indicates that although having a transplant is a hugely positive experience, having to take medications indefinitely is one of the biggest challenges. An ideal scenario would be no medications following a transplant. A compromise would be a minimal number of medications, with minimal restrictions and as simple a regimen as possible. Although there is considerable research going into fine-tuning the management of the immune response to a transplant, to date there is no universal regimen that enables patients to remain free of immunosuppressant medications, making adherence paramount to maintain long-term allograft survival. This paper reviews the available immunosuppressant regimens and factors influencing choice from both the clinician's and the patient's perspective. Factors influencing the decision-making process, such as quality of life for patients, their satisfaction, acceptability, and adherence uptake are reviewed. We conclude with a further assessment of patient choice as a factor in regimen selection, its impact on adherence, and its implications.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107347/1/Patient_involvement_selection_immunosuppressive_regimen_following_transplantation.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1177-889X</dc:source><dc:title>Patient involvement in selection of immunosuppressive regimen following transplantation.</dc:title><rioxxterms:author>Popoola, J</rioxxterms:author><rioxxterms:author>Greene, H</rioxxterms:author><rioxxterms:author>Kyegombe, M</rioxxterms:author><rioxxterms:author>MacPhee, IA</rioxxterms:author><rioxxterms:publication_date>2014-12-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2147/PPA.S38987</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107346
Date: 2015-03-04

RIOXX

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This is not a valid RIOXX record
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rioxxterms:project'' is not a valid project_id in rioxxterms:project

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PropertyError
rioxxterms:project'' is not a valid project_id in rioxxterms:project
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107346</identifier>
      <datestamp>2015-03-04T09:49:22Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years). Although these organisms have been eradicated to a large extent within westernized human populations, those living within rural areas of developing countries continue to suffer from high infection rates. Indeed, recent estimates indicate that approximately 2.5 billion people worldwide, mainly children, currently suffer from infection with intestinal helminths (also known as geohelminths and soil-transmitted helminths) . Paradoxically, the eradication of helminths is thought to contribute to the increased incidence of autoimmune diseases and allergy observed in developed countries. In this review, we will summarize our current understanding of host-helminth interactions at the mucosal surface that result in parasite expulsion or permit the establishment of chronic infections with luminal dwelling adult worms. We will also provide insight into the adaptive immune mechanisms that provide immune protection against re-infection with helminth larvae, a process that is likely to be key to the future development of successful vaccination strategies. Lastly, the contribution of helminths to immune modulation and particularly to the treatment of allergy and inflammatory bowel disease will be discussed.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107346/1/Mucosal_immune_responses_following_intestinal_nematode_infection.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1365-3024</dc:source><dc:title>Mucosal immune responses following intestinal nematode infection.</dc:title><rioxxterms:author>Zaph, C</rioxxterms:author><rioxxterms:author>Cooper, PJ</rioxxterms:author><rioxxterms:author>Harris, NL</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">88862/Z/09/Z</rioxxterms:project><rioxxterms:project funder_name="Canadian Institutes of Health Research"/><rioxxterms:publication_date>2014-09</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/pim.12090</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107345
Date: 2015-03-04

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107345</identifier>
      <datestamp>2015-03-04T09:26:23Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVES: The role of outdoor air pollution in the incidence of chronic obstructive pulmonary disease (COPD) remains unclear. We investigated this question using a large, nationally representative cohort based on primary care records linked to hospital admissions.&#13;
&#13;
METHODS: A cohort of 812 063 patients aged 40-89 years registered with 205 English general practices in 2002 without a COPD diagnosis was followed from 2003 to 2007. First COPD diagnoses recorded either by a general practitioner (GP) or on admission to hospital were identified. Annual average concentrations in 2002 for particulate matter with an aerodynamic diameter &lt;10 µm (PM10) and &lt;2.5 µm (PM2.5), nitrogen dioxide (NO2), ozone and sulfur dioxide (SO2) at 1 km(2) resolution were estimated from emission-based dispersion models. Hazard ratios (HRs) per interquartile range change were estimated from Cox models adjusting for age, sex, smoking, body mass index and area-level deprivation. RESULTS: 16 034 participants (1.92%) received a COPD diagnosis from their GP and 2910 participants (0.35%) were admitted to hospital for COPD. After adjustment, HRs for GP recorded COPD and PM10, PM2.5 and NO2 were close to unity, positive for SO2 (HR=1.07 (95% CI 1.03 to 1.11) per 2.2 µg/m(3)) and negative for ozone (HR=0.94 (0.89 to 1.00) per 3 µg/m(3)). For admissions HRs for PM2.5 and NO2 remained positive (HRs=1.05 (0.98 to 1.13) and 1.06 (0.98 to 1.15) per 1.9 µg/m(3) and 10.7 µg/m(3), respectively).&#13;
&#13;
CONCLUSIONS: This large population-based cohort study found limited, inconclusive evidence for associations between air pollution and COPD incidence. Further work, utilising improved estimates of air pollution over time and enhanced socioeconomic indicators, is required to clarify the association between air pollution and COPD incidence. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107345/1/Long_term_exposure_outdoor_air_pollution_incidence_chronic_pulmonary_disease.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1470-7926</dc:source><dc:title>Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort.</dc:title><rioxxterms:author>Atkinson, RW</rioxxterms:author><rioxxterms:author>Carey, IM</rioxxterms:author><rioxxterms:author>Kent, AJ</rioxxterms:author><rioxxterms:author>van Staa, TP</rioxxterms:author><rioxxterms:author>Anderson, HR</rioxxterms:author><rioxxterms:author>Cook, DG</rioxxterms:author><rioxxterms:publication_date>2015-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/oemed-2014-102266</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107344
Date: 2015-03-03

RIOXX

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This is not a valid RIOXX record
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rioxxterms:project'' is not a valid project_id in rioxxterms:project
rioxxterms:project'' is not a valid project_id in rioxxterms:project

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rioxxterms:project'' is not a valid project_id in rioxxterms:project
rioxxterms:project'' is not a valid project_id in rioxxterms:project
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107344</identifier>
      <datestamp>2015-03-03T15:36:19Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVE: To compare fat distribution and associations between fat depots and cardiometabolic traits in South Asians and Europeans.&#13;
&#13;
METHODS: Five hundred and fourteen South Asians and 669 Europeans, aged 56-86. Questionnaires, record review, blood testing, and coronary artery calcification scores provided diabetes and clinical plus subclinical coronary heart disease (CHD) diagnoses. Abdominal visceral (VAT) and subcutaneous adipose tissue, thigh subcutaneous adipose tissue (TSAT), intermuscular and intramuscular thigh fat and thigh muscle were measured by CT.&#13;
&#13;
RESULTS: Accounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle. Associations between depots and disease were stronger in South Asians than Europeans. In multivariable analyses in South Asians, VAT was positively associated with diabetes and CHD, while TSAT and thigh muscle were protective for diabetes, and thigh muscle for CHD. Differences in VAT and thigh muscle only partially explained the excess diabetes and CHD in South Asians versus Europeans. Insulin resistance did not account for the effects of TSAT or thigh muscle.&#13;
&#13;
CONCLUSIONS: Greater VAT and TSAT and lesser thigh muscle in South Asians contributed to ethnic differences in cardiometabolic disease. Effects of TSAT and thigh muscle were independent of insulin resistance. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107344/1/Thigh_fat_and_muscle_contribute_excess_cardiometabolic_risk_south_asians.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1930-739X</dc:source><dc:title>Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.</dc:title><rioxxterms:author>Eastwood, SV</rioxxterms:author><rioxxterms:author>Tillin, T</rioxxterms:author><rioxxterms:author>Wright, A</rioxxterms:author><rioxxterms:author>Mayet, J</rioxxterms:author><rioxxterms:author>Godsland, I</rioxxterms:author><rioxxterms:author>Forouhi, NG</rioxxterms:author><rioxxterms:author>Whincup, P</rioxxterms:author><rioxxterms:author>Hughes, AD</rioxxterms:author><rioxxterms:author>Chaturvedi, N</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">082464</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">MC_UP_A100_1003</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">MC_UU_12015/5</rioxxterms:project><rioxxterms:project funder_name="British Heart Foundation">SP/07/001/23603</rioxxterms:project><rioxxterms:project funder_name="British Heart Foundation"/><rioxxterms:project funder_name="Wellcome Trust"/><rioxxterms:publication_date>2014-09</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1002/oby.20796</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107343
Date: 2015-03-03

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107343</identifier>
      <datestamp>2015-03-03T13:55:08Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Recently, the US Food and Drug Administration issued an alert about an increased risk for suicidality during treatment with antiepileptic drugs (AEDs) for different indications, including epilepsy. We discuss the issue of suicide in epilepsy with special attention to AEDs and the assessment of suicide in people with epilepsy. It has been suggested that early medical treatment with AEDs might potentially reduce suicide risk of people with epilepsy, but it is of great importance that the choice of drug is tailored to the mental state of the patient. The issue of suicidality in epilepsy is likely to represent an example of how the underdiagnosis of psychiatric symptoms, the lack of input from professionals (eg, psychologists, social workers, and psychiatrists), and the delay in an optimized AED therapy may worsen the prognosis of the condition with the occurrence of severe complications such as suicide.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107343/1/Assessing_suicidal_risk_with_antiepileptic_drugs.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1178-2021</dc:source><dc:title>Assessing suicidal risk with antiepileptic drugs.</dc:title><rioxxterms:author>Mula, M</rioxxterms:author><rioxxterms:author>Bell, GS</rioxxterms:author><rioxxterms:author>Sander, JW</rioxxterms:author><rioxxterms:publication_date>2010-09-13</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2147/NDT.S11999</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107342
Date: 2015-02-27

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107342</identifier>
      <datestamp>2015-02-27T16:45:00Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>This study evaluates the validity and reliability of a new instrument developed to assess symptoms of depresonalization: the Structured Clinical Interview for the Depersonalization-Derealization Spectrum (SCI-DER). The instrument is based on a spectrum model that emphasizes soft-signs, sub-threshold syndromes as well as clinical and subsyndromal manifestations. Items of the interview include, in addition to DSM-IV criteria for depersonalization, a number of features derived from clinical experience and from a review of phenomenological descriptions. Study participants included 258 consecutive patients with mood and anxiety disorders, 16.7% bipolar I disorder, 18.6% bipolar II disorder, 32.9% major depression, 22.1% panic disorder, 4.7% obsessive compulsive disorder, and 1.5% generalized anxiety disorder; 2.7% patients were also diagnosed with depersonalization disorder. A comparison group of 42 unselected controls was enrolled at the same site. The SCI-DER showed excellent reliability and good concurrent validity with the Dissociative Experiences Scale. It significantly discriminated subjects with any diagnosis of mood and anxiety disorders from controls and subjects with depersonalization disorder from controls. The hypothesized structure of the instrument was confirmed empirically.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107342/1/Validity_reliability_of_structured_clinical_interview_depersonalization_derealization_spectrum.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1176-6328</dc:source><dc:title>Validity and reliability of the Structured Clinical Interview for Depersonalization-Derealization Spectrum (SCI-DER).</dc:title><rioxxterms:author>Mula, M</rioxxterms:author><rioxxterms:author>Pini, S</rioxxterms:author><rioxxterms:author>Calugi, S</rioxxterms:author><rioxxterms:author>Preve, M</rioxxterms:author><rioxxterms:author>Masini, M</rioxxterms:author><rioxxterms:author>Giovannini, I</rioxxterms:author><rioxxterms:author>Conversano, C</rioxxterms:author><rioxxterms:author>Rucci, P</rioxxterms:author><rioxxterms:author>Cassano, GB</rioxxterms:author><rioxxterms:publication_date>2008-10</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2147/NDT.S3622</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107341
Date: 2015-02-27

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107341</identifier>
      <datestamp>2015-02-27T14:52:06Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background: Rodents are incapable of emesis and consequently the emetic potential of glucagon-like peptide-1 receptor (GLP-1R) agonists in studies designed to assess a potential blood glucose lowering action of the compound was missed. Therefore, we investigated if the ferret, a carnivore with demonstrated translation capability in emesis research, would identify the emetic potential of the GLP-1R agonist, exendin-4, and any associated effects on gastric motor function, appetite and cardiovascular homeostasis.&#13;
&#13;
Methods: The biological activity of the GLP-1R ligands was investigated in vivo using a glucose tolerance test in pentobarbitone-anesthetised ferrets and in vitro using organ bath studies. Radiotelemetry was used to investigate the effect of exendin-4 on gastric myoelectric activity (GMA) and cardiovascular function in conscious ferrets; behaviour was also simultaneously assessed. Western blot was used to characterize GLP-1R distribution in the gastrointestinal and brain tissues.&#13;
&#13;
Results: In anesthetised ferrets, exendin-4 (30 nmol/kg, s.c.) reduced experimentally elevated blood glucose levels by 36.3%, whereas the GLP-1R antagonist, exendin (9–39) (300 nmol/kg, s.c.) antagonised the effect and increased AUC0–120 by 31.0% when injected alone (P &lt; 0.05). In animals with radiotelemetry devices, exendin-4 (100 nmol/kg, s.c.) induced emesis in 1/9 ferrets, but inhibited food intake and decreased heart rate variability (HRV) in all animals (P &lt; 0.05). In the animals not exhibiting emesis, there was no effect on GMA, mean arterial blood pressure, heart rate, or core body temperature. In the ferret exhibiting emesis, there was a shift in the GMA towards bradygastria with a decrease in power, and a concomitant decrease in HRV. Western blot revealed GLP-1R throughout the gastrointestinal tract but exendin-4 (up to 300 nM) and exendin (9–39), failed to contract or relax isolated ferret gut tissues. GLP-1R were found in all major brain regions and the levels were comparable those in the vagus nerve.&#13;
&#13;
Conclusions: Peripherally administered exendin-4 reduced blood glucose and inhibited feeding with a low emetic potential similar to that in humans (11% vs 12.8%). A disrupted GMA only occurred in the animal exhibiting emesis raising the possibility that disruption of the GMA may influence the probability of emesis occurring in response to treatment with GLP-1R agonists.&#13;
</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107341/1/Different_hypoglycaemic_anorectic_autonomic_emetic_effects_conscious_ferret.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1479-5876</dc:source><dc:title>Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret.</dc:title><rioxxterms:author>Lu, Z</rioxxterms:author><rioxxterms:author>Percie Du Sert, N</rioxxterms:author><rioxxterms:author>Chan, S</rioxxterms:author><rioxxterms:author>Yeung, CK</rioxxterms:author><rioxxterms:author>Lin, G</rioxxterms:author><rioxxterms:author>Yew, D</rioxxterms:author><rioxxterms:author>Andrews, P</rioxxterms:author><rioxxterms:author>Rudd, JA</rioxxterms:author><rioxxterms:publication_date>2014-12-10</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/s12967-014-0327-6</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107340
Date: 2015-02-27

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107340</identifier>
      <datestamp>2015-02-27T14:21:14Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously. Group 1 allergens of house dust mites (HDM) are meaningful targets in this quest because they are globally prevalent and clinically important triggers of allergic asthma. Group 1 HDM allergens are cysteine peptidases whose proteolytic activity triggers essential steps in the allergy cascade. Using the HDM allergen Der p 1 as an archetype for structure-based drug discovery, we have identified a series of novel, reversible inhibitors. Potency and selectivity were manipulated by optimizing drug interactions with enzyme binding pockets, while variation of terminal groups conferred the physicochemical and pharmacokinetic attributes required for inhaled delivery. Studies in animals challenged with the gamut of HDM allergens showed an attenuation of allergic responses by targeting just a single component, namely, Der p 1. Our findings suggest that these inhibitors may be used as novel therapies for allergic asthma.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107340/1/The_discovery_of_potent_selective_reversible_inhibitors_house_dust_mites_peptidase.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1520-4804</dc:source><dc:title>The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.</dc:title><rioxxterms:author>Newton, GK</rioxxterms:author><rioxxterms:author>Perrior, TR</rioxxterms:author><rioxxterms:author>Jenkins, K</rioxxterms:author><rioxxterms:author>Major, MR</rioxxterms:author><rioxxterms:author>Key, RE</rioxxterms:author><rioxxterms:author>Stewart, MR</rioxxterms:author><rioxxterms:author>Firth-Clark, S</rioxxterms:author><rioxxterms:author>Lloyd, SM</rioxxterms:author><rioxxterms:author>Zhang, J</rioxxterms:author><rioxxterms:author>Francis-Newton, NJ</rioxxterms:author><rioxxterms:author>Richardson, JP</rioxxterms:author><rioxxterms:author>Chen, J</rioxxterms:author><rioxxterms:author>Lai, P</rioxxterms:author><rioxxterms:author>Garrod, DR</rioxxterms:author><rioxxterms:author>Robinson, C</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust"/><rioxxterms:publication_date>2014-11-26</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1021/jm501102h</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107339
Date: 2015-02-27

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107339</identifier>
      <datestamp>2015-02-27T11:43:04Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107339/1/Contemporary_management_atrial_fibrillation_what_can_clinical_registries_stroke_prevention.pdf</dc:identifier><dc:language>en</dc:language><dc:source>2047-9980</dc:source><dc:title>Contemporary management of atrial fibrillation: what can clinical registries tell us about stroke prevention and current therapeutic approaches?</dc:title><rioxxterms:author>Lip, GY</rioxxterms:author><rioxxterms:author>Al-Khatib, SM</rioxxterms:author><rioxxterms:author>Cosio, FG</rioxxterms:author><rioxxterms:author>Banerjee, A</rioxxterms:author><rioxxterms:author>Savelieva, I</rioxxterms:author><rioxxterms:author>Ruskin, J</rioxxterms:author><rioxxterms:author>Blendea, D</rioxxterms:author><rioxxterms:author>Nattel, S</rioxxterms:author><rioxxterms:author>De Bono, J</rioxxterms:author><rioxxterms:author>Conroy, JM</rioxxterms:author><rioxxterms:author>Hess, PL</rioxxterms:author><rioxxterms:author>Guasch, E</rioxxterms:author><rioxxterms:author>Halperin, JL</rioxxterms:author><rioxxterms:author>Kirchhof, P</rioxxterms:author><rioxxterms:author>G Cosio, MD</rioxxterms:author><rioxxterms:author>Camm, AJ</rioxxterms:author><rioxxterms:project funder_name="Department of Health">1328</rioxxterms:project><rioxxterms:publication_date>2014-08</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1161/JAHA.114.001179</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107338
Date: 2015-02-27

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107338</identifier>
      <datestamp>2015-02-27T11:12:22Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVES: To examine associations between habitual physical activity (PA) and changes in PA and onset of coronary heart disease (CHD) and the pathways linking PA to CHD.&#13;
&#13;
DESIGN: British Regional Heart Study population-based cohort; men completed questionnaires in 1996 and 1998 to 2000, attended rescreen in 1998 to 2000, and were followed up to June 2010.&#13;
&#13;
SETTING: Community.&#13;
&#13;
PARTICIPANTS: Of 4,252 men recruited from primary care centers (77% of those invited and eligible) who were rescreened in 1998 to 2000, 3,320 were ambulatory and free from CHD, stroke, and heart failure and participated in the current study.&#13;
&#13;
MEASUREMENTS: Usual PA (regular walking and cycling, recreational activity and sport). Outcome was first fatal or nonfatal myocardial infarction.&#13;
&#13;
RESULTS: In 3,320 ambulatory men, 303 first and 184 fatal CHD events occurred during a median of 11 years of follow-up; 9% reported no usual PA, 23% occasional PA, and 68% light or more-intense PA. PA was inversely associated with novel risk markers C-reactive protein, D-dimer, von Willebrand Factor and N-terminal pro-brain natriuretic peptide (NT-proBNP). Compared with no usual PA, hazard ratios (HRs) for CHD events, adjusted for age and region, were 0.52 (95% confidence interval (CI) = 0.34-0.79) for occasional PA, 0.47 (95% CI = 0.30-0.74) for light PA, 0.51 (95% CI = 0.32-0.82) for moderate PA, and 0.44 (95% CI = 0.29-0.65) for moderately vigorous or vigorous PA (P for linear trend =.004). Adjustment for established and novel risk markers somewhat attenuated HRs and abolished linear trends. Compared with men who remained inactive, men who maintained at least light PA had an HR for CHD events of 0.73 (95% CI = 0.53-1.02) and men whose PA level increased had an HR of 0.86 (95% CI = 0.55-1.35).&#13;
&#13;
CONCLUSION: Even light PA was associated with significantly lower risk of CHD events in healthy older men, partly through inflammatory and hemostatic mechanisms and cardiac function (NT-proBNP).</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107338/1/Physical_activity_older_men_longitudinal_associations_inflammatory_hemostatic_biomarkers.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1532-5415</dc:source><dc:title>Physical activity in older men: longitudinal associations with inflammatory and hemostatic biomarkers, N-terminal pro-brain natriuretic peptide, and onset of coronary heart disease and mortality.</dc:title><rioxxterms:author>Jefferis, BJ</rioxxterms:author><rioxxterms:author>Whincup, PH</rioxxterms:author><rioxxterms:author>Lennon, LT</rioxxterms:author><rioxxterms:author>Papacosta, O</rioxxterms:author><rioxxterms:author>Goya Wannamethee, S</rioxxterms:author><rioxxterms:project funder_name="Department of Health">PDF-2010-03-23</rioxxterms:project><rioxxterms:project funder_name="British Heart Foundation">PG/09/024/26857</rioxxterms:project><rioxxterms:project funder_name="British Heart Foundation">RG/08/013/25942</rioxxterms:project><rioxxterms:publication_date>2014-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/jgs.12748</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107337
Date: 2015-02-27

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107337</identifier>
      <datestamp>2015-02-27T10:28:13Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.&#13;
&#13;
METHODS: The European Society of Intensive Care Medicine invited 12 experts to form a Task Force to update a previous consensus (Antonelli et al.: Intensive Care Med 33:575-590, 2007). The same five questions addressed in the earlier consensus were used as the outline for the literature search and review, with the aim of the Task Force to produce statements based on the available literature and evidence. These questions were: (1) What are the epidemiologic and pathophysiologic features of shock in the intensive care unit ? (2) Should we monitor preload and fluid responsiveness in shock ? (3) How and when should we monitor stroke volume or cardiac output in shock ? (4) What markers of the regional and microcirculation can be monitored, and how can cellular function be assessed in shock ? (5) What is the evidence for using hemodynamic monitoring to direct therapy in shock ? Four types of statements were used: definition, recommendation, best practice and statement of fact.&#13;
&#13;
RESULTS: Forty-four statements were made. The main new statements include: (1) statements on individualizing blood pressure targets; (2) statements on the assessment and prediction of fluid responsiveness; (3) statements on the use of echocardiography and hemodynamic monitoring.&#13;
&#13;
CONCLUSIONS: This consensus provides 44 statements that can be used at the bedside to diagnose, treat and monitor patients with shock. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107337/1/Consensus_circulatory_shock_hemodynamic_monitoring_task_force_European_Society.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1432-1238</dc:source><dc:title>Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.</dc:title><rioxxterms:author>Cecconi, M</rioxxterms:author><rioxxterms:author>De Backer, D</rioxxterms:author><rioxxterms:author>Antonelli, M</rioxxterms:author><rioxxterms:author>Beale, R</rioxxterms:author><rioxxterms:author>Bakker, J</rioxxterms:author><rioxxterms:author>Hofer, C</rioxxterms:author><rioxxterms:author>Jaeschke, R</rioxxterms:author><rioxxterms:author>Mebazaa, A</rioxxterms:author><rioxxterms:author>Pinsky, MR</rioxxterms:author><rioxxterms:author>Teboul, JL</rioxxterms:author><rioxxterms:author>Vincent, JL</rioxxterms:author><rioxxterms:author>Rhodes, A</rioxxterms:author><rioxxterms:publication_date>2014-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1007/s00134-014-3525-z</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107336
Date: 2015-02-27

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107336</identifier>
      <datestamp>2015-02-27T09:43:36Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: A large number of chronic obstructive pulmonary disease (COPD) patients in Japan remain undiagnosed, primarily due to the underuse of spirometry. Two studies were conducted to see whether the COPD Assessment Test (CAT) in primary care has the potential to identify those patients who need spirometry for a diagnosis of COPD and to determine whether patients with cardiovascular disease had airflow limitation, which could be detected by CAT.&#13;
&#13;
MATERIALS AND METHODS: Two multicenter, noninterventional, prospective studies (studies 1 and 2) were conducted across Japan. Patients in both studies were ≥40 years old with a smoking history. Those in study 1 were seen in primary care and had experienced repeated respiratory tract infections, but had no diagnosis of COPD. Patients in study 2 were identified in cardiovascular disease clinics when routinely visiting for their cardiovascular disease. All patients completed the CAT prior to lung-function testing by hand-held spirometry. The presence of airflow limitation was defined as a forced expiratory volume in 1 second (FEV1)/FEV6 ratio&lt;0.73.&#13;
&#13;
RESULTS: A total of 3,062 subjects completed the CAT (2,067 in study 1, 995 in study 2); 88.8% were male, and the mean age (±standard deviation) was 61.5±11.6 years. Airflow limitation was found in 400 (19.4%) patients in study 1, and 269 (27.0%) in study 2. The CAT score in patients with airflow limitation was significantly higher than in patients without airflow limitation in both studies: 8.6 (95% confidence interval [CI] 7.9-9.2) versus 7.4 (95% CI 7.1-7.6) in study 1, and 8.3 (95% CI 7.5-9.2) versus 6.4 (95% CI 6.0-6.8) in study 2 (both P&lt;0.001).&#13;
&#13;
CONCLUSION: These findings suggest that the CAT has the potential to identify patients with cardiovascular disease or a history of frequent chest infections who need spirometry to diagnose COPD. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107336/1/The_relationship_between_COPD_assessment_test_score_airflow_limitation_Japan.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1178-2005</dc:source><dc:title>The relationship between the COPD Assessment Test score and airflow limitation in Japan in patients aged over 40 years with a smoking history.</dc:title><rioxxterms:author>Yoshimoto, D</rioxxterms:author><rioxxterms:author>Nakano, Y</rioxxterms:author><rioxxterms:author>Onishi, K</rioxxterms:author><rioxxterms:author>Hagan, G</rioxxterms:author><rioxxterms:author>Jones, P</rioxxterms:author><rioxxterms:publication_date>2014-12-09</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2147/COPD.S61265</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107335
Date: 2015-02-26

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107335</identifier>
      <datestamp>2015-02-26T16:33:34Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVES: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC).&#13;
&#13;
METHODS: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups.&#13;
&#13;
RESULTS: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P &lt; 0.001) and haemoglobin (P = 0.001), but not between CD4 count and HDL-C, LDL-C and TC, or VL and any outcome. Among participants aged &lt; 30, 30-50 and &gt; 50 years, a 50 cells/μL lower CD4 count correlated with a 2.4 [95% confidence interval (CI) 1.7-3.0], 3.6 (95% CI 3.2-4.0) and 5.1 (95% CI 4.0-6.1) g/L lower haemoglobin concentration and a 0.09 (95% CI 0.07-0.11), 0.12 (95% CI 0.11-0.13) and 0.16 (95% CI 0.13-0.19) g/L lower albumin concentration, respectively.&#13;
&#13;
CONCLUSIONS: We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels. A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV. These findings increase our understanding of how the metabolic impact of HIV is influenced by age. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107335/1/The_effects_of_age_association_between_markers_HIV_progression_metabolic.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1468-1293</dc:source><dc:title>The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations.</dc:title><rioxxterms:author>Samuel, M</rioxxterms:author><rioxxterms:author>Jose, S</rioxxterms:author><rioxxterms:author>Winston, A</rioxxterms:author><rioxxterms:author>Nelson, M</rioxxterms:author><rioxxterms:author>Johnson, M</rioxxterms:author><rioxxterms:author>Chadwick, D</rioxxterms:author><rioxxterms:author>Fisher, M</rioxxterms:author><rioxxterms:author>Leen, C</rioxxterms:author><rioxxterms:author>Gompels, M</rioxxterms:author><rioxxterms:author>Gilson, R</rioxxterms:author><rioxxterms:author>Post, FA</rioxxterms:author><rioxxterms:author>Hay, P</rioxxterms:author><rioxxterms:author>Sabin, CA</rioxxterms:author><rioxxterms:author>UK Collaborative HIV Cohort Study, </rioxxterms:author><rioxxterms:project funder_name="Medical Research Council">G0000199</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">G0600337</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">G0900274</rioxxterms:project><rioxxterms:publication_date>2014-05</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/hiv.12103</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107334
Date: 2016-03-03

