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Base URL:  http://researchonline.lshtm.ac.uk/cgi/oai2
Sample date:  2017-10-05
Sample size:  100 records harvested

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ID: oai:researchonline.lshtm.ac.uk:105
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:105</identifier>
      <datestamp>2017-09-30T01:37:29Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Much of the literature on genome-wide association studies (GWAS) is based on the premise that an important proportion of common diseases is heritable and that this proportion is likely to be due to genetic variants detectable with extensive scans of the DNA. Heritability is estimated from family studies, including twin studies and is based on the comparison of the variation in disease among different members of particular families. Since there is a wide gap between the population variation in disease explained by the results of GWAS (usually &lt; 10% for common diseases) and estimates of heritability (often &gt; 50%), the question arises as to how to explain these differences. However, the premise for this question is based on two sources of misunderstanding: (i) confusion between variation and causation and (ii) confusion between heritability and genetic determination. As we show with a number of examples, variation is not causation and heritability is not genetic determination. Therefore, heritability studies do not provide valid estimates of the proportion of disease cases that are attributable to genetic factors. Such estimates in turn cannot be used to estimate the proportion of cases that are due to environmental factors.</dc:description><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>0143-3334</dc:source><dc:title>Genome-wide association studies may be misinterpreted: genes versus heritability</dc:title><rioxxterms:author>Vineis, P</rioxxterms:author><rioxxterms:author>Pearce, NE</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/carcin/bgr087</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:104
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:104</identifier>
      <datestamp>2017-09-30T05:08:05Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>SETTING: The burden of tuberculosis (TB) disease among household contacts of multidrug-resistant TB (MDR-TB) patients is poorly understood and might represent a target for transmission-interrupting interventions. DESIGN: This retrospective cohort study, conducted in Lima, Peru, from June to September 2008, estimated the incidence of TB disease among household contacts of MDR-TB patients in 358 households. RESULTS: Of 2112 household contacts in 80 households (22% of households), 108 (5%) developed TB disease during the study, giving an incidence rate of 2360 per 100000 contact follow-up years for each of the first 3 years after exposure. Drug susceptibility tests (DST) were available for 50 diseased contacts, of whom 36 (80%) had MDR-TB. Forty-two pairs of index-contact DSTs were available, among which the contact had an identical or less resistant phenotype than the index case in 27 pairs. Multivariate Cox regression demonstrated that male contacts (hazard ratio [HR] 2.8, P &lt; 0.05), with previous TB disease (HR 20.7, P &lt; 0.001) and with associated (non-human immunodeficiency virus) comorbidities (HR 11.2, P &lt; 0.001) were more likely to develop TB. CONCLUSION: The high percentage of diseased household contacts highlights an opportunity for household-level interventions to prevent transmission, whether or not these cases were all attributable to the index case.</dc:description><dc:language>en</dc:language><dc:publisher>International Union Against Tuberculosis and Lung Disease</dc:publisher><dc:source>1027-3719</dc:source><dc:title>Tuberculosis in household contacts of multidrug-resistant tuberculosis patients</dc:title><rioxxterms:author>Grandjean, L</rioxxterms:author><rioxxterms:author>Crossa, A</rioxxterms:author><rioxxterms:author>Gilman, RH</rioxxterms:author><rioxxterms:author>Herrera, C</rioxxterms:author><rioxxterms:author>Bonilla, C</rioxxterms:author><rioxxterms:author>Jave, O</rioxxterms:author><rioxxterms:author>Cabrera, JL</rioxxterms:author><rioxxterms:author>Martin, L</rioxxterms:author><rioxxterms:author>Escombe, AR</rioxxterms:author><rioxxterms:author>Moore, DAJ</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.5588/ijtld.11.0030</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:103
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:103</identifier>
      <datestamp>2017-10-01T06:13:35Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Objective: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. Methods: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. Results: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). Conclusion: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy. Neurology (R) 2011;77:1005-1012</dc:description><dc:language>en</dc:language><dc:publisher>American Academy of Neurology</dc:publisher><dc:source>0028-3878</dc:source><dc:title>Incidence of epilepsy A systematic review and meta-analysis</dc:title><rioxxterms:author>Ngugi, AK</rioxxterms:author><rioxxterms:author>Kariuki, SM</rioxxterms:author><rioxxterms:author>Bottomley, C</rioxxterms:author><rioxxterms:author>Kleinschmidt, I</rioxxterms:author><rioxxterms:author>Sander, JW</rioxxterms:author><rioxxterms:author>Newton, CR</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1212/WNL.0b013e31822cfc90</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:102
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:102</identifier>
      <datestamp>2017-09-30T03:47:58Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D636F6E666572656E63655F6974656D</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>SETTING: Two centres in Soweto and Cape Town, South Africa. OBJECTIVE: To assess the effects of timing of initiation of antiretroviral treatment (ART) and other factors on the risk of bacille Calmette-Guerin (BCG) related regional adenitis due to immune reconstitution inflammatory syndrome (BCG-IRIS) in human immunodeficiency virus (HIV) infected infants. DESIGN: HIV-infected infants aged 6-12 weeks with CD4 count &gt;= 25% enrolled in the Children with HIV Early Antiretroviral Therapy (CHER) Trial received early (before 12 weeks) or deferred (after immunological or clinical progression) ART; infants with CD4 count &lt;25% all received early ART. All received BCG vaccination after birth. Reactogenicity to BCG was assessed prospectively during routine study follow-up. RESULTS: Of 369 infants, 32 (8.7%) developed BCG-IRIS within 6 months of starting ART, 28 (88%) within 2 months after ART initiation. Of the 32 cases, 30(93.8%) had HIV-1 RNA &gt;750000 copies/ml at initiation. Incidence of BCG-IRIS was 10.9 and 54.3 per 100 person-years (py) among infants with CD4 count &gt;= 25% at enrolment receiving early (at median age 7.4 weeks) vs. deferred (23.2 weeks) ART, respectively (HR 0.24, 95% CI 0.11-0.53, P &lt; 0.001). Infants with CD4 count &lt;25% receiving early ART had intermediate incidence (41.7/100 py). Low CD4 counts and high HIV-1 RNA at initiation were the strongest independent risk factors for BCG-IRIS. CONCLUSIONS: Early ART initiation before immunological and/or clinical progression substantially reduces the risk of BCG-IRIS regional adenitis.</dc:description><dc:language>en</dc:language><dc:publisher>International Union Against Tuberculosis and Lung Disease</dc:publisher><dc:source>1027-3719</dc:source><dc:title>Early antiretroviral treatment reduces risk of bacille Calmette-Guerin immune reconstitution adenitis</dc:title><rioxxterms:author>Rabie, H</rioxxterms:author><rioxxterms:author>Violari, A</rioxxterms:author><rioxxterms:author>Duong, T</rioxxterms:author><rioxxterms:author>Madhi, SA</rioxxterms:author><rioxxterms:author>Josipovic, D</rioxxterms:author><rioxxterms:author>Innes, S</rioxxterms:author><rioxxterms:author>Dobbels, E</rioxxterms:author><rioxxterms:author>Lazarus, E</rioxxterms:author><rioxxterms:author>Panchia, R</rioxxterms:author><rioxxterms:author>Babiker, AG</rioxxterms:author><rioxxterms:author>Gibb, DM</rioxxterms:author><rioxxterms:author>Cotton, MF</rioxxterms:author><rioxxterms:author>Team, C</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.5588/ijtld.10.0721</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:101
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:101</identifier>
      <datestamp>2017-10-01T02:40:17Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>The transformation of malaria ookinetes into oocysts occurs in the mosquito midgut and is a major bottleneck for parasite transmission. The secreted ookinete surface protein, circumsporozoite- and thrombospondin-related adhesive protein (TRAP)-related protein (CTRP), is essential for this transition and hence constitutes a potential target for malaria transmission blockade. CTRP is a modular multidomain protein containing six tandem von Willebrand factor A-like (A) domains and seven tandem thrombospondin type I repeat-like (TS) domains. Here we present, to our knowledge, the first structure-function analysis of CTRP using genetically modified Plasmodium berghei parasites expressing mutant versions of the ctrp gene. Our data show that the A domains of CTRP are critical for ookinete gliding motility and oocyst formation whilst, unexpectedly, its TS domains are fully redundant. These results may have important implications for the design of CTRP-based transmission blocking strategies. (C) 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.</dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0020-7519</dc:source><dc:title>Vital functions of the malarial ookinete protein, CTRP, reside in the A domains</dc:title><rioxxterms:author>Ramakrishnan, C</rioxxterms:author><rioxxterms:author>Dessens, JT</rioxxterms:author><rioxxterms:author>Armson, R</rioxxterms:author><rioxxterms:author>Pinto, SB</rioxxterms:author><rioxxterms:author>Talman, AM</rioxxterms:author><rioxxterms:author>Blagborough, AM</rioxxterms:author><rioxxterms:author>Sinden, RE</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.ijpara.2011.05.007</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:100
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:100</identifier>
      <datestamp>2017-10-01T04:16:24Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>International Union Against Tuberculosis and Lung Disease</dc:publisher><dc:source>1027-3719</dc:source><dc:title>Pre-screening with GeneXpert® MTB/RIF may increase use of isoniazid preventive therapy in antiretroviral programmes.</dc:title><rioxxterms:author>Lawn, SD</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.5588/ijtld.11.0407</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:99
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:99</identifier>
      <datestamp>2017-09-30T23:37:15Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>Background: In Malawi, high case fatality rates in patients with tuberculosis, who were also co-infected with HIV, and high early death rates in people living with HIV during the initiation of antiretroviral treatment (ART) adversely impacted on treatment outcomes for the national tuberculosis and ART programmes respectively. This article i) discusses the operational research that was conducted in the country on cotrimoxazole preventive therapy, ii) outlines the steps that were taken to translate these findings into national policy and practice, iii) shows how the implementation of cotrimoxazole preventive therapy for both TB patients and HIV-infected patients starting ART was associated with reduced death rates, and iv) highlights lessons that can be learnt for other settings and interventions. Discussion: District and facility-based operational research was undertaken between 1999 and 2005 to assess the effectiveness of cotrimoxazole preventive therapy in reducing death rates in TB patients and subsequently in patients starting ART under routine programme conditions. Studies demonstrated significant reductions in case fatality in HIV-infected TB patients receiving cotrimoxazole and in HIV-infected patients about to start ART. Following the completion of research, the findings were rapidly disseminated nationally at stakeholder meetings convened by the Ministry of Health and internationally through conferences and peer-reviewed scientific publications. The Ministry of Health made policy changes based on the available evidence, following which there was countrywide distribution of the updated policy and guidelines. Policy was rapidly moved to practice with the development of monitoring tools, drug procurement and training packages. National programme performance improved which showed a significant decrease in case fatality rates in TB patients as well as a reduction in early death in people with HIV starting ART. Summary: Key lessons for moving this research endeavour through to policy and practice were the importance of placing operational research within the programme, defining relevant questions, obtaining "buy-in" from national programme staff at the beginning of projects and having key actors or "policy entrepreneurs" to push forward the policy-making process. Ultimately, any change in policy and practice has to benefit patients, and the ultimate judge of success is whether treatment outcomes improve or not.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/99/1/1471-2458-11-593.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BioMed Central</dc:publisher><dc:source>1471-2458</dc:source><dc:title>Operational research in malawi: making a difference with cotrimoxazole preventive therapy in patients with tuberculosis and HIV</dc:title><rioxxterms:author>Harries, AD</rioxxterms:author><rioxxterms:author>Zachariah, R</rioxxterms:author><rioxxterms:author>Chimzizi, R</rioxxterms:author><rioxxterms:author>Salaniponi, F</rioxxterms:author><rioxxterms:author>Gausi, F</rioxxterms:author><rioxxterms:author>Kanyerere, H</rioxxterms:author><rioxxterms:author>Schouten, EJ</rioxxterms:author><rioxxterms:author>Jahn, A</rioxxterms:author><rioxxterms:author>Makombe, SD</rioxxterms:author><rioxxterms:author>Chimbwandira, FM</rioxxterms:author><rioxxterms:author>Mpunga, J</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1471-2458-11-593</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:98
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:98</identifier>
      <datestamp>2017-10-01T00:58:32Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Human immunodeficiency virus (HIV) increases the risks of developing tuberculosis (TB) disease following infection, and speeds up disease progression. This has had a devastating effect on TB epidemics in sub-Saharan Africa, where incidence rates have more than trebled in the past twenty years. Current control methods for TB disease have failed to keep pace with this growth, and there is an urgent need to find TB control strategies that are effective in high-HIV prevalent settings. This article describes a discrete-event simulation model of endemic TB that includes the effects of HIV and of household structure on the transmission dynamics of TB. Incorporating a social structure allows us to compare the effectiveness of contact-tracing interventions with case-finding targeted at high risk groups. We describe the modeling of the household structure in some detail, as this has applications to the modeling of other infectious diseases.</dc:description><dc:language>en</dc:language><dc:publisher>Association for Computing Machinery</dc:publisher><dc:source>1049-3301</dc:source><dc:title>Incorporating Household Structure into a Discrete-Event Simulation Model of Tuberculosis and HIV</dc:title><rioxxterms:author>Mellor, GR</rioxxterms:author><rioxxterms:author>Currie, CSM</rioxxterms:author><rioxxterms:author>Corbett, EL</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1145/2000494.2000499</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:97
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:97</identifier>
      <datestamp>2017-10-01T05:27:05Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Objective: To explore maternal healthcare utilization in rural western China, and to analyze the socioeconomic and demographic determinants associated with use of maternal health services. Methods: Between July and August 2005, 14112 women from 45 counties in 10 western provinces of China were enrolled in a cross-sectional study by a multi-stage probability sampling method. The women completed a structured questionnaire, and a 2-level logistic regression model was used to examine the data. Results: The proportion of women who had prenatal care was 95%. The average number of prenatal visits was 4.94. The proportion of women who had more than 4 prenatal visits was 52.9%, and 66.9% of these had their first prenatal visit within 12 weeks of gestation. The hospital delivery rate was 86.3%. The frequency of postnatal visits was 84.8%, and the average number of postnatal visits was 2.19. Han ethnicity, higher education, lower parity, higher wealth index, and lower altitude of county had a higher odds ratio for more than 4 prenatal visits, hospital delivery, and postnatal visits. Conclusion: Maternal healthcare utilization seems to be associated with socio-economic and regional factors. The Chinese government should focus on the supply, funding, and quality of maternity services in rural areas. (C) 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.</dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>0020-7292</dc:source><dc:title>Use of maternal healthcare services in 10 provinces of rural western China</dc:title><rioxxterms:author>Liu, XN</rioxxterms:author><rioxxterms:author>Zhou, XY</rioxxterms:author><rioxxterms:author>Yan, H</rioxxterms:author><rioxxterms:author>Wang, DL</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.ijgo.2011.04.005</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:96
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
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ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:96</identifier>
      <datestamp>2017-09-30T06:56:25Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>1741-3842</dc:source><dc:title>Promoting recovery and preventing drug-related mortality: competing risks?</dc:title><rioxxterms:author>Hickman, M</rioxxterms:author><rioxxterms:author>Vickerman, P</rioxxterms:author><rioxxterms:author>Robertson, R</rioxxterms:author><rioxxterms:author>MacLeod, J</rioxxterms:author><rioxxterms:author>Strang, J</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/pubmed/fdr055</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:95
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:95</identifier>
      <datestamp>2017-10-01T08:24:43Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>: In most developed countries, HCV is primarily transmitted by injecting drug users (IDUs). HCV antiviral treatment is effective, and deemed cost-effective for those with no re-infection risk. However, few active IDUs are currently treated. Previous modelling studies have shown antiviral treatment for active IDUs could reduce HCV prevalence, and there is emerging interest in developing targeted IDU treatment programmes. However, the optimal timing and scale-up of treatment is unknown, given the real-world constraints commonly existing for health programmes. We explore how the optimal programme is affected by a variety of policy objectives, budget constraints, and prevalence settings. We develop a model of HCV transmission and treatment amongst active IDUs, determine the optimal treatment programme strategy over 10 years for two baseline chronic HCV prevalence scenarios (30% and 45%), a range of maximum annual budgets (£50,000-300,000 per 1,000 IDUs), and a variety of objectives: minimising health service costs and health utility losses; minimising prevalence at 10 years; minimising health service costs and health utility losses with a final time prevalence target; minimising health service costs with a final time prevalence target but neglecting health utility losses. The largest programme allowed for a given budget is the programme which minimises both prevalence at 10 years, and HCV health utility loss and heath service costs, with higher budgets resulting in greater cost-effectiveness (measured by cost per QALY gained compared to no treatment). However, if the objective is to achieve a 20% relative prevalence reduction at 10 years, while minimising both health service costs and losses in health utility, the optimal treatment strategy is an immediate expansion of coverage over 5-8 years, and is less cost-effective. By contrast, if the objective is only to minimise costs to the health service while attaining the 20% prevalence reduction, the programme is deferred until the final years of the decade, and is the least cost-effective of the scenarios.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/95/1/pone.0022309.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1932-6203</dc:source><dc:title>Optimal Control of Hepatitis C Antiviral Treatment Programme Delivery for Prevention amongst a Population of Injecting Drug Users</dc:title><rioxxterms:author>Martin, NK</rioxxterms:author><rioxxterms:author>Pitcher, AB</rioxxterms:author><rioxxterms:author>Vickerman, P</rioxxterms:author><rioxxterms:author>Vassall, A</rioxxterms:author><rioxxterms:author>Hickman, M</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0022309</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:94
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is a valid RIOXX record