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107334</identifier>
      <datestamp>2016-03-03T14:57:41Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2015-01-14">http://creativecommons.org/licenses/by/4.0/</ali:license_ref><dc:description>Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA. The interaction between the external environment and the human host plays an important role in the development of autoimmunity. In RA, the observation of anti-cyclic citrullinated peptide antibodies (ACPA) to autoantigens is well recognized. Citrullination is a post-translational modification mediated by peptidyl arginine deiminases, which exist in both mammalian and bacterial forms. Previous studies have shown how proteins expressed in the human extracellular matrix (ECM) acquire properties of damage-associated molecular patterns (DAMPs) in RA and include collagens, tenascin-C, and fibronectin (FN). ECM DAMPs can further potentiate tissue damage in RA. Recent work has shown that citrullination in RA occurs at mucosal sites, including the oral cavity and lung. Mucosal sites have been linked with bacterial infection, e.g., periodontal disease, where exogenous pathogens are implicated in the development of autoimmunity via an infectious trigger. Proteases produced at mucosal sites, both by bacteria and the human host, can induce the release of ECM DAMPs, thereby revealing neoepitopes which can be citrullinated and lead to an autoantibody response with further production of ACPA. In this perspectives article, the evidence for the interplay between the ECM and bacteria at human mucosal surfaces, which can become a focus for citrullination and the development of autoimmunity, is explored. Specific examples, with reference to collagen, fibrinogen, and FN, are discussed.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107334/1/Interaction_between_extracellular_matrix_molecules_microbial_pathogens.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1664-302X</dc:source><dc:title>Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model.</dc:title><rioxxterms:author>Sofat, N</rioxxterms:author><rioxxterms:author>Wait, R</rioxxterms:author><rioxxterms:author>Robertson, SD</rioxxterms:author><rioxxterms:author>Baines, DL</rioxxterms:author><rioxxterms:author>Baker, EH</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust" funder_id="http://dx.doi.org/10.13039/100004440"/><rioxxterms:publication_date>2014-01-14</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.3389/fmicb.2014.00783</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107333
Date: 2015-02-26

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107333</identifier>
      <datestamp>2015-02-26T15:56:40Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>A yearlong study was performed to examine the effect of antibiotic administration on the bacterial gut flora. Gram-negative facultative anaerobic bacteria were recovered from the feces of healthy adult volunteers administered amoxicillin, minocycline or placebo, and changes determined in antimicrobial resistance (AMR) gene carriage. Seventy percent of the 1039 facultative anaerobic isolates recovered were identified by MALDI-TOF as Escherichia coli. A microarray used to determine virulence and resistance gene carriage demonstrated that AMR genes were widespread in all administration groups, with the most common resistance genes being bla TEM, dfr, strB, tet(A), and tet(B). Following amoxicillin administration, an increase in the proportion of amoxicillin resistant E. coli and a three-fold increase in the levels of bla TEM gene carriage was observed, an effect not observed in the other two treatment groups. Detection of virulence genes, including stx1A, indicated not all E. coli were innocuous commensals. Approximately 150 E. coli collected from 6 participants were selected for pulse field gel electrophoresis (PFGE), and a subset used for characterisation of plasmids and Phenotypic Microarrays (PM). PFGE indicated some E. coli clones had persisted in volunteers for up to 1 year, while others were transient. Although there were no unique characteristics associated with plasmids from persistent or transient isolates, PM assays showed transient isolates had greater adaptability to a range of antiseptic biocides and tetracycline; characteristics which were lost in some, but not all persistent isolates. This study indicates healthy individuals carry bacteria harboring resistance to a variety of antibiotics and biocides in their intestinal tract. Antibiotic administration can have a temporary effect of selecting bacteria, showing co-resistance to multiple antibiotics, some of which can persist within the gut for up to 1 year.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107333/1/Antimicrobial_resistance_characteristics_fitness_Gram_negative_fecal_bacteria.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1664-302X</dc:source><dc:title>Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.</dc:title><rioxxterms:author>Kirchner, M</rioxxterms:author><rioxxterms:author>Mafura, M</rioxxterms:author><rioxxterms:author>Hunt, T</rioxxterms:author><rioxxterms:author>Abu-Oun, M</rioxxterms:author><rioxxterms:author>Nunez-Garcia, J</rioxxterms:author><rioxxterms:author>Hu, Y</rioxxterms:author><rioxxterms:author>Weile, J</rioxxterms:author><rioxxterms:author>Coates, A</rioxxterms:author><rioxxterms:author>Card, R</rioxxterms:author><rioxxterms:author>Anjum, MF</rioxxterms:author><rioxxterms:publication_date>2014-12-17</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.3389/fmicb.2014.00722</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107332
Date: 2015-03-18

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107332</identifier>
      <datestamp>2015-03-18T15:07:35Z</datestamp>
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      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Two years after the warning issued by the Food and Drug Administration on an increased risk of suicide for people taking antiepileptic drugs (AEDs), a number of pharmacoepidemiologic studies have been published but the scientific community is far from definitive answers. The present paper is aimed at reviewing available evidence on the association between AEDs and suicidal behavior, discussing major variables involved such as the relationship between epilepsy, depression, and suicide and the psychotropic potential of AEDs. All studies published so far show a lack of concordance and are constrained by various methodological limitations. What seems to be established is that mood disorders represent a frequent comorbidity in epilepsy and suicide is a serious complication more frequently encountered in epilepsy rather than in the general population. Moreover, a subgroup of patients appears to be at risk of developing treatment-emergent psychiatric adverse effects of AEDs independently of the specific mechanism of action of the drug. The prior history of suicide attempt, especially preceding the onset of the epilepsy, may represent a key element explaining why what is observed is independent of the specific mechanism of the drug. In general terms, risks associated with stopping, or not even starting, AEDs in epilepsy might well be in excess of the risk of suicide in epilepsy, as deaths due to accident and epilepsy itself may predominate. Clinicians need to pay attention not only to seizure patterns when choosing the appropriate AED but also to a number of different parameters (eg, age, gender, working needs, medical comorbidities, history of psychiatric disorders, and suicidality before epilepsy onset) and not the least the mental state of the patient. Missing severe complications such as suicidal behavior or delaying its treatment may worsen the prognosis of epilepsy.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107332/1/Suicidal_behavior_antiepileptic_drugs_epilepsy_analysis_emerging_evidence.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1179-1365</dc:source><dc:title>Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence.</dc:title><rioxxterms:author>Mula, M</rioxxterms:author><rioxxterms:author>Hesdorffer, DC</rioxxterms:author><rioxxterms:publication_date>2011-06-15</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2147/DHPS.S13070</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107331
Date: 2015-02-26

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107331</identifier>
      <datestamp>2015-02-26T14:49:52Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world. It is recognized that around 50% of patients with newly diagnosed epilepsy become seizure-free with the first drug treatment, so the choice of first antiepileptic drug is crucial. This paper provides a comprehensive overview of zonisamide as monotherapy for partial seizures, with special attention to the possibility of a once-daily regimen. The available data suggest that zonisamide is an effective and well tolerated option as monotherapy. Once-daily dosing is indicated, considering the long plasma half-life and linear pharmacokinetics of the drug. Zonisamide 300 mg was shown to be noninferior to carbamazepine 600 mg in terms of efficacy and safety, but even lower doses may be effective. Finally, the broad spectrum of efficacy in different seizure types, the low drug interaction potential, and the possibility of weight loss make zonisamide a preferred option in many epilepsy practices. Further data on monotherapy, especially in special populations, such as women of childbearing potential, are needed.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107331/1/Profile_once_daily_zonisamide_monotherapy_treatment_partial_seizures_adults.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1177-8881</dc:source><dc:title>Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults.</dc:title><rioxxterms:author>Mula, M</rioxxterms:author><rioxxterms:publication_date>2013-05-13</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2147/DDDT.S43612</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107330
Date: 2015-03-03

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107330</identifier>
      <datestamp>2015-03-03T13:06:28Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>AIMS/HYPOTHESIS: Lower birthweight (a marker of fetal undernutrition) is associated with higher risks of type 2 diabetes and cardiovascular disease (CVD) and could explain ethnic differences in these diseases. We examined associations between birthweight and risk markers for diabetes and CVD in UK-resident white European, South Asian and black African-Caribbean children.&#13;
&#13;
METHODS: In a cross-sectional study of risk markers for diabetes and CVD in 9- to 10-year-old children of different ethnic origins, birthweight was obtained from health records and/or parental recall. Associations between birthweight and risk markers were estimated using multilevel linear regression to account for clustering in children from the same school.&#13;
&#13;
RESULTS: Key data were available for 3,744 (66%) singleton study participants. In analyses adjusted for age, sex and ethnicity, birthweight was inversely associated with serum urate and positively associated with systolic BP. After additional height adjustment, lower birthweight (per 100 g) was associated with higher serum urate (0.52%; 95% CI 0.38, 0.66), fasting serum insulin (0.41%; 95% CI 0.08, 0.74), HbA1c (0.04%; 95% CI 0.00, 0.08), plasma glucose (0.06%; 95% CI 0.02, 0.10) and serum triacylglycerol (0.30%; 95% CI 0.09, 0.51) but not with BP or blood cholesterol. Birthweight was lower among children of South Asian (231 g lower; 95% CI 183, 280) and black African-Caribbean origin (81 g lower; 95% CI 30, 132). However, adjustment for birthweight had no effect on ethnic differences in risk markers. &#13;
&#13;
CONCLUSIONS/INTERPRETATION: Birthweight was inversely associated with urate and with insulin and glycaemia after adjustment for current height. Lower birthweight does not appear to explain emerging ethnic difference in risk markers for diabetes. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107330/1/Birthweight_risk_markers_type_2_diabetes_childhood_CHASE.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1432-0428</dc:source><dc:title>Birthweight and risk markers for type 2 diabetes and cardiovascular disease in childhood: the Child Heart and Health Study in England (CHASE).</dc:title><rioxxterms:author>Nightingale, CM</rioxxterms:author><rioxxterms:author>Rudnicka, AR</rioxxterms:author><rioxxterms:author>Owen, CG</rioxxterms:author><rioxxterms:author>Newton, SL</rioxxterms:author><rioxxterms:author>Bales, JL</rioxxterms:author><rioxxterms:author>Donin, AS</rioxxterms:author><rioxxterms:author>McKay, CM</rioxxterms:author><rioxxterms:author>Steer, PJ</rioxxterms:author><rioxxterms:author>Lawlor, DA</rioxxterms:author><rioxxterms:author>Sattar, N</rioxxterms:author><rioxxterms:author>Cook, DG</rioxxterms:author><rioxxterms:author>Whincup, PH</rioxxterms:author><rioxxterms:publication_date>2015-03</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1007/s00125-014-3474-7</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107329
Date: 2015-02-26

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107329</identifier>
      <datestamp>2015-02-26T11:46:43Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background. Transplant recipients require immunosuppression to prevent graft rejection. This conveys an increased risk of malignancy, particularly skin tumours. There is a need for up-to-date data for the South of England. Method. Pathology records were reviewed for 709 kidney transplant recipients on immunosuppression at our hospital from 1995 to 2008. Skin tumours were recorded/analysed. Results. Mean age at transplant was 46 years. Mean length of follow-up was 7.2 years and total follow-up was 4926 person-years. 53 (7.5%) patients (39/458 (8.5%) males and 14/251 (5.6%) females) developed ≥1 skin malignancy. Cumulative incidences of 4.0%, 7.5%, and 12.2% were observed for those with &lt;5, &lt;10, and ≥10 years follow-up, respectively. The rate was 45 tumours per 1000 person-years at risk. Additionally, 21 patients (3.0%) only had noninvasive tumours. 221 malignant skin tumours were found: 50.2% were SCCs, 47.1% BCCs, and 2.7% malignant melanomas. Mean years to first tumour were 5.8. Mean number of tumours per patient was 4, with mean interval of 12 months. Conclusions. Despite changes in transplantation practice during the time since the last data were published in this region, these findings are similar to previous studies. This adds to the evidence allowing clinicians to inform patients in this region of their risk.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107329/1/Malignant_and_noninvasive_skin_tumours_renal_transplant_recipients.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1687-6105</dc:source><dc:title>Malignant and noninvasive skin tumours in renal transplant recipients.</dc:title><rioxxterms:author>Roche, CD</rioxxterms:author><rioxxterms:author>Dobson, JS</rioxxterms:author><rioxxterms:author>Williams, SK</rioxxterms:author><rioxxterms:author>Quante, M</rioxxterms:author><rioxxterms:author>Popoola, J</rioxxterms:author><rioxxterms:author>Chow, JW</rioxxterms:author><rioxxterms:publication_date>2014-09-14</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1155/2014/409058</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107328
Date: 2015-02-26

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107328</identifier>
      <datestamp>2015-02-26T10:58:21Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>There are ~660,000 deaths from severe malaria each year. Intravenous artesunate (i.v. ARS) is the first-line treatment in adults and children. To optimize the dosing regimen of i.v. ARS, the largest pooled population pharmacokinetic study to date of the active metabolite dihydroartemisinin (DHA) was performed. The pooled dataset consisted of 71 adults and 195 children with severe malaria, with a mixture of sparse and rich sampling within the first 12 h after drug administration. A one-compartment model described the population pharmacokinetics of DHA adequately. Body weight had the greatest impact on DHA pharmacokinetics, resulting in lower DHA exposure for smaller children (6-10 kg) than adults. Post hoc estimates of DHA exposure were not significantly associated with parasitological outcomes. Comparable DHA exposure in smaller children and adults after i.v. ARS was achieved under a dose modification for intramuscular ARS proposed in a separate analysis of children.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107328/1/Population_pharmacokinetics_intravenous_artesunate_a_pooled_analysis.pdf</dc:identifier><dc:language>en</dc:language><dc:source>2163-8306</dc:source><dc:title>Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria.</dc:title><rioxxterms:author>Zaloumis, SG</rioxxterms:author><rioxxterms:author>Tarning, J</rioxxterms:author><rioxxterms:author>Krishna, S</rioxxterms:author><rioxxterms:author>Price, RN</rioxxterms:author><rioxxterms:author>White, NJ</rioxxterms:author><rioxxterms:author>Davis, TM</rioxxterms:author><rioxxterms:author>McCaw, JM</rioxxterms:author><rioxxterms:author>Olliaro, P</rioxxterms:author><rioxxterms:author>Maude, RJ</rioxxterms:author><rioxxterms:author>Kremsner, P</rioxxterms:author><rioxxterms:author>Dondorp, A</rioxxterms:author><rioxxterms:author>Gomes, M</rioxxterms:author><rioxxterms:author>Barnes, K</rioxxterms:author><rioxxterms:author>Simpson, JA</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">091625</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust">093956</rioxxterms:project><rioxxterms:publication_date>2014-11</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/psp.2014.43</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107327
Date: 2015-02-26

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107327</identifier>
      <datestamp>2015-02-26T10:35:52Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Associations of larger families with lower prevalences of hay fever, eczema and objective markers of allergic sensitization have been found fairly consistently in affluent countries, but little is known about these relationships in less affluent countries.&#13;
&#13;
METHODS: Questionnaire data for 210,200 children aged 6-7 years from 31 countries, and 337,226 children aged 13-14 years from 52 countries, were collected by Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC). Associations of disease symptoms and labels of asthma, rhinoconjunctivitis and eczema were analysed by numbers of total, older and younger siblings, using mixed (multi-level) logistic regression models to adjust for individual covariates and at the centre level for region, language and national affluence.&#13;
&#13;
RESULTS: In both age groups, inverse trends (P &lt; 0.0001) were observed for reported 'hay fever ever' and 'eczema ever' with increasing numbers of total siblings, and more specifically older siblings. These inverse associations were significantly (P &lt; 0.005) stronger in more affluent countries. In contrast, symptoms of severe asthma and severe eczema were positively associated (P &lt; 0.0001) with total sibship size in both age groups. These associations with disease severity were largely independent of position within the sibship and national GNI per capita.&#13;
&#13;
CONCLUSIONS: These global findings on sibship size and childhood asthma, rhinoconjunctivitis and eczema suggest at least two distinct trends. Inverse associations with older siblings (observations which prompted the 'hygiene hypothesis' for allergic disease) are mainly a phenomenon of more affluent countries, whereas greater severity of symptoms in larger families is globally more widespread. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107327/1/Siblings_asthma_rhinoconjunctivitis_and_eczema_worldwide_perspective.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1365-2222</dc:source><dc:title>Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the International Study of Asthma and Allergies in Childhood.</dc:title><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Aït-Khaled, N</rioxxterms:author><rioxxterms:author>Foliaki, S</rioxxterms:author><rioxxterms:author>Mallol, J</rioxxterms:author><rioxxterms:author>Odhiambo, J</rioxxterms:author><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:author>Williams, HC</rioxxterms:author><rioxxterms:author>ISAAC Phase Three Study Group, </rioxxterms:author><rioxxterms:publication_date>2015-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/cea.12349</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107325
Date: 2015-02-20

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107325</identifier>
      <datestamp>2015-02-20T16:13:28Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2014-07-04">http://creativecommons.org/licenses/by-nc/4.0</ali:license_ref><dc:description>OBJECTIVES: There is a lack of evidence regarding the effectiveness of graphic health warning labels (GHWL) in different individuals, including patients with chronic obstructive pulmonary disease (COPD). Investigating knowledge and attitudes may allow better implementation of future public health policies. We hypothesised that differences in the impact of GHWL exist between non-smokers, smokers and patients with COPD, with decreased efficacy in those groups who are longer and more frequently exposed to them. &#13;
&#13;
PARTICIPANTS AND SETTING: 163 participants (54% male, aged 21-80) including 60 non-smokers, 53 smokers and 50 patients with COPD (Gold stage II-IV), attending London respiratory outpatient clinics, participated in case-controlled surveys (50 items).&#13;
&#13;
OUTCOME MEASURES: Ten different GHWL were shown and demographics, smoking history, plans to quit, smoking-risk awareness, emotional response, processing and impact of GHWL on behaviour were recorded. Patients were further asked to prioritise the hypothetical treatment or prevention of five specific smoking-related diseases.&#13;
&#13;
RESULTS: Smokers, in particular those with COPD, were less susceptible to GHWL than non-smokers; 53.4% of all participants expressed fear when looking at GHWL, non-smokers (71.9%) more so than smokers (39.8%, p&lt;0.001). COPD participants were less aware of the consequences than non-COPD participants (p&lt;0.001), including an awareness of lung cancer (p=0.001). Lung cancer (95%), oral cancer (90.2%), heart disease (84.7%) and stroke (71.2%) were correctly associated with smoking, whereas blindness was least associated (23.9%). However, blindness was prioritised over oral cancer, stroke and in patients with COPD also over heart disease when participants were asked about hypothetical treatment or prevention.&#13;
&#13;
CONCLUSIONS: GHWL are most effective in non-smokers and a desensitisation effect was observed in smokers and patients with COPD. As a consequence, a tailored and concerted public health approach to use such messages is required and 'blindness' deserves to be mentioned in this context because of an unexpectedly high-deterring impact. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107325/1/A_cross_sectional_survey_investigating_desensitisation_graphic_health_warning.pdf</dc:identifier><dc:language>en</dc:language><dc:source>2044-6055</dc:source><dc:title>A cross-sectional survey investigating the desensitisation of graphic health warning labels and their impact on smokers, non-smokers and patients with COPD in a London cohort.</dc:title><rioxxterms:author>Ratneswaran, C</rioxxterms:author><rioxxterms:author>Chisnall, B</rioxxterms:author><rioxxterms:author>Drakatos, P</rioxxterms:author><rioxxterms:author>Sivakumar, S</rioxxterms:author><rioxxterms:author>Sivakumar, B</rioxxterms:author><rioxxterms:author>Barrecheguren, M</rioxxterms:author><rioxxterms:author>Douiri, A</rioxxterms:author><rioxxterms:author>Steier, J</rioxxterms:author><rioxxterms:publication_date>2014-07-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/bmjopen-2013-004782</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107324
Date: 2015-02-20

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107324</identifier>
      <datestamp>2015-02-20T14:57:10Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background:&#13;
Brisk walking in older people can increase step-counts and moderate to vigorous intensity physical activity (MVPA) in ≥10-minute bouts, as advised in World Health Organization guidelines. Previous interventions have reported step-count increases, but not change in objectively measured MVPA in older people. We assessed whether a primary care nurse-delivered complex intervention increased objectively measured step-counts and MVPA.&#13;
Methods and Findings:&#13;
A total of 988 60–75 year olds, able to increase walking and randomly selected from three UK family practices, were invited to participate in a parallel two-arm cluster randomised trial; randomisation was by household. Two-hundred-ninety-eight people from 250 households were randomised between 2011 and 2012; 150 individuals to the intervention group, 148 to the usual care control group. Intervention participants received four primary care nurse physical activity (PA) consultations over 3 months, incorporating behaviour change techniques, pedometer step-count and accelerometer PA intensity feedback, and an individual PA diary and plan. Assessors were not blinded to group status, but statistical analyses were conducted blind. The primary outcome was change in accelerometry assessed average daily step-counts between baseline and 3 months, with change at 12 months a secondary outcome. Other secondary outcomes were change from baseline in time in MVPA weekly in ≥10-minute bouts, accelerometer counts, and counts/minute at 3 months and 12 months. Other outcomes were adverse events, anthropometric measures, mood, and pain. Qualitative evaluations of intervention participants and practice nurses assessed the intervention’s acceptability. At 3 months, eight participants had withdrawn or were lost to follow-up, 280 (94%) individuals provided primary outcome data. At 3 months changes in both average daily step-counts and weekly MVPA in ≥10-minute bouts were significantly higher in the intervention than control group: by 1,037 (95% CI 513–1,560) steps/day and 63 (95% CI 40–87) minutes/week, respectively. At 12 months corresponding differences were 609 (95% CI 104–1,115) steps/day and 40 (95% CI 17–63) minutes/week. Counts and counts/minute showed similar effects to steps and MVPA. Adverse events, anthropometry, mood, and pain were similar in the two groups. Participants and practice nurses found the intervention acceptable and enjoyable.&#13;
Conclusions : &#13;
The PACE-Lift trial increased both step-counts and objectively measured MVPA in ≥10-minute bouts in 60–75 year olds at 3 and 12 months, with no effect on adverse events. To our knowledge, this is the first trial in this age group to demonstrate objective MVPA increases and highlights the value of individualised support incorporating objective PA assessment in a primary care setting.&#13;
Trial Registration: &#13;
Controlled-Trials.com ISRCTN42122561</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107324/1/A%20Primary%20Care%20Nurse%2DDelivered%20Walking%20Intervention%20in%20Older%20Adults%20PACE%20(Pedometer%20Accelerometer%20Consultation%20Evaluation)%2DLift%20Cluster%20Randomised%20Controlled%20Trial.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1549-1676</dc:source><dc:title>A Primary Care Nurse-Delivered Walking Intervention in Older Adults: PACE (Pedometer Accelerometer Consultation Evaluation)-Lift Cluster Randomised Controlled Trial.</dc:title><rioxxterms:author>Harris, T</rioxxterms:author><rioxxterms:author>Kerry, SM</rioxxterms:author><rioxxterms:author>Victor, CR</rioxxterms:author><rioxxterms:author>Ekelund, U</rioxxterms:author><rioxxterms:author>Woodcock, A</rioxxterms:author><rioxxterms:author>Iliffe, S</rioxxterms:author><rioxxterms:author>Whincup, PH</rioxxterms:author><rioxxterms:author>Beighton, C</rioxxterms:author><rioxxterms:author>Ussher, M</rioxxterms:author><rioxxterms:author>Limb, ES</rioxxterms:author><rioxxterms:author>David, L</rioxxterms:author><rioxxterms:author>Brewin, D</rioxxterms:author><rioxxterms:author>Adams, F</rioxxterms:author><rioxxterms:author>Rogers, A</rioxxterms:author><rioxxterms:author>Cook, DG</rioxxterms:author><rioxxterms:project funder_name="National Institute of Health Research (NIHR)">PB-PG-0909-20055</rioxxterms:project><rioxxterms:publication_date>2015-02-17</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pmed.1001783</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107323
Date: 2015-02-20

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107323</identifier>
      <datestamp>2015-02-20T15:41:19Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: A proportion of people with mental health problems require longer term care in a psychiatric or social care institution. However, there are no internationally agreed quality standards for institutional care and no method to assess common care standards across countries. We aimed to identify the key components of institutional care for people with longer term mental health problems and the effectiveness of these components.&#13;
&#13;
METHODS: We undertook a systematic review of the literature using comprehensive search terms in 11 electronic databases and identified 12,182 titles. We viewed 550 abstracts, reviewed 223 papers and included 110 of these. A "critical interpretative synthesis" of the evidence was used to identify domains of institutional care that are key to service users' recovery.&#13;
&#13;
RESULTS: We identified eight domains of institutional care that were key to service users' recovery: living conditions; interventions for schizophrenia; physical health; restraint and seclusion; staff training and support; therapeutic relationship; autonomy and service user involvement; and clinical governance. Evidence was strongest for specific interventions for the treatment of schizophrenia (family psychoeducation, cognitive behavioural therapy (CBT) and vocational rehabilitation).&#13;
&#13;
CONCLUSION: Institutions should, ideally, be community based, operate a flexible regime, maintain a low density of residents and maximise residents' privacy. For service users with a diagnosis of schizophrenia, specific interventions (CBT, family interventions involving psychoeducation, and supported employment) should be provided through integrated programmes. Restraint and seclusion should be avoided wherever possible and staff should have adequate training in de-escalation techniques. Regular staff supervision should be provided and this should support service user involvement in decision making and positive therapeutic relationships between staff and service users. There should be clear lines of clinical governance that ensure adherence to evidence-based guidelines and attention should be paid to service users' physical health through regular screening. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107323/1/A_systematic_review_of_international_published_literature_quality_institutional_care.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1471-244X</dc:source><dc:title>A systematic review of the international published literature relating to quality of institutional care for people with longer term mental health problems.</dc:title><rioxxterms:author>Taylor, TL</rioxxterms:author><rioxxterms:author>Killaspy, H</rioxxterms:author><rioxxterms:author>Wright, C</rioxxterms:author><rioxxterms:author>Turton, P</rioxxterms:author><rioxxterms:author>White, S</rioxxterms:author><rioxxterms:author>Kallert, TW</rioxxterms:author><rioxxterms:author>Schuster, M</rioxxterms:author><rioxxterms:author>Cervilla, JA</rioxxterms:author><rioxxterms:author>Brangier, P</rioxxterms:author><rioxxterms:author>Raboch, J</rioxxterms:author><rioxxterms:author>Kalisová, L</rioxxterms:author><rioxxterms:author>Onchev, G</rioxxterms:author><rioxxterms:author>Dimitrov, H</rioxxterms:author><rioxxterms:author>Mezzina, R</rioxxterms:author><rioxxterms:author>Wolf, K</rioxxterms:author><rioxxterms:author>Wiersma, D</rioxxterms:author><rioxxterms:author>Visser, E</rioxxterms:author><rioxxterms:author>Kiejna, A</rioxxterms:author><rioxxterms:author>Piotrowski, P</rioxxterms:author><rioxxterms:author>Ploumpidis, D</rioxxterms:author><rioxxterms:author>Gonidakis, F</rioxxterms:author><rioxxterms:author>Caldas-de-Almeida, J</rioxxterms:author><rioxxterms:author>Cardoso, G</rioxxterms:author><rioxxterms:author>King, MB</rioxxterms:author><rioxxterms:publication_date>2009-09-07</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1471-244X-9-55</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107322
Date: 2015-02-20