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:94</identifier>
      <datestamp>2017-09-30T17:41:42Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>Background: Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy that have been associated with a high fatality rate. Methods: In a multinational retrospective cohort study, LA was defined as arterial blood pH&lt;7.35, bicarbonate &lt;20 mmol/l and lactate above normal, and HL as confirmed blood lactate &gt;5 mmol/l. Logistic regression was used to identify factors associated with fatality. Sensitivity and specificity of different case definitions as predictors of death were compared. Results: The overall case-fatality rate was 19/110 (17.3%), but among acidotic patients it was 33% (16/49 cases). There were 10 asymptomatic patients and none of them died as a consequence of the event. The median lactate for fatal, non-fatal and all patients was 8.3 mmol/l (IQR 7.2-13.1), 6.4 mmol/l (IQR 5.4-7.8) and 6.7 mmol/l (IQR 5.5-8.1), respectively. After adjusting for age and current CD4(+) T-cell count, lactate &gt;7 mmol/l (OR 6.27, 95% CI 1.13-34.93), blood bicarbonate &lt;12 mmol/l (OR 10.02 relative to &gt;18 mmol/l, 95% CI 1.33-75.65) and concurrent opportunistic infections (OR 8.69, 95% CI 1.45-52.22) were independently associated with case fatality. Blood lactate &gt;7 mmol/l showed a sensitivity of 84% for fatality with a specificity of 60%, whereas bicarbonate &lt;12 mmol/l showed a better specificity (85%) but a poorer sensitivity (42%). Bicarbonate &lt;18 mmol/l appears to be as good as lactate &lt;7 mmol/l at predicting death (sensitivity 90% and specificity 54%). Conclusions: Our data suggest that blood lactate &gt;7 mmol/l and blood bicarbonate &lt;18 mmol/l appear to predict death and might help clinicians in selecting patients who may benefit from more intense monitoring.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/94/3/Bhaskaran_HLLA_fatality__AntivTher_re__subm_CLEAN%2801Aug2010%29_FINAL_AC_2.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>International Medical Press</dc:publisher><dc:source>1359-6535</dc:source><dc:title>Risk factors for fatality in HIV-infected patients with dideoxynucleoside-induced severe hyperlactataemia or lactic acidosis</dc:title><rioxxterms:author>Arenas-Pinto, A</rioxxterms:author><rioxxterms:author>Grant, A</rioxxterms:author><rioxxterms:author>Bhaskaran, K</rioxxterms:author><rioxxterms:author>Copas, A</rioxxterms:author><rioxxterms:author>Carr, A</rioxxterms:author><rioxxterms:author>Worm, SW</rioxxterms:author><rioxxterms:author>Martinez, E</rioxxterms:author><rioxxterms:author>Reiss, P</rioxxterms:author><rioxxterms:author>Dunn, D</rioxxterms:author><rioxxterms:author>Weber, R</rioxxterms:author><rioxxterms:author>Hoy, J</rioxxterms:author><rioxxterms:author>Weller, I</rioxxterms:author><rioxxterms:author>Lactic Acidosis Int Study, G</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>AM</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.3851/IMP1732</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:93
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:93</identifier>
      <datestamp>2017-10-01T05:30:21Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>BACKGROUND: Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analysed the interaction between human population density and lack of tap water as a cause of dengue fever outbreaks with the aim of identifying geographic areas at highest risk.&lt;br/&gt; METHODS AND FINDINGS: We conducted an individual-level cohort study in a population of 75,000 geo-referenced households in Vietnam over the course of two epidemics, on the basis of dengue hospital admissions (n = 3,013). We applied space-time scan statistics and mathematical models to confirm the findings. We identified a surprisingly narrow range of critical human population densities between around 3,000 to 7,000 people/km² prone to dengue outbreaks. In the study area, this population density was typical of villages and some peri-urban areas. Scan statistics showed that areas with a high population density or adequate water supply did not experience severe outbreaks. The risk of dengue was higher in rural than in urban areas, largely explained by lack of piped water supply, and in human population densities more often falling within the critical range. Mathematical modeling suggests that simple assumptions regarding area-level vector/host ratios may explain the occurrence of outbreaks.&lt;br/&gt; CONCLUSIONS: Rural areas may contribute at least as much to the dissemination of dengue fever as cities. Improving water supply and vector control in areas with a human population density critical for dengue transmission could increase the efficiency of control efforts. Please see later in the article for the Editors' Summary.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/93/1/pmed.1001082.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1549-1277</dc:source><dc:title>Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis</dc:title><rioxxterms:author>Schmidt, WP</rioxxterms:author><rioxxterms:author>Suzuki, M</rioxxterms:author><rioxxterms:author>Thiem, VD</rioxxterms:author><rioxxterms:author>White, RG</rioxxterms:author><rioxxterms:author>Tsuzuki, A</rioxxterms:author><rioxxterms:author>Yoshida, LM</rioxxterms:author><rioxxterms:author>Yanai, H</rioxxterms:author><rioxxterms:author>Haque, U</rioxxterms:author><rioxxterms:author>Tho, leH</rioxxterms:author><rioxxterms:author>Anh, DD</rioxxterms:author><rioxxterms:author>Ariyoshi, K</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pmed.1001082</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:92
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:92</identifier>
      <datestamp>2017-10-01T05:26:04Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>: Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones. The apparent number of clones observed in any single infection depends on the diversity of the polymorphic markers used for the analysis, and the relative abundance of rare clones, which frequently fail to be detected among PCR products derived from numerically dominant clones. However, minority clones are of clinical interest as they may harbour genes conferring drug resistance, leading to enhanced survival after treatment and the possibility of subsequent therapeutic failure. We deployed new generation sequencing to derive genome data for five non-propagated parasite isolates taken directly from 4 different patients treated for clinical malaria in a UK hospital. Analysis of depth of coverage and length of sequence intervals between paired reads identified both previously described and novel gene deletions and amplifications. Full-length sequence data was extracted for 6 loci considered to be under selection by antimalarial drugs, and both known and previously unknown amino acid substitutions were identified. Full mitochondrial genomes were extracted from the sequencing data for each isolate, and these are compared against a panel of polymorphic sites derived from published or unpublished but publicly available data. Finally, genome-wide analysis of clone multiplicity was performed, and the number of infecting parasite clones estimated for each isolate. Each patient harboured at least 3 clones of P. falciparum by this analysis, consistent with results obtained with conventional PCR analysis of polymorphic merozoite antigen loci. We conclude that genome sequencing of peripheral blood P. falciparum taken directly from malaria patients provides high quality data useful for drug resistance studies, genomic structural analyses and population genetics, and also robustly represents clonal multiplicity.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/92/1/pone.0023204.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1932-6203</dc:source><dc:title>Drug-Resistant Genotypes and Multi-Clonality in Plasmodium falciparum Analysed by Direct Genome Sequencing from Peripheral Blood of Malaria Patients</dc:title><rioxxterms:author>Robinson, T</rioxxterms:author><rioxxterms:author>Campino, SG</rioxxterms:author><rioxxterms:author>Auburn, S</rioxxterms:author><rioxxterms:author>Assefa, SA</rioxxterms:author><rioxxterms:author>Polley, SD</rioxxterms:author><rioxxterms:author>Manske, M</rioxxterms:author><rioxxterms:author>MacInnis, B</rioxxterms:author><rioxxterms:author>Rockett, KA</rioxxterms:author><rioxxterms:author>Maslen, GL</rioxxterms:author><rioxxterms:author>Sanders, M</rioxxterms:author><rioxxterms:author>Quail, MA</rioxxterms:author><rioxxterms:author>Chiodini, PL</rioxxterms:author><rioxxterms:author>Kwiatkowski, DP</rioxxterms:author><rioxxterms:author>Clark, TG</rioxxterms:author><rioxxterms:author>Sutherland, CJ</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0023204</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:91
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:91</identifier>
      <datestamp>2017-09-30T22:11:36Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Contracting out of health services increasingly involves a new role for governments as purchasers of services. To date, emphasis has been on contractual outcomes and the contracting process, which may benefit from improvements in developing countries, has been understudied. This article uses evidence from wide scale NGO contracting in Pakistan and examines the performance of government purchasers in managing the contracting process; draws comparisons with NGO managed contracting; and identifies purchaser skills needed for contracting NGOs. We found that the contracting process is complex and government purchasers struggled to manage the contracting process despite the provision of well-designed contracts and guidelines. Weaknesses were seen in three areas: (i) poor capacity for managing tendering; (ii) weak public sector governance resulting in slow processes, low interest and rent seeking pressures; and (iii) mistrust between government and the NGO sector. In comparison parallel contracting ventures managed by large NGOs generally resulted in faster implementation, closer contractual relationships, drew wider participation of NGOs and often provided technical support. Our findings do not dilute the importance of government in contracting but front the case for an independent purchasing agency, for example an experienced NGO, to manage public sector contracts for community based services with the government role instead being one of larger oversight. Copyright (C) 2011 John Wiley &amp; Sons, Ltd.</dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>0271-2075</dc:source><dc:title>BUREAUCRATS AS PURCHASERS OF HEALTH SERVICES: LIMITATIONS OF THE PUBLIC SECTOR FOR CONTRACTING</dc:title><rioxxterms:author>Zaidi, S</rioxxterms:author><rioxxterms:author>Mayhew, SH</rioxxterms:author><rioxxterms:author>Palmer, N</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1002/pad.581</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:90
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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PropertyError
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:90</identifier>
      <datestamp>2017-09-30T03:46:28Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it.
Vaccines have made a major contribution to global health in recent decades but they could do much more. In November 2011, a Royal Society discussion meeting, 'New vaccines for global health', was held in London to discuss the past contribution of vaccines to global health and to consider what more could be expected in the future. Papers presented at the meeting reviewed recent successes in the deployment of vaccines against major infections of childhood and the challenges faced in developing vaccines against some of the world's remaining major infectious diseases such as human immunodeficiency virus (HIV), malaria and tuberculosis. The important contribution that development of more effective veterinary vaccines could make to global health was also addressed. Some of the social and financial challenges to the development and deployment of new vaccines were reviewed. The latter issues were also discussed at a subsequent satellite meeting, 'Accelerating vaccine development', held at the Kavli Royal Society International Centre. Delegates at this meeting considered challenges to the more rapid development and deployment of both human and veterinary vaccines and how these might be addressed. Papers based on presentations at the discussion meeting and a summary of the main conclusions of the satellite meeting are included in this issue of Philosophical Transactions of the Royal Society B.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/90/1/rstb20110100.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Royal Society, The</dc:publisher><dc:source>0962-8436</dc:source><dc:title>Accelerating vaccine development and deployment: report of a Royal Society satellite meeting
Vaccines and global health</dc:title><rioxxterms:author>Bregu, M</rioxxterms:author><rioxxterms:author>Draper, SJ</rioxxterms:author><rioxxterms:author>Hill, AVS</rioxxterms:author><rioxxterms:author>Greenwood, BM</rioxxterms:author><rioxxterms:author>Greenwood, B</rioxxterms:author><rioxxterms:author>Salisbury, D</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1098/rstb.2011.0100</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:89
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is a valid RIOXX record

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:89</identifier>
      <datestamp>2017-09-30T02:52:22Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011-04-12">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>BACKGROUND: Drinking water from natural sources in coastal Bangladesh has become contaminated by varying degrees of salinity due to saltwater intrusion from rising sea levels, cyclone and storm surges, and upstream withdrawal of freshwater. OBJECTIVE: Our objective was to estimate salt intake from drinking water sources and examine environmental factors that may explain a seasonal excess of hypertension in pregnancy. METHODS: Water salinity data (1998-2000) for Dacope, in rural coastal Bangladesh, were obtained from the Centre for Environment and Geographic Information System in Bangladesh. Information on drinking water sources, 24-hr urine samples, and blood pressure was obtained from 343 pregnant Dacope women during the dry season (October 2009 through March 2010). The hospital-based prevalence of hypertension in pregnancy was determined for 969 pregnant women (July 2008 through March 2010). RESULTS: Average estimated sodium intakes from drinking water ranged from 5 to 16 g/day in the dry season, compared with 0.6-1.2 g/day in the rainy season. Average daily sodium excretion in urine was 3.4 g/day (range, 0.4-7.7 g/day). Women who drank shallow tube-well water were more likely to have urine sodium &gt; 100 mmol/day than women who drank rainwater [odds ratio (OR) = 2.05; 95% confidence interval (CI), 1.11-3.80]. The annual hospital prevalence of hypertension in pregnancy was higher in the dry season (OR = 12.2%; 95% CI, 9.5-14.8) than in the rainy season (OR = 5.1%; 95% CI, 2.91-7.26). CONCLUSIONS: The estimated salt intake from drinking water in this population exceeded recommended limits. The problem of saline intrusion into drinking water has multiple causes and is likely to be exacerbated by climate change-induced sea-level rise.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/89/1/ehp.1002804.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>National Institute of Environmental Health Sciences</dc:publisher><dc:source>0091-6765</dc:source><dc:title>Drinking Water Salinity and Maternal Health in Coastal Bangladesh: Implications of Climate Change</dc:title><dcterms:dateAccepted>2011-04-12</dcterms:dateAccepted><rioxxterms:author>Khan, AE</rioxxterms:author><rioxxterms:author>Ireson, A</rioxxterms:author><rioxxterms:author>Kovats, S</rioxxterms:author><rioxxterms:author>Mojumder, SK</rioxxterms:author><rioxxterms:author>Khusru, A</rioxxterms:author><rioxxterms:author>Rahman, A</rioxxterms:author><rioxxterms:author>Vineis, P</rioxxterms:author><rioxxterms:author>Labrese Ej, VP</rioxxterms:author><rioxxterms:publication_date>2011-04-12</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1289/ehp.1002804</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:88
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:88</identifier>
      <datestamp>2017-10-01T08:54:50Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>Background. Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement. We evaluated the use of a point-of-care (POC) diagnostic device for blood lactate measurement to assess the severity of illness in children admitted to a district hospital in Tanzania. Methods. Children between the ages of 2 months and 13 years with a history of fever were enrolled in the study during a period of 1 year. A full clinical history and examination were undertaken, and blood was collected for culture, microscopy, complete blood cell count, and POC measurement of blood lactate and glucose. Results. The study included 3248 children, of whom 164 (5.0%) died; 45 (27.4%) of these had raised levels of blood lactate (&gt; 5 mmol/L) but no deep breathing. Compared with mortality in children with lactate levels of &lt;= 3 mmol/L, the unadjusted odds of dying were 1.6 (95% confidence interval [CI],.8-3.0), 3.4 (95% CI, 1.5-7.5), and 8.9 (95% CI, 4.7-16.8) in children with blood lactate levels of 3.1-5.0, 5.1-8.0, or &gt; 8.0 mmol/L, respectively. The prevalence of raised lactate levels (. 5 mmol/L) was greater in children with malaria than in children with nonmalarial febrile illness (P &lt; .001) although the associated mortality was greater in slide-negative children. Conclusions. POC lactate measurement can contribute to the assessment of children admitted to hospital with febrile illness and can also create an opportunity for more hospitals in resource-poor settings to participate in clinical trials of interventions to reduce mortality associated with hyperlactatemia.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/88/1/Lactate_Revised_Ap_14_2011%2BJT_revised.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>1058-4838</dc:source><dc:title>Point-of-Care Measurement of Blood Lactate in Children Admitted With Febrile Illness to an African District Hospital</dc:title><rioxxterms:author>Mtove, G</rioxxterms:author><rioxxterms:author>Nadjm, B</rioxxterms:author><rioxxterms:author>Hendriksen, ICE</rioxxterms:author><rioxxterms:author>Amos, A</rioxxterms:author><rioxxterms:author>Muro, F</rioxxterms:author><rioxxterms:author>Todd, J</rioxxterms:author><rioxxterms:author>Reyburn, H</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>AM</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/cid/cir471</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:86
Date: 2017-09-30