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107322</identifier>
      <datestamp>2015-02-20T15:39:05Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Despite the progress over recent decades in developing community mental health services internationally, many people still receive treatment and care in institutional settings. Those most likely to reside longest in these facilities have the most complex mental health problems and are at most risk of potential abuses of care and exploitation. This study aimed to develop an international, standardised toolkit to assess the quality of care in longer term hospital and community based mental health units, including the degree to which human rights, social inclusion and autonomy are promoted.&#13;
&#13;
METHOD: The domains of care included in the toolkit were identified from a systematic literature review, international expert Delphi exercise, and review of care standards in ten European countries. The draft toolkit comprised 154 questions for unit managers. Inter-rater reliability was tested in 202 units across ten countries at different stages of deinstitutionalisation and development of community mental health services. Exploratory factor analysis was used to corroborate the allocation of items to domains. Feedback from those using the toolkit was collected about its usefulness and ease of completion.&#13;
&#13;
RESULTS: The toolkit had excellent inter-rater reliability and few items with narrow spread of response. Unit managers found the content highly relevant and were able to complete it in around 90 minutes. Minimal refinement was required and the final version comprised 145 questions assessing seven domains of care.&#13;
&#13;
CONCLUSIONS: Triangulation of qualitative and quantitative evidence directed the development of a robust and comprehensive international quality assessment toolkit for units in highly variable socioeconomic and political contexts. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107322/1/The_development_of_Quality_Indicator_Rehabilitative_Care_QuIRC.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1471-244X</dc:source><dc:title>The development of the Quality Indicator for Rehabilitative Care (QuIRC): a measure of best practice for facilities for people with longer term mental health problems.</dc:title><rioxxterms:author>Killaspy, H</rioxxterms:author><rioxxterms:author>White, S</rioxxterms:author><rioxxterms:author>Wright, C</rioxxterms:author><rioxxterms:author>Taylor, TL</rioxxterms:author><rioxxterms:author>Turton, P</rioxxterms:author><rioxxterms:author>Schützwohl, M</rioxxterms:author><rioxxterms:author>Schuster, M</rioxxterms:author><rioxxterms:author>Cervilla, JA</rioxxterms:author><rioxxterms:author>Brangier, P</rioxxterms:author><rioxxterms:author>Raboch, J</rioxxterms:author><rioxxterms:author>Kališová, L</rioxxterms:author><rioxxterms:author>Onchev, G</rioxxterms:author><rioxxterms:author>Alexiev, S</rioxxterms:author><rioxxterms:author>Mezzina, R</rioxxterms:author><rioxxterms:author>Ridente, P</rioxxterms:author><rioxxterms:author>Wiersma, D</rioxxterms:author><rioxxterms:author>Visser, E</rioxxterms:author><rioxxterms:author>Kiejna, A</rioxxterms:author><rioxxterms:author>Adamowski, T</rioxxterms:author><rioxxterms:author>Ploumpidis, D</rioxxterms:author><rioxxterms:author>Gonidakis, F</rioxxterms:author><rioxxterms:author>Caldas-de-Almeida, J</rioxxterms:author><rioxxterms:author>Cardoso, G</rioxxterms:author><rioxxterms:author>King, MB</rioxxterms:author><rioxxterms:publication_date>2011-03-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1471-244X-11-35</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107321
Date: 2015-02-20

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107321</identifier>
      <datestamp>2015-02-20T15:36:40Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: This study aims to build a measure for assessing and reviewing the living conditions, care and human rights of people with longer term mental health problems in psychiatric and social care institutions. Protection of their human rights is imperative since impaired mental capacity secondary to mental illness can make them vulnerable to abuse and exploitation from others. They also constitute a major resource pressure for mental health services, social services, informal carers and society as a whole. &#13;
&#13;
METHODS/DESIGN: This study uses an iterative methodology to develop a toolkit to assess internationally agreed domains of care that are considered most important for recovery. These domains are identified by collating results from: i) a systematic review of the literature on institutional care for this service user group; ii) a review of the relevant care standards in each participating country; iii) Delphi exercises in partner countries with mental health professionals, service users, carers and advocates. Common domains and cross-cutting themes are agreed by the principal researchers and an international expert panel. Items are developed to assess these domains and incorporated into the toolkit which is designed to be administered through a face to face interview with the institution's manager. The toolkit is refined in response to inter-rater reliability testing, feedback from interviewers and interviewees regarding its utility, and feedback from key stakeholders in each country about its ability to deliver information that can be used within each country's established systems for quality assessment and review. Cross-validation of the toolkit ratings against service users' quality of life, autonomy and markers of recovery tests whether it can deliver a proxy-measure of the service users' experiences of care and the institution's promotion of their human rights and recovery. The ability of the toolkit to assess the "value for money" delivered by institutions is investigated by comparing toolkit ratings and service costs.&#13;
&#13;
DISCUSSION: The study will deliver the first international tool for the assessment of the quality of institutional care for people with longer term mental health problems that is accurate, reliable, informative, useful and easy to use. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107321/1/Study_protocol_for_development_European_measure_best_practice.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1471-244X</dc:source><dc:title>Study protocol for the development of a European measure of best practice for people with long term mental health problems in institutional care (DEMoBinc).</dc:title><rioxxterms:author>Killaspy, H</rioxxterms:author><rioxxterms:author>King, M</rioxxterms:author><rioxxterms:author>Wright, C</rioxxterms:author><rioxxterms:author>White, S</rioxxterms:author><rioxxterms:author>McCrone, P</rioxxterms:author><rioxxterms:author>Kallert, T</rioxxterms:author><rioxxterms:author>Cervilla, J</rioxxterms:author><rioxxterms:author>Raboch, J</rioxxterms:author><rioxxterms:author>Onchev, G</rioxxterms:author><rioxxterms:author>Mezzina, R</rioxxterms:author><rioxxterms:author>Wiersma, D</rioxxterms:author><rioxxterms:author>Kiejna, A</rioxxterms:author><rioxxterms:author>Ploumpidis, D</rioxxterms:author><rioxxterms:author>Caldas de Almeida, JM</rioxxterms:author><rioxxterms:publication_date>2009-06-13</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1471-244X-9-36</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107320
Date: 2015-02-20

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107320</identifier>
      <datestamp>2015-02-20T15:32:36Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Organizational culture is manifest in patterns of behaviour underpinned by beliefs, values, attitudes and assumptions, which can influence working practices. Cultural factors and working practices have been suggested to influence the transition of young people moving from child to adult mental health services. Failure to manage and integrate transitional care effectively can lead to young people losing contact with health and social care systems, resulting in adverse effects on health, well-being and potential.&#13;
&#13;
METHODS: The study aim was to identify the organisational factors which facilitate or impede transition of young people from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS) from the perspective of health professionals and representatives of voluntary organisations. Specific objectives were (i) to explore organizational cultures, structures, processes and resources which influence transition from child to adult mental health services; (ii) identify factors which constitute barriers and facilitators to transition and continuity of care and (iii) make recommendations for service improvements. Within an exploratory, qualitative design thirty four semi-structured interviews were conducted with health and social care professionals working in CAMHS and AMHS in four NHS Mental Health Trusts and four voluntary organizations, in England.&#13;
&#13;
RESULTS: A cultural divide appears to exist between CAMHS and AMHS, characterized by different beliefs, attitudes, mutual misperceptions and a lack of understanding of different service structures. This is exacerbated by working practices relating to communication and information transfer which could impact negatively on transition, relational, informational and cross boundary continuity of care. There is also evidence of a cultural shift, with some positive approaches to collaborative working across services and agencies, involving joint posts, parallel working, shared clinics and joint meetings.&#13;
&#13;
CONCLUSIONS: Cultural factors embodied in mutual misperceptions, attitudes, beliefs exist between CAMHS and AMHS. Working practices can exert either positive or negative effects on transition and continuity of care. Implementation of shared education and training, standardised approaches to record keeping and information transfer, supported by compatible IT resources are recommended, alongside management strategies which evaluate the achievement of outcomes related to transition and continuity of care. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107320/1/Talking_a_different_language_exploration_of_influence_organizational_cultures.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1472-6963</dc:source><dc:title>'Talking a different language': an exploration of the influence of organizational cultures and working practices on transition from child to adult mental health services.</dc:title><rioxxterms:author>McLaren, S</rioxxterms:author><rioxxterms:author>Belling, R</rioxxterms:author><rioxxterms:author>Paul, M</rioxxterms:author><rioxxterms:author>Ford, T</rioxxterms:author><rioxxterms:author>Kramer, T</rioxxterms:author><rioxxterms:author>Weaver, T</rioxxterms:author><rioxxterms:author>Hovish, K</rioxxterms:author><rioxxterms:author>Islam, Z</rioxxterms:author><rioxxterms:author>White, S</rioxxterms:author><rioxxterms:author>Singh, SP</rioxxterms:author><rioxxterms:project funder_name="Medical Research Council">G108/625</rioxxterms:project><rioxxterms:publication_date>2013-07-03</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1472-6963-13-254</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107319
Date: 2015-02-20

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107319</identifier>
      <datestamp>2015-02-20T15:21:10Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVE: The objective of this study is to assess the effect of maternal HIV and Mycobacterium tuberculosis (Mtb) infection on cellular responses to bacille Calmette-Guérin (BCG) immunization.&#13;
&#13;
DESIGN: A mother-infant cohort study.&#13;
&#13;
METHODS: Samples were collected from mother-infant pairs at delivery. Infants were BCG-vaccinated at 6 weeks of age and a repeat blood sample was collected from infants at 16 weeks of age. BCG-specific T-cell proliferation and intracellular cytokine expression were measured by flow cytometry. Secreted cytokines and chemokines in cell culture supernatants were analysed using a Multiplex assay.&#13;
&#13;
RESULTS: One hundred and nine (47 HIV-exposed and 62 HIV-unexposed) mother-infants pairs were recruited after delivery and followed longitudinally. At birth, proportions of mycobacteria-specific proliferating T cells were not associated with either in-utero HIV exposure or maternal Mtb sensitization. However, in-utero HIV exposure affected infant-specific T-cell subsets [tumour necrosis factor-alpha (TNF-α) single positive proliferating CD4⁺ T cells and interferon-gamma (IFN-γ), TNF-α dual-positive CD4⁺ T cells]. Levels of TNF-α protein in cell culture supernatants were also significantly higher in HIV-exposed infants born to Mtb-sensitized mothers. In the presence of maternal Mtb sensitization, frequencies of maternal and newborn BCG-specific proliferating CD4⁺ T cells were positively correlated. Following BCG vaccination, there was no demonstrable effect of HIV exposure or maternal Mtb infection on infant BCG-specific T-cell proliferative responses or concentrations of secreted cytokines and chemokines.&#13;
&#13;
CONCLUSION: Effects of maternal HIV and Mtb infection on infant immune profiles at birth are transient only, and HIV-exposed, noninfected infants have the same potential to respond to and be protected by BCG vaccination as HIV-unexposed infants. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107319/1/The_impact_of_HIV_exposure_and_maternal_Mycobacterium.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1473-5571</dc:source><dc:title>The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination.</dc:title><rioxxterms:author>Jones, CE</rioxxterms:author><rioxxterms:author>Hesseling, AC</rioxxterms:author><rioxxterms:author>Tena-Coki, NG</rioxxterms:author><rioxxterms:author>Scriba, TJ</rioxxterms:author><rioxxterms:author>Chegou, NN</rioxxterms:author><rioxxterms:author>Kidd, M</rioxxterms:author><rioxxterms:author>Wilkinson, RJ</rioxxterms:author><rioxxterms:author>Kampmann, B</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">100693</rioxxterms:project><rioxxterms:publication_date>2015-01-14</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1097/QAD.0000000000000536</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107314
Date: 2015-02-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107314</identifier>
      <datestamp>2015-02-10T14:51:44Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias. Using DNA screening and sequencing methods, over 700 different LQTS-causing mutations have been identified in 13 genes worldwide. Despite this, the genetic cause of 30-50% of LQTS is presently unknown. MicroRNAs (miRNAs) are small (∼ 22 nucleotides) noncoding RNAs which post-transcriptionally regulate gene expression by binding complementary sequences within messenger RNAs (mRNAs). The human genome encodes over 1800 miRNAs, which target about 60% of human genes. Consequently, miRNAs are likely to regulate many complex processes in the body, indeed aberrant expression of various miRNA species has been implicated in numerous disease states, including cardiovascular diseases. MiR-1 and MiR-133A are the most abundant miRNAs in the heart and have both been reported to regulate cardiac ion channels. We hypothesized that, as a consequence of their role in regulating cardiac ion channels, genetic variation in the genes which encode MiR-1 and MiR-133A might explain some cases of LQTS. Four miRNA genes (miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2), which encode MiR-1 and MiR-133A, were sequenced in 125 LQTS probands. No genetic variants were identified in miR-1-1 or miR-133a-1; but in miR-1-2 we identified a single substitution (n.100A&gt; G) and in miR-133a-2 we identified two substitutions (n.-19G&gt; A and n.98C&gt; T). None of the variants affect the mature miRNA products. Our findings indicate that sequence variants of miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2 are not a cause of LQTS in this cohort.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107314/1/MicroRNAs_cardiac_arrhythmia_DNA_sequence_variation.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1502-7686</dc:source><dc:title>MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.</dc:title><rioxxterms:author>Hedley, PL</rioxxterms:author><rioxxterms:author>Carlsen, AL</rioxxterms:author><rioxxterms:author>Christiansen, KM</rioxxterms:author><rioxxterms:author>Kanters, JK</rioxxterms:author><rioxxterms:author>Behr, ER</rioxxterms:author><rioxxterms:author>Corfield, VA</rioxxterms:author><rioxxterms:author>Christiansen, M</rioxxterms:author><rioxxterms:publication_date>2014-09</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.3109/00365513.2014.905696</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107301
Date: 2015-02-17

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107301</identifier>
      <datestamp>2015-02-17T11:20:06Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies. Fourteen out of 103 infiltrating ductal carcinomas exhibited positive membrane staining. Fifty-four of these tumours had lymph node involvement of which nine contained stained cells. These were all cases where the primary tumour was positive. In this series there was no correlation between c-erbB-2 overexpression and lymph node status. In five of the positive cases studied there was an associated in situ component which was also positively stained. Ten out of 24 pure intraduct carcinomas showed membrane staining, but none of the 149 benign conditions studied, which included 22 radial scars and 13 cases of atypical ductal proliferation, demonstrated the pattern of staining associated with overexpression. It is concluded that the c-erbB-2 protein is overexpressed in a minority (approximately 14%) of infiltrating ductal carcinomas and only in cells that are cytologically malignant. Overexpression of c-erbB-2 is considered in relation to pathogenesis.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107301/1/c_erbB_2_expression_benign_malignant_breast_disease.pdf</dc:identifier><dc:language>en</dc:language><dc:source>0007-0920</dc:source><dc:title>c-erbB-2 expression in benign and malignant breast disease.</dc:title><rioxxterms:author>Gusterson, BA</rioxxterms:author><rioxxterms:author>Machin, LG</rioxxterms:author><rioxxterms:author>Gullick, WJ</rioxxterms:author><rioxxterms:author>Gibbs, NM</rioxxterms:author><rioxxterms:author>Powles, TJ</rioxxterms:author><rioxxterms:author>Elliott, C</rioxxterms:author><rioxxterms:author>Ashley, S</rioxxterms:author><rioxxterms:author>Monaghan, P</rioxxterms:author><rioxxterms:author>Harrison, S</rioxxterms:author><rioxxterms:publication_date>1988-10</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/bjc.1988.239 </rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107294
Date: 2017-07-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107294</identifier>
      <datestamp>2017-07-10T15:33:10Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>The biological processes controlling human growth are diverse, complex and poorly understood. Genetic factors are important and human height has been shown to be a highly polygenic trait to which common and rare genetic variation contributes. Weaver syndrome is a human overgrowth condition characterised by tall stature, dysmorphic facial features, learning disability and variable additional features. We performed exome sequencing in four individuals with Weaver syndrome, identifying a mutation in the histone methyltransferase, EZH2, in each case. Sequencing of EZH2 in additional individuals with overgrowth identified a further 15 mutations. The EZH2 mutation spectrum in Weaver syndrome shows considerable overlap with the inactivating somatic EZH2 mutations recently reported in myeloid malignancies. Our data establish EZH2 mutations as the cause of Weaver syndrome and provide further links between histone modifications and regulation of human growth.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107294/1/Germline_mutations_oncogene_EZH2.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1949-2553</dc:source><dc:title>Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.</dc:title><rioxxterms:author>Tatton-Brown, K</rioxxterms:author><rioxxterms:author>Hanks, S</rioxxterms:author><rioxxterms:author>Ruark, E</rioxxterms:author><rioxxterms:author>Zachariou, A</rioxxterms:author><rioxxterms:author>Duarte, SDELV</rioxxterms:author><rioxxterms:author>Ramsay, E</rioxxterms:author><rioxxterms:author>Snape, K</rioxxterms:author><rioxxterms:author>Murray, A</rioxxterms:author><rioxxterms:author>Perdeaux, ER</rioxxterms:author><rioxxterms:author>Seal, S</rioxxterms:author><rioxxterms:author>Loveday, C</rioxxterms:author><rioxxterms:author>Banka, S</rioxxterms:author><rioxxterms:author>Clericuzio, C</rioxxterms:author><rioxxterms:author>Flinter, F</rioxxterms:author><rioxxterms:author>Magee, A</rioxxterms:author><rioxxterms:author>McConnell, V</rioxxterms:author><rioxxterms:author>Patton, M</rioxxterms:author><rioxxterms:author>Raith, W</rioxxterms:author><rioxxterms:author>Rankin, J</rioxxterms:author><rioxxterms:author>Splitt, M</rioxxterms:author><rioxxterms:author>Strenger, V</rioxxterms:author><rioxxterms:author>Taylor, C</rioxxterms:author><rioxxterms:author>Wheeler, P</rioxxterms:author><rioxxterms:author>Temple, KI</rioxxterms:author><rioxxterms:author>Cole, T</rioxxterms:author><rioxxterms:author>Childhood Overgrowth Collaboration, </rioxxterms:author><rioxxterms:author>Douglas, J</rioxxterms:author><rioxxterms:author>Rahman, N</rioxxterms:author><rioxxterms:publication_date>2011-12-21</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.18632/oncotarget.385</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107275
Date: 2015-02-10

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107275</identifier>
      <datestamp>2015-02-10T10:51:11Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVE: To use patient-level data from the ADVANCE study to evaluate the cost-effectiveness of transcatheter aortic valve implantation (TAVI) compared to medical management (MM) in patients with severe aortic stenosis from the perspective of the UK NHS.&#13;
&#13;
METHODS: A published decision-analytic model was adapted to include information on TAVI from the ADVANCE study. Patient-level data informed the choice as well as the form of mathematical functions that were used to model all-cause mortality, health-related quality of life and hospitalisations. TAVI-related resource use protocols were based on the ADVANCE study. MM was modelled on publicly available information from the PARTNER-B study. The outcome measures were incremental cost-effectiveness ratios (ICERs) estimated at a range of time horizons with benefits expressed as quality-adjusted life-years (QALY). Extensive sensitivity/subgroup analyses were undertaken to explore the impact of uncertainty in key clinical areas.&#13;
&#13;
RESULTS: Using a 5-year time horizon, the ICER for the comparison of all ADVANCE to all PARTNER-B patients was £13 943 per QALY gained. For the subset of ADVANCE patients classified as high risk (Logistic EuroSCORE &gt;20%) the ICER was £17 718 per QALY gained). The ICER was below £30 000 per QALY gained in all sensitivity analyses relating to choice of MM data source and alternative modelling approaches for key parameters. When the time horizon was extended to 10 years, all ICERs generated in all analyses were below £20 000 per QALY gained.&#13;
&#13;
CONCLUSION: TAVI is highly likely to be a cost-effective treatment for patients with severe aortic stenosis. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107275/1/Cost_utility_transcatheter_aortic_valve_implantation.pdf</dc:identifier><dc:language>en</dc:language><dc:source>2053-3624</dc:source><dc:title>Cost-utility of transcatheter aortic valve implantation for inoperable patients with severe aortic stenosis treated by medical management: a UK cost-utility analysis based on patient-level data from the ADVANCE study.</dc:title><rioxxterms:author>Brecker, S</rioxxterms:author><rioxxterms:author>Mealing, S</rioxxterms:author><rioxxterms:author>Padhiar, A</rioxxterms:author><rioxxterms:author>Eaton, J</rioxxterms:author><rioxxterms:author>Sculpher, M</rioxxterms:author><rioxxterms:author>Busca, R</rioxxterms:author><rioxxterms:author>Bosmans, J</rioxxterms:author><rioxxterms:author>Gerckens, UJ</rioxxterms:author><rioxxterms:author>Wenaweser, P</rioxxterms:author><rioxxterms:author>Tamburino, C</rioxxterms:author><rioxxterms:author>Bleiziffer, S</rioxxterms:author><rioxxterms:author>Piazza, N</rioxxterms:author><rioxxterms:author>Moat, N</rioxxterms:author><rioxxterms:author>Linke, A</rioxxterms:author><rioxxterms:publication_date>2014-10-23</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/openhrt-2014-000155</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107274
Date: 2015-02-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107274</identifier>
      <datestamp>2015-02-10T11:16:22Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Elevated serum cardiac troponin T (cTnT) and I (cTnI) can occur in patients with chronic kidney disease. Differences in cTn concentrations between cTnT and cTnI have been reported but the mechanism of such discrepancy has not been investigated. This study investigates the clearance of cTn with the aid of an in vitro model of haemodialysis (HD).&#13;
&#13;
METHODS: Serum was obtained before and after a single session of dialysis from 53 patients receiving HD and assayed for cTnT and cTnI. An in vitro model of the dialysis process was used to investigate the mechanism of clearance of cTn during HD.&#13;
&#13;
RESULTS: Serum cTnI was significantly lower (p=0.043) following a session of HD whereas cTnT concentrations were similar to those obtained before HD. Using an in vitro model of dialysis, it was demonstrated that cTnI is not dialysed from the vascular compartment but adheres to the dialyser membrane.&#13;
&#13;
CONCLUSIONS: The adherence of cTnI to the dialyser membrane is responsible for the observed decrease in serum cTnI following a session of dialysis. The adherence of cTnT or T-I-C complex to the dialyser membrane could not be demonstrated and supports the observation that pre-HD and post-HD serum concentrations of cTnT are similar. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107274/1/Cardiac_troponin_I_not_T_adheres_polysulfone.pdf</dc:identifier><dc:language>en</dc:language><dc:source>2053-3624</dc:source><dc:title>Cardiac troponin I but not cardiac troponin T adheres to polysulfone dialyser membranes in an in vitro haemodialysis model: explanation for lower serum cTnI concentrations following dialysis.</dc:title><rioxxterms:author>Gaze, DC</rioxxterms:author><rioxxterms:author>Collinson, PO</rioxxterms:author><rioxxterms:publication_date>2014-06-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/openhrt-2014-000108</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107271
Date: 2015-02-17

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107271</identifier>
      <datestamp>2015-02-17T10:58:58Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity of various ISG products; the multifunctional NS1 protein is responsible for most of these activities. To determine the importance of other viral genes in the interplay between the virus and the host IFN response, we characterized populations and selected mutants of wild-type viruses selected by passage through non-IFN-responsive cells. We reasoned that, by allowing replication to occur in the absence of the selection pressure exerted by IFN, the virus could mutate at positions that would normally be restricted and could thus find new optimal sequence solutions. Deep sequencing of selected virus populations and individual virus mutants indicated that nonsynonymous mutations occurred at many phylogenetically conserved positions in nearly all virus genes. Most individual mutants selected for further characterization induced IFN and ISGs and were unable to counteract the effects of exogenous IFN, yet only one contained a mutation in NS1. The relevance of these mutations for the virus phenotype was verified by reverse genetics. Of note, several virus mutants expressing intact NS1 proteins exhibited alterations in the M1/M2 proteins and accumulated large amounts of deleted genomic RNAs but nonetheless replicated to high titers. This suggests that the overproduction of IFN inducers by these viruses can override NS1-mediated IFN modulation. Altogether, the results suggest that influenza viruses replicating in IFN-competent cells have tuned their complete genomes to evade the cellular innate immune system and that serial replication in non-IFN-responsive cells allows the virus to relax from these constraints and find a new genome consensus within its sequence space.&#13;
&#13;
IMPORTANCE In natural virus infections, the production of interferons leads to an antiviral state in cells that effectively limits virus replication. The interferon response places considerable selection pressure on viruses, and they have evolved a variety of ways to evade it. Although the influenza virus NS1 protein is a powerful interferon antagonist, the contributions of other viral genes to interferon evasion have not been well characterized. Here, we examined the effects of alleviating the selection pressure exerted by interferon by serially passaging influenza viruses in cells unable to respond to interferon. Viruses that grew to high titers had mutations at many normally conserved positions in nearly all genes and were not restricted to the NS1 gene. Our results demonstrate that influenza viruses have fine-tuned their entire genomes to evade the interferon response, and by removing interferon-mediated constraints, viruses can mutate at genome positions normally restricted by the interferon response.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107271/1/An_unbiased_genetic_screen_reveals_polygenic.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1098-5514</dc:source><dc:title>An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.</dc:title><rioxxterms:author>Pérez-Cidoncha, M</rioxxterms:author><rioxxterms:author>Killip, MJ</rioxxterms:author><rioxxterms:author>Oliveros, JC</rioxxterms:author><rioxxterms:author>Asensio, VJ</rioxxterms:author><rioxxterms:author>Fernández, Y</rioxxterms:author><rioxxterms:author>Bengoechea, JA</rioxxterms:author><rioxxterms:author>Randall, RE</rioxxterms:author><rioxxterms:author>Ortín, J</rioxxterms:author><rioxxterms:publication_date>2014-05</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1128/JVI.00014-14</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107242
Date: 2015-02-17

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107242</identifier>
      <datestamp>2015-02-17T11:28:44Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>INTRODUCTION: Asthma is now one of the most common long-term conditions in the UK. It is therefore important to develop a comprehensive appreciation of the healthcare and societal costs in order to inform decisions on care provision and planning. We plan to build on our earlier estimates of national prevalence and costs from asthma by filling the data gaps previously identified in relation to healthcare and broadening the field of enquiry to include societal costs. This work will provide the first UK-wide estimates of the costs of asthma. In the context of asthma for the UK and its member countries (ie, England, Northern Ireland, Scotland and Wales), we seek to: (1) produce a detailed overview of estimates of incidence, prevalence and healthcare utilisation; (2) estimate health and societal costs; (3) identify any remaining information gaps and explore the feasibility of filling these and (4) provide insights into future research that has the potential to inform changes in policy leading to the provision of more cost-effective care. &#13;
&#13;
METHODS AND ANALYSIS: Secondary analyses of data from national health surveys, primary care, prescribing, emergency care, hospital, mortality and administrative data sources will be undertaken to estimate prevalence, healthcare utilisation and outcomes from asthma. Data linkages and economic modelling will be undertaken in an attempt to populate data gaps and estimate costs. Separate prevalence and cost estimates will be calculated for each of the UK-member countries and these will then be aggregated to generate UK-wide estimates.&#13;
&#13;
ETHICS AND DISSEMINATION: Approvals have been obtained from the NHS Scotland Information Services Division's Privacy Advisory Committee, the Secure Anonymised Information Linkage Collaboration Review System, the NHS South-East Scotland Research Ethics Service and The University of Edinburgh's Centre for Population Health Sciences Research Ethics Committee. We will produce a report for Asthma-UK, submit papers to peer-reviewed journals and construct an interactive map. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107242/1/Estimating_prevalence_asthma_UK.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>2044-6055</dc:source><dc:title>Estimating the incidence, prevalence and true cost of asthma in the UK: secondary analysis of national stand-alone and linked databases in England, Northern Ireland, Scotland and Wales-a study protocol.</dc:title><rioxxterms:author>Mukherjee, M</rioxxterms:author><rioxxterms:author>Gupta, R</rioxxterms:author><rioxxterms:author>Farr, A</rioxxterms:author><rioxxterms:author>Heaven, M</rioxxterms:author><rioxxterms:author>Stoddart, A</rioxxterms:author><rioxxterms:author>Nwaru, BI</rioxxterms:author><rioxxterms:author>Fitzsimmons, D</rioxxterms:author><rioxxterms:author>Chamberlain, G</rioxxterms:author><rioxxterms:author>Bandyopadhyay, A</rioxxterms:author><rioxxterms:author>Fischbacher, C</rioxxterms:author><rioxxterms:author>Dibben, C</rioxxterms:author><rioxxterms:author>Shields, M</rioxxterms:author><rioxxterms:author>Phillips, C</rioxxterms:author><rioxxterms:author>Strachan, D</rioxxterms:author><rioxxterms:author>Davies, G</rioxxterms:author><rioxxterms:author>McKinstry, B</rioxxterms:author><rioxxterms:author>Sheikh, A</rioxxterms:author><rioxxterms:author>Burden and True Cost of Asthma in the UK Research Team, </rioxxterms:author><rioxxterms:publication_date>2014-11</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/bmjopen-2014-006647</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107220
Date: 2015-02-17

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107220</identifier>
      <datestamp>2015-02-17T14:19:35Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>A mutation in the small GTPase Rab38 gives rise to the mouse coat color phenotype "chocolate" (cht), implicating Rab38 in the regulation of melanogenesis. However, its role remains poorly characterized. We report that cht Rab38(G19V) is inactive and that the nearly normal pigmentation in cht melanocytes results from functional compensation by the closely related Rab32. In cht cells treated with Rab32-specific small interfering RNA, a dramatic loss of pigmentation is observed. In addition to mature melanosomes, Rab38 and Rab32 localize to perinuclear vesicles carrying tyrosinase and tyrosinase-related protein 1, consistent with a role in the intracellular sorting of these proteins. In Rab38/Rab32-deficient cells, tyrosinase appears to be mistargeted and degraded after exit from the trans-Golgi network (TGN). This suggests that Rab38 and Rab32 regulate a critical step in the trafficking of melanogenic enzymes, in particular, tyrosinase, from the TGN to melanosomes. This work identifies a key role for the Rab38/Rab32 subfamily of Rab proteins in the biogenesis of melanosomes and potentially other lysosome-related organelles.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107220/1/Rab38_rab32_control.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Rockefeller University Press</dc:publisher><dc:source>1540-8140</dc:source><dc:title>Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.</dc:title><rioxxterms:author>Wasmeier, C</rioxxterms:author><rioxxterms:author>Romao, M</rioxxterms:author><rioxxterms:author>Plowright, L</rioxxterms:author><rioxxterms:author>Bennett, DC</rioxxterms:author><rioxxterms:author>Raposo, G</rioxxterms:author><rioxxterms:author>Seabra, MC</rioxxterms:author><rioxxterms:publication_date>2006-10-23</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1083/jcb.200606050</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107219
Date: 2015-02-17

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107219</identifier>
      <datestamp>2015-02-17T11:34:05Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Associations between circulating markers of dysglycaemia and coronary heart disease (CHD) risk in people without diabetes have not been reliably characterised. We report new data from a prospective study and a systematic review to help quantify these associations.&#13;
&#13;
METHODS AND FINDINGS: Fasting and post-load glucose levels were measured in 18,569 participants in the population-based Reykjavik study, yielding 4,664 incident CHD outcomes during 23.5 y of mean follow-up. In people with no known history of diabetes at the baseline survey, the hazard ratio (HR) for CHD, adjusted for several conventional risk factors, was 2.37 (95% CI 1.79-3.14) in individuals with fasting glucose &gt; or = 7.0 mmol/l compared to those &lt; 7 mmol/l. At fasting glucose values below 7 mmol/l, adjusted HRs were 0.95 (0.89-1.01) per 1 mmol/l higher fasting glucose and 1.03 (1.01-1.05) per 1 mmol/l higher post-load glucose. HRs for CHD risk were generally modest and nonsignificant across tenths of glucose values below 7 mmol/l. We did a meta-analysis of 26 additional relevant prospective studies identified in a systematic review of Western cohort studies that recorded fasting glucose, post-load glucose, or glycated haemoglobin (HbA(1c)) levels. In this combined analysis, in which participants with a self-reported history of diabetes and/or fasting blood glucose &gt; or = 7 mmol/l at baseline were excluded, relative risks for CHD, adjusted for several conventional risk factors, were: 1.06 (1.00-1.12) per 1 mmol/l higher fasting glucose (23 cohorts, 10,808 cases, 255,171 participants); 1.05 (1.03-1.07) per 1 mmol/l higher post-load glucose (15 cohorts, 12,652 cases, 102,382 participants); and 1.20 (1.10-1.31) per 1% higher HbA(1c) (9 cohorts, 1639 cases, 49,099 participants).&#13;
&#13;
CONCLUSIONS: In the Reykjavik Study and a meta-analysis of other Western prospective studies, fasting and post-load glucose levels were modestly associated with CHD risk in people without diabetes. The meta-analysis suggested a somewhat stronger association between HbA(1c) levels and CHD risk. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107219/1/Markers_dysglycaemia.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1549-1676</dc:source><dc:title>Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review.</dc:title><rioxxterms:author>Sarwar, N</rioxxterms:author><rioxxterms:author>Aspelund, T</rioxxterms:author><rioxxterms:author>Eiriksdottir, G</rioxxterms:author><rioxxterms:author>Gobin, R</rioxxterms:author><rioxxterms:author>Seshasai, SR</rioxxterms:author><rioxxterms:author>Forouhi, NG</rioxxterms:author><rioxxterms:author>Sigurdsson, G</rioxxterms:author><rioxxterms:author>Danesh, J</rioxxterms:author><rioxxterms:author>Gudnason, V</rioxxterms:author><rioxxterms:publication_date>2010-05-25</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pmed.1000278</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107196
Date: 2015-02-17

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107196</identifier>
      <datestamp>2015-02-17T11:31:24Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Short-term changes in ambient particulate matter with aerodynamic diameters &lt; 10 micro m (PM10) have been associated with short-term fluctuations in mortality or morbidity in many studies. In this study, we tested whether those deaths are just advanced by a few days or weeks using a multicity hierarchical modeling approach for all-cause, respiratory, and cardiovascular deaths, for all ages and stratifying by age groups, within the APHEA-2 (Air Pollution and Health: A European Approach) project. We fit a Poisson regression and used an unconstrained distributed lag to model the effect of PM10 exposure on deaths up to 40 days after the exposure. In baseline models using PM10 the day of and day before the death, we found that the overall PM10 effect (per 10 micro g/m3) was 0.74% [95% confidence interval (95% CI), -0.17 to 1.66] for respiratory deaths and 0.69% (95% CI, 0.31-1.08) for cardiovascular deaths. In unrestricted distributed lag models, the effect estimates increased to 4.2% (95% CI, 1.08-7.42) for respiratory deaths and to 1.97% (95% CI, 1.38-2.55) for cardiovascular deaths. Our study confirms that most of the effect of air pollution is not simply advanced by a few weeks and that effects persist for more than a month after exposure. The effect size estimate for PM10 doubles when we considered longer-term effects for all deaths and for cardiovascular deaths and becomes five times higher for respiratory deaths. We found similar effects when stratifying by age groups. These larger effects are important for risk assessment.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107196/1/ehp0111%2D001188.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000184992700029&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0091-6765</dc:source><dc:title>The temporal pattern of respiratory and heart disease mortality in response to air pollution</dc:title><rioxxterms:author>Zanobetti, A</rioxxterms:author><rioxxterms:author>Schwartz, J</rioxxterms:author><rioxxterms:author>Samoli, E</rioxxterms:author><rioxxterms:author>Gryparis, A</rioxxterms:author><rioxxterms:author>Touloumi, G</rioxxterms:author><rioxxterms:author>Peacock, J</rioxxterms:author><rioxxterms:author>Anderson, RH</rioxxterms:author><rioxxterms:author>Le Tertre, A</rioxxterms:author><rioxxterms:author>Bobros, J</rioxxterms:author><rioxxterms:author>Celko, M</rioxxterms:author><rioxxterms:author>Goren, A</rioxxterms:author><rioxxterms:author>Forsberg, B</rioxxterms:author><rioxxterms:author>Michelozzi, P</rioxxterms:author><rioxxterms:author>Rabczenko, D</rioxxterms:author><rioxxterms:author>Hoyos, SP</rioxxterms:author><rioxxterms:author>Wichmann, HE</rioxxterms:author><rioxxterms:author>Katsouyanni, K</rioxxterms:author><rioxxterms:publication_date>2003-07-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107195
Date: 2015-02-12

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      <datestamp>2015-02-12T15:22:30Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Certain short-chain carboxylic acids (SCCA) appear to share a common teratogenic potential, although the structural requirements for activity remain obscure. By using a whole rat embryo culture model system, several biochemical processes have been examined, either as potential initial sites of teratogenic action or as early steps in the pathway to malformation. Valproate, methoxyacetate, and butyrate were the prototype SCCA examined. Measurement of [14C]glucose utilization and lactate production confirmed that energy production by the early organogenesis embryo is predominantly from glycolysis. While the positive control agent, iodoacetate, caused a significant inhibition of lactate production, none of the SCCA affected this process or glucose utilization at teratogenic concentrations. Valproate did not influence embryonic acetyl CoA levels, in marked contrast to the reported response of adult liver, the other major target of valproate toxicity. Pinocytosis by the visceral yolk sac (VYS) was measured by the uptake of [125I]polyvinylpyrrolidone. This process ultimately supplies the embryo with amino-acids and is essential for normal development. SCCA induce morphological abnormalities of the VYS in embryo culture. Pinocytosis was slightly reduced by valporate, but not the other SCCA. However, comparison with the action of an antiserum, for which inhibition of pinocytosis is the initial teratogenic insult, suggests that this is not the mechanism for valproate. Incorporation of [3H]thymidine into embryo or yolk sac was not affected after 3 hr of SCCA exposure, but there was a marked effect of the positive control, hydroxyurea. This suggests that DNA synthesis is not directly influenced by SCCA.(ABSTRACT TRUNCATED AT 250 WORDS)</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107195/1/envhper00441%2D0100.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>NATL INST ENVIRON HEALTH SCI</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=A1986G349000011&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0091-6765</dc:source><dc:title>SHORT-CHAIN CARBOXYLIC-ACIDS, A NEW CLASS OF TERATOGENS - STUDIES OF POTENTIAL BIOCHEMICAL-MECHANISMS</dc:title><rioxxterms:author>Coakley, ME</rioxxterms:author><rioxxterms:author>Rawlings, SJ</rioxxterms:author><rioxxterms:author>Brown, NA</rioxxterms:author><rioxxterms:publication_date>1986-12-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107182
Date: 2017-03-27

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    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107182</identifier>
      <datestamp>2017-03-27T15:17:11Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107182/8/art%253A10.1186%252F1752%2D153X%2D4%2D2.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BIOMED CENTRAL LTD</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000274691100001&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1752-153X</dc:source><dc:title>Correction: Determination of metal ion content of&#13;
beverages and estimation of target hazard&#13;
quotients: a comparative study</dc:title><dcterms:dateAccepted>2010-02-01</dcterms:dateAccepted><rioxxterms:author>Hague, T</rioxxterms:author><rioxxterms:author>Petroczi, A</rioxxterms:author><rioxxterms:author>Andrews, PLR</rioxxterms:author><rioxxterms:author>Barker, J</rioxxterms:author><rioxxterms:author>Naughton, DP</rioxxterms:author><rioxxterms:publication_date>2010-02-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1752-153X-4-2</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107179
Date: 2015-02-12

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107179</identifier>
      <datestamp>2015-02-12T15:18:04Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Short-term effects of air pollution on daily mortality in eight western and five central-eastern European countries have been reported previously, as part of the APHEA project. One intriguing finding was that the effects were lower in central-eastern European cities. The analysis used sinusoidal terms for seasonal control and polynomial terms for meteorologic variables, but this is a more rigid approach than the currently accepted method, which uses generalized additive models (GAM). We therefore reanalyzed the original data to examine the sensitivity of the results to the statistical model. The data were identical to those used in the earlier analyses. The outcome was the daily total number of deaths, and the pollutants analyzed were black smoke (BS) and sulfur dioxide (SO(2)). The analyses were restricted to days with pollutant concentration &lt; 200 microg/m(3) and &lt; 150 microg/m(3) alternately. We used Poisson regression in a GAM model, and combined individual city regression coefficients using fixed and random-effect models. An increase in BS by 50 microg/m(3) was associated with a 2.2% and 3.1% increase in mortality when analysis was restricted to days &lt; 200 microg/m(3) and &lt; 150 microg/m(3), respectively. The corresponding figures were 5.0% and 5.6% for a similar increase in SO(2). These estimates are larger than the ones published previously: by 69% for BS and 55% for SO(2). The increase occurred only in central-eastern European cities. The ratio of western to central-eastern cities for estimates was reduced to 1.3 for BS (previously 4.8) and 2.6 for SO(2) (previously 4.4). We conclude that part of the heterogeneity in the estimates of air pollution effects between western and central-eastern cities reported in previous publications was caused by the statistical approach used and the inclusion of days with pollutant levels above 150 microg/m(3). However, these results must be investigated further. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107179/1/ehp0109%2D000349.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000168413600024&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0091-6765</dc:source><dc:title>Investigating regional differences in short-term effects of air pollution on daily mortality in the APHEA project: A sensitivity analysis for controlling long-term trends and seasonality</dc:title><rioxxterms:author>Samoli, E</rioxxterms:author><rioxxterms:author>Schwartz, J</rioxxterms:author><rioxxterms:author>Wojtyniak, B</rioxxterms:author><rioxxterms:author>Touloumi, G</rioxxterms:author><rioxxterms:author>Spix, C</rioxxterms:author><rioxxterms:author>Balducci, F</rioxxterms:author><rioxxterms:author>Medina, S</rioxxterms:author><rioxxterms:author>Rossi, G</rioxxterms:author><rioxxterms:author>Sunyer, J</rioxxterms:author><rioxxterms:author>Bacharova, L</rioxxterms:author><rioxxterms:author>Anderson, HR</rioxxterms:author><rioxxterms:author>Katsouyanni, K</rioxxterms:author><rioxxterms:publication_date>2001-04-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107161
Date: 2015-04-16

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107161</identifier>
      <datestamp>2015-04-16T09:37:04Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objective:The objective of this study is to estimate life expectancies of HIV-positive patients conditional on response to antiretroviral therapy (ART).&#13;
&#13;
Methods: Patients aged more than 20 years who started ART during 2000–2010 (excluding IDU) in HIV clinics contributing to the UK CHIC Study were followed for mortality until 2012. We determined the latest CD4+ cell count and viral load before ART and in each of years 1–5 of ART. For each duration of ART, life tables based on estimated mortality rates by sex, age, latest CD4+ cell count and viral suppression (HIV-1 RNA &lt;400copies/ml), were used to estimate expected age at death for ages 20–85 years.&#13;
&#13;
Results: Of 21388 patients who started ART, 961 (4.5%) died during 110697 person-years. At start of ART, expected age at death [95% confidence interval (CI)] of 35-year-old men with CD4+ cell count less than 200, 200–349, at least 350cells/μl was 71 (68–73), 78 (74–82) and 77 (72–81) years, respectively, compared with 78 years for men in the general UK population. Thirty-five-year-old men who increased their CD4+ cell count in the first year of ART from less than 200 to 200–349 or at least 350cells/μl and achieved viral suppression gained 7 and 10 years, respectively. After 5 years on ART, expected age at death of 35-year-old men varied from 54 (48–61) (CD4+ cell count &lt;200cells/μl and no viral suppression) to 80 (76–83) years (CD4+ cell count ≥350cells/μl and viral suppression).&#13;
&#13;
Conclusion: Successfully treated HIV-positive individuals have a normal life expectancy. Patients who started ART with a low CD4+ cell count significantly improve their life expectancy if they have a good CD4+ cell count response and undetectable viral load.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107161/1/aids%2D28%2D1193.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>LIPPINCOTT WILLIAMS &amp; WILKINS</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000335654000012&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0269-9370</dc:source><dc:title>Impact on life expectancy of HIV-1 positive individuals of CD4(+) cell count and viral load response to antiretroviral therapy</dc:title><rioxxterms:author>May, MT</rioxxterms:author><rioxxterms:author>Gompels, M</rioxxterms:author><rioxxterms:author>Delpech, V</rioxxterms:author><rioxxterms:author>Porter, K</rioxxterms:author><rioxxterms:author>Orkin, C</rioxxterms:author><rioxxterms:author>Kegg, S</rioxxterms:author><rioxxterms:author>Hay, P</rioxxterms:author><rioxxterms:author>Johnson, M</rioxxterms:author><rioxxterms:author>Palfreeman, A</rioxxterms:author><rioxxterms:author>Gilson, R</rioxxterms:author><rioxxterms:author>Chadwick, D</rioxxterms:author><rioxxterms:author>Martin, F</rioxxterms:author><rioxxterms:author>Hill, T</rioxxterms:author><rioxxterms:author>Walsh, J</rioxxterms:author><rioxxterms:author>Post, F</rioxxterms:author><rioxxterms:author>Fisher, M</rioxxterms:author><rioxxterms:author>Ainsworth, J</rioxxterms:author><rioxxterms:author>Jose, S</rioxxterms:author><rioxxterms:author>Leen, C</rioxxterms:author><rioxxterms:author>Nelson, M</rioxxterms:author><rioxxterms:author>Anderson, J</rioxxterms:author><rioxxterms:author>Sabin, C</rioxxterms:author><rioxxterms:author>UK Collaborative HIV Cohort (UK CHIC) Study, </rioxxterms:author><rioxxterms:publication_date>2014-05-15</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1097/QAD.0000000000000243</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107152
Date: 2015-02-12

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107152</identifier>
      <datestamp>2015-02-12T14:55:22Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107152/1/rcse9502%2D96.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>ROYAL COLLEGE OF SURGEONS ENGLAND</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000316593600003&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0035-8843</dc:source><dc:title>Improving the outcomes from ruptured abdominal aortic aneurysm: interdisciplinary best practice guidelines</dc:title><rioxxterms:author>Hinchliffe, RJ</rioxxterms:author><rioxxterms:author>Powell, JT</rioxxterms:author><rioxxterms:publication_date>2013-03-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1308/003588413X13511609956778</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107148
Date: 2015-02-17

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107148</identifier>
      <datestamp>2015-02-17T15:10:09Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objective:To understand lay beliefs and attitudes, religious teachings, and professional perceptions in relation to diabetes prevention in the Bangladeshi community.&#13;
&#13;
Design: Qualitative study (focus groups and semistructured interviews).&#13;
&#13;
Setting: Tower Hamlets, a socioeconomically deprived London borough, United Kingdom.&#13;
&#13;
Participants: Bangladeshi people without diabetes (phase 1), religious leaders and Islamic scholars (phase 2), and health professionals (phase 3).&#13;
&#13;
Methods: 17 focus groups were run using purposive sampling in three sequential phases. Thematic analysis was used iteratively to achieve progressive focusing and to develop theory. To explore tensions in preliminary data fictional vignettes were created, which were discussed by participants in subsequent phases. The PEN-3 multilevel theoretical framework was used to inform data analysis and synthesis.&#13;
&#13;
Results: Most lay participants accepted the concept of diabetes prevention and were more knowledgeable than expected. Practical and structural barriers to a healthy lifestyle were commonly reported. There was a strong desire to comply with cultural norms, particularly those relating to modesty. Religious leaders provided considerable support from Islamic teachings for messages about diabetes prevention. Some clinicians incorrectly perceived Bangladeshis to be poorly informed and fatalistic, although they also expressed concerns about their own limited cultural understanding.&#13;
&#13;
Conclusion: Contrary to the views of health professionals and earlier research, poor knowledge was not the main barrier to healthy lifestyle choices. The norms and expectations of Islam offer many opportunities for supporting diabetes prevention. Interventions designed for the white population, however, need adaptation before they will be meaningful to many Bangladeshis. Religion may have an important part to play in supporting health promotion in this community. The potential for collaborative working between health educators and religious leaders should be explored further and the low cultural understanding of health professionals addressed.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107148/1/bmj.a1931.full.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>B M J PUBLISHING GROUP</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000261235900001&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0959-535X</dc:source><dc:title>Prevention of type 2 diabetes in British Bangladeshis: qualitative study of community, religious, and professional perspectives</dc:title><rioxxterms:author>Grace, C</rioxxterms:author><rioxxterms:author>Begum, R</rioxxterms:author><rioxxterms:author>Subhani, S</rioxxterms:author><rioxxterms:author>Kopelman, P</rioxxterms:author><rioxxterms:author>Greenhalgh, T</rioxxterms:author><rioxxterms:publication_date>2008-11-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/bmj.a1931</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107146
Date: 2015-02-10

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107146</identifier>
      <datestamp>2015-02-10T11:31:39Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R). Individuals with this condition typically present in infancy or childhood with signs and symptoms of cortisol insufficiency, but disturbances in the renin-angiotensin system, aldosterone synthesis or sodium homeostasis are not a well-documented association of FGD1. As ACTH stimulation has been shown to stimulate aldosterone release in normal controls, and other causes of hyponatraemia can occur in children with cortisol deficiency, we investigated whether MC2R changes might be identified in children with primary adrenal failure who were being treated for mineralocorticoid insufficiency.&#13;
&#13;
Design: Mutational analysis of MC2R by direct sequencing.&#13;
&#13;
Patients: Children (n = 22) who had been diagnosed with salt-losing forms of adrenal hypoplasia (19 isolated cases, 3 familial), and who were negative for mutations in DAX1 (NR0B1) and SF1 (NR5A1).&#13;
&#13;
Results: MC2R mutations were found in three individuals or kindred (I: homozygous S74I; II: novel compound heterozygous R146H/560delT; III: novel homozygous 579-581delTGT). These changes represent severely disruptive loss-of-function mutations in this G-protein coupled receptor, including the first reported homozygous frameshift mutation. The apparent disturbances in sodium homeostasis were mild, manifest at times of stress (e.g. infection, salt-restriction, heat), and likely resolved with time.&#13;
&#13;
Conclusions: MC2R mutations should be considered in children who have primary adrenal failure with apparent mild disturbances in renin-sodium homeostasis. These children may have been misdiagnosed as having salt-losing adrenal hypoplasia. Making this diagnosis has important implications for treatment, counselling and long-term prognosis</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107146/1/j.1365%2D2265.2006.02709.x.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>WILEY-BLACKWELL</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000243441600008&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0300-0664</dc:source><dc:title>Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia</dc:title><rioxxterms:author>Lin, L</rioxxterms:author><rioxxterms:author>Hindmarsh, PC</rioxxterms:author><rioxxterms:author>Metherell, LA</rioxxterms:author><rioxxterms:author>Alzyoud, M</rioxxterms:author><rioxxterms:author>Al-Ali, M</rioxxterms:author><rioxxterms:author>Brain, CE</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:author>Dattani, MT</rioxxterms:author><rioxxterms:author>Achermann, JC</rioxxterms:author><rioxxterms:publication_date>2007-02-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1365-2265.2006.02709.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107145
Date: 2015-02-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107145</identifier>
      <datestamp>2015-02-10T13:22:44Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objective: The polymorphic deletion of exon 3 of the GH receptor (d3-GHR) has recently been linked to the magnitude of growth response to recombinant human GH (rhGH) therapy in short children with or without GH deficiency. We investigated this association in a large multinational cohort from the Network of European Studies of Genes in Growth (NESTEGG), comprising short children born small for gestational age (SGA).&#13;
&#13;
Design: The study included short prepubertal SGA children treated with rhGH for 1 or 2 years.&#13;
&#13;
Population: Two hundred and forty white Caucasian SGA children (138 male, 102 female) aged 6·6 ± 2·3 years with a height at –3·0 ± 0·7 SDS at start of rhGH treatment; 193 ethnically matched controls.&#13;
&#13;
Methods: The GHR polymorphism (fl/fl, fl/d3 or d3/d3) was genotyped by polymerase chain reaction (PCR) multiplex assay. Growth velocity (G/V) in cm/year and changes in GV during the first and second year of rhGH treatment were evaluated.&#13;
&#13;
Results: The change in GV was significantly greater in SGA children carrying one or two copies of the d3-GHR allele (P = 0·038 for the first year and P = 0·041 for the second year of GH treatment), but the change in height was not significantly different. Birthweight was significantly lower in SGA children with the d3/d3 genotype than in SGA children with the fl/fl genotype (P = 0·034) and in those with the fl/d3 genotype (P = 0·016).&#13;
&#13;
Conclusion: Our data, based on a large cohort, showed that the exon 3 GHR polymorphism is associated with responsiveness to rhGH treatment in SGA children with short stature.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107145/1/j.1365%2D2265.2007.02911.x.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BLACKWELL PUBLISHING</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000248978000021&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0300-0664</dc:source><dc:title>GH responsiveness in a large multinational cohort of SGA children with short stature (NESTEGG) is related to the exon 3 GHR polymorphism</dc:title><rioxxterms:author>Tauber, M</rioxxterms:author><rioxxterms:author>Ester, W</rioxxterms:author><rioxxterms:author>Auriol, F</rioxxterms:author><rioxxterms:author>Molinas, C</rioxxterms:author><rioxxterms:author>Fauvel, J</rioxxterms:author><rioxxterms:author>Caliebe, J</rioxxterms:author><rioxxterms:author>Nugent, T</rioxxterms:author><rioxxterms:author>Fryklund, L</rioxxterms:author><rioxxterms:author>Ranke, MB</rioxxterms:author><rioxxterms:author>Savage, MO</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:author>Johnston, LB</rioxxterms:author><rioxxterms:author>Hokken-Koelega, AC</rioxxterms:author><rioxxterms:author>NESTEGG group, </rioxxterms:author><rioxxterms:publication_date>2007-09-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1365-2265.2007.02911.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107144
Date: 2015-02-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107144</identifier>
      <datestamp>2015-02-10T13:25:53Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterised by isolated glucocorticoid deficiency. Mutations in the ACTH receptor/melanocortin 2 receptor (MC2R), the MC2R accessory protein (MRAP) or the STAR protein (STAR) cause FGD types 1, 2 and 3, respectively, accounting for ∼50% of all cases.&#13;
&#13;
Patient and methods We report a neonate of Indian origin, who was diagnosed with FGD in the first few days of life. He presented with hypoglycaemic seizures and was noted to have generalised intense hyperpigmentation and normal male genitalia. Biochemical investigations revealed hypocortisolaemia (cortisol 0.223 μg/dl; NR 1–23 μg/dl) and elevated plasma ACTH (170 pg/ml). Serum electrolytes, aldosterone and plasma renin activity were normal. Peak cortisol following a standard synacthen test was 0.018 μg/dl. He responded to hydrocortisone treatment and continues on replacement. Patient DNA was analysed by direct sequencing. The effect of the novel mutation was assessed by an in vitro splicing assay using wild type and mutant heterologous minigenes.&#13;
&#13;
Results A novel homozygous mutation c.106+2_3dupTA was found in the MRAP gene. Both parents were heterozygous for the mutation. In an in vitro splicing assay, the mutation resulted in the skipping of exon 3.&#13;
&#13;
Conclusion We have identified a novel MRAP mutation where disruption of the intron 3 splice-site results in a prematurely terminated translation product. This protein (if produced) would lack the transmembrane domain that is essential for MC2R interaction. We predict that this would cause complete lack of ACTH response thus explaining the early presentation in this case.&#13;
</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107144/1/987.full.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BIOSCIENTIFICA LTD</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000297687900018&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0804-4643</dc:source><dc:title>Neonatal presentation of familial glucocorticoid deficiency resulting from a novel splice mutation in the melanocortin 2 receptor accessory protein</dc:title><rioxxterms:author>Jain, V</rioxxterms:author><rioxxterms:author>Metherell, LA</rioxxterms:author><rioxxterms:author>David, A</rioxxterms:author><rioxxterms:author>Sharma, R</rioxxterms:author><rioxxterms:author>Sharma, PK</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:author>Chan, LF</rioxxterms:author><rioxxterms:publication_date>2011-12-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1530/EJE-11-0581</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107129
Date: 2015-02-19