RIOXX

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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:86</identifier>
      <datestamp>2017-09-30T17:57:03Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>International Union Against Tuberculosis and Lung Disease</dc:publisher><dc:source>1027-3719</dc:source><dc:title>Reactivation or re-infection? reply</dc:title><rioxxterms:author>Houben, R</rioxxterms:author><rioxxterms:author>Glynn, JR</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.5588/ijtld.11.0115-2</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:85
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:85</identifier>
      <datestamp>2017-10-01T13:32:16Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/85/1/pmed.1001073.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1549-1277</dc:source><dc:title>Building the field of health policy and systems research: framing the questions.</dc:title><rioxxterms:author>Sheikh, K</rioxxterms:author><rioxxterms:author>Gilson, L</rioxxterms:author><rioxxterms:author>Agyepong, IA</rioxxterms:author><rioxxterms:author>Hanson, K</rioxxterms:author><rioxxterms:author>Ssengooba, F</rioxxterms:author><rioxxterms:author>Bennett, S</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pmed.1001073</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:83
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:83</identifier>
      <datestamp>2017-09-30T09:33:47Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>Objective: Asthma is the most common chronic disease in childhood and has been designated a public health problem due to the increase in its prevalence in recent decades, the amount of health service expenditure it absorbs and an absence of consensus about its etiology. The relationships among psychosocial factors and the occurrence, symptomatology, and severity of asthma have recently been considered. There is still controversy about the association between asthma and a child's mental health, since the pathways through which this relationship is established are complex and not well researched. This study aims to investigate whether behavior problems are associated with the prevalence of asthma symptoms in a large urban center in Latin America. Methods: It is a cross-section study of 869 children between 6 and 12 years old, residents of Salvador, Brazil. The International Study of Allergy and Asthma in Childhood (ISAAC) instrument was used to evaluate prevalence of asthma symptoms. The Child Behavior Checklist (CBCL) was employed to evaluate behavioral problems. Results: 19.26% (n = 212) of the children presented symptoms of asthma. 35% were classified as having clinical behavioral problems. Poisson's robust regression model demonstrated a statistically significant association between the presence of behavioral problems and asthma symptoms occurrence (PR: 1.43; 95% Cl: 1.10-1.85). Conclusion: These results suggest an association between behavioral problems and pediatric asthma, and support the inclusion of mental health care in the provision of services for asthma morbidity. (C) 2011 Elsevier Inc. All rights reserved.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/83/1/main.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0022-3999</dc:source><dc:title>Behavior problems and prevalence of asthma symptoms among Brazilian children</dc:title><rioxxterms:author>Feitosa, CA</rioxxterms:author><rioxxterms:author>Santos, DN</rioxxterms:author><rioxxterms:author>Do Carmo, MBB</rioxxterms:author><rioxxterms:author>Santos, LM</rioxxterms:author><rioxxterms:author>Teles, CAS</rioxxterms:author><rioxxterms:author>Rodrigues, LC</rioxxterms:author><rioxxterms:author>Barreto, ML</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.jpsychores.2011.02.004</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:82
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:82</identifier>
      <datestamp>2017-09-30T19:39:52Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011-04-08">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>: Modelling is valuable in the planning and evaluation of interventions, especially when a controlled trial is ethically or logistically impossible. Models are often used to calculate the expected course of events in the absence of more formal assessments. They are also used to derive estimates of rare or future events from recorded intermediate points. When developing models, decisions are needed about the appropriate level of complexity to be represented and about model structure and assumptions. The degree of rigor in model development and assessment can vary greatly, and there is a danger that existing beliefs inappropriately influence judgments about model assumptions and results.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/82/1/1-s2.0-S014067361061505X-main.pdf__tid%3Dfcce4e36-c454-11e5-80ee-00000aacb362%26acdnat%3D1453830680_4e9cad6b2a702ebc713ac0104200c18e</dc:identifier><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0140-6736</dc:source><dc:title>Mathematical models in the evaluation of health programmes</dc:title><rioxxterms:author>Garnett, GP</rioxxterms:author><rioxxterms:author>Cousens, S</rioxxterms:author><rioxxterms:author>Hallett, TB</rioxxterms:author><rioxxterms:author>Steketee, R</rioxxterms:author><rioxxterms:author>Walker, N</rioxxterms:author><rioxxterms:publication_date>2011-04-08</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/S0140-6736(10)61505-X</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:81
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      <identifier>oai:researchonline.lshtm.ac.uk:81</identifier>
      <datestamp>2017-10-01T02:21:16Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Georg Thieme Verlag</dc:publisher><dc:source>0032-0943</dc:source><dc:title>In vitro screening of selected medicinal plants against Schistosoma mansoni larvae</dc:title><rioxxterms:author>Karamustafa, SD</rioxxterms:author><rioxxterms:author>Mansour, N</rioxxterms:author><rioxxterms:author>Bickle, Q</rioxxterms:author><rioxxterms:author>Tasdemir, D</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:80
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:80</identifier>
      <datestamp>2017-09-30T04:14:39Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Objectives To estimate incidence of injury to patients attributed to misadventures during surgical and medical care by age group and to examine recent trends. Design Analysis of routine morbidity and mortality data categorized by the 9th and 10th revisions of the International Classification of Diseases. Participants Children 0-14 years and adults ?15 years. Setting England and Wales during 1999 to 2008 (hospital episodes) and 1979 to 2009 (deaths). Main outcome measures We calculated deaths per million person-years and per 1000 hospital episodes; hospital episodes per 100,000 person-years and per 100,000 procedures performed. Results The rate of death attributed to misadventures during surgical and medical care in patients aged 75 years and older was over 50 times (rate ratio 57.2; 95% confidence interval 38.3-85.3) higher than in children aged 1-14 years. Estimated hospital episode rates were 20 times (RR 20.0; 18.9-21.2) higher in patients aged 75 years and older. Mortality attributed to misadventures declined from 1.1 (0.9-1.4) deaths per million person-years in 1979 to 0.4 (0.2-0.6) in 2009. Hospital episodes of misadventures decreased between 1999 and 2008 from 30.8 (29.9-31.8) episodes per 100,000 procedures to 23.25 (22.5-24.1), but increased from 7.8 (7.6-8.1) per 100,000 person-years to 9.8 (9.5-10.1). Conclusions Misadventures during surgical and medical care are an important cause of avoidable injury. Older patients appear to be at higher risk of experiencing and dying from misadventure. Interpretation of recent trends is limited by uncertainties regarding the consistency and coverage of coding.</dc:description><dc:language>en</dc:language><dc:publisher>SAGE Publications</dc:publisher><dc:source>0141-0768</dc:source><dc:title>Misadventures to patients during surgical and medical care in England and Wales: an analysis of deaths and hospital episodes.</dc:title><rioxxterms:author>Ker, K</rioxxterms:author><rioxxterms:author>Edwards, P</rioxxterms:author><rioxxterms:author>Roberts, I</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1258/jrsm.2011.100408</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:79
Date: 2017-09-30

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:79</identifier>
      <datestamp>2017-09-30T02:27:58Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>There has been growing interest in the comparison of health system performance within and between countries, using a range of different indicators. This study examines trends in amenable mortality, as one measure of health system performance, in sixteen high-income countries.</dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0168-8510</dc:source><dc:title>Variations in amenable mortality-Trends in 16 high-income nations.</dc:title><rioxxterms:author>Nolte, E</rioxxterms:author><rioxxterms:author>McKee, M</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.healthpol.2011.08.002</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:78
Date: 2017-10-01

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:78</identifier>
      <datestamp>2017-10-01T12:07:09Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>OBJECTIVE: To characterize the tissue and cellular changes found in trachomatous scarring (TS) and inflammation using in vivo confocal microscopy (IVCM). DESIGN: Two complimentary case-control studies. PARTICIPANTS: The first study included 363 cases with TS (without trichiasis), of whom 328 had IVCM assessment, and 363 control subjects, of whom 319 had IVCM assessment. The second study included 34 cases with trachomatous trichiasis (TT), of whom 28 had IVCM assessment, and 33 control subjects, of whom 26 had IVCM assessment. METHODS: All participants were examined with ×2.5 loupes. The IVCM examination of the upper tarsal conjunctiva was carried out with a Heidelberg Retina Tomograph 3 with the Rostock Cornea Module (Heidelberg Engineering GmbH, Dossenheim, Germany). MAIN OUTCOME MEASURES: The IVCM images were graded in a masked manner using a previously published grading system evaluating the inflammatory infiltrate density; the presence or absence of dendritiform cells (DCs), tissue edema, and papillae; and the level of subepithelial connective tissue organization. RESULTS: Subjects with clinical scarring had a characteristic appearance on IVCM of well-defined bands and sheets of scar tissue visible. Similar changes were also seen in some clinically normal subjects consistent with subclinical scarring. Scarred subjects had more DCs and an elevated inflammatory infiltrate, even after adjusting for other factors, including the level of clinical inflammation. Cellular activity was usually seen only in or just below the epithelium, rarely being seen deeper than 30 ?m from the surface. The presence of tissue edema was strongly associated with the level of clinical inflammation. CONCLUSIONS: In vivo confocal microscopy can be quantitatively used to study inflammatory and scarring changes in the conjunctiva. Dendritic cells seem to be closely associated with the scarring process in trachoma and are likely to be an important target in antifibrotic therapies or the development of a chlamydial vaccine. The increased number of inflammatory cells seen in scarred subjects is consistent with the immunopathologic nature of the disease. The localization of cellular activity close to the conjunctival surface supports the view that the epithelium plays a central role in the pathogenesis of trachoma. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/78/1/mmc4.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0161-6420</dc:source><dc:title>In Vivo Confocal Microscopy in Scarring Trachoma.</dc:title><rioxxterms:author>Hu, VH</rioxxterms:author><rioxxterms:author>Weiss, HA</rioxxterms:author><rioxxterms:author>Massae, P</rioxxterms:author><rioxxterms:author>Courtright, P</rioxxterms:author><rioxxterms:author>Makupa, W</rioxxterms:author><rioxxterms:author>Mabey, DC</rioxxterms:author><rioxxterms:author>Bailey, RL</rioxxterms:author><rioxxterms:author>Burton, MJ</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.ophtha.2011.04.014</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:77
Date: 2017-10-01

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:77</identifier>
      <datestamp>2017-10-01T08:10:22Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>ABSTRACT: Whilst some populations have recently experienced dramatic declines in malaria, the majority of those most at risk of Plasmodium falciparum malaria still lack access to effective treatment with artemisinin combination therapy (ACT) and others are already facing parasites resistant to artemisinins.In this context, there is a crucial need to improve both access to and targeting of ACT through greater availability of good quality ACT and parasitological diagnosis. This is an issue of increasing urgency notably in the private commercial sector, which, in many countries, plays an important role in the provision of malaria treatment. The Affordable Medicines Facility for malaria (AMFm) is a recent initiative that aims to increase the provision of affordable ACT in public, private and NGO sectors through a manufacturer-level subsidy. However, to date, there is little documented experience in the programmatic implementation of subsidized ACT in the private sector. Cambodia is in the unique position of having more than 10 years of experience not only in implementing subsidized ACT, but also rapid diagnostic tests (RDT) as part of a nationwide social marketing programme. The programme includes behaviour change communication and the training of private providers as well as the sale and distribution of Malarine, the recommended ACT, and Malacheck, the RDT. This paper describes and evaluates this experience by drawing on the results of household and provider surveys conducted since the start of the programme.The available evidence suggests that providers' and consumers' awareness of Malarine increased rapidly, but that of Malacheck much less so. In addition, improvements in ACT and RDT availability and uptake were relatively slow, particularly in more remote areas.The lack of standardization in the survey methods and the gaps in the data highlight the importance of establishing a clear system for monitoring and evaluation for similar initiatives. Despite these limitations, a number of important lessons can still be learnt. These include the importance of a comprehensive communications strategy and of a sustained and reliable supply of products, with attention to the geographical reach of both. Other important challenges relate to the difficulty in incentivising providers and consumers not only to choose the recommended drug, but to precede this with a confirmatory blood test and ensure that providers adhere to the test results and patients to the treatment regime. In Cambodia, this is particularly complicated due to problems inherent to the drug itself and the emergence of artemisinin resistance.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/77/1/1475-2875-10-243.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BioMed Central</dc:publisher><dc:source>1475-2875</dc:source><dc:title>Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia.</dc:title><rioxxterms:author>Yeung, S</rioxxterms:author><rioxxterms:author>Patouillard, E</rioxxterms:author><rioxxterms:author>Allen, H</rioxxterms:author><rioxxterms:author>Socheat, D</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1475-2875-10-243</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:76
Date: 2017-09-30

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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>OBJECTIVE:: To assess the diagnostic accuracy of the urine lipoarabinomannan (LAM) test among ambulatory HIV-infected persons. DESIGN:: Cross-sectional. METHODS:: HIV-infected persons consecutively presenting to the HIV Clinic at Tembisa Main Clinic in Ekhuruleni, South Africa, were screened for symptoms of tuberculosis (TB) and asked to provide sputum and blood samples for smears for acid-fast bacilli and mycobacterial culture and a urine specimen for a LAM enzyme-linked immunosorbent assay. Fine needle aspirates were obtained from participants with enlarged lymph nodes and sent for histopathology. Nonpregnant participants underwent chest x-ray. RESULTS:: Four hundred twenty-two HIV-infected participants were enrolled with median age 37 years (interquartile range: 31-44 years), median CD4+ T-cell count 215 cells per microliter (interquartile range: 107-347 cells/?L), and 212 (50%) receiving antiretroviral therapy. Thirty (7%) had active TB: 18 with only pulmonary TB, 5 with only extrapulmonary TB, and 7 with both pulmonary TB and extrapulmonary TB. Twenty-seven percent [95% confidence interval (CI): 12% to 48%] of TB cases were sputum acid-fast bacilli positive. The sensitivity and specificity of the urine LAM compared with the gold standard of positive bacteriology or histopathology were 32% (95% CI: 16% to 52%) and 98% (95% CI: 96% to 99%), respectively. Urine LAM had higher sensitivity in TB cases with higher bacillary burdens, though these differences were not statistically significant. CONCLUSIONS:: The sensitivity of urine LAM testing is inadequate to replace mycobacterial culture. In contrast to prior research on the urine LAM, this study was conducted among less sick, ambulatory HIV-infected patients presenting for routine care.</dc:description><dc:language>en</dc:language><dc:publisher>Lippincott, Williams &amp; Wilkins</dc:publisher><dc:source>1525-4135</dc:source><dc:title>Diagnostic Accuracy of a Urine Lipoarabinomannan Enzyme-Linked Immunosorbent Assay for Screening Ambulatory HIV-Infected Persons for Tuberculosis.</dc:title><rioxxterms:author>Gounder, CR</rioxxterms:author><rioxxterms:author>Kufa, T</rioxxterms:author><rioxxterms:author>Wada, NI</rioxxterms:author><rioxxterms:author>Mngomezulu, V</rioxxterms:author><rioxxterms:author>Charalambous, S</rioxxterms:author><rioxxterms:author>Hanifa, Y</rioxxterms:author><rioxxterms:author>Fielding, K</rioxxterms:author><rioxxterms:author>Grant, A</rioxxterms:author><rioxxterms:author>Dorman, S</rioxxterms:author><rioxxterms:author>Chaisson, RE</rioxxterms:author><rioxxterms:author>Churchyard, GJ</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1097/QAI.0b013e31822b75d4</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:75
Date: 2017-10-01

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:75</identifier>
      <datestamp>2017-10-01T09:38:27Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>OBJECTIVE: To study associations between aspirin use and early and late aging macula disorder (AMD).&lt;br/&gt; DESIGN: Population-based cross-sectional European Eye Study in 7 centers from northern to southern Europe.&lt;br/&gt; PARTICIPANTS: In total, 4691 participants 65 years of age and older, collected by random sampling.&lt;br/&gt; METHODS: Aspirin intake and possible confounders for AMD were ascertained by a structured questionnaire. Ophthalmic and basic systemic measurements were performed in a standardized way. The study classified AMD according to the modified International Classification System on digitized fundus images at 1 grading center. Nonfasting blood samples were analyzed in a single laboratory. Associations were analyzed by logistic regression.&lt;br/&gt; MAIN OUTCOME MEASURES: Odds ratios (ORs) for AMD in aspirin users.&lt;br/&gt; RESULTS: Early AMD was present in 36.4% of the participants and late AMD was present in 3.3% of participants. Monthly aspirin use was reported by 1931 (41.2%), at least once weekly by 7%, and daily use by 17.3%. For daily aspirin users, the ORs, adjusted for potential confounders, showed a steady increase with increasing severity of AMD grades. These were: grade 1, 1.26 (95% confidence interval [CI], 1.08-1.46; P&lt;0.001); grade 2, 1.42 (95% CI, 1.18-1.70), and wet late AMD, 2.22 (95% CI, 1.61-3.05).&lt;br/&gt; CONCLUSIONS: Frequent aspirin use was associated with early AMD and wet late AMD, and the ORs rose with increasing frequency of consumption. This interesting observation warrants further evaluation of the associations between aspirin use and AMD.&lt;br/&gt; FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0161-6420</dc:source><dc:title>Associations between Aspirin Use and Aging Macula Disorder The European Eye Study.</dc:title><rioxxterms:author>de Jong, PT</rioxxterms:author><rioxxterms:author>Chakravarthy, U</rioxxterms:author><rioxxterms:author>Rahu, M</rioxxterms:author><rioxxterms:author>Seland, J</rioxxterms:author><rioxxterms:author>Soubrane, G</rioxxterms:author><rioxxterms:author>Topouzis, F</rioxxterms:author><rioxxterms:author>Vingerling, JR</rioxxterms:author><rioxxterms:author>Vioque, J</rioxxterms:author><rioxxterms:author>Young, I</rioxxterms:author><rioxxterms:author>Fletcher, AE</rioxxterms:author><rioxxterms:publication_date>2012</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.ophtha.2011.06.025</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:74
Date: 2017-09-30