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107129</identifier>
      <datestamp>2015-02-19T08:58:19Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR) (MIM No.152950) is a rare autosomal dominant condition for which a causative gene has recently been identified. Mutations in the kinesin family member 11 (KIF11) gene have now been described in 16 families worldwide. This is a review of the condition based on the clinical features of 37 individuals from 22 families. This report includes nine previously unreported families and additional information for some of those reported previously. The condition arose de novo in 8/20 families (40%). The parental results were not available for two probands. The mutations were varied and include missense, nonsense, frameshift, and splice site and are distributed evenly throughout the KIF11 gene. In our cohort, 86% had microcephaly, 78% had an ocular abnormality consistent with the diagnosis, 46% had lymphoedema, 73% had mild-moderate learning difficulties, 8% had epilepsy, and 8% had a cardiac anomaly. We identified three individuals with KIF11 mutations but no clinical features of MCLMR demonstrating reduced penetrance. The variable expression of the phenotype and the presence of mildly affected individuals indicates that the prevalence may be higher than expected, and we would therefore recommend a low threshold for genetic testing.</dc:description><dc:format>ERROR: cannot open `/www/sgul/eprints3/archives/sgul/documents/disk0/00/10/71/29/01/Jones' (No such file or directory)
ERROR: cannot open `et' (No such file or directory)
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ERROR: cannot read `(null)' (Bad</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107129/1/Jones%20et%20al%20%2D%20AMENDED%20further%20revisions.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>NATURE PUBLISHING GROUP</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000338342700009&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1018-4813</dc:source><dc:title>Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations</dc:title><rioxxterms:author>Jones, GE</rioxxterms:author><rioxxterms:author>Ostergaard, P</rioxxterms:author><rioxxterms:author>Moore, AT</rioxxterms:author><rioxxterms:author>Connell, FC</rioxxterms:author><rioxxterms:author>Williams, D</rioxxterms:author><rioxxterms:author>Quarrell, O</rioxxterms:author><rioxxterms:author>Brady, AF</rioxxterms:author><rioxxterms:author>Spier, I</rioxxterms:author><rioxxterms:author>Hazan, F</rioxxterms:author><rioxxterms:author>Moldovan, O</rioxxterms:author><rioxxterms:author>Wieczorek, D</rioxxterms:author><rioxxterms:author>Mikat, B</rioxxterms:author><rioxxterms:author>Petit, F</rioxxterms:author><rioxxterms:author>Coubes, C</rioxxterms:author><rioxxterms:author>Saul, RA</rioxxterms:author><rioxxterms:author>Brice, G</rioxxterms:author><rioxxterms:author>Gordon, K</rioxxterms:author><rioxxterms:author>Jeffery, S</rioxxterms:author><rioxxterms:author>Mortimer, PS</rioxxterms:author><rioxxterms:author>Vasudevan, PC</rioxxterms:author><rioxxterms:author>Mansour, S</rioxxterms:author><rioxxterms:publication_date>2014-07-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>AM</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/ejhg.2013.263</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107120
Date: 2015-02-20

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107120</identifier>
      <datestamp>2015-02-20T10:05:27Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>AIM:&#13;
The human embryo-maternal interface in the first trimester of pregnancy is an area of extensive tissue remodeling. Because collagen is the most abundant constituent of the extracellular matrix of the placental bed, successful invasion must involve its rapid turnover. We compared the nature and distribution of collagen fibrils in decidua basalis and parietalis.&#13;
METHODS:&#13;
We used a direct-vision hysteroscopic technique to obtain biopsies of the decidua basalis and parietalis from 11 women undergoing pregnancy termination in the first trimester. The biopsies were subjected to light, transmission and scanning electron microscopy, and immunohistochemical studies using mouse monoclonal antibodies against cytokeratin 7 and collagen types I, III and V.&#13;
RESULTS:&#13;
Collagen fibrils in the stroma of decidua basalis were significantly thicker when compared to those in decidua parietalis (56.48 ± 1.37 nm vs 45.64 ± 0.85 nm; P &lt; 0.0001 [mean ± standard error]) between 9 and 12 weeks gestation, but this difference in thickness was not observed at gestations below 9 weeks. In basalis, the fibrils appeared disrupted at most places surrounding the decidual/trophoblast cells while a uniform regular arrangement was preserved throughout most of parietalis.&#13;
&#13;
CONCLUSION:&#13;
There are differences in the ultrastructure of collagen fibrils between basalis and parietalis, with thicker and disrupted fibrils within abundant amorphous tissue in basalis, and thinner uniform fibrils in parietalis. These differences may reflect an adaptive response by decidua or a direct consequence of the invading trophoblast cells.</dc:description><dc:format>application/x-zip</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107120/2/licence.docx</dc:identifier><dc:language>en</dc:language><dc:publisher>WILEY-BLACKWELL</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000329141700012&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1341-8076</dc:source><dc:title>Differences in collagen ultrastructure of human first trimester decidua basalis and parietalis: Implications for trophoblastic invasion of the placental bed</dc:title><rioxxterms:author>Sinai Talaulikar, V</rioxxterms:author><rioxxterms:author>Kronenberger, K</rioxxterms:author><rioxxterms:author>Bax, BE</rioxxterms:author><rioxxterms:author>Moss, R</rioxxterms:author><rioxxterms:author>Manyonda, I</rioxxterms:author><rioxxterms:publication_date>2014-01-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/jog.12127</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107119
Date: 2016-07-12

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107119</identifier>
      <datestamp>2016-07-12T16:22:14Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP. TP deficiency leads to plasma and tissue accumulations of thymidine and deoxyuridine which generate imbalances within the mitochondrial nucleotide pools, ultimately leading to mitochondrial dysfunction.1 MNGIE is characterized clinically by leukoencephalopathy, external ophthalmoplegia, peripheral polyneuropathy, cachexia, and enteric neuromyopathy manifesting as gastrointestinal dysmotility. The condition is relentlessly progressive, with patients usually dying from a combination of nutritional and neuromuscular failure at an average age of 37 years.2 Allogeneic hematopoietic stem cell transplantation (AHSCT) offers a permanent cure. Clinical and biochemical improvements following AHSCT have been reported but it carries a high mortality risk and is limited by matched donor availability.3 A consensus proposal for standardizing AHSCT recommends treatment of patients without irreversible end-stage disease and with an optimally matched donor; a majority of patients are ineligible and thus there is a critical requirement for an alternative treatment.</dc:description><dc:format>application/x-zip</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107119/7/licence.docx</dc:identifier><dc:language>en</dc:language><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/23966250</dc:relation><dc:source>0028-3878</dc:source><dc:title>Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement.</dc:title><rioxxterms:author>Bax, BE</rioxxterms:author><rioxxterms:author>Bain, MD</rioxxterms:author><rioxxterms:author>Scarpelli, M</rioxxterms:author><rioxxterms:author>Filosto, M</rioxxterms:author><rioxxterms:author>Tonin, P</rioxxterms:author><rioxxterms:author>Moran, N</rioxxterms:author><rioxxterms:publication_date>2013-10-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1212/WNL.0b013e3182a6cb4b</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107091
Date: 2016-03-23

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107091</identifier>
      <datestamp>2016-03-23T10:20:30Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2014-03-11">http://creativecommons.org/licenses/by/2.0/</ali:license_ref><dc:description>Background: In pregnancies complicated by early-onset extreme fetal growth restriction, there is a high risk of&#13;
preterm birth and an overall dismal fetal prognosis. Sildenafil has been suggested to improve this prognosis.&#13;
The first aim of this review is to assess whether sildenafil benefits or harms these babies. The second aim is to analyse if these effects are modified in a clinically meaningful way by factors related to the women or the trial&#13;
protocol.&#13;
&#13;
Methods/Design: The STRIDER (Sildenafil Therapy In Dismal prognosis Early-onset intrauterine growth Restriction)&#13;
Individual Participant Data (IPD) Study Group will conduct a prospective IPD and aggregate data systematic review with&#13;
meta-analysis and trial sequential analysis. The STRIDER IPD Study Group started trial planning and funding applications in 2012. Three trials will be launched in 2014, recruiting for three years. Further trials are planned to commence in 2015. The primary outcome for babies is being alive at term gestation without evidence of serious adverse neonatal outcome. The latter is defined as severe central nervous system injury (severe intraventricular haemorrhage (grade 3 and 4) or cystic periventricular leukomalacia, demonstrated by ultrasound and/or magnetic resonance imaging) or other severe morbidity (bronchopulmonary dysplasia, retinopathy of prematurity requiring treatment, or necrotising enterocolitis requiring surgery). The secondary outcomes are improved fetal growth velocity assessed by ultrasound&#13;
abdominal circumference measurements, gestational age and birth weight (centile) at delivery, and age-adequate&#13;
performance on the two-year Bayley scales of infant and toddler development-III (composite cognitive score&#13;
and composite motor score). Subgroup and sensitivity analyses in the IPD meta-analysis include assessment of&#13;
the influence of several patient characteristics: an abnormal or normal serum level of placental growth factor,&#13;
absent/reversed umbilical arterial end diastolic flow at commencement of treatment, and other patient characteristics&#13;
available at baseline such as gestational age and estimated fetal weight. The secondary outcomes for mothers include&#13;
co-incidence and severity of the maternal syndrome of pre-eclampsia, mortality, and other serious adverse events.&#13;
&#13;
Discussion: Trials are expected to start in 2013–2014 and end in 2016–2017. Data analyses of individual trials are&#13;
expected to finish in 2019. Given the pre-planned and agreed IPD protocol, these results should be available in 2020</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107091/1/2046%2D4053%2D3%2D23.pdf</dc:identifier><dc:language>en</dc:language><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/24618418</dc:relation><dc:source>2046-4053</dc:source><dc:title>STRIDER: Sildenafil Therapy In Dismal prognosis Early-onset intrauterine growth Restriction--a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis.</dc:title><rioxxterms:author>Ganzevoort, W</rioxxterms:author><rioxxterms:author>Alfirevic, Z</rioxxterms:author><rioxxterms:author>von Dadelszen, P</rioxxterms:author><rioxxterms:author>Kenny, L</rioxxterms:author><rioxxterms:author>Papageorghiou, A</rioxxterms:author><rioxxterms:author>van Wassenaer-Leemhuis, A</rioxxterms:author><rioxxterms:author>Gluud, C</rioxxterms:author><rioxxterms:author>Mol, BW</rioxxterms:author><rioxxterms:author>Baker, PN</rioxxterms:author><rioxxterms:publication_date>2014-03-11</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/2046-4053-3-23</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107073
Date: 2015-02-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107073</identifier>
      <datestamp>2015-02-10T13:28:56Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background: The leukocyte common antigen related receptor (LAR) protein has been shown to modulate the signal transduction of a number of different growth factors, including insulin and insulin-like growth factor 1. Splice variants exhibit differing roles and are expressed according to tissue type and developmental stage.&#13;
&#13;
Results: Using 5'RACE, we identified a 5'UTR within intron 11 of the rat LAR gene. We demonstrated that this gives rise to a novel isoform of the LAR transcript encoded from the identified region within intron 11. By priming across the site from exon 11 to exon 15 we show that the novel 5'UTR is not represented in the full-length transcript and thus, it produces a truncated form of the LAR mRNA. We examined the tissue distribution of this novel isoform and&#13;
found it to be exclusively expressed in liver. We additionally identified a liver specific 150 kDa band&#13;
with western blotting which we propose may represent the protein product of the novel transcript. Luciferase assays showed the region immediately upstream of the 5'UTR to possesses considerable promoter activity and that this may be conferred by the presence of a number of putative binding&#13;
sites for liver enriched transcription factors.&#13;
&#13;
Conclusion: In summary, we describe a novel, liver specific, truncated isoform of the LAR transcript transcribed under the control of an intronic promoter, potentially representing a previously unidentified modulator of hepatic insulin signalling.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107073/1/1471%2D2199%2D10%2D30.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BIOMED CENTRAL LTD</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000265849700002&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1471-2199</dc:source><dc:title>A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5 ' UTR located within intron 11</dc:title><rioxxterms:author>Welham, SJ</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:author>Salter, AM</rioxxterms:author><rioxxterms:publication_date>2009-04-08</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1471-2199-10-30</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107053
Date: 2015-02-10

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107053</identifier>
      <datestamp>2015-02-10T13:31:10Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background: Most services provided by health and social care organisations for older people living at home rely&#13;
on interprofessional working (IPW). Although there is research investigating what supports and inhibits how&#13;
professionals work together, less is known about how different service models deliver care to older people and&#13;
how effectiveness is measured. The aim of this study was to describe how IPW for older people living at home is&#13;
delivered, enacted and evaluated in England.&#13;
&#13;
Method: An online survey of health and social care managers across England directly involved in providing&#13;
services to older people, and a review of local strategies for older people services produced by primary care&#13;
organisations and local government adult services organisations in England.&#13;
&#13;
Results: The online survey achieved a 31% response rate and search strategies identified 50 local strategies that&#13;
addressed IPW for older people living at home across health and social care organisations. IPW definitions varied, but&#13;
there was an internal consistency of language informed by budgeting and organisation specific definitions of IPW.&#13;
Community Services for Older People, Intermediate Care and Re-enablement (rehabilitation) Teams were the&#13;
services most frequently identified as involving IPW. Other IPW services identified were problem or disease specific&#13;
and reflected issues highlighted in local strategies. There was limited agreement about what interventions or&#13;
strategies supported the process of IPW. Older people and their carers were not reported to be involved in the&#13;
evaluation of the services they received and it was unclear how organisations and managers judged the&#13;
effectiveness of IPW, particularly for services that had an open-ended commitment to the care of older people.&#13;
&#13;
Conclusion: Health and social care organisations and their managers recognise the value and importance of IPW.&#13;
There is a theoretical literature on what supports IPW and what it can achieve. The need for precision may not be&#13;
so necessary for the terms used to describe IPW. However, there is a need for shared identification of both user/&#13;
patient outcomes that arise from IPW and greater understanding of what kind of model of IPW achieves what kind of outcomes for older people living at home.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107053/1/1472%2D6963%2D11%2D337.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BIOMED CENTRAL LTD</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000301443800001&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1472-6963</dc:source><dc:title>Models of inter professional working for older people living at home: a survey and review of the local strategies of english health and social care statutory organisations</dc:title><rioxxterms:author>Goodman, C</rioxxterms:author><rioxxterms:author>Drennan, V</rioxxterms:author><rioxxterms:author>Scheibl, F</rioxxterms:author><rioxxterms:author>Shah, D</rioxxterms:author><rioxxterms:author>Manthorpe, J</rioxxterms:author><rioxxterms:author>Gage, H</rioxxterms:author><rioxxterms:author>Iliffe, S</rioxxterms:author><rioxxterms:publication_date>2011-12-14</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1472-6963-11-337</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107044
Date: 2015-02-10

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107044</identifier>
      <datestamp>2015-02-10T13:33:41Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Purpose: This qualitative study explored the impact and appropriateness of structured pro-active care reviews by&#13;
practice nurses for patients with chronic or recurrent depression and dysthymia within the ProCEED trial.&#13;
ProCEED (Pro-active Care and its Evaluation for Enduring Depression) was a United Kingdom wide randomised&#13;
controlled trial, comparing usual general practitioner care with structured ‘pro-active care’ which involved 3 monthly&#13;
review appointments with practice nurses over 2 years for patients with chronic or recurrent depression.&#13;
&#13;
Method: In-depth interviews were completed with 41 participants: 26 patients receiving pro-active care and 15&#13;
practice nurses providing this care. Interview transcripts were analysed thematically using a ‘framework’ approach.&#13;
&#13;
Results: Patients perceived the practice nurses to be appropriate professionals to engage with regarding their&#13;
depression and most nurses felt confident in a case management role. The development of a therapeutic alliance&#13;
between the patient and nurse was central to this model and, where it appeared lacking, dissatisfaction was felt by&#13;
both patients and nurses with a likely negative impact on outcomes. Patient and nurse factors impacting on the&#13;
therapeutic alliance were identified and nurse typologies explored.&#13;
&#13;
Discussion: Pro-active care reviews utilising practice nurses as case managers were found acceptable by the&#13;
majority of patients and practice nurses and may be a suitable way to provide care for patients with long-term&#13;
depression in primary care. Motivated and interested practice nurses could be an appropriate and valuable resource for this patient group. This has implications for resource decisions by clinicians and commissioners within primary care.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107044/1/pone.0075810.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>PUBLIC LIBRARY SCIENCE</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000326240100129&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1932-6203</dc:source><dc:title>Structured Pro-Active Care for Chronic Depression by Practice Nurses in Primary Care: A Qualitative Evaluation</dc:title><rioxxterms:author>Bennett, M</rioxxterms:author><rioxxterms:author>Walters, K</rioxxterms:author><rioxxterms:author>Drennan, V</rioxxterms:author><rioxxterms:author>Buszewicz, M</rioxxterms:author><rioxxterms:publication_date>2013-09-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0075810</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107042
Date: 2015-02-10

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107042</identifier>
      <datestamp>2015-02-10T13:42:18Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background: Over 12,000 hospital admissions in the UK result from substance misuse, therefore issues surrounding&#13;
this need to be addressed early on in a doctor’s training to facilitate their interaction with this client group.&#13;
Currently, undergraduate medical education includes teaching substance misuse issues, yet how this is formally&#13;
integrated into the curriculum remains unclear.&#13;
&#13;
Methods: Semi-structured interviews with 17 key members of staff responsible for the whole or part of the&#13;
undergraduate medical curriculum were conducted to identify the methods used to teach substance misuse. Using&#13;
a previously devised toolkit, 19 curriculum co-ordinators then mapped the actual teaching sessions that addressed&#13;
substance misuse learning objectives.&#13;
&#13;
Results: Substance misuse teaching was delivered primarily in psychiatry modules but learning objectives were also&#13;
found in other areas such as primary care placements and problem-based learning. On average, 53 teaching&#13;
sessions per medical school focused on bio-psycho-social models of addiction whereas only 23 sessions per medical&#13;
school focused on professionalism, fitness to practice and students’ own health in relation to substance misuse.&#13;
Many sessions addressed specific learning objectives relating to the clinical features of substance dependence&#13;
whereas few focused on iatrogenic addiction.&#13;
&#13;
Conclusions: Substance misuse teaching is now inter-disciplinary and the frequent focus on clinical, psychological and social effects of substance misuse emphasises the bio-psycho-social approach underlying clinical practice. Some areas however are not frequently taught in the formal curriculum and these need to be addressed in future changes to medical education.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107042/1/1472%2D6920%2D14%2D34.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BIOMED CENTRAL LTD</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000334384800001&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1472-6920</dc:source><dc:title>Substance misuse teaching in undergraduate medical education</dc:title><rioxxterms:author>Carroll, J</rioxxterms:author><rioxxterms:author>Goodair, C</rioxxterms:author><rioxxterms:author>Chaytor, A</rioxxterms:author><rioxxterms:author>Notley, C</rioxxterms:author><rioxxterms:author>Ghodse, H</rioxxterms:author><rioxxterms:author>Kopelman, P</rioxxterms:author><rioxxterms:publication_date>2014-02-17</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1472-6920-14-34</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:107036
Date: 2015-04-29

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:107036</identifier>
      <datestamp>2015-04-29T14:30:02Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Introduction: Bronchiolitis Obliterans Organising Pneumonia (BOOP) may often present initially as a recurrent spontaneous pneumothorax and then develop multi-system complications.&#13;
&#13;
Case presentation: A 17-year-old boy presented with a pneumothorax, which developed into rapidly progressive Bronchiolitis Obliterans Organising Pneumonia (BOOP). He developed multiorgan dysfunction (including adult respiratory distress syndrome, oliguric renal failure, acute&#13;
coronary syndrome, cardiac failure and a right atrial thrombus) which necessitated prolonged intensive care. Diagnosis was confirmed on open lung biopsy and he responded well to treatment with corticosteroids.&#13;
&#13;
Conclusion: BOOP is exquisitely sensitive to oral corticosteroids but if the diagnosis is not considered in such patients and appropriate treatment instituted early, BOOP may often lead to&#13;
prolonged hospital admission with considerable morbidity.</dc:description><dc:format>ERROR: cannot open `/www/sgul/eprints3/archives/sgul/documents/disk0/00/10/70/36/01/1752-1947-2-145' (No such file or directory)
ERROR: cannot open `JMCR.pdf' (No such file or directory)</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/107036/1/1752%2D1947%2D2%2D145%20JMCR.pdf</dc:identifier><dc:language>en</dc:language><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/18460192</dc:relation><dc:source>1752-1947</dc:source><dc:title>Rapidly progressive Bronchiolitis Obliterans Organising Pneumonia presenting with pneumothorax, persistent air leak, acute respiratory distress syndrome and multi-organ dysfunction: a case report.</dc:title><rioxxterms:author>Chakravorty, I</rioxxterms:author><rioxxterms:author>Oldfield, WL</rioxxterms:author><rioxxterms:author>Gómez, CM</rioxxterms:author><rioxxterms:publication_date>2008-05-06</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1752-1947-2-145</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:105328
Date: 2015-11-18

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:105328</identifier>
      <datestamp>2015-11-18T15:19:29Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background: Soil-transmitted helminths (STH) infect more than 2 billion humans worldwide, causing significant morbidity in children. There are few data on the epidemiology and risk factors for infection in pre-school children. To investigate risk factors for infection in early childhood, we analysed data prospectively collected in the ECUAVIDA birth cohort in Ecuador.&#13;
Methods and Findings:&#13;
Children were recruited at birth and followed up to 3 years of age with periodic collection of stool samples that were examined microscopically for STH parasites. Data on social, demographic, and environmental risk factors were collected from the mother at time of enrolment. Associations between exposures and detection of STH infections were analysed by multivariable logistic regression. Data were analysed from 1,697 children for whom a stool sample was obtained at 3 years. 42.3% had at least one STH infection in the first 3 years of life and the most common infections were caused by A. lumbricoides (33.2% of children) and T. trichiura (21.2%). Hookworm infection was detected in 0.9% of children. Risk of STH infection was associated with factors indicative of poverty in our study population such as Afro-Ecuadorian ethnicity and low maternal educational level. Maternal STH infections during pregnancy were strong risk factors for any childhood STH infection, infections with either A. lumbricoides or T. trichiura, and early age of first STH infection. Children of mothers with moderate to high infections intensities with A. lumbricoides were most at risk.&#13;
Conclusions: &#13;
Our data show high rates of infection with STH parasites during the first 3 years of life in an Ecuadorian birth cohort, an observation that was strongly associated with maternal STH infections during pregnancy. The targeted treatment of women of childbearing age, in particular before pregnancy, with anthelmintic drugs could offer a novel approach to the prevention of STH infections in pre-school children.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/105328/1/pntd.0002718.pdf</dc:identifier><dc:language>en</dc:language><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/24587469</dc:relation><dc:source>1935-2735</dc:source><dc:title>Risk Factors for Soil-Transmitted Helminth Infections during the First 3 Years of Life in the Tropics; Findings from a Birth Cohort.</dc:title><rioxxterms:author>Menzies, SK</rioxxterms:author><rioxxterms:author>Rodriguez, A</rioxxterms:author><rioxxterms:author>Chico, M</rioxxterms:author><rioxxterms:author>Sandoval, C</rioxxterms:author><rioxxterms:author>Broncano, N</rioxxterms:author><rioxxterms:author>Guadalupe, I</rioxxterms:author><rioxxterms:author>Cooper, PJ</rioxxterms:author><rioxxterms:publication_date>2014-02-27</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pntd.0002718</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:105032
Date: 2015-04-17

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:105032</identifier>
      <datestamp>2015-04-17T12:09:32Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011-11">http://creativecommons.org/licenses/by-nd-sa/4.0</ali:license_ref><dc:description>BACKGROUND AND OBJECTIVE: Myomectomy is considered a highly morbid procedure due to the risk of high intraoperative blood loss. Meticulous surgical techniques can reduce operative morbidity. Our aim was to evaluate and compare the intraoperative blood loss between two surgical techniques: 1) the uterine vascular cutoff technique and 2) the classical technique.&#13;
&#13;
DESIGN AND SETTING: Retrospective chart review conducted between 1 July 2008 until 30 June 2010 in a tertiary care referral center to compare surgical outcomes of two groups.&#13;
&#13;
PATIENTS AND METHODS: The sample included 136 patients: 30 patients had their surgeries performed with the uterine vascular cutoff technique, and the remainder (106 patients) had myomectomies performed with the classical technique. The uterine vascular cutoff technique was performed by the same surgeon for all 30 patients, whereas myomectomy with the classical technique was performed by several gynecologists.&#13;
&#13;
RESULTS: There was no significant difference between the two groups in parity and operation time; however, patients in the first group had a statistically significant higher mean age (39.1 [7.6] vs 35.8 [6.9] years; P=.025) and, on average, bigger fibroid size by gestational week (20.1 [7.3] vs 17 [5.2] weeks; P=.0094), with standard deviation shown in parentheses. There was a statistically significant lesser drop in hemoglobin concentration among patients in the first group (1.23 [1.2] vs 2.25 [1.4] g/dL; P=.0003), and the postoperative hemoglobin was significantly higher in the first group (10.5 [1.6] vs 9.7 [1.7] g/dL; P=.036). The hospital stay was shorter for patients in the first group (5.8 [1.7] vs 7.1 [2.9] days; P=.031).&#13;
&#13;
CONCLUSION: The vascular cutoff technique leads to less intraoperative blood loss without increasing the operative time, patients tolerate this technique very well, and the technique is associated with shorter hospital stay, all of which could contribute to less postoperative morbidity. </dc:description><dc:format>ERROR: cannot open `/www/sgul/eprints3/archives/sgul/documents/disk0/00/10/50/32/01/Effect' (No such file or directory)
ERROR: cannot open `of' (No such file or directory)
ERROR: cannot open `uterine' (No such file or directory)
ERROR: cannot open `blood'</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/105032/1/Effect%20of%20uterine%20blood%20supply%20cutoff%20during%20myomectomy.pdf</dc:identifier><dc:language>en</dc:language><dc:source>0975-4466</dc:source><dc:title>The effect of uterine blood supply cutoff during myomectomy.</dc:title><rioxxterms:author>Alobaid, A</rioxxterms:author><rioxxterms:author>Alqadri, T</rioxxterms:author><rioxxterms:author>Serat, F</rioxxterms:author><rioxxterms:author>Riaz, M</rioxxterms:author><rioxxterms:author>Alobaid, S</rioxxterms:author><rioxxterms:author>Aldakhil, L</rioxxterms:author><rioxxterms:publication_date>2011-11</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.4103/0256-4947.87096</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:104155
Date: 2017-08-23

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:104155</identifier>
      <datestamp>2017-08-23T13:28:11Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2014-01-01">http://creativecommons.org/licenses/by-nc/4.0</ali:license_ref><dc:description>OBJECTIVE: Little is known about whether levels of physical fitness, which is related to adiposity and physical activity (PA), have changed in children, particularly the progressive increase in childhood obesity levels. We aimed to examine the time trends in resting pulse rate (a marker of physical fitness) among UK children, in order to better understand the trends in levels of physical fitness in recent decades. DESIGN AND SETTING: We used a cross-sectional study design and included data on over 22 000 children aged 9-11 years (mean 10.3 years) from five population-based studies conducted in the UK between 1980 and 2008. MAIN OUTCOME MEASURES: Resting pulse rate (bpm). RESULTS: Observed mean resting pulse rate was higher for girls than boys (82.2 bpm vs 78.7 bpm). During the study period mean pulse rate increased by 0.07 bpm/year (95% CI 0.04 to 0.09) among boys and to a lesser extent among girls, by 0.04 bpm/year (0.01 to 0.06) (p&lt;0.05 for gender interaction). For boys, there was an indication that the trend was steeper after the mid-1990 s, compared to that prior to 1994 (annual increase 0.14 vs 0.04 bpm). The trends for Body Mass Index (BMI) accounted for only 13.8% (11.3% to 16.3%) of increase in pulse rate for boys and 17.2% (9.4% to 24.9%) for girls. CONCLUSIONS: Increases in mean resting pulse rate have occurred during the period 1980-2008 in girls and especially in boys. The increase was not explained by increased BMI. The observed trends in children, though modest, could have important public health implications for future cardiovascular risk.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/104155/1/10.full.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1468-2044</dc:source><dc:title>Trends in resting pulse rates in 9-11-year-old children in the UK 1980-2008.</dc:title><dcterms:dateAccepted>2013-09-15</dcterms:dateAccepted><rioxxterms:author>Peters, H</rioxxterms:author><rioxxterms:author>Whincup, PH</rioxxterms:author><rioxxterms:author>Cook, DG</rioxxterms:author><rioxxterms:author>Law, C</rioxxterms:author><rioxxterms:author>Li, L</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">038976/Z/93/Z</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">G0400546</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">G0601941</rioxxterms:project><rioxxterms:project funder_name="Department of Health"/><rioxxterms:publication_date>2014-01-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/archdischild-2013-304699</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:103828
Date: 2015-02-11

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:103828</identifier>
      <datestamp>2015-02-11T12:36:44Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2013-12-01">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>Regulated secretion from endothelial cells is mediated by Weibel–Palade body (WPB) exocytosis. Plasma membrane cholesterol is implicated in regulating secretory granule exocytosis and fusion pore dynamics; however, its role in modulating WPB exocytosis is not clear. To address this we combined high-resolution electrochemical analysis of WPB fusion pore dynamics, by amperometry, with high-speed optical imaging of WPB exocytosis following cholesterol depletion or supplementation in human umbilical vein endothelial cells. We identified serotonin (5-HT) immunoreactivity in WPBs, and VMAT1 expression allowing detection of secreted 5-HT as discrete current spikes during exocytosis. A high proportion of spikes (∼75%) had pre-spike foot signals, indicating that WPB fusion proceeds via an initial narrow pore. Cholesterol depletion significantly reduced pre-spike foot signal duration and increased the rate of fusion pore expansion, whereas cholesterol supplementation had broadly the reverse effect. Cholesterol depletion slowed the onset of hormone-evoked WPB exocytosis, whereas its supplementation increased the rate of WPB exocytosis and hormone-evoked proregion secretion. Our results provide the first analysis of WPB fusion pore dynamics and highlight an important role for cholesterol in the regulation of WPB exocytosis. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/103828/1/supp_126.23.5490_JCS138438.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>COMPANY OF BIOLOGISTS LTD</dc:publisher><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/24127569</dc:relation><dc:source>0021-9533</dc:source><dc:title>Characterisation of Weibel-Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis</dc:title><rioxxterms:author>Cookson, EA</rioxxterms:author><rioxxterms:author>Conte, IL</rioxxterms:author><rioxxterms:author>Dempster, J</rioxxterms:author><rioxxterms:author>Hannah, MJ</rioxxterms:author><rioxxterms:author>Carter, T</rioxxterms:author><rioxxterms:publication_date>2013-12-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1242/jcs.138438</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:103807
Date: 2017-08-23

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:103807</identifier>
      <datestamp>2017-08-23T15:45:34Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2013-12">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>Although an insidious history of episodic memory difficulty is a typical presenting symptom of Alzheimer's disease, detailed neuropsychological profiling frequently demonstrates deficits in other cognitive domains, including language. Previous studies from our group have shown that language changes may be reflected in connected speech production in the earliest stages of typical Alzheimer's disease. The aim of the present study was to identify features of connected speech that could be used to examine longitudinal profiles of impairment in Alzheimer's disease. Samples of connected speech were obtained from 15 former participants in a longitudinal cohort study of ageing and dementia, in whom Alzheimer's disease was diagnosed during life and confirmed at post-mortem. All patients met clinical and neuropsychological criteria for mild cognitive impairment between 6 and 18 months before converting to a status of probable Alzheimer's disease. In a subset of these patients neuropsychological data were available, both at the point of conversion to Alzheimer's disease, and after disease severity had progressed from the mild to moderate stage. Connected speech samples from these patients were examined at later disease stages. Spoken language samples were obtained using the Cookie Theft picture description task. Samples were analysed using measures of syntactic complexity, lexical content, speech production, fluency and semantic content. Individual case analysis revealed that subtle changes in language were evident during the prodromal stages of Alzheimer's disease, with two-thirds of patients with mild cognitive impairment showing significant but heterogeneous changes in connected speech. However, impairments at the mild cognitive impairment stage did not necessarily entail deficits at mild or moderate stages of disease, suggesting non-language influences on some aspects of performance. Subsequent examination of these measures revealed significant linear trends over the three stages of disease in syntactic complexity, semantic and lexical content. The findings suggest, first, that there is a progressive disruption in language integrity, detectable from the prodromal stage in a subset of patients with Alzheimer's disease, and secondly that measures of semantic and lexical content and syntactic complexity best capture the global progression of linguistic impairment through the successive clinical stages of disease. The identification of disease-specific language impairment in prodromal Alzheimer's disease could enhance clinicians' ability to distinguish probable Alzheimer's disease from changes attributable to ageing, while longitudinal assessment could provide a simple approach to disease monitoring in therapeutic trials.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/103807/1/awt269.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1460-2156</dc:source><dc:title>Connected speech as a marker of disease progression in autopsy-proven Alzheimer's disease.</dc:title><dcterms:dateAccepted>2013-08-02</dcterms:dateAccepted><rioxxterms:author>Ahmed, S</rioxxterms:author><rioxxterms:author>Haigh, A-MF</rioxxterms:author><rioxxterms:author>de Jager, CA</rioxxterms:author><rioxxterms:author>Garrard, P</rioxxterms:author><rioxxterms:project funder_name="Medical Research Council">G0801370</rioxxterms:project><rioxxterms:publication_date>2013-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/brain/awt269</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:103763
Date: 2017-08-23

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:103763</identifier>
      <datestamp>2017-08-23T13:53:47Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2014-01-01">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>BACKGROUND: The Cryptococcus neoformans polysaccharide capsule is a well-characterized virulence factor with immunomodulatory properties. The organism and/or shed capsule is postulated to raise intracranial pressure (ICP) in cryptococcal meningitis (CM) by mechanical obstruction of cerebrospinal fluid (CSF) outflow. Little is known regarding capsule phenotype in human cryptococcosis. We investigated the relationship of ex vivo CSF capsular phenotype with ICP and CSF immune response, as well as in vitro phenotype. METHODS: In total, 134 human immunodeficiency virus (HIV)-infected Ugandan adults with CM had serial lumbar punctures with measurement of CSF opening pressures, quantitative cultures, ex vivo capsule size and shedding, viscosity, and CSF cytokines; 108 had complete data. Induced capsular size and shedding were measured in vitro for 48 C. neoformans isolates. RESULTS: Cryptococcal strains producing larger ex vivo capsules in the baseline (pretreatment) CSF correlated with higher ICP (P = .02), slower rate of fungal clearance (P = .02), and paucity of CSF inflammation, including decreased CSF white blood cell (WBC) count (P &lt; .001), interleukin (IL)-4 (P = .02), IL-6 (P = .01), IL-7 (P = .04), IL-8 (P = .03), and interferon γ (P = .03). CSF capsule shedding did not correlate with ICP. On multivariable analysis, capsule size remained independently associated with ICP. Ex vivo capsular size and shedding did not correlate with that of the same isolates grown in vitro. CONCLUSIONS: Cryptococcal capsule size ex vivo is an important contributor to virulence in human cryptococcal meningitis.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/103763/1/jit435.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1537-6613</dc:source><dc:title>Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.</dc:title><dcterms:dateAccepted>2013-07-30</dcterms:dateAccepted><rioxxterms:author>Robertson, EJ</rioxxterms:author><rioxxterms:author>Najjuka, G</rioxxterms:author><rioxxterms:author>Rolfes, MA</rioxxterms:author><rioxxterms:author>Akampurira, A</rioxxterms:author><rioxxterms:author>Jain, N</rioxxterms:author><rioxxterms:author>Anantharanjit, J</rioxxterms:author><rioxxterms:author>von Hohenberg, M</rioxxterms:author><rioxxterms:author>Tassieri, M</rioxxterms:author><rioxxterms:author>Carlsson, A</rioxxterms:author><rioxxterms:author>Meya, DB</rioxxterms:author><rioxxterms:author>Harrison, TS</rioxxterms:author><rioxxterms:author>Fries, BC</rioxxterms:author><rioxxterms:author>Boulware, DR</rioxxterms:author><rioxxterms:author>Bicanic, T</rioxxterms:author><rioxxterms:project funder_name="NIAID NIH HHS">U01 AI089244</rioxxterms:project><rioxxterms:project funder_name="NIAID NIH HHS">K23AI073192</rioxxterms:project><rioxxterms:project funder_name="NINDS NIH HHS">R21NS065713</rioxxterms:project><rioxxterms:project funder_name="NIAID NIH HHS">P30 AI051519</rioxxterms:project><rioxxterms:project funder_name="PHS HHS">R21 A1087564</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust" funder_id="http://dx.doi.org/10.13039/100004440">100714</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust" funder_id="http://dx.doi.org/10.13039/100004440">WT 089966</rioxxterms:project><rioxxterms:project funder_name="NINDS NIH HHS">R21 NS065713</rioxxterms:project><rioxxterms:project funder_name="NIAID NIH HHS">U01AI089244</rioxxterms:project><rioxxterms:project funder_name="NIAID NIH HHS">R01 AI059681</rioxxterms:project><rioxxterms:project funder_name="NIAID NIH HHS">K23 AI073192</rioxxterms:project><rioxxterms:publication_date>2014-01-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/infdis/jit435</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:103664
Date: 2017-05-17

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:103664</identifier>
      <datestamp>2017-05-17T12:08:45Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Diagnosis of Clostridium difficile infection is controversial because of many laboratory methods, compounded by two reference methods. Cytotoxigenic culture detects toxigenic C difficile and gives a positive result more frequently (eg, because of colonisation, which means that individuals can have the bacterium but no free toxin) than does the cytotoxin assay, which detects preformed toxin in faeces. We aimed to validate the reference methods according to clinical outcomes and to derive an optimum laboratory diagnostic algorithm for C difficile infection. METHODS: In this prospective, multicentre study, we did cytotoxigenic culture and cytotoxin assays on 12,420 faecal samples in four UK laboratories. We also performed tests that represent the three main targets for C difficile detection: bacterium (glutamate dehydrogenase), toxins, or toxin genes. We used routine blood test results, length of hospital stay, and 30-day mortality to clinically validate the reference methods. Data were categorised by reference method result: group 1, cytotoxin assay positive; group 2, cytotoxigenic culture positive and cytotoxin assay negative; and group 3, both reference methods negative. FINDINGS: Clinical and reference assay data were available for 6522 inpatient episodes. On univariate analysis, mortality was significantly higher in group 1 than in group 2 (72/435 [16·6%] vs 20/207 [9·7%], p=0·044) and in group 3 (503/5880 [8·6%], p&lt;0·001), but not in group 2 compared with group 3 (p=0·4). A multivariate analysis accounting for potential confounders confirmed the mortality differences between groups 1 and 3 (OR 1·61, 95% CI 1·12-2·31). Multistage algorithms performed better than did standalone assays. INTERPRETATION: We noted no increase in mortality when toxigenic C difficile alone was present. Toxin (cytotoxin assay) positivity correlated with clinical outcome, and so this reference method best defines true cases of C difficile infection. A new diagnostic category of potential C difficile excretor (cytotoxigenic culture positive but cytotoxin assay negative) could be used to characterise patients with diarrhoea that is probably not due to C difficile infection, but who can cause cross-infection.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/103664/7/1%2Ds2.0%2DS1473309913702007%2Dmain.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1474-4457</dc:source><dc:title>Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection.</dc:title><rioxxterms:author>Planche, TD</rioxxterms:author><rioxxterms:author>Davies, KA</rioxxterms:author><rioxxterms:author>Coen, PG</rioxxterms:author><rioxxterms:author>Finney, JM</rioxxterms:author><rioxxterms:author>Monahan, IM</rioxxterms:author><rioxxterms:author>Morris, KA</rioxxterms:author><rioxxterms:author>O'Connor, L</rioxxterms:author><rioxxterms:author>Oakley, SJ</rioxxterms:author><rioxxterms:author>Pope, CF</rioxxterms:author><rioxxterms:author>Wren, MW</rioxxterms:author><rioxxterms:author>Shetty, NP</rioxxterms:author><rioxxterms:author>Crook, DW</rioxxterms:author><rioxxterms:author>Wilcox, MH</rioxxterms:author><rioxxterms:project funder_name="Department of Health"/><rioxxterms:publication_date>2013-11</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/S1473-3099(13)70200-7</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:103097
Date: 2016-01-29

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:103097</identifier>
      <datestamp>2016-01-29T11:55:32Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations. We have previously shown that glucose concentrations are elevated in airway surface liquid (ASL) of people with CF, particularly in those with CFRD. We therefore explored the hypotheses that glucose homeostasis is altered in CF airway epithelia and that elevation of glucose flux into ASL drives increased bacterial growth, with an effect over and above other cystic fibrosis transmembrane conductance regulator (CFTR)-related ASL abnormalities. The aim of this study was to compare the mechanisms governing airway glucose homeostasis in CF and non-CF primary human bronchial epithelial (HBE) monolayers, under normal conditions and in the presence of Ps. aeruginosa filtrate. HBE-bacterial co-cultures were performed in the presence of 5 mM or 15 mM basolateral glucose to investigate how changes in blood glucose, such as those seen in CFRD, affects luminal Ps. aeruginosa growth. Calu-3 cell monolayers were used to evaluate the potential importance of glucose on Ps. aeruginosa growth, in comparison to other hallmarks of the CF ASL, namely mucus hyperviscosity and impaired CFTR-dependent fluid secretions. We show that elevation of basolateral glucose promotes the apical growth of Ps. aeruginosa on CF airway epithelial monolayers more than non-CF monolayers. Ps. aeruginosa secretions elicited more glucose flux across CF airway epithelial monolayers compared to non-CF monolayers which we propose increases glucose availability in ASL for bacterial growth. In addition, elevating basolateral glucose increased Ps. aeruginosa growth over and above any CFTR-dependent effects and the presence or absence of mucus in Calu-3 airway epithelia-bacteria co-cultures. Together these studies highlight the importance of glucose as an additional factor in promoting Ps. aeruginosa growth and respiratory infection in CF disease.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/103097/1/pone.0076283.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>PUBLIC LIBRARY SCIENCE</dc:publisher><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/24124542</dc:relation><dc:source>1932-6203</dc:source><dc:title>Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth.</dc:title><rioxxterms:author>Garnett, JP</rioxxterms:author><rioxxterms:author>Gray, MA</rioxxterms:author><rioxxterms:author>Tarran, R</rioxxterms:author><rioxxterms:author>Brodlie, M</rioxxterms:author><rioxxterms:author>Ward, C</rioxxterms:author><rioxxterms:author>Baker, EH</rioxxterms:author><rioxxterms:author>Baines, DL</rioxxterms:author><rioxxterms:publication_date>2013</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0076283</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:102927
Date: 2017-06-08

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:102927</identifier>
      <datestamp>2017-06-08T12:07:21Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) have no detectable germline mutations in the known cancer predisposition genes. Using whole-genome sequencing, supplemented by linkage and association analysis, we identified specific heterozygous POLE or POLD1 germline variants in several multiple-adenoma and/or CRC cases but in no controls. The variants associated with susceptibility, POLE p.Leu424Val and POLD1 p.Ser478Asn, have high penetrance, and POLD1 mutation was also associated with endometrial cancer predisposition. The mutations map to equivalent sites in the proofreading (exonuclease) domain of DNA polymerases ɛ and δ and are predicted to cause a defect in the correction of mispaired bases inserted during DNA replication. In agreement with this prediction, the tumors from mutation carriers were microsatellite stable but tended to acquire base substitution mutations, as confirmed by yeast functional assays. Further analysis of published data showed that the recently described group of hypermutant, microsatellite-stable CRCs is likely to be caused by somatic POLE mutations affecting the exonuclease domain.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/102927/1/NIHMS53122%2Dsupplement%2D1.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Nature Publishing Group</dc:publisher><dc:source>Nature Genetics</dc:source><dc:title>Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.</dc:title><rioxxterms:author>Palles, C</rioxxterms:author><rioxxterms:author>Cazier, J-B</rioxxterms:author><rioxxterms:author>Howarth, KM</rioxxterms:author><rioxxterms:author>Domingo, E</rioxxterms:author><rioxxterms:author>Jones, AM</rioxxterms:author><rioxxterms:author>Broderick, P</rioxxterms:author><rioxxterms:author>Kemp, Z</rioxxterms:author><rioxxterms:author>Spain, SL</rioxxterms:author><rioxxterms:author>Guarino, E</rioxxterms:author><rioxxterms:author>Salguero, I</rioxxterms:author><rioxxterms:author>Sherborne, A</rioxxterms:author><rioxxterms:author>Chubb, D</rioxxterms:author><rioxxterms:author>Carvajal-Carmona, LG</rioxxterms:author><rioxxterms:author>Ma, Y</rioxxterms:author><rioxxterms:author>Kaur, K</rioxxterms:author><rioxxterms:author>Dobbins, S</rioxxterms:author><rioxxterms:author>Barclay, E</rioxxterms:author><rioxxterms:author>Gorman, M</rioxxterms:author><rioxxterms:author>Martin, L</rioxxterms:author><rioxxterms:author>Kovac, MB</rioxxterms:author><rioxxterms:author>Humphray, S</rioxxterms:author><rioxxterms:author>CORGI Consortium, </rioxxterms:author><rioxxterms:author>WGS500 Consortium, </rioxxterms:author><rioxxterms:author>Lucassen, A</rioxxterms:author><rioxxterms:author>Holmes, CC</rioxxterms:author><rioxxterms:author>Bentley, D</rioxxterms:author><rioxxterms:author>Donnelly, P</rioxxterms:author><rioxxterms:author>Taylor, J</rioxxterms:author><rioxxterms:author>Petridis, C</rioxxterms:author><rioxxterms:author>Roylance, R</rioxxterms:author><rioxxterms:author>Sawyer, EJ</rioxxterms:author><rioxxterms:author>Kerr, DJ</rioxxterms:author><rioxxterms:author>Clark, S</rioxxterms:author><rioxxterms:author>Grimes, J</rioxxterms:author><rioxxterms:author>Kearsey, SE</rioxxterms:author><rioxxterms:author>Thomas, HJW</rioxxterms:author><rioxxterms:author>McVean, G</rioxxterms:author><rioxxterms:author>Houlston, RS</rioxxterms:author><rioxxterms:author>Tomlinson, I</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">090532/Z/09/Z</rioxxterms:project><rioxxterms:project funder_name="Biotechnology and Biological Sciences Research Council">BB/I02593X/1</rioxxterms:project><rioxxterms:project funder_name="Cancer Research UK">C1298/A8362</rioxxterms:project><rioxxterms:project funder_name="Cancer Research UK">A10417</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust">090532</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust">084818</rioxxterms:project><rioxxterms:project funder_name="Cancer Research UK">C6199/A10417</rioxxterms:project><rioxxterms:project funder_name="Cancer Research UK">10589</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">MC_UP_A390_1107</rioxxterms:project><rioxxterms:publication_date>2013-02</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/ng.2503</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:102796
Date: 2015-03-03

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:102796</identifier>
      <datestamp>2015-03-03T10:19:46Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>OBJECTIVE: The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction.&#13;
&#13;
METHODS AND RESULTS: Coronary endothelial function was assessed in 490 patients between November 1993 and February 2007. Fasting lipids and nuclear magnetic resonance (NMR) lipoprotein particle subclasses were measured. There were 325 females and 165 males with a mean age of 49.8+/-11.6 years. Coronary endothelial dysfunction (epicardial constriction&gt;20% or increase in coronary blood flow&lt;50% in response to intracoronary acetylcholine) was diagnosed in 273 patients, the majority of whom (64.5%) had microvascular dysfunction. Total cholesterol and LDL-C (low density lipoprotein cholesterol) were not associated with endothelial dysfunction. One-way analysis and multivariate methods adjusting for age, gender, diabetes, hypertension and lipid-lowering agent use were used to determine the correlation between lipoprotein subclasses and coronary endothelial dysfunction. Epicardial endothelial dysfunction was significantly correlated with total (p=0.03) and small LDLp (LDL particles) (p&lt;0.01) and inversely correlated with total and large HDLp (high density lipoprotein particles) (p&lt;0.01).&#13;
&#13;
CONCLUSIONS: Epicardial, but not microvascular, coronary endothelial dysfunction was associated directly with LDL particles and inversely with HDL particles, suggesting location-dependent impact of lipoprotein particles on the coronary circulation. </dc:description><dc:format>application/x-zip</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/102796/6/licence.docx</dc:identifier><dc:language>en</dc:language><dc:source>1879-1484</dc:source><dc:title>Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy.</dc:title><rioxxterms:author>Ford, MA</rioxxterms:author><rioxxterms:author>McConnell, JP</rioxxterms:author><rioxxterms:author>Lavi, S</rioxxterms:author><rioxxterms:author>Rihal, CS</rioxxterms:author><rioxxterms:author>Prasad, A</rioxxterms:author><rioxxterms:author>Sandhu, GS</rioxxterms:author><rioxxterms:author>Hartman, SJ</rioxxterms:author><rioxxterms:author>Lerman, LO</rioxxterms:author><rioxxterms:author>Lerman, A</rioxxterms:author><rioxxterms:project funder_name="NHLBI NIH HHS">K24 HL069840</rioxxterms:project><rioxxterms:project funder_name="NHLBI NIH HHS">K24 HL069840-05</rioxxterms:project><rioxxterms:project funder_name="NIA NIH HHS">R01 AG031750</rioxxterms:project><rioxxterms:project funder_name="NHLBI NIH HHS">R01 HL063911</rioxxterms:project><rioxxterms:project funder_name="NHLBI NIH HHS">R01 HL063911-04</rioxxterms:project><rioxxterms:project funder_name="NHLBI NIH HHS">R01 HL092954</rioxxterms:project><rioxxterms:publication_date>2009-11</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.atherosclerosis.2009.04.039</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:102320
Date: 2015-02-17

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      <identifier>oai:openaccess.sgul.ac.uk:102320</identifier>
      <datestamp>2015-02-17T16:00:06Z</datestamp>
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      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objectives: We sought to determine the frequency and outcomes with symptomatic arrhythmia in patients with apical ballooning syndrome (ABS).&#13;
&#13;
Methods: A retrospective review of the Mayo Clinic Angiography database was conducted to identify patients who met the Mayo criteria for ABS. Patients with documented arrhythmias formed the study group, and 31 randomly selected patients with ABS but without arrhythmia formed the control group.&#13;
&#13;
Results: Out of 105 patients identified with ABS, 6 (5.7%) women aged 69 +/- 9 years experienced significant arrhythmia (ventricular fibrillation, asystole), 2 patients died, and 1 required permanent pacemaker implantation. When compared with controls, the study group showed no significant difference with respect to ECG characteristics (QT, QRS duration or axis) except for R-R interval variability (see comments below) (30.6±6 vs 14.5±17 p = 0.0004), QTc, and P-R interval. Patients without arrhythmia were more likely to be on beta-blocker therapy than the study population (33% vs 80.6% p = 0.02).&#13;
&#13;
Conclusion: Life-threatening arrhythmia is uncommon (5.7%) with ABS despite marked, structural abnormalities. When arrhythmias do occur, the outcome is poor. Prominent variability in R-R intervals appears to be predictive of significant arrhythmias in ABS. The role of beta-blocker therapy in preventing arrhythmia with ABS requires further investigation.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/102320/1/ipej080182%2D00.pdf</dc:identifier><dc:language>en</dc:language><dc:relation>http://www.ncbi.nlm.nih.gov/pubmed/18679529</dc:relation><dc:source> 0972-6292</dc:source><dc:title>Malignant arrhythmia in apical ballooning syndrome: risk factors and outcomes.</dc:title><rioxxterms:author>Dib, C</rioxxterms:author><rioxxterms:author>Prasad, A</rioxxterms:author><rioxxterms:author>Friedman, PA</rioxxterms:author><rioxxterms:author>Ahmad, E</rioxxterms:author><rioxxterms:author>Rihal, CS</rioxxterms:author><rioxxterms:author>Hammill, SC</rioxxterms:author><rioxxterms:author>Asirvatham, SJ</rioxxterms:author><rioxxterms:publication_date>2008-08-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101672
Date: 2015-02-20

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101672</identifier>
      <datestamp>2015-02-20T14:09:31Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Correlates of immune protection in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis are poorly defined. A clearer understanding of these immune responses is essential to inform rational development of immunotherapies.&#13;
&#13;
METHODS: Cryptococcal-specific peripheral CD4(+) T-cell responses were measured in 44 patients with HIV-associated cryptococcal meningitis at baseline and during follow-up. Responses were assessed following ex vivo cryptococcal mannoprotein stimulation, using 13-color flow-cytometry. The relationships between cryptococcal-specific CD4(+) T-cell responses, clinical parameters at presentation, and outcome were investigated.&#13;
&#13;
RESULTS: Cryptococcal-specific CD4(+) T-cell responses were characterized by the production of macrophage inflammatory protein 1α, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α). Conversely, minimal interleukin 4 and interleukin 17 production was detected. Patients surviving to 2 weeks had significantly different functional CD4(+) T-cell responses as compared to those who died. Patients with a response predominantly consisting of IFN-γ or TNF-α production had a 2-week mortality of 0% (0/20), compared with 25% (6/24) in those without this response (P =.025). Such patients also had lower fungal burdens (10 400 vs 390 000 colony-forming units/mL; P &lt;.001), higher cerebrospinal fluid lymphocyte counts (122 vs 8 cells/μL; P &lt;.001), and a trend toward faster rates of clearance of infection.&#13;
&#13;
CONCLUSIONS: The phenotype of the peripheral CD4(+) T-cell response to Cryptococcus was associated with disease severity and outcome in HIV-associated cryptococcal meningitis. IFN-γ/TNF-α-predominant responses were associated with survival. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/101672/1/The_phenotype_of_Cryptococcus_specific_CD4_memory.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1537-6613</dc:source><dc:title>The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis.</dc:title><rioxxterms:author>Jarvis, JN</rioxxterms:author><rioxxterms:author>Casazza, JP</rioxxterms:author><rioxxterms:author>Stone, HH</rioxxterms:author><rioxxterms:author>Meintjes, G</rioxxterms:author><rioxxterms:author>Lawn, SD</rioxxterms:author><rioxxterms:author>Levitz, SM</rioxxterms:author><rioxxterms:author>Harrison, TS</rioxxterms:author><rioxxterms:author>Koup, RA</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">088590</rioxxterms:project><rioxxterms:project funder_name="NIAID NIH HHS">R01 AI025780</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust">WT081794</rioxxterms:project><rioxxterms:publication_date>2013-06-15</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/infdis/jit099</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101625
Date: 2017-07-11

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101625</identifier>
      <datestamp>2017-07-11T15:31:47Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Expression of recombinant vaccine antigens and monoclonal antibodies using plant viral vectors has developed extensively during the past several years. The approach benefits from high yields of recombinant protein obtained within days after transient delivery of viral vectors to leaves of Nicotiana benthamiana, a tobacco relative. Modified viral genomes of both RNA and DNA viruses have been created. Geminiviruses such as bean yellow dwarf virus (BeYDV) have a small, single stranded DNA genome that replicates in the nucleus of an infected plant cell, using the cellular DNA synthesis apparatus and a virus-encoded replication initiator protein (Rep). BeYDV-derived expression vectors contain deletions of the viral genes encoding coat and movement proteins and insertion of an expression cassette for a protein of interest. Delivery of the geminiviral vector to leaf cells via Agrobacterium-mediated delivery produces very high levels of recombinant DNA that can act as a transcription template, yielding high levels of mRNA for the protein of interest. Several vaccine antigens, including Norwalk virus capsid protein and hepatitis B core antigen, were expressed using the BeYDV vector at levels up to 1 mg per g of leaf mass. BeYDV replicons can be stacked in the same vector molecule by linking them in tandem, which enables production of multi-subunit proteins like monoclonal antibody (mAb) heavy and light chains. The protective mAb 6D8 against Ebola virus was produced at 0.5 mg per g of leaf mass. Multi-replicon vectors could be conveniently used to produce protein complexes, e.g. virus-like particles that require two or more subunits.</dc:description><dc:language>en</dc:language><dc:source>Hum Vaccin</dc:source><dc:title>Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants.</dc:title><rioxxterms:author>Chen, Q</rioxxterms:author><rioxxterms:author>He, J</rioxxterms:author><rioxxterms:author>Phoolcharoen, W</rioxxterms:author><rioxxterms:author>Mason, HS</rioxxterms:author><rioxxterms:publication_date>2011-03</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.4161/hv.7.3.14262</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101552
Date: 2015-02-05