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:74</identifier>
      <datestamp>2017-09-30T23:08:01Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>BACKGROUND: Many of the established risk factors for breast cancer implicate circulating hormone levels in the aetiology of the disease. Increased levels of postmenopausal endogenous oestradiol (E2) have been found to increase the risk of breast cancer, but no such association has been confirmed in premenopausal women. We carried out a meta-analysis to summarise the available evidence in women before the menopause.&lt;br/&gt; METHODS: We identified seven prospective studies of premenopausal endogenous E2 and breast cancer risk, including 693 breast cancer cases. From each study we extracted odds ratios of breast cancer between quantiles of endogenous E2, or for unit or s.d. increases in (log transformed) E2, or (where odds ratios were unavailable) summary statistics for the distributions of E2 in breast cancer cases and unaffected controls. Estimates for a doubling of endogenous E2 were obtained from these extracted estimates, and random-effect meta-analysis was used to obtain a pooled estimate across the studies.&lt;br/&gt; RESULTS: Overall, we found weak evidence of a positive association between circulating E2 levels and the risk of breast cancer, with a doubling of E2 associated with an odds ratio of 1.10 (95% CI: 0.96, 1.27).&lt;br/&gt; CONCLUSION: Our findings are consistent with the hypothesis of a positive association between premenopausal endogenous E2 and breast cancer risk.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/74/1/bjc2011358a.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Cancer Research UK</dc:publisher><dc:source>0007-0920</dc:source><dc:title>Premenopausal endogenous oestrogen levels and breast cancer risk: a meta-analysis.</dc:title><rioxxterms:author>Walker, K</rioxxterms:author><rioxxterms:author>Bratton, DJ</rioxxterms:author><rioxxterms:author>Frost, C</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/bjc.2011.358</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:73
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:73</identifier>
      <datestamp>2017-09-30T15:52:38Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>: SUMMARYThe domestic dog is the reservoir host of Leishmania infantum, the causative agent of zoonotic visceral leishmaniasis endemic in Mediterranean Europe. Targeted control requires predictive risk maps of canine leishmaniasis (CanL), which are now explored. We databased 2187 published and unpublished surveys of CanL in southern Europe. A total of 947 western surveys met inclusion criteria for analysis, including serological identification of infection (504, 369 dogs tested 1971-2006). Seroprevalence was 23·2% overall (median 10%). Logistic regression models within a GIS framework identified the main environmental predictors of CanL seroprevalence in Portugal, Spain, France and Italy, or in France alone. A 10-fold cross-validation approach determined model capacity to predict point-values of seroprevalence and the correct seroprevalence class (&lt;5%, 5-20%, &gt;20%). Both the four-country and France-only models performed reasonably well for predicting correctly the &lt;5% and &gt;20% seroprevalence classes (AUC &gt;0·70). However, the France-only model performed much better for France than the four-country model. The four-country model adequately predicted regions of CanL emergence in northern Italy (&lt;5% seroprevalence). Both models poorly predicted intermediate point seroprevalences (5-20%) within regional foci, because surveys were biased towards known rural foci and Mediterranean bioclimates. Our recommendations for standardizing surveys would permit higher-resolution risk mapping.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/73/1/Predict.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Cambridge University Press (CUP)</dc:publisher><dc:source>0031-1820</dc:source><dc:title>Predicting the distribution of canine leishmaniasis in western Europe based on environmental variables.</dc:title><rioxxterms:author>Franco, AO</rioxxterms:author><rioxxterms:author>Davies, CR</rioxxterms:author><rioxxterms:author>Mylne, A</rioxxterms:author><rioxxterms:author>Dedet, JP</rioxxterms:author><rioxxterms:author>Gállego, M</rioxxterms:author><rioxxterms:author>Ballart, C</rioxxterms:author><rioxxterms:author>Gramiccia, M</rioxxterms:author><rioxxterms:author>Gradoni, L</rioxxterms:author><rioxxterms:author>Molina, R</rioxxterms:author><rioxxterms:author>Gálvez, R</rioxxterms:author><rioxxterms:author>Morillas-Márquez, F</rioxxterms:author><rioxxterms:author>Barón-López, S</rioxxterms:author><rioxxterms:author>Pires, CA</rioxxterms:author><rioxxterms:author>Afonso, MO</rioxxterms:author><rioxxterms:author>Ready, PD</rioxxterms:author><rioxxterms:author>Cox, J</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1017/S003118201100148X</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:72
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:72</identifier>
      <datestamp>2017-09-30T08:39:34Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media thickness. Design: Cross-sectional observational study. Methods: A total of 706 Korean adults was selected from the Healthy Twin Study. The intima-media thickness of common, carotid bifurcation, and internal carotid artery were measured using B-mode ultrasound. Behavioral and biological cardiovascular risk factors were measured. Quantitative genetic and linear mixed analyses were performed to examine inherited and environmental contributions to intima-media thickness variation. Results: Heritability of intima-media thickness was moderately high with estimates (95% confidence intervals) of 0.48 (0.37, 0.59), 0.38(0.27, 0.49), and 0.45(0.34, 0.55) for common, carotid bifurcation, and internal carotid artery, respectively. The additive genetic cross-trait correlations between the segments ranged between 0.43 and 0.75, suggesting a shared genetic influence on the three carotid segments. Additive inherited effects contributed 21% and 31% (common and internal carotid, respectively) to the total variance of the intima-media thickness, while measured cardiovascular risk factors accounted for 46% and 26% (common and internal carotid, respectively). The cardiovascular risk factors significantly associated with carotid intima-media thickness were as follows: in men, alcohol use (bifurcation); physical activity (common and internal); BMI (all segments); diabetes (bifurcation and internal); hypertension (internal); and HDL-cholesterol (common and bifurcation); and in women, smoking (bifurcation), hypertension (common), total and LDL cholesterol (bifurcation and internal), and hs-CRP (common and internal). Conclusions: Individual cardiovascular risk factors were differentially associated with carotid intima-media thickness by segments and sex. Inherited effects made a heterogeneous contribution to intima-media thickness by segment. These findings may explain the differences in cardiovascular disease occurrence between men and women.</dc:description><dc:language>en</dc:language><dc:publisher>SAGE Publications</dc:publisher><dc:source>1741-8267</dc:source><dc:title>Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: the Healthy Twin Study.</dc:title><rioxxterms:author>Lee, K</rioxxterms:author><rioxxterms:author>Sung, J</rioxxterms:author><rioxxterms:author>Lee, SC</rioxxterms:author><rioxxterms:author>Park, SW</rioxxterms:author><rioxxterms:author>Kim, YS</rioxxterms:author><rioxxterms:author>Lee, JY</rioxxterms:author><rioxxterms:author>Ebrahim, S</rioxxterms:author><rioxxterms:author>Song, YM</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1177/1741826711422763</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:71
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:71</identifier>
      <datestamp>2017-09-30T22:25:47Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>: The systematic collection of behavioural information is an important component of second-generation HIV surveillance. The extent of behavioural surveillance among injecting drug users (IDUs) in Europe was examined using data collected through a questionnaire sent to all 31 countries of the European Union and European Free Trade Association as part of a European-wide behavioural surveillance mapping study on HIV and other sexually transmitted infections. The questionnaire was returned by 28 countries during August to September 2008: 16 reported behavioural surveillance studies (two provided no further details). A total of 12 countries used repeated surveys for behavioural surveillance and five used their Treatment Demand Indicator system (three used both approaches). The data collected focused on drug use, injecting practices, testing for HIV and hepatitis C virus and access to healthcare. Eight countries had set national indicators: three indicators were each reported by five countries: the sharing any injecting equipment, uptake of HIV testing and uptake of hepatitis C virus testing. The recall periods used varied. Seven countries reported conducting one-off behavioural surveys (in one country without a repeated survey, these resulted an informal surveillance structure). All countries used convenience sampling, with service-based recruitment being the most common approach. Four countries had used respondent-driven sampling. Three fifths of the countries responding (18/28) reported behavioural surveillance activities among IDUs; however, harmonisation of behavioural surveillance indicators is needed. 

</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/71/1/9art19960.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>European Centre for Disease Prevention and Control</dc:publisher><dc:source>1025-496X</dc:source><dc:title>Mapping HIV-related behavioural surveillance among injecting drug users in Europe, 2008.</dc:title><rioxxterms:author>Hope, V</rioxxterms:author><rioxxterms:author>Jeannin, A</rioxxterms:author><rioxxterms:author>Spencer, B</rioxxterms:author><rioxxterms:author>Gervasoni, JP</rioxxterms:author><rioxxterms:author>van de Laar, MJ</rioxxterms:author><rioxxterms:author>Dubois-Arber, F</rioxxterms:author><rioxxterms:author>ECDC HIV and STI Behavioural Surveillance Mapping Group</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:70
Date: 2017-09-30

RIOXX

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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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      <identifier>oai:researchonline.lshtm.ac.uk:70</identifier>
      <datestamp>2017-09-30T21:11:01Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>BACKGROUND: A key conclusion of the Four Cities Study, carried out to explore reasons for heterogeneity in the HIV epidemic between two cities in sub-Saharan Africa with relatively low prevalence (Cotonou and Yaoundé) and two with high prevalence (Kisumu and Ndola), was that differences in biological cofactors outweighed differences in sexual risk behaviours. The authors explore an alternative hypothesis, that risk behaviours were historically higher in the high-prevalence cities. They also investigate the effects of different prevalence of male circumcision on the HIV epidemics in the four cities.&lt;br/&gt; METHODS: A transmission model was fitted to data from the Four Cities Study. Default scenarios included biological cofactor effects on HIV transmission. Counter-factual scenarios were simulated without biological cofactors, with and without higher historical sexual behaviours, and with various rates of male circumcision.&lt;br/&gt; RESULTS: Simulated adult HIV prevalence in 1997 for the default scenarios was 3.1%, 7.8%, 28.9% and 27.1% in Cotonou, Yaoundé, Kisumu and Ndola, respectively, in line with data. Without biological cofactors, even implausibly high historical levels of risk behaviour in East Africa could not reproduce the observed heterogeneity in the late 1990s. Increasing the proportion of men circumcised in Ndola from 10% to 100% reduced HIV prevalence in 1997 to 7%. Decreasing the proportion circumcised in Yaoundé from 100% to 10% increased HIV prevalence to 26%.&lt;br/&gt; CONCLUSIONS: Differences in male circumcision rates are likely to have played a key role in the heterogeneous spread of HIV across Africa. The effect of circumcision interventions can vary depending on the epidemic setting, with a larger effect in more generalised epidemics.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>1368-4973</dc:source><dc:title>Attempting to explain heterogeneous HIV epidemics in sub-Saharan Africa: potential role of historical changes in risk behaviour and male circumcision.</dc:title><rioxxterms:author>Orroth, KK</rioxxterms:author><rioxxterms:author>White, RG</rioxxterms:author><rioxxterms:author>Freeman, EE</rioxxterms:author><rioxxterms:author>Bakker, R</rioxxterms:author><rioxxterms:author>Buvé, A</rioxxterms:author><rioxxterms:author>Glynn, JR</rioxxterms:author><rioxxterms:author>Habbema, JD</rioxxterms:author><rioxxterms:author>Hayes, RJ</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/sextrans-2011-050174</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:69
Date: 2017-09-30

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:69</identifier>
      <datestamp>2017-09-30T07:17:41Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Both disease-specific and generic patient-reported outcome measures provide information about the health status of patients. Generally, disease-specific measures provide more clinical information than generic measures but do not provide a utility weight. The aim of this study was to assess the comparability of the information captured by a disease-specific measure, the Oxford Hip Score (OHS), and a generic measure, the EQ-5D, and the viability of mapping between them to obtain utilities for the OHS.</dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>1098-3015</dc:source><dc:title>Comparison of the Underlying Constructs of the EQ-5D and Oxford Hip Score: Implications for Mapping.</dc:title><rioxxterms:author>Oppe, M</rioxxterms:author><rioxxterms:author>Devlin, N</rioxxterms:author><rioxxterms:author>Black, N</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.jval.2011.03.003</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:68
Date: 2017-10-01

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:68</identifier>
      <datestamp>2017-10-01T07:46:07Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>All European health systems face several common challenges related to increases in lifestyle and chronic diseases, a decreasing future workforce, inequalities in health and the consequences of societal changes. Primary care, which has the potential to help meet these challenges, would benefit from the contribution of health services research (HSR) on a wide range of topics. As funding for such research is limited, priorities need to be defined.</dc:description><dc:language>en</dc:language><dc:publisher>Radcliffe Medical Press</dc:publisher><dc:source>1479-1072</dc:source><dc:title>Priorities for health services research in primary care.</dc:title><rioxxterms:author>Schäfer, W</rioxxterms:author><rioxxterms:author>Groenewegen, PP</rioxxterms:author><rioxxterms:author>Hansen, J</rioxxterms:author><rioxxterms:author>Black, N</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:67
Date: 2017-10-01

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      <identifier>oai:researchonline.lshtm.ac.uk:67</identifier>
      <datestamp>2017-10-01T05:20:26Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Kings Fund</dc:publisher><dc:title>Understanding New Labour's market reforms of the English NHS</dc:title><rioxxterms:author>Mays, N</rioxxterms:author><rioxxterms:author>Dixon, A</rioxxterms:author><rioxxterms:author>Jones, L</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Book</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:66
Date: 2017-10-01

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:66</identifier>
      <datestamp>2017-10-01T03:10:15Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>ABSTRACT: BACKGROUND: Health reforms in Bulgaria have introduced major changes to the financing, delivery and regulation of health care. As in many other countries of Central and Eastern Europe, these included introducing general practice, establishing a health insurance system, reorganizing hospital services, and setting up new payment mechanisms for providers, including patient co-payments. Our study explored perceptions of regulatory barriers to equity in Bulgarian child health services. METHODS: 50 qualitative in-depth interviews with users, providers and policy-makers concerned with child health services in Bulgaria, conducted in two villages, one town of 70,000 inhabitants, and the capital Sofia. RESULTS: The participants in our study reported a variety of regulatory barriers which undermined the principles of equity and, as far as the health insurance system is concerned, solidarity. These included non-participation in the compulsory health insurance system, informal payments, and charging user fees to exempted patients. The participants also reported seemingly unnecessary treatments in the growing private sector. These regulatory failures were associated with the fast pace of reforms, lack of consultation, inadequate public financing of the health system, a perceived "commercialization" of medicine, and weak enforcement of legislation. A recurrent theme from the interviews was the need for better information about patient rights and services covered by the health insurance system. CONCLUSIONS: Regulatory barriers to equity and compliance in daily practice deserve more attention from policy-makers when embarking on health reforms. New financing sources and an increasing role of the private sector need to be accompanied by an appropriate and enforceable regulatory framework to control the behavior of health care providers and ensure equity in access to health services.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/66/1/1472-6963-11-219.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BioMed Central</dc:publisher><dc:source>1472-6963</dc:source><dc:title>Regulatory barriers to equity in a health system in transition: a qualitative study in Bulgaria.</dc:title><rioxxterms:author>Rechel, B</rioxxterms:author><rioxxterms:author>Blackburn, CM</rioxxterms:author><rioxxterms:author>Spencer, NJ</rioxxterms:author><rioxxterms:author>Rechel, B</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1472-6963-11-219</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:65
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:65</identifier>
      <datestamp>2017-09-30T10:45:09Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011-09-20">http://creativecommons.org/licenses/by-nc/4.0</ali:license_ref><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/65/1/bmj.d5789.full.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0959-8138</dc:source><dc:title>More than meets the eye in correcting refractive error in low income countries.</dc:title><rioxxterms:author>Bastawrous, A</rioxxterms:author><rioxxterms:author>Aldawoud, M</rioxxterms:author><rioxxterms:publication_date>2011-09-20</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/bmj.d5789</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:64
Date: 2017-09-30

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:64</identifier>
      <datestamp>2017-09-30T19:52:37Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>OBJECTIVE: To quantify the effects of a thermostatic control system in social (public) housing on the prevalence of dangerous (&gt;60°C) water temperatures and on fuel consumption.&lt;br/&gt; DESIGN: Pair-matched double-blind cluster randomised controlled trial.&lt;br/&gt; SETTING: Social housing in a deprived inner-London borough.&lt;br/&gt; PARTICIPANTS: 150 households recruited as clusters from 22 social housing estates. Four small estates were combined into two clusters (resulting in a total of 10 pairs of clusters).&lt;br/&gt; INTERVENTION: Social housing estate boiler houses were randomised to a thermostatic control sterilisation programme (heating water to 65°C during 00:00-06:00 h and to 50°C from 06:00 to 00:00 h daily) or to standard control (constant temperature 65°C).&lt;br/&gt; MAIN OUTCOME MEASURES: Water temperature over 60°C ('dangerous') after running taps for 1 min and daily fuel consumption (cubic feet of gas).&lt;br/&gt; RESULTS: 10 clusters (80 households) were allocated to the sterilisation programme and 10 clusters (70 households) to control, of which 73 and 67 households, respectively, were analysed. Prevalence of dangerous (&gt;60°C) hot water temperatures at 1 min was significantly reduced with the sterilisation programme (mean of cluster prevalence 1% in sterilisation programme group vs 34% in control group; absolute difference 33%, 95% CI 12% to 54%; p=0.006). Prevalence of high (&gt;55°C) hot water temperatures at 1 min was significantly reduced (31% sterilisation vs 59% control; absolute difference 28%, 95% CI 9% to 47%; p=0.009). Gas consumption per day reduced more in the control group than in the sterilisation programme group, although not statistically significantly (p=0.125).&lt;br/&gt; CONCLUSIONS: The thermostatic control with daily sterilisation was effective in capping hot water temperatures and therefore reduced scald risk. Although expected to save energy, fuel consumption was increased relative to the control group. Trial registration ClinicalTrials.gov ID: NCT00874692.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/64/1/Social_Housing_Scald_Risk_Reduction_Edwards_PJ_PRE-PUBLICATION_VERSION.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0003-9888</dc:source><dc:title>Scald risk in social housing can be reduced through thermostatic control system without increasing Legionella risk: a cluster randomised trial.</dc:title><rioxxterms:author>Edwards, P</rioxxterms:author><rioxxterms:author>Durand, MA</rioxxterms:author><rioxxterms:author>Hollister, M</rioxxterms:author><rioxxterms:author>Green, J</rioxxterms:author><rioxxterms:author>Lutchmun, S</rioxxterms:author><rioxxterms:author>Kessel, A</rioxxterms:author><rioxxterms:author>Roberts, I</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>AM</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/archdischild-2011-300606</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:63
Date: 2015-05-31

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:63</identifier>
      <datestamp>2015-05-31T13:24:58Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Many childhood cancer survivors have psychosocial late effects. We studied the risks for cohabitation and subsequent separation. Through the Danish Cancer Register, we identified a nationwide, population-based cohort of all 1877 childhood cancer survivors born from 1965 to 1980, and in whom cancer was diagnosed between 1965 and 1996 before they were 20 years of age. A sex-matched and age-matched population-based control cohort was used for comparison (n=45,449). Demographic and socioeconomic data were obtained from national registers and explored by discrete-time Cox regression analyses. Childhood cancer survivors had a reduced rate of cohabitation [rate ratio (RR) 0.78; 95% confidence interval (CI): 0.73-0.83], owing to lower rates among survivors of both noncentral nervous system (CNS) tumors (RR 0.88; 95% CI: 0.83-0.95) and CNS tumors (RR 0.52; 95% CI: 0.45-0.59). Male CNS tumor survivors had a nonsignificantly lower rate (RR 0.47; 95% CI: 0.38-0.58) than females (RR 0.56; 95% CI: 0.47-0.68). The rates of separation were almost identical to those of controls. In conclusion, the rate of cohabitation was lower for all childhood cancer survivors than for the population-based controls, with the most pronounced reduction among survivors of CNS tumors. Mental deficits after cranial irradiation are likely to be the major risk factor.</dc:description><dc:language>en</dc:language><dc:publisher>Lippincott, Williams &amp; Wilkins</dc:publisher><dc:source>1077-4114</dc:source><dc:title>Marriage and Divorce Among Childhood Cancer Survivors.</dc:title><rioxxterms:author>Koch, SV</rioxxterms:author><rioxxterms:author>Kejs, AM</rioxxterms:author><rioxxterms:author>Engholm, G</rioxxterms:author><rioxxterms:author>Møller, H</rioxxterms:author><rioxxterms:author>Johansen, C</rioxxterms:author><rioxxterms:author>Schmiegelow, K</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1097/MPH.0b013e31822820a1</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:62
Date: 2017-09-30

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:62</identifier>
      <datestamp>2017-09-30T12:08:10Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>BACKGROUND: Russia's market reforms in the early 1990s led to marked social inequalities. We analysed inequalities in risks of dying for Russian men by occupational class and perceived social status in the post-transition era.&lt;br/&gt; METHODS: Cox proportional analysis of the hazard of dying by occupational class, education, household income and perceived social status was performed for 593 deaths that occurred between 1994 and 2006 using a representative sample of Russia's male population (n?=?6586 people, 40?046 person-years). Occupational class was coded based on the European Socio-Economic Classification; social status was based on survey questionnaires about people's perceived economic, power and respect status.&lt;br/&gt; RESULTS: Manual occupational class is significantly associated with greater hazards of dying among men, after adjusting for age, education and other potential confounding variables. Groups at highest risk were men who were manual workers, manual supervisors and technicians, and lower sales and service workers. Substantial gaps in life expectancy at age 21 of up to 10 years were observed between male managers and professionals and manual workers.&lt;br/&gt; CONCLUSION: Substantial inequalities in risks of dying exist by both occupational class and perceived status in Russia, with patterns by class differing from those in the west.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>1101-1262</dc:source><dc:title>Inequalities in male mortality by occupational class, perceived status and education in Russia, 1994-2006.</dc:title><rioxxterms:author>Bessudnov, A</rioxxterms:author><rioxxterms:author>McKee, M</rioxxterms:author><rioxxterms:author>Stuckler, D</rioxxterms:author><rioxxterms:publication_date>2012</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/eurpub/ckr130</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:61
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:61</identifier>
      <datestamp>2017-09-30T19:00:10Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>: The ability to predict Externally Visible Characteristics (EVCs) from DNA, also referred to as Forensic DNA Phenotyping (FDP), is an exciting new chapter in forensic genetics holding great promise for tracing unknown individuals who are unidentifiable via standard forensic short tandem repeat (STR) profiling. For the purpose of DNA-based eye colour prediction, we previously developed the IrisPlex system consisting of a multiplex genotyping assay and a prediction model based on genotype and phenotype data from 3804 Dutch Europeans. Recently, we performed a forensic developmental validation study of the highly sensitive IrisPlex assay, which currently represents the only validated tool available for DNA-based prediction of eye colour in forensic applications. In the present study, we validate the IrisPlex prediction model by extending our initially described model towards genotype and phenotype data from multiple European populations. We performed IrisPlex analysis on 3840 individuals from seven sites across Europe as part of the European Eye (EUREYE) study for which DNA and high-resolution eye images were available. The accuracy rate of correctly predicting an individual's eye colour as being blue or brown, above the empirically established probability threshold of 0.7, was on average 94% across all seven European populations, ranging from 91% to 98%, despite the large variation in eye colour frequencies between the populations. The overall prediction accuracies expressed by the area under the receiver characteristic operating curves (AUC) were 0.96 for blue and 0.96 for brown eyes, which is considerably higher than those established before. The IrisPlex prediction model parameters generated from this multi-population European dataset, and thus its prediction capabilities, were highly comparable to those previously established. Therefore, the increased information regarding eye colour phenotype and genotype distributions across Europe, and the system's ability to provide eye colour predictions across Europe accurately, both highlight additional evidence for the utility of the IrisPlex system in forensic casework.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>1872-4973</dc:source><dc:title>DNA-based eye colour prediction across Europe with the IrisPlex system.</dc:title><rioxxterms:author>Walsh, S</rioxxterms:author><rioxxterms:author>Wollstein, A</rioxxterms:author><rioxxterms:author>Liu, F</rioxxterms:author><rioxxterms:author>Chakravarthy, U</rioxxterms:author><rioxxterms:author>Rahu, M</rioxxterms:author><rioxxterms:author>Seland, JH</rioxxterms:author><rioxxterms:author>Soubrane, G</rioxxterms:author><rioxxterms:author>Tomazzoli, L</rioxxterms:author><rioxxterms:author>Topouzis, F</rioxxterms:author><rioxxterms:author>Vingerling, JR</rioxxterms:author><rioxxterms:author>Vioque, J</rioxxterms:author><rioxxterms:author>Fletcher, AE</rioxxterms:author><rioxxterms:author>Ballantyne, KN</rioxxterms:author><rioxxterms:author>Kayser, M</rioxxterms:author><rioxxterms:publication_date>2012</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.fsigen.2011.07.009</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:60
Date: 2017-10-01

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:60</identifier>
      <datestamp>2017-10-01T13:27:30Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>: Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160) demonstrating associations between late AMD and APO?4 (odds ratio [OR] = 0.72 per haplotype; confidence interval [CI]: 0.65-0.74; P = 4.41×10(-11) ) and APO?2 (OR = 1.83 for homozygote carriers; CI: 1.04-3.23; P = 0.04), following adjustment for age group and sex within each study and smoking status. No evidence of interaction between APOE and sex or smoking was found. Ever smokers had significant increased risk relative to never smokers for both neovascular (OR = 1.54; CI: 1.38-1.72; P = 2.8×10(-15) ) and atrophic (OR = 1.38; CI: 1.18-1.61; P = 3.37×10(-5) ) AMD but not early AMD (OR = 0.94; CI: 0.86-1.03; P = 0.16), implicating smoking as a major contributing factor to disease progression from early signs to the visually disabling late forms. Extended haplotype analysis incorporating rs405509 did not identify additional risks beyond ?2 and ?4 haplotypes. Our expanded analysis substantially improves our understanding of the association between the APOE locus and AMD. It further provides evidence supporting the role of cholesterol modulation, and low-density cholesterol specifically, in AMD disease etiology.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>1059-7794</dc:source><dc:title>Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies.</dc:title><rioxxterms:author>McKay, GJ</rioxxterms:author><rioxxterms:author>Patterson, CC</rioxxterms:author><rioxxterms:author>Chakravarthy, U</rioxxterms:author><rioxxterms:author>Dasari, S</rioxxterms:author><rioxxterms:author>Klaver, CC</rioxxterms:author><rioxxterms:author>Vingerling, JR</rioxxterms:author><rioxxterms:author>Ho, L</rioxxterms:author><rioxxterms:author>de Jong, PT</rioxxterms:author><rioxxterms:author>Fletcher, AE</rioxxterms:author><rioxxterms:author>Young, IS</rioxxterms:author><rioxxterms:author>Seland, JH</rioxxterms:author><rioxxterms:author>Rahu, M</rioxxterms:author><rioxxterms:author>Soubrane, G</rioxxterms:author><rioxxterms:author>Tomazzoli, L</rioxxterms:author><rioxxterms:author>Topouzis, F</rioxxterms:author><rioxxterms:author>Vioque, J</rioxxterms:author><rioxxterms:author>Hingorani, AD</rioxxterms:author><rioxxterms:author>Sofat, R</rioxxterms:author><rioxxterms:author>Dean, M</rioxxterms:author><rioxxterms:author>Sawitzke, J</rioxxterms:author><rioxxterms:author>Seddon, JM</rioxxterms:author><rioxxterms:author>Peter, I</rioxxterms:author><rioxxterms:author>Webster, AR</rioxxterms:author><rioxxterms:author>Moore, AT</rioxxterms:author><rioxxterms:author>Yates, JR</rioxxterms:author><rioxxterms:author>Cipriani, V</rioxxterms:author><rioxxterms:author>Fritsche, LG</rioxxterms:author><rioxxterms:author>Weber, BH</rioxxterms:author><rioxxterms:author>Keilhauer, CN</rioxxterms:author><rioxxterms:author>Lotery, AJ</rioxxterms:author><rioxxterms:author>Ennis, S</rioxxterms:author><rioxxterms:author>Klein, ML</rioxxterms:author><rioxxterms:author>Francis, PJ</rioxxterms:author><rioxxterms:author>Stambolian, D</rioxxterms:author><rioxxterms:author>Orlin, A</rioxxterms:author><rioxxterms:author>Gorin, MB</rioxxterms:author><rioxxterms:author>Weeks, DE</rioxxterms:author><rioxxterms:author>Kuo, CL</rioxxterms:author><rioxxterms:author>Swaroop, A</rioxxterms:author><rioxxterms:author>Othman, M</rioxxterms:author><rioxxterms:author>Kanda, A</rioxxterms:author><rioxxterms:author>Chen, W</rioxxterms:author><rioxxterms:author>Abecasis, GR</rioxxterms:author><rioxxterms:author>Wright, AF</rioxxterms:author><rioxxterms:author>Hayward, C</rioxxterms:author><rioxxterms:author>Baird, PN</rioxxterms:author><rioxxterms:author>Guymer, RH</rioxxterms:author><rioxxterms:author>Attia, J</rioxxterms:author><rioxxterms:author>Thakkinstian, A</rioxxterms:author><rioxxterms:author>Silvestri, G</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1002/humu.21577</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:59
Date: 2017-09-30

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:59</identifier>
      <datestamp>2017-09-30T03:50:42Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>: To report blood pressure control in the Hypertension in the Very Elderly Trial, a placebo-controlled trial of hypertensive (systolic blood pressure (SBP) 160-199?mm?Hg, diastolic blood pressure (DBP) &lt;110?mm?Hg) participants over the age of 80 years, given treatment in three steps: indapamide slow release 1.5?mg alone, indapamide plus 2?mg perindopril and indapamide plus 4?mg perindopril. The difference in control between participants with combined systolic and diastolic hypertension (SDH, DBP?90?mm?Hg) and those with isolated systolic hypertension (ISH, DBP&lt;90?mm?Hg) is determined together with the effects of increments in the treatment regimen. At 2 years, the active treatment lowered blood pressure by 16.5/6.9?mm?Hg more than that on placebo in participants with SDH and by 19.3/4.8?mm?Hg more in those with ISH. The 2-year falls in pressure on placebo alone were 13.2/8.5?mm?Hg in SDH and 8.2/1.5?mm?Hg in ISH participants. With full titration of active treatment, 62% of SDH participants achieved goal SBP (&lt;150?mm?Hg) by 2 years and 71% of those with ISH. The corresponding results for DBP control (&lt;80?mm?Hg) were 40 and 78%. The addition of active perindopril 2?mg roughly doubled the percentage controlled, as did increasing to 4 from 2?mg. Blood pressure control was good with ISH and better than with SDH. The fall in SBP accounted for the observed 30% reduction in strokes, but the 21% reduction in total mortality and 64% reduction in heart failure were greater than predicted.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Nature Publishing Group</dc:publisher><dc:source>0950-9240</dc:source><dc:title>Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET).</dc:title><rioxxterms:author>Bulpitt, CJ</rioxxterms:author><rioxxterms:author>Beckett, NS</rioxxterms:author><rioxxterms:author>Peters, R</rioxxterms:author><rioxxterms:author>Leonetti, G</rioxxterms:author><rioxxterms:author>Gergova, V</rioxxterms:author><rioxxterms:author>Fagard, R</rioxxterms:author><rioxxterms:author>Burch, LA</rioxxterms:author><rioxxterms:author>Banya, W</rioxxterms:author><rioxxterms:author>Fletcher, AE</rioxxterms:author><rioxxterms:publication_date>2012</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1038/jhh.2011.10</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:57
Date: 2017-10-01

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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      <identifier>oai:researchonline.lshtm.ac.uk:57</identifier>
      <datestamp>2017-10-01T11:17:09Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/57/1/colorectal_cancer_comorbidity_in_NZ-2.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>New Zealand Medical Association</dc:publisher><dc:source>0028-8446</dc:source><dc:title>Comorbidity among patients with colon cancer in New Zealand</dc:title><rioxxterms:author>Sarfati, D</rioxxterms:author><rioxxterms:author>Tan, L</rioxxterms:author><rioxxterms:author>Blakely, T</rioxxterms:author><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:56
Date: 2017-09-30

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:56</identifier>
      <datestamp>2017-09-30T04:35:46Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>Epidemiology and demography in public health</dc:source><dc:title>Environmental and occupational epidemiology</dc:title><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:author>Douwes, J</rioxxterms:author><rioxxterms:contributor>Killewo, J</rioxxterms:contributor><rioxxterms:contributor>Heggenhouwer, HK</rioxxterms:contributor><rioxxterms:contributor>Quah, SR</rioxxterms:contributor><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Book chapter</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:55
Date: 2017-10-01

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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      <identifier>oai:researchonline.lshtm.ac.uk:55</identifier>
      <datestamp>2017-10-01T03:18:55Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>New Zealand Medical Association</dc:publisher><dc:source>0028-8446</dc:source><dc:title>Occupational mortality in New Zealand males 2001-2005</dc:title><rioxxterms:author>Holmes, E</rioxxterms:author><rioxxterms:author>Davies, A</rioxxterms:author><rioxxterms:author>Wright, C</rioxxterms:author><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:author>Borman, B</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:54
Date: 2017-10-01