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101552</identifier>
      <datestamp>2015-02-05T15:12:38Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>PURPOSE: To determine the prevalence of cancer-related fatigue syndrome (CRFS) in a population of disease-free breast cancer survivors and to investigate the relationship between CRFS and clinical variables.&#13;
&#13;
PATIENTS AND METHODS: Women (200) were recruited. All participants were between 3 months and 2 years after completion of primary therapy for breast cancer and were disease free. Subjects completed a diagnostic interview for CRFS and structured psychiatric interview. Participants also completed quality of life, mood and fatigue questionnaires, and provided a blood sample for haematological and biochemical analysis and a 24-h urine specimen for cortisol estimation. Subjects wore a wrist actigraph for 7 days to measure activity and sleep.&#13;
&#13;
RESULTS: Sixty women (30% of participants) were found to fulfil the criteria for CRFS. There were statistically significant differences between fatigued and non-fatigued women with respect to fatigue severity (p&lt;0.01), mood (p&lt;0.01) and quality of life scores (p&lt;0.05). There were significant differences in blood variables including raised total white cell count and lower sodium (all p&lt;0.02). There was no difference in the 24h urinary free cortisol levels. Actigraphic data demonstrated significant differences in sleep quality and disturbance, but not in overall levels of daytime activity or circadian rhythm.&#13;
&#13;
CONCLUSION: CRFS affects 30% of women after breast cancer treatment and has significant effects on quality of life and mood. There is some evidence that CRFS is related to sleep disturbance or to a persistent inflammatory or immune response. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/101552/1/A_comparison_characteristics_disease_free_breast_cancer_survivors.pdf</dc:identifier><dc:language>en</dc:language><dc:source>0959-8049</dc:source><dc:title>A comparison of the characteristics of disease-free breast cancer survivors with or without cancer-related fatigue syndrome.</dc:title><rioxxterms:author>Alexander, S</rioxxterms:author><rioxxterms:author>Minton, O</rioxxterms:author><rioxxterms:author>Andrews, P</rioxxterms:author><rioxxterms:author>Stone, P</rioxxterms:author><rioxxterms:project funder_name="Cancer Research UK">A10090</rioxxterms:project><rioxxterms:project funder_name="Cancer Research UK">C11075/A7143</rioxxterms:project><rioxxterms:publication_date>2009-02</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.ejca.2008.09.010</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101429
Date: 2015-02-10

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101429</identifier>
      <datestamp>2015-02-10T13:49:59Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterized by isolated glucocorticoid deficiency with preserved mineralocorticoid secretion. Mutations in the ACTH receptor (MC2R) account for approximately 25% of all FGD cases, but since these are usually missense mutations, a degree of receptor function is frequently retained. A recent report, however, suggested that disturbances in the renin-aldosterone axis were seen in some patients with potentially more severe MC2R mutations. Furthermore, MC2R knock out mice have overt aldosterone deficiency and hyperkalaemia despite preservation of a normal zona glomerulosa. We wished to determine whether a group of patients with severe nonsense mutations of the MC2R exhibited evidence of mineralocorticoid deficiency, thereby challenging the conventional diagnostic feature of FGD which might result in diagnostic misclassification.</dc:description><dc:format>ERROR: cannot open `/www/sgul/eprints3/archives/sgul/documents/disk0/00/10/14/29/01/Homozygous' (No such file or directory)
ERROR: cannot open `nonsense' (No such file or directory)
ERROR: cannot open `and' (No such file or directory)
ERROR: cannot open `</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/101429/1/Homozygous%20nonsense%20and%20frameshift%20mutations%20of%20the%20ACTH.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Blackwell Publishing</dc:publisher><dc:source>0300-0664</dc:source><dc:title>Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency.</dc:title><rioxxterms:author>Chan, LF</rioxxterms:author><rioxxterms:author>Metherell, LA</rioxxterms:author><rioxxterms:author>Krude, H</rioxxterms:author><rioxxterms:author>Ball, C</rioxxterms:author><rioxxterms:author>O'Riordan, SM</rioxxterms:author><rioxxterms:author>Costigan, C</rioxxterms:author><rioxxterms:author>Lynch, SA</rioxxterms:author><rioxxterms:author>Savage, MO</rioxxterms:author><rioxxterms:author>Cavarzere, P</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:publication_date>2009-08-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1365-2265.2008.03511.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101402
Date: 2015-02-11

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101402</identifier>
      <datestamp>2015-02-11T14:37:34Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the underlying molecular and cellular mechanisms behind these deficits are not fully understood. Here we provide evidence of a mechanism by which Aβ42 affects synaptic transmission regulating neurotransmitter release. &#13;
&#13;
METHODOLOGY/FINDINGS: We first showed that application of 50 nM Aβ42 in cultured neurones is followed by its internalisation and translocation to synaptic contacts. Interestingly, our results demonstrate that with time, Aβ42 can be detected at the presynaptic terminals where it interacts with Synaptophysin. Furthermore, data from dissociated hippocampal neurons as well as biochemical data provide evidence that Aβ42 disrupts the complex formed between Synaptophysin and VAMP2 increasing the amount of primed vesicles and exocytosis. Finally, electrophysiology recordings in brain slices confirmed that Aβ42 affects baseline transmission. &#13;
&#13;
CONCLUSIONS/SIGNIFICANCE: Our observations provide a necessary and timely insight into cellular mechanisms that underlie the initial pathological events that lead to synaptic dysfunction in Alzheimer's disease. Our results demonstrate a new mechanism by which Aβ42 affects synaptic activity. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/101402/1/pone.0043201.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>PUBLIC LIBRARY SCIENCE</dc:publisher><dc:source>1932-6203</dc:source><dc:title>Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2.</dc:title><rioxxterms:author>Russell, CL</rioxxterms:author><rioxxterms:author>Semerdjieva, S</rioxxterms:author><rioxxterms:author>Empson, RM</rioxxterms:author><rioxxterms:author>Austen, BM</rioxxterms:author><rioxxterms:author>Beesley, PW</rioxxterms:author><rioxxterms:author>Alifragis, P</rioxxterms:author><rioxxterms:publication_date>2012-08-15</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0043201</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101295
Date: 2015-02-10

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101295</identifier>
      <datestamp>2015-02-10T13:56:39Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex following receptor activation.&#13;
&#13;
The melanocortin 2 receptor (MC2R) accessory protein (MRAP) is a small single-transmembrane domain protein that plays a pivotal role in the function of the MC2R. The pituitary hormone, ACTH, acts via this receptor complex to stimulate adrenal steroidogenesis. Using both coimmunoprecipitation and bioluminescence resonance energy transfer (BRET), we show that the MC2R is constitutively homodimerized in cells. Furthermore, consistent with previous data, we also show that MRAP exists as an antiparallel homodimer. ACTH enhanced the BRET signal between MC2R homodimers as well as MC2R-MRAP heterodimers. However, ACTH did not enhance the physical interaction between these dimers as determined by coimmunoprecipitation. Real-time BRET analysis of the MRAP-MC2R interaction revealed two distinct phases of the ACTH-dependent BRET increase, an initial complex series of changes occurring over the first 2 min and a later persistent increase in BRET signal. The slower ACTH-dependent phase was inhibited by the protein kinase A inhibitor KT5720, suggesting that signal transduction was a prerequisite for this later conformational change. The MRAP-MC2R BRET approach provides a unique tool with which to analyze the activation of this receptor.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/101295/1/en%252E2010%2D1053.pdf</dc:identifier><dc:language>en</dc:language><dc:source>0013-7227</dc:source><dc:title>Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells</dc:title><rioxxterms:author>Cooray, SN</rioxxterms:author><rioxxterms:author>Chung, TT</rioxxterms:author><rioxxterms:author>Mazhar, K</rioxxterms:author><rioxxterms:author>Szidonya, L</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:publication_date>2011-02-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1210/en.2010-1053</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:101131
Date: 2015-05-13

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:101131</identifier>
      <datestamp>2015-05-13T13:27:00Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objective To develop a scoring system to measure physical morbidity in critical care – the Chelsea Critical Care Physical Assessment Tool (CPAx). Method The development process was iterative involving content validity indices (CVI), a focus group and an observational study of 33 patients to test construct validity against the Medical Research Council score for muscle strength, peak cough flow, Australian Therapy Outcome Measures score, Glasgow Coma Scale score, Bloomsbury sedation score, Sequential Organ Failure Assessment score, Short Form 36 (SF-36) score, days of mechanical ventilation and inter-rater reliability. Participants Trauma and general critical care patients from two London teaching hospitals. Results Users of the CPAx felt that it possessed content validity, giving a final CVI of 1.00 (P &lt; 0.05). Construct validation data showed moderate to strong significant correlations between the CPAx score and all secondary measures, apart from the mental component of the SF-36 which demonstrated weak correlation with the CPAx score (r = 0.024, P = 0.720). Reliability testing showed internal consistency of α = 0.798 and inter-rater reliability of κ = 0.988 (95% confidence interval 0.791 to 1.000) between five raters. Conclusion This pilot work supports proof of concept of the CPAx as a measure of physical morbidity in the critical care population, and is a cogent argument for further investigation of the scoring system. </dc:description><dc:format>text/plain; charset=unknown</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/101131/1/licence.txt</dc:identifier><dc:language>en</dc:language><dc:publisher>ELSEVIER SCI LTD</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000314158000005&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0031-9406</dc:source><dc:title>The Chelsea Critical Care Physical Assessment Tool (CPAx): validation of an innovative new tool to measure physical morbidity in the general adult critical care population; an observational proof-of-concept pilot study.</dc:title><rioxxterms:author>Corner, EJ</rioxxterms:author><rioxxterms:author>Wood, H</rioxxterms:author><rioxxterms:author>Englebretsen, C</rioxxterms:author><rioxxterms:author>Thomas, A</rioxxterms:author><rioxxterms:author>Grant, RL</rioxxterms:author><rioxxterms:author>Nikoletou, D</rioxxterms:author><rioxxterms:author>Soni, N</rioxxterms:author><rioxxterms:publication_date>2013-03-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.physio.2012.01.003</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:100943
Date: 2016-08-26

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:100943</identifier>
      <datestamp>2016-08-26T10:23:13Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:format>ERROR: cannot open `/www/sgul/eprints3/archives/sgul/documents/disk0/00/10/09/43/01/Jin' (No such file or directory)
ERROR: cannot open `NEJM' (No such file or directory)
ERROR: cannot open `2010.pdf' (No such file or directory)</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/100943/1/Jin%20NEJM%202010.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>MASSACHUSETTS MEDICAL SOC</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000277311200006&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0028-4793</dc:source><dc:title>Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo.</dc:title><rioxxterms:author>Jin, Y</rioxxterms:author><rioxxterms:author>Birlea, SA</rioxxterms:author><rioxxterms:author>Fain, PR</rioxxterms:author><rioxxterms:author>Gowan, K</rioxxterms:author><rioxxterms:author>Riccardi, SL</rioxxterms:author><rioxxterms:author>Holland, PJ</rioxxterms:author><rioxxterms:author>Mailloux, CM</rioxxterms:author><rioxxterms:author>Sufit, AJ</rioxxterms:author><rioxxterms:author>Hutton, SM</rioxxterms:author><rioxxterms:author>Amadi-Myers, A</rioxxterms:author><rioxxterms:author>Bennett, DC</rioxxterms:author><rioxxterms:author>Wallace, MR</rioxxterms:author><rioxxterms:author>McCormack, WT</rioxxterms:author><rioxxterms:author>Kemp, EH</rioxxterms:author><rioxxterms:author>Gawkrodger, DJ</rioxxterms:author><rioxxterms:author>Weetman, AP</rioxxterms:author><rioxxterms:author>Picardo, M</rioxxterms:author><rioxxterms:author>Leone, G</rioxxterms:author><rioxxterms:author>Taïeb, A</rioxxterms:author><rioxxterms:author>Jouary, T</rioxxterms:author><rioxxterms:author>Ezzedine, K</rioxxterms:author><rioxxterms:author>van Geel, N</rioxxterms:author><rioxxterms:author>Lambert, J</rioxxterms:author><rioxxterms:author>Overbeck, A</rioxxterms:author><rioxxterms:author>Spritz, RA</rioxxterms:author><rioxxterms:publication_date>2010-05-06</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1056/NEJMoa0908547</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:100905
Date: 2015-02-10

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:100905</identifier>
      <datestamp>2015-02-10T14:01:11Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Context:&#13;
Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory protein (MRAP)[. The disorder is known as FGD type 1 and 2, respectively.&#13;
&#13;
Objective:&#13;
The aim of the study was to compare the phenotype/genotype relationships between FGD 1 and 2.&#13;
&#13;
Design and patients:&#13;
Forty patients with missense MC2R mutations and 22 patients with MRAP mutations were included. Forty-four of these patients had been referred for genetic screening and 18 were patients published by other authors.&#13;
&#13;
Results:&#13;
The median age at presentation for FGD type 1 was variable at 2·0 years; range 0·02–16 years, and this was associated with unusually tall stature, mean height SDS + 1·75 ± 1·53 (mean ± SD). In contrast, FGD type 2 presented at a much earlier median age (0·08 years; range at birth to 1·6 years) (P &lt; 0·01) and patients were of normal height SDS + 0·12 ± 1·35 (P &lt; 0·001). No differences in baseline cortisol or ACTH levels were seen between FGD types 1 and 2.&#13;
&#13;
Conclusion:&#13;
FGD type 2 appears to present earlier. This may reflect the functional significance of the underlying mutations in that all MRAP mutations are nonsense or splice site mutations that result in abolition of a functional protein, whereas most of the MC2R mutations are missense mutations and give rise to proteins with some residual function. Tall stature is associated with mutations in MC2R but not in MRAP. There were no other significant clinical distinctions between the two.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/100905/1/cen0072%2D0589.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>WILEY-BLACKWELL PUBLISHING, INC</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000276013000003&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0300-0664</dc:source><dc:title>Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2</dc:title><rioxxterms:author>Chung, TT</rioxxterms:author><rioxxterms:author>Chan, LF</rioxxterms:author><rioxxterms:author>Metherell, LA</rioxxterms:author><rioxxterms:author>Clark, AJ</rioxxterms:author><rioxxterms:publication_date>2010-05-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1365-2265.2009.03663.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:100764
Date: 2015-02-05

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:100764</identifier>
      <datestamp>2015-02-05T11:28:48Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Cryptococcosis is a life-threatening fungal disease with a high rate of mortality among HIV/AIDS patients across the world. The ability to penetrate the blood-brain barrier (BBB) is central to the pathogenesis of cryptococcosis, but the way in which this occurs remains unclear. Here we use both mouse and human brain derived endothelial cells (bEnd3 and hCMEC/D3) to accurately quantify fungal uptake and survival within brain endothelial cells. Our data indicate that the adherence and internalisation of cryptococci by brain microvascular endothelial cells is an infrequent event involving small numbers of cryptococcal yeast cells. Interestingly, this process requires neither active signalling from the fungus nor the presence of the fungal capsule. Thus entry into brain microvascular endothelial cells is most likely a passive event that occurs following ‘trapping’ within capillary beds of the BBB.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/100764/1/pone.0035455.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1932-6203</dc:source><dc:title>Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells.</dc:title><rioxxterms:author>Sabiiti, W</rioxxterms:author><rioxxterms:author>May, RC</rioxxterms:author><rioxxterms:publication_date>2012-04-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0035455</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:100243
Date: 2015-02-11

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:100243</identifier>
      <datestamp>2015-02-11T14:35:39Z</datestamp>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/100243/1/55186_0_art_file_470177_lng6jn_convrt.pdf</dc:identifier><dc:language>en</dc:language><dc:source>PLOSone</dc:source><dc:title>Amyloid-ß Acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2</dc:title><rioxxterms:author>Austen, BM</rioxxterms:author><rioxxterms:author>Russell, CL</rioxxterms:author><rioxxterms:author>Semerdjieva, S</rioxxterms:author><rioxxterms:author>Empson, RM</rioxxterms:author><rioxxterms:author>Beesley, PW</rioxxterms:author><rioxxterms:author>Alifragis, P</rioxxterms:author><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:2074
Date: 2015-02-10

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:2074</identifier>
      <datestamp>2015-02-10T14:05:28Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background:&#13;
The United Kingdom NHS Breast Screening Programme was established in 1988, and women aged between 50 and 70 are routinely invited at three yearly intervals. Expected United Kingdom interval cancer rates have been calculated previously, but this is the first publication from an exercise to collate individual-based interval cancer data at a national level.&#13;
&#13;
Methods:&#13;
Interval cancer case ascertainment is achieved by the regular exchange of data between Regional Breast Screening Quality Assurance Reference Centres and Cancer Registries. The present analysis includes interval cancers identified in women screened between 1st April 1997 and 31st March 2003, who were aged between 50 and 64 at the time of their last routine screen.&#13;
&#13;
Results:&#13;
In the periods &gt;0–&lt;12 months, 12–&lt;24 months and 24–&lt;36 months after a negative screen, we found overall interval cancer rates and regional ranges of 0.55 (0.43–0.76), 1.13 (0.92–1.47) and 1.22 (0.93–1.57) per 1000 women screened, respectively. Rates in the period 33–&lt;36 months showed a decline, possibly associated with early re-screening or delayed presentation.&#13;
&#13;
Conclusions:&#13;
Interval cancer rates were higher than the expected rates in the 24-month period after a negative screen, but were similar to published results from other countries. Increases in background incidence may mean that the expected rates are underestimated. It is also possible that, as a result of incomplete case ascertainment, interval cancers rates were underestimated in some regions in which rates were less than the expected.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/2074/1/bjc20113a.pdf</dc:identifier><dc:language>en</dc:language><dc:source>0007-0920</dc:source><dc:title>Interval cancers in the NHS breast cancer screening programme in England, Wales and Northern Ireland.</dc:title><rioxxterms:author>Bennett, RL</rioxxterms:author><rioxxterms:author>Sellars, SJ</rioxxterms:author><rioxxterms:author>Moss, SM</rioxxterms:author><rioxxterms:publication_date>2011-10-04</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/bjc.2011.3</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:2068
Date: 2015-02-04

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:2068</identifier>
      <datestamp>2015-02-04T15:31:30Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Objectives: To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death.&#13;
&#13;
Design: Systematic review and meta-analysis.&#13;
&#13;
Data sources: PubMed from 1966 to 23 November 2009.&#13;
&#13;
Study selection: Prospective longitudinal studies that used magnetic resonance imaging and assessed the impact of white matter hyperintensities on risk of incident stroke, cognitive decline, dementia, and death, and, for the meta-analysis, studies that provided risk estimates for a categorical measure of white matter hyperintensities, assessing the impact of these lesions on risk of stroke, dementia, and death.&#13;
&#13;
Data extraction: Population studied, duration of follow-up, method used to measure white matter hyperintensities, definition of the outcome, and measure of the association of white matter hyperintensities with the outcome.&#13;
&#13;
Data synthesis: 46 longitudinal studies evaluated the association of white matter hyperintensities with risk of stroke (n=12), cognitive decline (n=19), dementia (n=17), and death (n=10). 22 studies could be included in a meta-analysis (nine of stroke, nine of dementia, eight of death). White matter hyperintensities were associated with an increased risk of stroke (hazard ratio 3.3, 95% confidence interval 2.6 to 4.4), dementia (1.9, 1.3 to 2.8), and death (2.0, 1.6 to 2.7). An association of white matter hyperintensities with a faster decline in global cognitive performance, executive function, and processing speed was also suggested.&#13;
&#13;
Conclusion: White matter hyperintensities predict an increased risk of stroke, dementia, and death. Therefore white matter hyperintensities indicate an increased risk of cerebrovascular events when identified as part of diagnostic investigations, and support their use as an intermediate marker in a research setting. Their discovery should prompt detailed screening for risk factors of stroke and dementia.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/2068/1/The_clinical_importance_white_matter_hyperintensities_brain.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1756-1833</dc:source><dc:title>The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis.</dc:title><rioxxterms:author>Debette, S</rioxxterms:author><rioxxterms:author>Markus, HS</rioxxterms:author><rioxxterms:publication_date>2010-05</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:1813
Date: 2016-03-10

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:1813</identifier>
      <datestamp>2016-03-10T16:40:03Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Transepithelial transport of Na+ across the lung epithelium via amiloride-sensitive Na+ channels (ENaC) regulates fluid volume in the lung lumen. Activators of AMP-activated protein kinase (AMPK), the adenosine monophosphate mimetic AICAR, and the biguanide metformin decreased amiloride-sensitive apical Na+ conductance (GNa+) in human H441 airway epithelial cell monolayers. Cell-attached patch-clamp recordings identified two distinct constitutively active cation channels in the apical membrane that were likely to contribute to GNa+: a 5-pS highly Na+ selective ENaC-like channel (HSC) and an 18-pS nonselective cation channel (NSC). Substituting NaCl with NMDG-Cl in the patch pipette solution shifted the reversal potentials of HSC and NSC, respectively, from +23 mV to −38 mV and 0 mV to −35 mV. Amiloride at 1 μM inhibited HSC activity and 56% of short-circuit current (Isc), whereas 10 μM amiloride partially reduced NSC activity and inhibited a further 30% of Isc. Neither conductance was associated with CNG channels as there was no effect of 10 μM pimoside on Isc, HSC, or NSC activity, and 8-bromo-cGMP (0.3–0.1 mM) did not induce or increase HSC or NSC activity. Pretreatment of H441 monolayers with 2 mM AICAR inhibited HSC/NSC activity by 90%, and this effect was reversed by the AMPK inhibitor Compound C. All three ENaC proteins were identified in the apical membrane of H441 monolayers, but no change in their abundance was detected after treatment with AICAR. In conclusion, activation of AMPK with AICAR in H441 cell monolayers is associated with inhibition of two distinct amiloride-sensitive Na+-permeable channels by a mechanism that likely reduces channel open probability.</dc:description><dc:language>en</dc:language><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000260535000013&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1040-0605</dc:source><dc:title>AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers</dc:title><rioxxterms:author>Albert, AP</rioxxterms:author><rioxxterms:author>Woollhead, AM</rioxxterms:author><rioxxterms:author>Mace, OJ</rioxxterms:author><rioxxterms:author>Baines, DL</rioxxterms:author><rioxxterms:publication_date>2008-11-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1152/ajplung.90353.2008</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:1723
Date: 2016-03-18

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:1723</identifier>
      <datestamp>2016-03-18T13:32:03Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Background:&#13;
There is a lack of tools to evaluate and compare Electronic patient record (EPR) systems to inform a rational choice or development agenda.&#13;
&#13;
Objective:&#13;
To develop a tool kit to measure the impact of different EPR system features on the consultation.&#13;
&#13;
Methods:&#13;
We first developed a specification to overcome the limitations of existing methods. We divided this into work packages: (1) developing a method to display multichannel video of the consultation; (2) code and measure activities, including computer use and verbal interactions; (3) automate the capture of nonverbal interactions; (4) aggregate multiple observations into a single navigable output; and (5) produce an output interpretable by software developers. We piloted this method by filming live consultations (n = 22) by 4 general practitioners (GPs) using different EPR systems. We compared the time taken and variations during coded data entry, prescribing, and blood pressure (BP) recording. We used nonparametric tests to make statistical comparisons. We contrasted methods of BP recording using Unified Modeling Language (UML) sequence diagrams.&#13;
&#13;
Results:&#13;
We found that 4 channels of video were optimal. We identified an existing application for manual coding of video output. We developed in-house tools for capturing use of keyboard and mouse and to time stamp speech. The transcript is then typed within this time stamp. Although we managed to capture body language using pattern recognition software, we were unable to use this data quantitatively. We loaded these observational outputs into our aggregation tool, which allows simultaneous navigation and viewing of multiple files. This also creates a single exportable file in XML format, which we used to develop UML sequence diagrams. In our pilot, the GP using the EMIS LV (Egton Medical Information Systems Limited, Leeds, UK) system took the longest time to code data (mean 11.5 s, 95% CI 8.7-14.2). Nonparametric comparison of EMIS LV with the other systems showed a significant difference, with EMIS PCS (Egton Medical Information Systems Limited, Leeds, UK) (P = .007), iSoft Synergy (iSOFT, Banbury, UK) (P = .014), and INPS Vision (INPS, London, UK) (P = .006) facilitating faster coding. In contrast, prescribing was fastest with EMIS LV (mean 23.7 s, 95% CI 20.5-26.8), but nonparametric comparison showed no statistically significant difference. UML sequence diagrams showed that the simplest BP recording interface was not the easiest to use, as users spent longer navigating or looking up previous blood pressures separately. Complex interfaces with free-text boxes left clinicians unsure of what to add.&#13;
&#13;
Conclusions:&#13;
The ALFA method allows the precise observation of the clinical consultation. It enables rigorous comparison of core elements of EPR systems. Pilot data suggests its capacity to demonstrate differences between systems. Its outputs could provide the evidence base for making more objective choices between systems.&#13;
Keywords: Video recordings, process assessment, observation, attitude to computer, professional-patient relations, general practice, family practice, decision modeling, process assessment, medical informatics, computers, medical records systems, computerized, electronic patient record (EPR), electronic medical record (EMR), evaluation methodologies, usability</dc:description><dc:language>en</dc:language><dc:publisher>JOURNAL MEDICAL INTERNET RESEARCH</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000263213900010&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1438-8871</dc:source><dc:title>The ALFA (Activity Log Files Aggregation) Toolkit: A Method for Precise Observation of the Consultation</dc:title><rioxxterms:author>de Lusignan, S</rioxxterms:author><rioxxterms:author>Kumarapeli, P</rioxxterms:author><rioxxterms:author>Chan, T</rioxxterms:author><rioxxterms:author>Pflug, B</rioxxterms:author><rioxxterms:author>van Vlymen, J</rioxxterms:author><rioxxterms:author>Jones, B</rioxxterms:author><rioxxterms:author>Freeman, GK</rioxxterms:author><rioxxterms:publication_date>2008-01-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.2196/jmir.1080</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:1488
Date: 2015-02-03

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ali:license_ref'2011-05' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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ali:license_ref'2011-05' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:1488</identifier>
      <datestamp>2015-02-03T12:12:23Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011-05">http://creativecommons.org/licenses/by-nd-sa/4.0</ali:license_ref><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/1488/1/Improving_reporting_animal_research_ARRIVE.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1754-8411</dc:source><dc:title>Improving the reporting of animal research: when will we ARRIVE?</dc:title><rioxxterms:author>Percie du Sert, N</rioxxterms:author><rioxxterms:publication_date>2011-05</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1242/dmm.007971</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:1238
Date: 2015-02-11

RIOXX

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:1238</identifier>
      <datestamp>2015-02-11T11:20:25Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Glucose concentrations of normal human airway surface liquid are approximately 12.5 times lower than blood glucose concentrations indicating that glucose uptake by epithelial cells may play a role in maintaining lung glucose homeostasis. We have therefore investigated potential glucose uptake mechanisms in non-polarised and polarised H441 human airway epithelial cells and bronchial biopsies. We detected mRNA and protein for glucose transporter type 2 (GLUT2) and glucose transporter type 4 (GLUT4) in non-polarised cells but GLUT4 was not detected in the plasma membrane. In polarised cells, GLUT2 protein was detected in both apical and basolateral membranes. Furthermore, GLUT2 protein was localised to epithelial cells of human bronchial mucosa biopsies. In non-polarised H441 cells, uptake of D: -glucose and deoxyglucose was similar. Uptake of both was inhibited by phloretin indicating that glucose uptake was via GLUT-mediated transport. Phloretin-sensitive transport remained the predominant route for glucose uptake across apical and basolateral membranes of polarised cells and was maximal at 5-10 mM glucose. We could not conclusively demonstrate sodium/glucose transporter-mediated transport in non-polarised or polarised cells. Our study provides the first evidence that glucose transport in human airway epithelial cells in vitro and in vivo utilises GLUT2 transporters. We speculate that these transporters could contribute to glucose uptake/homeostasis in the human airway. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/1238/1/424_2008_Article_459.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>SPRINGER</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000256825000018&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0031-6768</dc:source><dc:title>Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells</dc:title><rioxxterms:author>Kalsi, KK</rioxxterms:author><rioxxterms:author>Baker, EH</rioxxterms:author><rioxxterms:author>Medina, RA</rioxxterms:author><rioxxterms:author>Rice, S</rioxxterms:author><rioxxterms:author>Wood, DM</rioxxterms:author><rioxxterms:author>Ratoff, JC</rioxxterms:author><rioxxterms:author>Philips, BJ</rioxxterms:author><rioxxterms:author>Baines, DL</rioxxterms:author><rioxxterms:publication_date>2008-08-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1007/s00424-008-0459-8</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:1031
Date: 2015-02-03