RIOXX

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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:54</identifier>
      <datestamp>2017-10-01T04:45:17Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>There has been a global epidemic of asthma during the past half-century. More recently, the prevalence has leveled off or declined in many Western countries, whereas the prevalence in less affluent nations is still increasing. The reasons for this and the different geographical patterns of asthma prevalence remain unclear. This paper provides an epidemiologic perspective on whether allergen exposure and allergies can explain these trends. In particular, the paper discusses 1) geographical and temporal trends in asthma and the role of allergens and allergy, 2) the importance of nonallergic mechanisms, 3) nonallergenic exposures that may modify the risk of allergies and asthma, and 4) new and emerging risk and protective factors. Although allergy and asthma are closely related, allergen exposure and allergy alone cannot explain current time trends and geographical patterns of asthma. Population-based studies focusing on recently identified risk and protective factors may provide further insight.</dc:description><dc:language>en</dc:language><dc:publisher>Current Medicine Group</dc:publisher><dc:source>1529-7322</dc:source><dc:title>Importance of Allergy in Asthma: An Epidemiologic Perspective</dc:title><rioxxterms:author>Douwes, J</rioxxterms:author><rioxxterms:author>Brooks, C</rioxxterms:author><rioxxterms:author>van Dalen, C</rioxxterms:author><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1007/s11882-011-0215-6</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:53
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:53</identifier>
      <datestamp>2017-09-30T17:50:21Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Methods An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol. Results A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma [OR 0.81; 95% confidence interval (CI) 0.70-0.94] and meningioma (OR 0.79; 95% CI 0.68-0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed &gt;= 10 years after first phone use (glioma: OR 0.98; 95% CI 0.76-1.26; meningioma: OR 0.83; 95% CI 0.61-1.14). ORs were &lt; 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the 10th decile of recalled cumulative call time, &gt;= 1640 h, the OR was 1.40 (95% CI 1.03-1.89) for glioma, and 1.15 (95% CI 0.81-1.62) for meningioma; but there are implausible values of reported use in this group. ORs for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the CIs around the lobe-specific estimates were wide. ORs for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side. Conclusions Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation.</dc:description><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>0300-5771</dc:source><dc:title>Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study</dc:title><rioxxterms:author>Cardis, E</rioxxterms:author><rioxxterms:author>Deltour, I</rioxxterms:author><rioxxterms:author>Vrijheid, M</rioxxterms:author><rioxxterms:author>Combalot, E</rioxxterms:author><rioxxterms:author>Moissonnier, M</rioxxterms:author><rioxxterms:author>Tardy, H</rioxxterms:author><rioxxterms:author>Armstrong, B</rioxxterms:author><rioxxterms:author>Giles, G</rioxxterms:author><rioxxterms:author>Brown, J</rioxxterms:author><rioxxterms:author>Siemiatycki, J</rioxxterms:author><rioxxterms:author>Parent, ME</rioxxterms:author><rioxxterms:author>Nadon, L</rioxxterms:author><rioxxterms:author>Krewski, D</rioxxterms:author><rioxxterms:author>McBride, ML</rioxxterms:author><rioxxterms:author>Johansen, C</rioxxterms:author><rioxxterms:author>Collatz, CH</rioxxterms:author><rioxxterms:author>Auvinen, A</rioxxterms:author><rioxxterms:author>Kurttio, P</rioxxterms:author><rioxxterms:author>Lahkola, A</rioxxterms:author><rioxxterms:author>Salminen, T</rioxxterms:author><rioxxterms:author>Hours, M</rioxxterms:author><rioxxterms:author>Bernard, M</rioxxterms:author><rioxxterms:author>Montestruq, L</rioxxterms:author><rioxxterms:author>Schuz, J</rioxxterms:author><rioxxterms:author>Berg-Beckhoff, G</rioxxterms:author><rioxxterms:author>Schlehofer, B</rioxxterms:author><rioxxterms:author>Blettner, M</rioxxterms:author><rioxxterms:author>Sadetzki, S</rioxxterms:author><rioxxterms:author>Chetrit, A</rioxxterms:author><rioxxterms:author>Jarus-Hakak, A</rioxxterms:author><rioxxterms:author>Lagorio, S</rioxxterms:author><rioxxterms:author>Iavarone, I</rioxxterms:author><rioxxterms:author>Takebayashi, T</rioxxterms:author><rioxxterms:author>Yamaguchi, N</rioxxterms:author><rioxxterms:author>Woodward, A</rioxxterms:author><rioxxterms:author>Cook, A</rioxxterms:author><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:author>Tynes, T</rioxxterms:author><rioxxterms:author>Blaasaas, KG</rioxxterms:author><rioxxterms:author>Klaeboe, L</rioxxterms:author><rioxxterms:author>Feychting, M</rioxxterms:author><rioxxterms:author>Lonn, S</rioxxterms:author><rioxxterms:author>Ahlbom, A</rioxxterms:author><rioxxterms:author>McKinney, PA</rioxxterms:author><rioxxterms:author>Hepworth, SJ</rioxxterms:author><rioxxterms:author>Muir, KR</rioxxterms:author><rioxxterms:author>Swerdlow, AJ</rioxxterms:author><rioxxterms:author>Schoemaker, MJ</rioxxterms:author><rioxxterms:author>Grp, IS</rioxxterms:author><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/ije/dyq079</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:50
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
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      <identifier>oai:researchonline.lshtm.ac.uk:50</identifier>
      <datestamp>2017-09-30T22:01:30Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>: To explore attitudes toward circumcision among men who have sex with men (MSM) in London and the feasibility of conducting research into circumcision and HIV prevention in this population.</dc:description><dc:language>en</dc:language><dc:publisher>Lippincott, Williams &amp; Wilkins</dc:publisher><dc:source>0148-5717</dc:source><dc:title>Circumcision Among Men Who Have Sex With Men in London, United Kingdom: An Unlikely Strategy for HIV Prevention.</dc:title><rioxxterms:author>Thornton, AC</rioxxterms:author><rioxxterms:author>Lattimore, S</rioxxterms:author><rioxxterms:author>Delpech, V</rioxxterms:author><rioxxterms:author>Weiss, HA</rioxxterms:author><rioxxterms:author>Elford, J</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1097/OLQ.0b013e318221562a</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:49
Date: 2017-10-01

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:49</identifier>
      <datestamp>2017-10-01T06:59:16Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>To investigate associations between air pollution levels and myocardial infarction (MI) on short timescales, with data at an hourly temporal resolution.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/49/1/bhak865915.w1_default.pdf</dc:identifier><dc:language>en</dc:language><dc:source>1468-5833</dc:source><dc:title>The effects of hourly differences in air pollution on the risk of myocardial infarction: case crossover analysis of the MINAP database.</dc:title><rioxxterms:author>Bhaskaran, K</rioxxterms:author><rioxxterms:author>Hajat, S</rioxxterms:author><rioxxterms:author>Armstrong, B</rioxxterms:author><rioxxterms:author>Haines, A</rioxxterms:author><rioxxterms:author>Herrett, E</rioxxterms:author><rioxxterms:author>Wilkinson, P</rioxxterms:author><rioxxterms:author>Smeeth, L</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/bmj.d5531</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:48
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:48</identifier>
      <datestamp>2017-09-30T19:17:00Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Clin Microbiol Infect 2011; 17: 1478-1483 ABSTRACT: Although there have been significant advances in the treatment of visceral leishmaniasis (VL), there remain challenges to ensure that treatments effective in India are also effective in other regions of the world and to identify treatment for post kala-azar dermal leishmaniasis as well as the opportunity to develop a safe oral short-course treatment. At the same time, there have been few advances for the treatment of simple or complex forms of cutaneous leishmaniasis (CL), other than topical paromomycin formulations. The main challenge for CL is to ensure that this disease is on the research and development agenda, so that new drugs are evaluated or compounds are screened in appropriate models, and that the standardization of quality of clinical trials is guaranteed. Problems also remain in the treatment of HIV/leishmaniasis co-infected patients. We are some way from having the ideal treatments for VL and CL and drug research and development for these diseases must remain focused.</dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>1198-743X</dc:source><dc:title>Leishmaniasis chemotherapy-challenges and opportunities.</dc:title><rioxxterms:author>Croft, SL</rioxxterms:author><rioxxterms:author>Olliaro, P</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1469-0691.2011.03630.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:47
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:47</identifier>
      <datestamp>2017-09-30T10:07:18Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>For a quarter of century, mathematical models have been used to study the spread and control of HIV amongst men who have sex with men (MSM). We searched MEDLINE and EMBASE databases up to the end of 2010 and reviewed this literature to summarise the methodologies used, key model developments, and the recommended strategies for HIV control amongst MSM. Of 742 studies identified, 127 studies met the inclusion criteria. Most studies employed deterministic modelling methods (80%). Over time we saw an increase in model complexity regarding antiretroviral therapy (ART), and a corresponding decrease in complexity regarding sexual behaviours. Formal estimation of model parameters was carried out in only a small proportion of the studies (22%) while model validation was considered by an even smaller proportion (17%), somewhat reducing confidence in the findings from the studies. Nonetheless, a number of common conclusions emerged, including (1) identification of the importance of assumptions regarding changes in infectivity and sexual contact rates on the impact of ART on HIV incidence, that subsequently led to empirical studies to gather these data, and (2) recommendation that multiple strategies would be required for effective HIV control amongst MSM. The role of mathematical models in studying epidemics is clear, and the lack of formal inference and validation highlights the need for further developments in this area. Improved methodologies for parameter estimation and systematic sensitivity analysis will help generate predictions that more fully express uncertainty, allowing better informed decision making in public health.</dc:description><dc:language>en</dc:language><dc:publisher>Springer Verlag</dc:publisher><dc:source>0393-2990</dc:source><dc:title>Mathematical models for the study of HIV spread and control amongst men who have sex with men.</dc:title><rioxxterms:author>Punyacharoensin, N</rioxxterms:author><rioxxterms:author>Edmunds, WJ</rioxxterms:author><rioxxterms:author>De Angelis, D</rioxxterms:author><rioxxterms:author>White, RG</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1007/s10654-011-9614-1</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:46
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:46</identifier>
      <datestamp>2017-09-30T17:08:04Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>Despite recent decreases in HIV incidence in many sub-Saharan African countries, there is little evidence that specific behavioural interventions have led to a reduction in HIV among young people. Further and wider-scale decreases in HIV require better understanding of when behaviour change occurs and why. The MEMA kwa Vijana adolescent sexual and reproductive health intervention has been implemented in rural Mwanza, Tanzania since 1999. A long-term evaluation in 2007/8 found that the intervention improved knowledge, attitudes to sex and some reported risk behaviours, but not HIV or HSV2 prevalence. The aim of this paper was to assess the differential impact of the intervention according to gender, age, marital status, number of years of exposure and time since last exposure to the intervention.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/46/1/pone.0024866.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1932-6203</dc:source><dc:title>The Long-Term Impact of the MEMA kwa Vijana Adolescent Sexual and Reproductive Health Intervention: Effect of Dose and Time since Intervention Exposure.</dc:title><rioxxterms:author>Doyle, AM</rioxxterms:author><rioxxterms:author>Weiss, HA</rioxxterms:author><rioxxterms:author>Maganja, K</rioxxterms:author><rioxxterms:author>Kapiga, S</rioxxterms:author><rioxxterms:author>McCormack, S</rioxxterms:author><rioxxterms:author>Watson-Jones, D</rioxxterms:author><rioxxterms:author>Changalucha, J</rioxxterms:author><rioxxterms:author>Hayes, RJ</rioxxterms:author><rioxxterms:author>Ross, DA</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0024866</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:45
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
This is not a valid RIOXX record
PropertyError
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:45</identifier>
      <datestamp>2017-09-30T02:31:42Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>BACKGROUND: Fatty acids (FA) modulate the immune system, and it has been proposed that they affect the incidence of IgE-mediated allergic diseases. We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring.&lt;br/&gt; METHODS: We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Maternal dietary intake during pregnancy (8th month) was assessed by a validated 181-item food frequency questionnaire. The occurrence of asthma was assessed at the age of 5 yr with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for the statistical analyses.&lt;br/&gt; RESULTS: Low maternal intakes of ?-linolenic acid (18:3n-3) [lowest quarter vs. mid-half HR 1.67 (95% CI 1.12-2.48)] and total n-3-polyunsaturated fatty acids (PUFA) [HR 1.66 (95% CI 1.11-2.48)] during pregnancy were associated with an increased risk of asthma in the offspring, while a low intake of arachidonic acid (20:4n-6) [HR 0.52 (95% CI 0.32-0.84)] and high intake of total saturated fatty acids [highest quarter vs. mid-half HR 0.55 (95% CI 0.34-0.90)] and palmitic acid (16:0) [HR 0.51 (95% CI 0.31-0.83)] were associated with a decreased risk of asthma. The ratios of n-6 to n-3-PUFA and 18:2n-6 to 18:3n-3, and the maternal intake of oils, fish and fish products, showed no association with the risk of asthma. The associations found were independent of several perinatal and clinical confounders.&lt;br/&gt; CONCLUSION: Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal ?-linolenic acid, total n-3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>0905-6157</dc:source><dc:title>Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring.</dc:title><rioxxterms:author>Lumia, M</rioxxterms:author><rioxxterms:author>Luukkainen, P</rioxxterms:author><rioxxterms:author>Tapanainen, H</rioxxterms:author><rioxxterms:author>Kaila, M</rioxxterms:author><rioxxterms:author>Erkkola, M</rioxxterms:author><rioxxterms:author>Uusitalo, L</rioxxterms:author><rioxxterms:author>Niinistö, S</rioxxterms:author><rioxxterms:author>Kenward, MG</rioxxterms:author><rioxxterms:author>Ilonen, J</rioxxterms:author><rioxxterms:author>Simell, O</rioxxterms:author><rioxxterms:author>Knip, M</rioxxterms:author><rioxxterms:author>Veijola, R</rioxxterms:author><rioxxterms:author>Virtanen, SM</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1399-3038.2011.01202.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:44
Date: 2017-09-30

RIOXX

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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref

RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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ali:license_ref'2011' in the 'start_date' attribute is not in valid ISO8601 ('yyyy-mm-dd') format in ali:license_ref
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:44</identifier>
      <datestamp>2017-09-30T05:25:17Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref><dc:description>BACKGROUND: . Unique identifier: NCT00327574.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/44/1/ukmss-36573.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>American Heart Association</dc:publisher><dc:source>0009-7322</dc:source><dc:title>Cost-Effectiveness of Community-Based Strategies for Blood Pressure Control in a Low-Income Developing Country: Findings From a Cluster-Randomized, Factorial-Controlled Trial.</dc:title><rioxxterms:author>Jafar, TH</rioxxterms:author><rioxxterms:author>Islam, M</rioxxterms:author><rioxxterms:author>Bux, R</rioxxterms:author><rioxxterms:author>Poulter, N</rioxxterms:author><rioxxterms:author>Hatcher, J</rioxxterms:author><rioxxterms:author>Chaturvedi, N</rioxxterms:author><rioxxterms:author>Ebrahim, S</rioxxterms:author><rioxxterms:author>Cosgrove, P</rioxxterms:author><rioxxterms:author>for the Hypertension Research Group</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>AM</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1161/CIRCULATIONAHA.111.039990</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:43
Date: 2017-09-30

RIOXX

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RCUK-RIOXX

RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
This is not a valid RCUK-RIOXX record
PropertyError
rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
dcterms:dateAcceptedMinimum of 1 value(s) required for dcterms:dateAccepted - found 0 values
dc:identifierMinimum of 1 value(s) required for dc:identifier - found 0 values
ali:license_refMinimum of 1 value(s) required for ali:license_ref - found 0 values
<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:43</identifier>
      <datestamp>2017-09-30T15:22:13Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>BACKGROUND: Inhaled nitric oxide (iNO) is an effective therapy for pulmonary hypertension and hypoxic respiratory failure in term infants. Fourteen randomized controlled trials (n = 3430 infants) have been conducted on preterm infants at risk for chronic lung disease (CLD). The study results seem contradictory.&lt;br/&gt; DESIGN/METHODS: Individual-patient data meta-analysis included randomized controlled trials of preterm infants (&lt;37 weeks' gestation). Outcomes were adjusted for trial differences and correlation between siblings.&lt;br/&gt; RESULTS: Data from 3298 infants in 12 trials (96%) were analyzed. There was no statistically significant effect of iNO on death or CLD (59% vs 61%: relative risk [RR]: 0.96 [95% confidence interval (CI): 0.92-1.01]; P = .11) or severe neurologic events on imaging (25% vs 23%: RR: 1.12 [95% CI: 0.98-1.28]; P = .09). There were no statistically significant differences in iNO effect according to any of the patient-level characteristics tested. In trials that used a starting iNO dose of &gt;5 vs ≤ 5 ppm there was evidence of improved outcome (interaction P = .02); however, these differences were not observed at other levels of exposure to iNO. This result was driven primarily by 1 trial, which also differed according to overall dose, duration, timing, and indication for treatment; a significant reduction in death or CLD (RR: 0.85 [95% CI: 0.74-0.98]) was found.&lt;br/&gt; CONCLUSIONS: Routine use of iNO for treatment of respiratory failure in preterm infants cannot be recommended. The use of a higher starting dose might be associated with improved outcome, but because there were differences in the designs of these trials, it requires further examination.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>American Academy of Pediatrics</dc:publisher><dc:source>0031-4005</dc:source><dc:title>Inhaled Nitric Oxide in Preterm Infants: An Individual-Patient Data Meta-analysis of Randomized Trials.</dc:title><rioxxterms:author>Askie, LM</rioxxterms:author><rioxxterms:author>Ballard, RA</rioxxterms:author><rioxxterms:author>Cutter, GR</rioxxterms:author><rioxxterms:author>Dani, C</rioxxterms:author><rioxxterms:author>Elbourne, D</rioxxterms:author><rioxxterms:author>Field, D</rioxxterms:author><rioxxterms:author>Hascoet, JM</rioxxterms:author><rioxxterms:author>Hibbs, AM</rioxxterms:author><rioxxterms:author>Kinsella, JP</rioxxterms:author><rioxxterms:author>Mercier, JC</rioxxterms:author><rioxxterms:author>Rich, W</rioxxterms:author><rioxxterms:author>Schreiber, MD</rioxxterms:author><rioxxterms:author>Wongsiridej, PS</rioxxterms:author><rioxxterms:author>Subhedar, NV</rioxxterms:author><rioxxterms:author>Van Meurs, KP</rioxxterms:author><rioxxterms:author>Voysey, M</rioxxterms:author><rioxxterms:author>Barrington, K</rioxxterms:author><rioxxterms:author>Ehrenkranz, RA</rioxxterms:author><rioxxterms:author>Finer, NN</rioxxterms:author><rioxxterms:author>Meta-analysis of Preterm Patients on Inhaled Nitric Oxide Collab</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1542/peds.2010-2725</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:42
Date: 2017-09-30