RIOXX

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:1031</identifier>
      <datestamp>2015-02-03T12:04:06Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>BACKGROUND: Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in isolates of Plasmodium vivax (PvDHFR) although anti-folates have not been widely used for the treatment of this infection. Here the interactions between DHFR inhibitors and modelled structures of the DHFR enzymes of Plasmodium malariae (PmDHFR) and Plasmodium ovale (PoDHFR) are described, along with an investigation of the effect of recently reported mutations within PmDHFR. &#13;
&#13;
METHODS: DHFR models for PmDHFR and PoDHFR were constructed using the solved PfDHFR-TS and PvDHFR structures respectively as templates. The modelled structures were docked with three DHFR inhibitors as ligands and more detailed interactions were explored via simulation of molecular dynamics. &#13;
&#13;
RESULTS: Highly accurate models were obtained containing sets of residues that mediate ligand binding which are highly comparable to those mediating binding in known crystal structures. Within this set, there were differences in the relative contribution of individual residues to inhibitor binding. Modelling of PmDHFR mutant sequences revealed that PmDHFR I170M was associated with a significant reduction in binding energy to all DHFR inhibitors studied, while the other predicted resistance mutations had lesser or no effects on ligand binding. &#13;
&#13;
CONCLUSIONS: Binding of DHFR inhibitors to the active sites of all four Plasmodium enzymes is broadly similar, being determined by an analogous set of seven residues. PmDHFR mutations found in field isolates influenced inhibitor interactions to a varying extent. In the case of the isolated I170M mutation, the loss of interaction with pyrimethamine suggests that DHFR-inhibitor interactions in P. malariae are different to those seen for DHFRs from P. falciparum and P. vivax. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/1031/1/Computational_analysis_binding_between_malarial.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1475-2875</dc:source><dc:title>Computational analysis of binding between malarial dihydrofolate reductases and anti-folates.</dc:title><rioxxterms:author>Choowongkomon, K</rioxxterms:author><rioxxterms:author>Theppabutr, S</rioxxterms:author><rioxxterms:author>Songtawee, N</rioxxterms:author><rioxxterms:author>Day, NP</rioxxterms:author><rioxxterms:author>White, NJ</rioxxterms:author><rioxxterms:author>Woodrow, CJ</rioxxterms:author><rioxxterms:author>Imwong, M</rioxxterms:author><rioxxterms:project funder_name="Wellcome Trust">080867/Z/06/Z</rioxxterms:project><rioxxterms:project funder_name="Wellcome Trust">093956</rioxxterms:project><rioxxterms:project funder_name="Medical Research Council">G108/667</rioxxterms:project><rioxxterms:publication_date>2010-03-02</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1475-2875-9-65</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:881
Date: 2015-02-20

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rioxxterms:project'' is not a valid project_id in rioxxterms:project

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rioxxterms:project'' is not a valid project_id in rioxxterms:project
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:881</identifier>
      <datestamp>2015-02-20T15:18:45Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Abdominal aortic aneurysms (AAA) are characterized by pathological remodeling of the aortic extracellular matrix (ECM). However, besides the well-characterized elastolysis and collagenolysis little is known about changes in other ECM proteins. Previous proteomics studies on AAA focused on cellular changes without emphasis on the ECM. In the present study, ECM proteins and their degradation products were selectively extracted from aneurysmal and control aortas using a solubility-based subfractionation methodology and analyzed by gel-liquid chromatography-tandem MS and label-free quantitation. The proteomics analysis revealed novel changes in the ECM of AAA, including increased expression as well as degradation of collagen XII, thrombospondin 2, aortic carboxypeptidase-like protein, periostin, fibronectin and tenascin. Proteomics also confirmed the accumulation of macrophage metalloelastase (MMP-12). Incubation of control aortic tissue with recombinant MMP-12 resulted in the extensive fragmentation of these glycoproteins, most of which are novel substrates of MMP-12. In conclusion, our proteomics methodology allowed the first detailed analysis of the ECM in AAA and identified markers of pathological ECM remodeling related to MMP-12 activity.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/881/1/Extracellular_matrix_composition_remodeling_human_abdomial_aortic.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1535-9484</dc:source><dc:title>Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach.</dc:title><rioxxterms:author>Didangelos, A</rioxxterms:author><rioxxterms:author>Yin, X</rioxxterms:author><rioxxterms:author>Mandal, K</rioxxterms:author><rioxxterms:author>Saje, A</rioxxterms:author><rioxxterms:author>Smith, A</rioxxterms:author><rioxxterms:author>Xu, Q</rioxxterms:author><rioxxterms:author>Jahangiri, M</rioxxterms:author><rioxxterms:author>Mayr, M</rioxxterms:author><rioxxterms:project funder_name="British Heart Foundation">FS/08/002/24537</rioxxterms:project><rioxxterms:project funder_name="British Heart Foundation"/><rioxxterms:publication_date>2011-08</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1074/mcp.M111.008128</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:868
Date: 2015-03-03

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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:868</identifier>
      <datestamp>2015-03-03T13:24:20Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Obesity is associated with elevated inflammatory signals from various adipose tissue depots. This study aimed to evaluate release of regulated on activation, normal T cell expressed and secreted (RANTES) by human adipose tissue in vivo and ex vivo, in reference to monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) release. Arteriovenous differences of RANTES, MCP-1, and IL-6 were studied in vivo across the abdominal subcutaneous adipose tissue in healthy Caucasian subjects with a wide range of adiposity. Systemic levels and ex vivo RANTES release were studied in abdominal subcutaneous, gastric fat pad, and omental adipose tissue from morbidly obese bariatric surgery patients and in thoracic subcutaneous and epicardial adipose tissue from cardiac surgery patients without coronary artery disease. Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity. However, in vivo release of MCP-1 and RANTES, but not IL-6, was lower than circulating levels. Ex vivo release of RANTES was greater from the gastric fat pad compared with omental (P = 0.01) and subcutaneous (P = 0.001) tissue. Epicardial adipose tissue released less RANTES than thoracic subcutaneous adipose tissue in lean (P = 0.04) but not obese subjects. Indexes of obesity correlated with epicardial RANTES but not with systemic RANTES or its release from other depots. In conclusion, RANTES is released by human subcutaneous adipose tissue in vivo and in varying amounts by other depots ex vivo. While it appears unlikely that the adipose organ contributes significantly to circulating levels, local implications of this chemokine deserve further investigation.</dc:description><dc:language>en</dc:language><dc:publisher>AMERICAN PHYSIOLOGICAL SOCIETY</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000266342500008&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0193-1849</dc:source><dc:title>RANTES release by human adipose tissue in vivo and evidence for depot-specific differences</dc:title><rioxxterms:author>Madani, R</rioxxterms:author><rioxxterms:author>Karastergiou, K</rioxxterms:author><rioxxterms:author>Ogston, NC</rioxxterms:author><rioxxterms:author>Miheisi, N</rioxxterms:author><rioxxterms:author>Bhome, R</rioxxterms:author><rioxxterms:author>Haloob, N</rioxxterms:author><rioxxterms:author>Tan, GD</rioxxterms:author><rioxxterms:author>Karpe, F</rioxxterms:author><rioxxterms:author>Malone-Lee, J</rioxxterms:author><rioxxterms:author>Hashemi, M</rioxxterms:author><rioxxterms:author>Jahangiri, M</rioxxterms:author><rioxxterms:author>Mohamed-Ali, V</rioxxterms:author><rioxxterms:publication_date>2009-06-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1152/ajpendo.90511.2008</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:586
Date: 2015-02-12

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:586</identifier>
      <datestamp>2015-02-12T15:23:18Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>The causal interpretation of reported associations between daily air pollution and daily admissions requires consideration of residual confounding, correlation between pollutants, and effect modification. If results obtained in Hong Kong and London--which differ in climate, lifestyle, and many other respects--were similar, a causal association would be supported. We used identical statistical methods for the analysis in each city. Associations between daily admissions and pollutant levels were estimated using Poisson regression. Nonparametric smoothing methods were used to model seasonality and the nonlinear dependence of admissions on temperature, humidity, and influenza admissions. For respiratory admissions (&gt; or = 65 years of age), significant positive associations were observed with particulate matter &lt; 10 microm in aerodynamic diameter (PM(10), nitrogen dioxide, sulfur dioxide, and ozone in both cities. These associations tended to be stronger at shorter lags in Hong Kong and at longer lags in London. Associations were stronger in the cool season in Hong Kong and in the warm season in London, periods during which levels of humidity are at their lowest in each city. For cardiac admissions (all ages) in both cities, significant positive associations were observed for PM(10), NO(2), and SO(2) with similar lag patterns. Associations tended to be stronger in the cool season. The associations with NO(2) and SO(2) were the most robust in two-pollutant models. Patterns of association for pollutants with ischemic heart disease were similar in the two cities. The associations between O(3) and cardiac admissions were negative in London but positive in Hong Kong. We conclude that air pollution has remarkably similar associations with daily cardiorespiratory admissions in both cities, in spite of considerable differences between cities in social, lifestyle, and environmental factors. The results strengthen the argument that air pollution causes detrimental short-term health effects. </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/586/1/ehp0110%2D000067.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000173864000028&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0091-6765</dc:source><dc:title>A tale of two cities: Effects of air pollution on hospital admissions in Hong Kong and London compared</dc:title><rioxxterms:author>Wong, CM</rioxxterms:author><rioxxterms:author>Atkinson, RW</rioxxterms:author><rioxxterms:author>Anderson, HR</rioxxterms:author><rioxxterms:author>Hedley, AJ</rioxxterms:author><rioxxterms:author>Ma, S</rioxxterms:author><rioxxterms:author>Chau, PY</rioxxterms:author><rioxxterms:author>Lam, TH</rioxxterms:author><rioxxterms:publication_date>2002-01-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:512
Date: 2016-03-15

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:512</identifier>
      <datestamp>2016-03-15T15:52:45Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Background:&#13;
Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart disease and major stroke subtypes. We aimed to quantify these associations for a wide range of circumstances.&#13;
&#13;
Methods:&#13;
We undertook a meta-analysis of individual records of diabetes, fasting blood glucose concentration, and other risk factors in people without initial vascular disease from studies in the Emerging Risk Factors Collaboration. We combined within-study regressions that were adjusted for age, sex, smoking, systolic blood pressure, and body-mass index to calculate hazard ratios (HRs) for vascular disease.&#13;
&#13;
Findings:&#13;
Analyses included data for 698 782 people (52 765 non-fatal or fatal vascular outcomes; 8·49 million person-years at risk) from 102 prospective studies. Adjusted HRs with diabetes were: 2·00 (95% CI 1·83–2·19) for coronary heart disease; 2·27 (1·95–2·65) for ischaemic stroke; 1·56 (1·19–2·05) for haemorrhagic stroke; 1·84 (1·59–2·13) for unclassified stroke; and 1·73 (1·51–1·98) for the aggregate of other vascular deaths. HRs did not change appreciably after further adjustment for lipid, inflammatory, or renal markers. HRs for coronary heart disease were higher in women than in men, at 40–59 years than at 70 years and older, and with fatal than with non-fatal disease. At an adult population-wide prevalence of 10%, diabetes was estimated to account for 11% (10–12%) of vascular deaths. Fasting blood glucose concentration was non-linearly related to vascular risk, with no significant associations between 3·90 mmol/L and 5·59 mmol/L. Compared with fasting blood glucose concentrations of 3·90–5·59 mmol/L, HRs for coronary heart disease were: 1·07 (0·97–1·18) for lower than 3·90 mmol/L; 1·11 (1·04–1·18) for 5·60–6·09 mmol/L; and 1·17 (1·08–1·26) for 6·10–6·99 mmol/L. In people without a history of diabetes, information about fasting blood glucose concentration or impaired fasting glucose status did not significantly improve metrics of vascular disease prediction when added to information about several conventional risk factors.&#13;
&#13;
Interpretation:&#13;
Diabetes confers about a two-fold excess risk for a wide range of vascular diseases, independently from other conventional risk factors. In people without diabetes, fasting blood glucose concentration is modestly and non-linearly associated with risk of vascular disease.</dc:description><dc:language>en</dc:language><dc:publisher>ELSEVIER SCIENCE INC</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000279652900018&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0140-6736</dc:source><dc:title>Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies</dc:title><rioxxterms:author>Emerging Risk Factors Collaboration, </rioxxterms:author><rioxxterms:author>Sarwar, N</rioxxterms:author><rioxxterms:author>Gao, P</rioxxterms:author><rioxxterms:author>Seshasai, SR</rioxxterms:author><rioxxterms:author>Gobin, R</rioxxterms:author><rioxxterms:author>Kaptoge, S</rioxxterms:author><rioxxterms:author>Di Angelantonio, E</rioxxterms:author><rioxxterms:author>Ingelsson, E</rioxxterms:author><rioxxterms:author>Lawlor, DA</rioxxterms:author><rioxxterms:author>Selvin, E</rioxxterms:author><rioxxterms:author>Stampfer, M</rioxxterms:author><rioxxterms:author>Stehouwer, CD</rioxxterms:author><rioxxterms:author>Lewington, S</rioxxterms:author><rioxxterms:author>Pennells, L</rioxxterms:author><rioxxterms:author>Thompson, A</rioxxterms:author><rioxxterms:author>Sattar, N</rioxxterms:author><rioxxterms:author>White, IR</rioxxterms:author><rioxxterms:author>Ray, KK</rioxxterms:author><rioxxterms:author>Danesh, J</rioxxterms:author><rioxxterms:publication_date>2010-06-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/S0140-6736(10)60484-9</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:487
Date: 2015-03-03

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:487</identifier>
      <datestamp>2015-03-03T11:24:15Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes. Application of diC8-PIP2, a water soluble form of PIP2, to quiescent inside-out patches evoked single channel currents with a unitary conductance of 1.9 pS. DiC8-PIP2-evoked channel currentswere inhibited by anti-TRPC1 antibodies and these characteristics are identical to SOCs evoked by cyclopiazonic acid (CPA) and BAPTA-AM. SOCs stimulated by CPA, BAPTA-AM and the phorbol ester phorbol 12,13-dibutyrate (PDBu) were reduced by anti-PIP2 antibodies and by depletion of tissue PIP2 levels by pre-treatment of preparations with wortmannin and LY294002. However, these reagents did not alter the ability of PIP2 to activate SOCs in inside-out patches. Co-immunoprecipitation techniques demonstrated association&#13;
between TRPC1 and PIP2 at rest, which was greatly decreased by wortmannin and LY294002. Pre-treatment of cells with PDBu, which activates protein kinase C (PKC), augmented SOC&#13;
activation by PIP2 whereas the PKC inhibitor chelerythrine decreased SOC stimulation by PIP2. Co-immunoprecipitation experiments provide evidence that PKC-dependent phosphorylation of TRPC1 occurs constitutively and was increased by CPA and PDBu but decreased by&#13;
chelerythrine. These novel results show that PIP2 can activate TRPC1 SOCs in native vascular myocytes and plays an important role in SOC activation by CPA, BAPTA-AM and&#13;
PDBu. Moreover, the permissive role of PIP2 in SOC activation requires PKC-dependent phosphorylation of TRPC1.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/487/1/tjp0587%2D0531.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>WILEY-BLACKWELL PUBLISHING, INC</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000262944900006&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0022-3751</dc:source><dc:title>Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes</dc:title><rioxxterms:author>Saleh, SN</rioxxterms:author><rioxxterms:author>Albert, AP</rioxxterms:author><rioxxterms:author>Large, WA</rioxxterms:author><rioxxterms:publication_date>2009-02-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1113/jphysiol.2008.166678</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:463
Date: 2015-05-01

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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:463</identifier>
      <datestamp>2015-05-01T13:08:44Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background&#13;
In the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), early recurrent carotid&#13;
stenosis was more common in patients assigned to endovascular treatment than it was in patients assigned to&#13;
endarterectomy (CEA), raising concerns about the long-term eff ectiveness of endovascular treatment. We aimed to&#13;
investigate the long-term risks of restenosis in patients included in CAVATAS.&#13;
Methods&#13;
413 patients who were randomly assigned in CAVATAS and completed treatment for carotid stenosis(200 patients had endovascular treatment and 213 patients had endarterectomy) had prospective clinical follow-up at a median of 5 years and carotid duplex ultrasound at a median of 4 years. We investigated the cumulative long-term incidence of carotid restenosis after endovascular treatment and endarterectomy, the effect of the use of stents on restenosis after endovascular treatment, risk factors for the development of restenosis, and the eff ect of carotid restenosis on the risk of recurrent cerebrovascular events. Analysis was by intention to treat. This study is registered, number ISRCTN01425573.&#13;
&#13;
Findings&#13;
Severe carotid restenosis (≥70%) or occlusion occurred significantly more often in patients in the endovascular&#13;
arm than in patients in the endarterectomy arm (adjusted hazard ratio [HR] 3·17, 95% CI 1·89–5·32; p&lt;0·0001). The&#13;
estimated 5-year incidence of restenosis was 30·7% in the endovascular arm and 10·5% in the endarterectomy arm.&#13;
Patients in the endovascular arm who were treated with a stent (n=50) had a signifi cantly lower risk of developing&#13;
restenosis of 70% or greater compared with those treated with balloon angioplasty alone (n=145; HR 0·43, 0·19–0·97;&#13;
p=0·04). Current smoking or a history of smoking was a predictor of restenosis of 70% or more (2·32, 1·19–4·54;&#13;
p=0·01) and the early fi nding of moderate stenosis (50–69%) up to 60 days after treatment was associated with the risk of progression to restenosis of 70% or more (3·76, 1·88–7·52; p=0·0002). The composite endpoint of ipsilateral&#13;
non-perioperative stroke or transient ischaemic attack occurred more often in patients in whom restenosis of 70% or&#13;
more was diagnosed in the fi rst year after treatment compared with patients without restenosis of 70% or more&#13;
(5-year incidence 23%vs 11%; HR 2·18, 1·04–4·54; p=0·04), but the increase in ipsilateral stroke alone was not&#13;
significant (10% vs 5%; 1·67, 0·54–5·11).&#13;
&#13;
Interpretation&#13;
Restenosis is about three times more common after endovascular treatment than after endarterectomy and is associated with recurrent ipsilateral cerebrovascular symptoms; however, the risk of recurrent ipsilateral stroke&#13;
is low. Further data are required from on-going trials of stenting versus endarterectomy to ascertain whether long-&#13;
term ultrasound follow-up is necessary after carotid revascularisation&#13;
</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/463/1/1%2Ds2.0%2DS1474442209702273%2Dmain.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>ELSEVIER SCIENCE INC</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000270111200013&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1474-4422</dc:source><dc:title>Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial</dc:title><rioxxterms:author>Bonati, LH</rioxxterms:author><rioxxterms:author>Ederle, J</rioxxterms:author><rioxxterms:author>McCabe, DJ</rioxxterms:author><rioxxterms:author>Dobson, J</rioxxterms:author><rioxxterms:author>Featherstone, RL</rioxxterms:author><rioxxterms:author>Gaines, PA</rioxxterms:author><rioxxterms:author>Beard, JD</rioxxterms:author><rioxxterms:author>Venables, GS</rioxxterms:author><rioxxterms:author>Markus, HS</rioxxterms:author><rioxxterms:author>Clifton, A</rioxxterms:author><rioxxterms:author>Sandercock, P</rioxxterms:author><rioxxterms:author>Brown, MM</rioxxterms:author><rioxxterms:author>CAVATAS Investigators, </rioxxterms:author><rioxxterms:publication_date>2009-10-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/S1474-4422(09)70227-3</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:411
Date: 2017-02-02

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    <header>
      <identifier>oai:openaccess.sgul.ac.uk:411</identifier>
      <datestamp>2017-02-02T14:47:10Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/411/1/jg1045857.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>ROCKEFELLER UNIV PRESS</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=A1994PT78200003&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>0022-1295</dc:source><dc:title>ORIGINS OF OPEN-CHANNEL NOISE IN THE LARGE POTASSIUM CHANNEL OF SARCOPLASMIC-RETICULUM</dc:title><rioxxterms:author>Hainsworth, AH</rioxxterms:author><rioxxterms:author>Levis, RA</rioxxterms:author><rioxxterms:author>Eisenberg, RS</rioxxterms:author><rioxxterms:publication_date>1994-11-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1085/jgp.104.5.857</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:256
Date: 2015-04-30

RIOXX

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This is not a valid RCUK-RIOXX record
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:256</identifier>
      <datestamp>2015-04-30T16:01:41Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Endovascular treatment (angioplasty with or without stenting) is an alternative to carotid endarterectomy for carotid artery stenosis but there are scarce long-term efficacy data showing that it prevents stroke. We therefore report the long-term results of the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS).&#13;
Methods&#13;
&#13;
Between March, 1992, and July, 1997, patients who presented at a participating centre with a confirmed stenosis of the internal carotid artery that was deemed equally suitable for either carotid endarterectomy or endovascular treatment were randomly assigned to either treatment in equal proportions by telephone or fax from the randomisation service at the Oxford Clinical Trials Unit, UK. Patients were seen by an independent neurologist at 1 and 6 months after treatment and then every year after randomisation for as long as possible, up to a maximum of 11 years. Major outcome events were transient ischaemic attack, non-disabling, disabling, and fatal stroke, myocardial infarction, and death from any other cause. Outcomes were adjudicated on by investigators who were masked to treatment. Analysis was by intention to treat. This study is registered, number ISRCTN 01425573.&#13;
&#13;
Findings&#13;
504 patients with stenosis of the carotid artery (90% symptomatic) were randomly assigned to endovascular treatment (n=251) or surgery (n=253). Within 30 days of treatment, there were more minor strokes that lasted less than 7 days in the endovascular group (8 vs 1) but the number of other strokes in any territory or death was the same (25 vs 25). There were more cranial nerve palsies (22 vs 0) in the endarterectomy group than in the endovascular group. Median length of follow up in both groups was 5 years (IQR 2–6). By comparing endovascular treatment with endarterectomy after the 30-day post-treatment period, the 8-year incidence and hazard ratio (HR) at the end of follow-up for ipsilateral non-perioperative stroke was 11·3% versus 8·6% (HR 1·22, 95% CI 0·59–2·54); for ipsilateral non-perioperative stroke or TIA was 19·3% versus 17·2% (1·29, 0·78–2·14); and for any non-perioperative stroke was 21·1% versus 15·4% (1·66, 0·99–2·80).&#13;
Interpretation&#13;
&#13;
More patients had stroke during follow-up in the endovascular group than in the surgical group, but the rate of ipsilateral non-perioperative stroke was low in both groups and none of the differences in the stroke outcome measures was significant. However, the study was underpowered and the confidence intervals were wide. More long-term data are needed from the on going stenting versus endarterectomy trials.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/256/10/1%2Ds2.0%2DS1474442209702285%2Dmain.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>ELSEVIER SCIENCE INC</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000270111200012&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1474-4422</dc:source><dc:title>Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial</dc:title><rioxxterms:author>Ederle, J</rioxxterms:author><rioxxterms:author>Bonati, LH</rioxxterms:author><rioxxterms:author>Dobson, J</rioxxterms:author><rioxxterms:author>Featherstone, RL</rioxxterms:author><rioxxterms:author>Gaines, PA</rioxxterms:author><rioxxterms:author>Beard, JD</rioxxterms:author><rioxxterms:author>Venables, GS</rioxxterms:author><rioxxterms:author>Markus, HS</rioxxterms:author><rioxxterms:author>Clifton, A</rioxxterms:author><rioxxterms:author>Sandercock, P</rioxxterms:author><rioxxterms:author>Brown, MM</rioxxterms:author><rioxxterms:author>CAVATAS Investigators, </rioxxterms:author><rioxxterms:publication_date>2009-10-01</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/S1474-4422(09)70228-5</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:openaccess.sgul.ac.uk:227
Date: 2015-04-29

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PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:openaccess.sgul.ac.uk:227</identifier>
      <datestamp>2015-04-29T14:22:35Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Purpose: To evaluate genetic susceptibility of lysyl oxidase-like 1 (LOXL1) gene polymorphisms to exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in a case-control cohort of American and European patients.&#13;
&#13;
Methods: DNA from a total of 620 individuals including 287 exfoliation patients and 333 healthy control subjects were&#13;
extracted by standard methods. Three single nucleotide polymorphisms (SNPs) of rs1048661 (R141L), rs3825942&#13;
(G153D), and rs2165241 were genotyped in these individuals by SNaPshot Assay. The seven coding exons of the LOXL1 gene and their immediate flanking regions were directly sequenced in 95 affected patients. Data management and&#13;
case-control association studies were performed with SNP-STAT and PLINK programs. The obtained DNA sequences&#13;
were evaluated with the STADEN package.&#13;
&#13;
Results: The 287 unrelated exfoliation cases comprised of 171 American patients (mostly of European background) and&#13;
116 patients from 12 European countries. This phenotype was further divided into patients with exfoliation only and no&#13;
glaucoma (XFO; n=95), exfoliation with glaucoma (XFG; n=133), and exfoliation unclassified (XFU; n=59). Genotypic&#13;
data were analyzed separately for XFO, XFG, XFU, and XFS (all exfoliations; n=287) and for Americans and Europeans.&#13;
The observed genotypic frequencies for each exfoliation phenotype or population were tabulated separately and tested for deviation from the Hardy–Weinberg equilibrium (HWE) using a standard Χ2 test. There were no HWE deviations and no significant genotypic differences between these subcategories for the three studied SNPs. For the combined exfoliation cohort, homozygote genotypes of G/G (rs1048661), G/G (rs3825942), and T/T (rs2165241) were significantly overrepresented. Likewise, case-control allelic association for rs1048661 (p=7.74x10−9), rs3825942 (p=3.10x10−17), and rs2165241 (p=4.85x10−24) were highly significant. The corresponding two-locus haplotype frequencies of GG for rs1048661-rs3825942 (p=1.47x10−27), GT for rs1048661-rs2165241 (p=1.29x10−24), and GT for rs3825942-rs2165241 (p=2.02x10−24) were highly associated with exfoliation phenotypes. The combined effect of these three SNPs revealed that the GGT haplotype is overrepresented by 66% in exfoliation cases, and this deviation from controls is highly significant&#13;
(p=1.93x10−24). This haplotype constituted a major risk factor for development of exfoliation in both XFS and XFG. By contrast, the GAC haplotype was significantly underrepresented (p=4.99x10−18) in exfoliation cases by 83% and may potentially have a protective effect for this condition with an estimated attributable risk percent reduction of 457%. The only other haplotype that was significantly different between cases and controls was TGC (p=5.82x10−9). No observation was made for the GAT haplotype. The combined three haplotypes of GGT, GAC, and TGC were associated with 91% of the exfoliation syndrome cases in the studied populations. Seven coding exons of LOXL1 were also sequenced in 95 affected cases. In addition to the three above-mentioned SNPs, 12 other variations were also observed in these patients(G240G, D292D, A320A, V385V, rs2304719, IVS3+23C&gt;T, IVS3–155G&gt;A, IVS3–101G&gt;A, IVS4+49G&gt;A,&#13;
rs2304721, IVS5–121C&gt;T, and rs2304722). None were considered a disease-causing mutation.&#13;
&#13;
Conclusions: We confirmed a strong association with LOXL1 variants in our patients. For the LOXL1 gene, individual&#13;
alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and&#13;
European populations. The GGT haplotype constitutes a major risk haplotype for exfoliation, and GAC may have a&#13;
protective role. DNA sequencing of 95 affected patients did not show any mutations in this gene. The LOXL1 SNPs are&#13;
located in the 15q24.1 band and within a genetic locus (GLC1N) that is associated with primary open-angle glaucoma&#13;
(POAG). However, the LOXL1 genetic predisposition is only limited to exfoliation with or without glaucoma and does&#13;
not include the POAG phenotype.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://openaccess.sgul.ac.uk/227/1/mv%2Dv14%2D533.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>MOLECULAR VISION</dc:publisher><dc:relation>http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=000256662400001&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=3511c51bff905dacd4f7fd11b0dd8b6d</dc:relation><dc:source>1090-0535</dc:source><dc:title>Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma</dc:title><rioxxterms:author>Aragon-Martin, JA</rioxxterms:author><rioxxterms:author>Ritch, R</rioxxterms:author><rioxxterms:author>Liebmann, J</rioxxterms:author><rioxxterms:author>O'Brien, C</rioxxterms:author><rioxxterms:author>Blaaow, K</rioxxterms:author><rioxxterms:author>Mercieca, F</rioxxterms:author><rioxxterms:author>Spiteri, A</rioxxterms:author><rioxxterms:author>Cobb, CJ</rioxxterms:author><rioxxterms:author>Damji, KF</rioxxterms:author><rioxxterms:author>Tarkkanen, A</rioxxterms:author><rioxxterms:author>Rezaie, T</rioxxterms:author><rioxxterms:author>Child, AH</rioxxterms:author><rioxxterms:author>Sarfarazi, M</rioxxterms:author><rioxxterms:publication_date>2008-03-17</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>

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