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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rioxxterms:projectMinimum of 1 value(s) required for rioxxterms:project - found 0 values
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:42</identifier>
      <datestamp>2017-09-30T03:56:55Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>: A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci for estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), grade, node status, tumor size, and ductal or lobular morphology. We genotyped rs11249433 at 1p.11.2, and two highly correlated SNPs rs999737 and rs10483813 (r(2)= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies. Analyses by tumor characteristics focused on subjects reporting to be white women of European ancestry and were based on 25 458 cases, of which 87% had ER data. The SNP at 1p11.2 showed significantly stronger associations with ER-positive tumors [per-allele odds ratio (OR) for ER-positive tumors was 1.13, 95% CI = 1.10-1.16 and, for ER-negative tumors, OR was 1.03, 95% CI = 0.98-1.07, case-only P-heterogeneity = 7.6 × 10(-5)]. The association with ER-positive tumors was stronger for tumors of lower grade (case-only P= 6.7 × 10(-3)) and lobular histology (case-only P= 0.01). SNPs at 14q24.1 were associated with risk for most tumor subtypes evaluated, including triple-negative breast cancers, which has not been described previously. Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>0964-6906</dc:source><dc:title>Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.</dc:title><rioxxterms:author>Figueroa, JD</rioxxterms:author><rioxxterms:author>Garcia-Closas, M</rioxxterms:author><rioxxterms:author>Humphreys, M</rioxxterms:author><rioxxterms:author>Platte, R</rioxxterms:author><rioxxterms:author>Hopper, JL</rioxxterms:author><rioxxterms:author>Southey, MC</rioxxterms:author><rioxxterms:author>Apicella, C</rioxxterms:author><rioxxterms:author>Hammet, F</rioxxterms:author><rioxxterms:author>Schmidt, MK</rioxxterms:author><rioxxterms:author>Broeks, A</rioxxterms:author><rioxxterms:author>Tollenaar, RA</rioxxterms:author><rioxxterms:author>Van't Veer, LJ</rioxxterms:author><rioxxterms:author>Fasching, PA</rioxxterms:author><rioxxterms:author>Beckmann, MW</rioxxterms:author><rioxxterms:author>Ekici, AB</rioxxterms:author><rioxxterms:author>Strick, R</rioxxterms:author><rioxxterms:author>Peto, J</rioxxterms:author><rioxxterms:author>dos Santos Silva, I</rioxxterms:author><rioxxterms:author>Fletcher, O</rioxxterms:author><rioxxterms:author>Johnson, N</rioxxterms:author><rioxxterms:author>Sawyer, E</rioxxterms:author><rioxxterms:author>Tomlinson, I</rioxxterms:author><rioxxterms:author>Kerin, M</rioxxterms:author><rioxxterms:author>Burwinkel, B</rioxxterms:author><rioxxterms:author>Marme, F</rioxxterms:author><rioxxterms:author>Schneeweiss, A</rioxxterms:author><rioxxterms:author>Sohn, C</rioxxterms:author><rioxxterms:author>Bojesen, S</rioxxterms:author><rioxxterms:author>Flyger, H</rioxxterms:author><rioxxterms:author>Nordestgaard, BG</rioxxterms:author><rioxxterms:author>Benítez, J</rioxxterms:author><rioxxterms:author>Milne, RL</rioxxterms:author><rioxxterms:author>Ignacio Arias, J</rioxxterms:author><rioxxterms:author>Zamora, MP</rioxxterms:author><rioxxterms:author>Brenner, H</rioxxterms:author><rioxxterms:author>Müller, H</rioxxterms:author><rioxxterms:author>Arndt, V</rioxxterms:author><rioxxterms:author>Rahman, N</rioxxterms:author><rioxxterms:author>Turnbull, C</rioxxterms:author><rioxxterms:author>Seal, S</rioxxterms:author><rioxxterms:author>Renwick, A</rioxxterms:author><rioxxterms:author>Brauch, H</rioxxterms:author><rioxxterms:author>Justenhoven, C</rioxxterms:author><rioxxterms:author>Brüning, T</rioxxterms:author><rioxxterms:author>GENICA Network</rioxxterms:author><rioxxterms:author>Chang-Claude, J</rioxxterms:author><rioxxterms:author>Hein, R</rioxxterms:author><rioxxterms:author>Wang-Gohrke, S</rioxxterms:author><rioxxterms:author>Dörk, T</rioxxterms:author><rioxxterms:author>Schürmann, P</rioxxterms:author><rioxxterms:author>Bremer, M</rioxxterms:author><rioxxterms:author>Hillemanns, P</rioxxterms:author><rioxxterms:author>Nevanlinna, H</rioxxterms:author><rioxxterms:author>Heikkinen, T</rioxxterms:author><rioxxterms:author>Aittomäki, K</rioxxterms:author><rioxxterms:author>Blomqvist, C</rioxxterms:author><rioxxterms:author>Bogdanova, N</rioxxterms:author><rioxxterms:author>Antonenkova, N</rioxxterms:author><rioxxterms:author>Rogov, YI</rioxxterms:author><rioxxterms:author>Karstens, JH</rioxxterms:author><rioxxterms:author>Bermisheva, M</rioxxterms:author><rioxxterms:author>Prokofieva, D</rioxxterms:author><rioxxterms:author>Gantcev, SH</rioxxterms:author><rioxxterms:author>Khusnutdinova, E</rioxxterms:author><rioxxterms:author>Lindblom, A</rioxxterms:author><rioxxterms:author>Margolin, S</rioxxterms:author><rioxxterms:author>Chenevix-Trench, G</rioxxterms:author><rioxxterms:author>Beesley, J</rioxxterms:author><rioxxterms:author>Chen, X</rioxxterms:author><rioxxterms:author>kConFab AOCS Management Group</rioxxterms:author><rioxxterms:author>Mannermaa, A</rioxxterms:author><rioxxterms:author>Kosma, VM</rioxxterms:author><rioxxterms:author>Soini, Y</rioxxterms:author><rioxxterms:author>Kataja, V</rioxxterms:author><rioxxterms:author>Lambrechts, D</rioxxterms:author><rioxxterms:author>Yesilyurt, BT</rioxxterms:author><rioxxterms:author>Chrisiaens, MR</rioxxterms:author><rioxxterms:author>Peeters, S</rioxxterms:author><rioxxterms:author>Radice, P</rioxxterms:author><rioxxterms:author>Peterlongo, P</rioxxterms:author><rioxxterms:author>Manoukian, S</rioxxterms:author><rioxxterms:author>Barile, M</rioxxterms:author><rioxxterms:author>Couch, F</rioxxterms:author><rioxxterms:author>Lee, AM</rioxxterms:author><rioxxterms:author>Diasio, R</rioxxterms:author><rioxxterms:author>Wang, X</rioxxterms:author><rioxxterms:author>Giles, GG</rioxxterms:author><rioxxterms:author>Severi, G</rioxxterms:author><rioxxterms:author>Baglietto, L</rioxxterms:author><rioxxterms:author>Maclean, C</rioxxterms:author><rioxxterms:author>Offit, K</rioxxterms:author><rioxxterms:author>Robson, M</rioxxterms:author><rioxxterms:author>Joseph, V</rioxxterms:author><rioxxterms:author>Gaudet, M</rioxxterms:author><rioxxterms:author>John, EM</rioxxterms:author><rioxxterms:author>Winqvist, R</rioxxterms:author><rioxxterms:author>Pylkäs, K</rioxxterms:author><rioxxterms:author>Jukkola-Vuorinen, A</rioxxterms:author><rioxxterms:author>Grip, M</rioxxterms:author><rioxxterms:author>Andrulis, I</rioxxterms:author><rioxxterms:author>Knight, JA</rioxxterms:author><rioxxterms:author>Mulligan, AM</rioxxterms:author><rioxxterms:author>O'Malley, FP</rioxxterms:author><rioxxterms:author>Brinton, LA</rioxxterms:author><rioxxterms:author>Sherman, ME</rioxxterms:author><rioxxterms:author>Lissowska, J</rioxxterms:author><rioxxterms:author>Chanock, SJ</rioxxterms:author><rioxxterms:author>Hooning, M</rioxxterms:author><rioxxterms:author>Martens, JW</rioxxterms:author><rioxxterms:author>van den Ouweland, AM</rioxxterms:author><rioxxterms:author>Collée, JM</rioxxterms:author><rioxxterms:author>Hall, P</rioxxterms:author><rioxxterms:author>Czene, K</rioxxterms:author><rioxxterms:author>Cox, A</rioxxterms:author><rioxxterms:author>Brock, IW</rioxxterms:author><rioxxterms:author>Reed, MW</rioxxterms:author><rioxxterms:author>Cross, SS</rioxxterms:author><rioxxterms:author>Pharoah, P</rioxxterms:author><rioxxterms:author>Dunning, AM</rioxxterms:author><rioxxterms:author>Kang, D</rioxxterms:author><rioxxterms:author>Yoo, KY</rioxxterms:author><rioxxterms:author>Noh, DY</rioxxterms:author><rioxxterms:author>Ahn, SH</rioxxterms:author><rioxxterms:author>Jakubowska, A</rioxxterms:author><rioxxterms:author>Lubinski, J</rioxxterms:author><rioxxterms:author>Jaworska, K</rioxxterms:author><rioxxterms:author>Durda, K</rioxxterms:author><rioxxterms:author>Sangrajrang, S</rioxxterms:author><rioxxterms:author>Gaborieau, V</rioxxterms:author><rioxxterms:author>Brennan, P</rioxxterms:author><rioxxterms:author>McKay, J</rioxxterms:author><rioxxterms:author>Shen, CY</rioxxterms:author><rioxxterms:author>Ding, SL</rioxxterms:author><rioxxterms:author>Hsu, HM</rioxxterms:author><rioxxterms:author>Yu, JC</rioxxterms:author><rioxxterms:author>Anton-Culver, H</rioxxterms:author><rioxxterms:author>Ziogas, A</rioxxterms:author><rioxxterms:author>Ashworth, A</rioxxterms:author><rioxxterms:author>Swerdlow, A</rioxxterms:author><rioxxterms:author>Jones, M</rioxxterms:author><rioxxterms:author>Orr, N</rioxxterms:author><rioxxterms:author>Trentham-Dietz, A</rioxxterms:author><rioxxterms:author>Egan, K</rioxxterms:author><rioxxterms:author>Newcomb, P</rioxxterms:author><rioxxterms:author>Titus-Ernstoff, L</rioxxterms:author><rioxxterms:author>Easton, D</rioxxterms:author><rioxxterms:author>Spurdle, AB</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1093/hmg/ddr368</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:41
Date: 2017-09-30

RIOXX

Base RIOXX scheme designed for low-level interoperability
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:41</identifier>
      <datestamp>2017-09-30T18:16:15Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>: Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>American Association for Cancer Research</dc:publisher><dc:source>0008-5472</dc:source><dc:title>Common breast cancer susceptibility loci are associated with triple negative breast cancer.</dc:title><rioxxterms:author>Stevens, KN</rioxxterms:author><rioxxterms:author>Vachon, CM</rioxxterms:author><rioxxterms:author>Lee, AM</rioxxterms:author><rioxxterms:author>Slager, S</rioxxterms:author><rioxxterms:author>Lesnick, T</rioxxterms:author><rioxxterms:author>Olswold, C</rioxxterms:author><rioxxterms:author>Fasching, PA</rioxxterms:author><rioxxterms:author>Miron, P</rioxxterms:author><rioxxterms:author>Eccles, D</rioxxterms:author><rioxxterms:author>Carpenter, JE</rioxxterms:author><rioxxterms:author>Godwin, AK</rioxxterms:author><rioxxterms:author>Ambrosone, C</rioxxterms:author><rioxxterms:author>Winqvist, R</rioxxterms:author><rioxxterms:author>Brauch, H</rioxxterms:author><rioxxterms:author>GENICA consortium</rioxxterms:author><rioxxterms:author>Schmidt, MK</rioxxterms:author><rioxxterms:author>Cox, A</rioxxterms:author><rioxxterms:author>Cross, SS</rioxxterms:author><rioxxterms:author>Sawyer, E</rioxxterms:author><rioxxterms:author>Hartmann, A</rioxxterms:author><rioxxterms:author>Beckmann, MW</rioxxterms:author><rioxxterms:author>Schulz-Wendtland, R</rioxxterms:author><rioxxterms:author>Ekici, AB</rioxxterms:author><rioxxterms:author>Tapper, WJ</rioxxterms:author><rioxxterms:author>Gerty, SM</rioxxterms:author><rioxxterms:author>Durcan, L</rioxxterms:author><rioxxterms:author>Graham, N</rioxxterms:author><rioxxterms:author>Hein, R</rioxxterms:author><rioxxterms:author>Nickels, S</rioxxterms:author><rioxxterms:author>Flesch-Janys, D</rioxxterms:author><rioxxterms:author>Heinz, J</rioxxterms:author><rioxxterms:author>Sinn, HP</rioxxterms:author><rioxxterms:author>Konstantopoulou, I</rioxxterms:author><rioxxterms:author>Fostira, F</rioxxterms:author><rioxxterms:author>Pectasides, D</rioxxterms:author><rioxxterms:author>Dimopoulos, AM</rioxxterms:author><rioxxterms:author>Fountzilas, G</rioxxterms:author><rioxxterms:author>Clarke, CL</rioxxterms:author><rioxxterms:author>Balleine, R</rioxxterms:author><rioxxterms:author>Olson, JE</rioxxterms:author><rioxxterms:author>Fredericksen, Z</rioxxterms:author><rioxxterms:author>Diasio, RB</rioxxterms:author><rioxxterms:author>Pathak, H</rioxxterms:author><rioxxterms:author>Ross, E</rioxxterms:author><rioxxterms:author>Weaver, J</rioxxterms:author><rioxxterms:author>Rüdiger, T</rioxxterms:author><rioxxterms:author>Försti, A</rioxxterms:author><rioxxterms:author>Dünnebier, T</rioxxterms:author><rioxxterms:author>Ademuyiwa, F</rioxxterms:author><rioxxterms:author>Kulkarni, S</rioxxterms:author><rioxxterms:author>Pylkäs, K</rioxxterms:author><rioxxterms:author>Jukkola-Vuorinen, A</rioxxterms:author><rioxxterms:author>Ko, YD</rioxxterms:author><rioxxterms:author>Van Limbergen, E</rioxxterms:author><rioxxterms:author>Janssen, H</rioxxterms:author><rioxxterms:author>Peto, J</rioxxterms:author><rioxxterms:author>Fletcher, O</rioxxterms:author><rioxxterms:author>Giles, GG</rioxxterms:author><rioxxterms:author>Baglietto, L</rioxxterms:author><rioxxterms:author>Verhoef, S</rioxxterms:author><rioxxterms:author>Tomlinson, I</rioxxterms:author><rioxxterms:author>Kosma, VM</rioxxterms:author><rioxxterms:author>Beesley, J</rioxxterms:author><rioxxterms:author>Greco, D</rioxxterms:author><rioxxterms:author>Blomqvist, C</rioxxterms:author><rioxxterms:author>Irwanto, A</rioxxterms:author><rioxxterms:author>Liu, J</rioxxterms:author><rioxxterms:author>Blows, FM</rioxxterms:author><rioxxterms:author>Dawson, SJ</rioxxterms:author><rioxxterms:author>Margolin, S</rioxxterms:author><rioxxterms:author>Mannermaa, A</rioxxterms:author><rioxxterms:author>Martin, NG</rioxxterms:author><rioxxterms:author>Montgomery, GW</rioxxterms:author><rioxxterms:author>Lambrechts, D</rioxxterms:author><rioxxterms:author>dos Santos Silva, I</rioxxterms:author><rioxxterms:author>Severi, G</rioxxterms:author><rioxxterms:author>Hamann, U</rioxxterms:author><rioxxterms:author>Pharoah, P</rioxxterms:author><rioxxterms:author>Easton, DF</rioxxterms:author><rioxxterms:author>Chang-Claude, J</rioxxterms:author><rioxxterms:author>Yannoukakos, D</rioxxterms:author><rioxxterms:author>Nevanlinna, H</rioxxterms:author><rioxxterms:author>Wang, X</rioxxterms:author><rioxxterms:author>Couch, FJ</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1158/0008-5472.CAN-11-1266</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:40
Date: 2017-10-01

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:40</identifier>
      <datestamp>2017-10-01T06:13:18Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>BACKGROUND: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium.&lt;br/&gt; METHODS: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression.&lt;br/&gt; RESULTS: For white Europeans, the per-allele OR associated with 5p12-rs10941679 was 1.11 (95% CI = 1.08-1.14, P = 7 × 10(-18)) for invasive breast cancer and 1.10 (95% CI = 1.01-1.21, P = 0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR = 1.07, 95%CI = 0.99-1.15, P = 0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)-positive disease (per-allele OR = 1.16, 95% CI = 1.12-1.20, P = 1 × 10(-18) vs. OR = 1.03, 95% CI = 0.99-1.07, P = 0.2 for PR-negative disease; P(heterogeneity) = 2 × 10(-7)); heterogeneity by ER status was not observed (P = 0.2) once PR status was accounted for. The association was also stronger for lower grade tumors [per-allele OR (95% CI) = 1.20 (1.14-1.25), 1.13 (1.09-1.16), and 1.04 (0.99-1.08) for grade 1, 2, and 3/4, respectively; P(trend) = 5 × 10(-7)].&lt;br/&gt; CONCLUSION: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer.&lt;br/&gt; IMPACT: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants.&lt;br/&gt; </dc:description><dc:language>en</dc:language><dc:publisher>American Association for Cancer Research</dc:publisher><dc:source>1055-9965</dc:source><dc:title>Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer.</dc:title><rioxxterms:author>Milne, RL</rioxxterms:author><rioxxterms:author>Goode, EL</rioxxterms:author><rioxxterms:author>García-Closas, M</rioxxterms:author><rioxxterms:author>Couch, FJ</rioxxterms:author><rioxxterms:author>Severi, G</rioxxterms:author><rioxxterms:author>Hein, R</rioxxterms:author><rioxxterms:author>Fredericksen, Z</rioxxterms:author><rioxxterms:author>Malats, N</rioxxterms:author><rioxxterms:author>Zamora, MP</rioxxterms:author><rioxxterms:author>Arias Pérez, JI</rioxxterms:author><rioxxterms:author>Benítez, J</rioxxterms:author><rioxxterms:author>Dörk, T</rioxxterms:author><rioxxterms:author>Schürmann, P</rioxxterms:author><rioxxterms:author>Karstens, JH</rioxxterms:author><rioxxterms:author>Hillemanns, P</rioxxterms:author><rioxxterms:author>Cox, A</rioxxterms:author><rioxxterms:author>Brock, IW</rioxxterms:author><rioxxterms:author>Elliot, G</rioxxterms:author><rioxxterms:author>Cross, SS</rioxxterms:author><rioxxterms:author>Seal, S</rioxxterms:author><rioxxterms:author>Turnbull, C</rioxxterms:author><rioxxterms:author>Renwick, A</rioxxterms:author><rioxxterms:author>Rahman, N</rioxxterms:author><rioxxterms:author>Shen, CY</rioxxterms:author><rioxxterms:author>Yu, JC</rioxxterms:author><rioxxterms:author>Huang, CS</rioxxterms:author><rioxxterms:author>Hou, MF</rioxxterms:author><rioxxterms:author>Nordestgaard, BG</rioxxterms:author><rioxxterms:author>Bojesen, SE</rioxxterms:author><rioxxterms:author>Lanng, C</rioxxterms:author><rioxxterms:author>Grenaker Alnæs, G</rioxxterms:author><rioxxterms:author>Kristensen, V</rioxxterms:author><rioxxterms:author>Børrensen-Dale, AL</rioxxterms:author><rioxxterms:author>Hopper, JL</rioxxterms:author><rioxxterms:author>Dite, GS</rioxxterms:author><rioxxterms:author>Apicella, C</rioxxterms:author><rioxxterms:author>Southey, MC</rioxxterms:author><rioxxterms:author>Lambrechts, D</rioxxterms:author><rioxxterms:author>Yesilyurt, BT</rioxxterms:author><rioxxterms:author>Floris, G</rioxxterms:author><rioxxterms:author>Leunen, K</rioxxterms:author><rioxxterms:author>Sangrajrang, S</rioxxterms:author><rioxxterms:author>Gaborieau, V</rioxxterms:author><rioxxterms:author>Brennan, P</rioxxterms:author><rioxxterms:author>McKay, J</rioxxterms:author><rioxxterms:author>Chang-Claude, J</rioxxterms:author><rioxxterms:author>Wang-Gohrke, S</rioxxterms:author><rioxxterms:author>Radice, P</rioxxterms:author><rioxxterms:author>Peterlongo, P</rioxxterms:author><rioxxterms:author>Manoukian, S</rioxxterms:author><rioxxterms:author>Barile, M</rioxxterms:author><rioxxterms:author>Giles, GG</rioxxterms:author><rioxxterms:author>Baglietto, L</rioxxterms:author><rioxxterms:author>John, EM</rioxxterms:author><rioxxterms:author>Miron, A</rioxxterms:author><rioxxterms:author>Chanock, SJ</rioxxterms:author><rioxxterms:author>Lissowska, J</rioxxterms:author><rioxxterms:author>Sherman, ME</rioxxterms:author><rioxxterms:author>Figueroa, JD</rioxxterms:author><rioxxterms:author>Bogdanova, NV</rioxxterms:author><rioxxterms:author>Antonenkova, NN</rioxxterms:author><rioxxterms:author>Zalutsky, IV</rioxxterms:author><rioxxterms:author>Rogov, YI</rioxxterms:author><rioxxterms:author>Fasching, PA</rioxxterms:author><rioxxterms:author>Bayer, CM</rioxxterms:author><rioxxterms:author>Ekici, AB</rioxxterms:author><rioxxterms:author>Beckmann, MW</rioxxterms:author><rioxxterms:author>Brenner, H</rioxxterms:author><rioxxterms:author>Müller, H</rioxxterms:author><rioxxterms:author>Arndt, V</rioxxterms:author><rioxxterms:author>Stegmaier, C</rioxxterms:author><rioxxterms:author>Andrulis, IL</rioxxterms:author><rioxxterms:author>Knight, JA</rioxxterms:author><rioxxterms:author>Glendon, G</rioxxterms:author><rioxxterms:author>Mulligan, AM</rioxxterms:author><rioxxterms:author>Mannermaa, A</rioxxterms:author><rioxxterms:author>Kataja, V</rioxxterms:author><rioxxterms:author>Kosma, VM</rioxxterms:author><rioxxterms:author>Hartikainen, JM</rioxxterms:author><rioxxterms:author>Meindl, A</rioxxterms:author><rioxxterms:author>Heil, J</rioxxterms:author><rioxxterms:author>Bartram, CR</rioxxterms:author><rioxxterms:author>Schmutzler, RK</rioxxterms:author><rioxxterms:author>Thomas, GD</rioxxterms:author><rioxxterms:author>Hoover, RN</rioxxterms:author><rioxxterms:author>Fletcher, O</rioxxterms:author><rioxxterms:author>Gibson, LJ</rioxxterms:author><rioxxterms:author>dos Santos Silva, I</rioxxterms:author><rioxxterms:author>Peto, J</rioxxterms:author><rioxxterms:author>Nickels, S</rioxxterms:author><rioxxterms:author>Flesch-Janys, D</rioxxterms:author><rioxxterms:author>Anton-Culver, H</rioxxterms:author><rioxxterms:author>Ziogas, A</rioxxterms:author><rioxxterms:author>Sawyer, E</rioxxterms:author><rioxxterms:author>Tomlinson, I</rioxxterms:author><rioxxterms:author>Kerin, M</rioxxterms:author><rioxxterms:author>Miller, N</rioxxterms:author><rioxxterms:author>Schmidt, MK</rioxxterms:author><rioxxterms:author>Broeks, A</rioxxterms:author><rioxxterms:author>Van 't Veer, LJ</rioxxterms:author><rioxxterms:author>Tollenaar, RA</rioxxterms:author><rioxxterms:author>Pharoah, PD</rioxxterms:author><rioxxterms:author>Dunning, AM</rioxxterms:author><rioxxterms:author>Pooley, KA</rioxxterms:author><rioxxterms:author>Marme, F</rioxxterms:author><rioxxterms:author>Schneeweiss, A</rioxxterms:author><rioxxterms:author>Sohn, C</rioxxterms:author><rioxxterms:author>Burwinkel, B</rioxxterms:author><rioxxterms:author>Jakubowska, A</rioxxterms:author><rioxxterms:author>Lubinski, J</rioxxterms:author><rioxxterms:author>Jaworska, K</rioxxterms:author><rioxxterms:author>Durda, K</rioxxterms:author><rioxxterms:author>Kang, D</rioxxterms:author><rioxxterms:author>Yoo, KY</rioxxterms:author><rioxxterms:author>Noh, DY</rioxxterms:author><rioxxterms:author>Ahn, SH</rioxxterms:author><rioxxterms:author>Hunter, DJ</rioxxterms:author><rioxxterms:author>Hankinson, SE</rioxxterms:author><rioxxterms:author>Kraft, P</rioxxterms:author><rioxxterms:author>Lindstrom, S</rioxxterms:author><rioxxterms:author>Chen, X</rioxxterms:author><rioxxterms:author>Beesley, J</rioxxterms:author><rioxxterms:author>Hamann, U</rioxxterms:author><rioxxterms:author>Harth, V</rioxxterms:author><rioxxterms:author>Justenhoven, C</rioxxterms:author><rioxxterms:author>GENICA Network</rioxxterms:author><rioxxterms:author>Winqvist, R</rioxxterms:author><rioxxterms:author>Pylkäs, K</rioxxterms:author><rioxxterms:author>Jukkola-Vuorinen, A</rioxxterms:author><rioxxterms:author>Grip, M</rioxxterms:author><rioxxterms:author>Hooning, M</rioxxterms:author><rioxxterms:author>Hollestelle, A</rioxxterms:author><rioxxterms:author>Oldenburg, RA</rioxxterms:author><rioxxterms:author>Tilanus-Linthorst, M</rioxxterms:author><rioxxterms:author>Khusnutdinova, E</rioxxterms:author><rioxxterms:author>Bermisheva, M</rioxxterms:author><rioxxterms:author>Prokofieva, D</rioxxterms:author><rioxxterms:author>Farahtdinova, A</rioxxterms:author><rioxxterms:author>Olson, JE</rioxxterms:author><rioxxterms:author>Wang, X</rioxxterms:author><rioxxterms:author>Humphreys, MK</rioxxterms:author><rioxxterms:author>Wang, Q</rioxxterms:author><rioxxterms:author>Chenevix-Trench, G</rioxxterms:author><rioxxterms:author>kConFab Investigators</rioxxterms:author><rioxxterms:author>AOCS Group</rioxxterms:author><rioxxterms:author>Easton, DF</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1158/1055-9965.EPI-11-0569</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:39
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:39</identifier>
      <datestamp>2017-09-30T17:57:06Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Previous studies have suggested that interviewer-administered questionnaires can under-estimate the prevalence of depression and suicidal ideation when compared with self-administered ones. We report here on differences in prevalence of reporting mental health between four questionnaire delivery modes (QDM).</dc:description><dc:language>en</dc:language><dc:publisher>Elsevier</dc:publisher><dc:source>0165-0327</dc:source><dc:title>Difference in prevalence of common mental disorder as measured using four questionnaire delivery methods among young people in rural Zimbabwe.</dc:title><rioxxterms:author>Langhaug, LF</rioxxterms:author><rioxxterms:author>Cheung, YB</rioxxterms:author><rioxxterms:author>Pascoe, S</rioxxterms:author><rioxxterms:author>Hayes, R</rioxxterms:author><rioxxterms:author>Cowan, FM</rioxxterms:author><rioxxterms:publication_date>2009</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1016/j.jad.2009.02.003</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:38
Date: 2017-09-30

RIOXX

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:38</identifier>
      <datestamp>2017-09-30T07:46:04Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><dc:description>: SUMMARYIn developed countries the majority of hepatitis C virus (HCV) infections occur in injecting drug users (IDUs) with prevalence in IDUs often high, but with wide geographical differences within countries. Estimates of local prevalence are needed for planning services for IDUs, but it is not practical to conduct HCV seroprevalence surveys in all areas. In this study survey data from IDUs attending specialist services were collected in 52/149 sites in England between 2006 and 2008. Spatially correlated random-effects models were used to estimate HCV prevalence for all sites, using auxiliary data to aid prediction. Estimates ranged from 14% to 82%, with larger cities, London and the North West having the highest HCV prevalence. The methods used generated robust estimates for each area, with a well-identified spatial pattern that improved predictions. Such models may be of use in other areas of study where surveillance data are sparse.&lt;br/&gt; </dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/38/1/EI8.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Cambridge University Press (CUP)</dc:publisher><dc:source>0950-2688</dc:source><dc:title>Spatial mapping of hepatitis C prevalence in recent injecting drug users in contact with services.</dc:title><rioxxterms:author>Harris, RJ</rioxxterms:author><rioxxterms:author>Hope, VD</rioxxterms:author><rioxxterms:author>Morongiu, A</rioxxterms:author><rioxxterms:author>Hickman, M</rioxxterms:author><rioxxterms:author>Ncube, F</rioxxterms:author><rioxxterms:author>DE Angelis, D</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1017/S0950268811001634</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:37
Date: 2017-09-30

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:37</identifier>
      <datestamp>2017-09-30T10:24:08Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Institute of Southeast Asian Studies</dc:publisher><dc:source>Improving Health Sector Performance: Institutions, Motivations and Incentives</dc:source><dc:title>Increasing Uptake of Reproductive Health Services Using Innovative Financing Models: Experiences of Marie Stopes International</dc:title><rioxxterms:author>Katz, C</rioxxterms:author><rioxxterms:author>Ngo, TD</rioxxterms:author><rioxxterms:contributor>Sen, H. Jalilian &amp;, V</rioxxterms:contributor><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Book chapter</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:36
Date: 2017-10-01

RIOXX

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:36</identifier>
      <datestamp>2017-10-01T03:30:02Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2010">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here. In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13-14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution. Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence. The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/36/1/1465-9921-11-8.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>BioMed Central</dc:publisher><dc:source>1465-9921</dc:source><dc:title>Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One</dc:title><rioxxterms:author>Asher, MI</rioxxterms:author><rioxxterms:author>Stewart, AW</rioxxterms:author><rioxxterms:author>Mallol, J</rioxxterms:author><rioxxterms:author>Montefort, S</rioxxterms:author><rioxxterms:author>Lai, CKW</rioxxterms:author><rioxxterms:author>Ait-Khaled, N</rioxxterms:author><rioxxterms:author>Odhiambo, J</rioxxterms:author><rioxxterms:author>Isaac Phase One Study Grp  [Inc Pearce, N]</rioxxterms:author><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1186/1465-9921-11-8</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:35
Date: 2017-09-30

RIOXX

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:35</identifier>
      <datestamp>2017-09-30T20:11:16Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Background The increasing prevalence of asthma and allergy might be related to diet, particularly in Western countries. A study was undertaken to assess the association between dietary factors, asthma and allergy in a large international study including objective measurements of atopy. Methods Between 1995 and 2005, cross-sectional studies were performed in 29 centres in 20 countries. Parental questionnaires were used to collect information on allergic diseases and exposure factors and data from 50 004 randomly selected schoolchildren (8-12 years, 29 579 with skin prick testing) were analysed. Random effect models for meta-analysis were applied to calculate combined ORs. Results Fruit intake was associated with a low prevalence of current wheeze in affluent (OR(adj) 0.86, 95% CI 0.73 to 1.02) and non-affluent countries (OR(adj) 0.71, 95% CI 0.57 to 0.88). Consumption of fish in affluent countries (OR(adj) 0.85, 95% CI 0.74 to 0.97) and of cooked green vegetables in non-affluent countries (OR(adj) 0.78, 95% CI 0.65 to 0.95) was associated with a lower prevalence of current wheeze. Overall, more frequent consumption of fruit, vegetables and fish was associated with a lower lifetime prevalence of asthma, whereas high burger consumption was associated with higher lifetime asthma prevalence. None of the food items was associated with allergic sensitisation. Except for fruit juice and fruit consumption, no associations were found with atopic wheeze. Food selection according to the 'Mediterranean diet' was associated with a lower prevalence of current wheeze and asthma ever (p(trend)=0.03). Conclusion Diet is associated with wheeze and asthma but not with allergic sensitisation in children. These results provide further evidence that adherence to the 'Mediterranean diet' may provide some protection against wheeze and asthma in childhood.</dc:description><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0040-6376</dc:source><dc:title>Effect of diet on asthma and allergic sensitisation in the International Study on Allergies and Asthma in Childhood (ISAAC) Phase Two</dc:title><rioxxterms:author>Nagel, G</rioxxterms:author><rioxxterms:author>Weinmayr, G</rioxxterms:author><rioxxterms:author>Kleiner, A</rioxxterms:author><rioxxterms:author>Garcia-Marcos, L</rioxxterms:author><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Isaac Phase Two Study Grp  [Inc Pearce, N]</rioxxterms:author><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/thx.2009.128256</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:34
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:34</identifier>
      <datestamp>2017-09-30T11:11:04Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Rationale: Bronchial responsiveness is an objectively measurable trait related to asthma. Its prevalence and association with asthma symptoms among children in many countries are unknown. Objectives: To investigate international variations in bronchial responsiveness (BR) and their associations with asthma symptoms and atopic sensitization. Methods: Bronchial challenge tests were conducted in 6,826 schoolchildren (aged 8-12 years) in 16 countries using hypertonic (4.5%) saline. FEV(1) was measured at baseline and after inhalation for 0.5, 1, 2, 4, and 8 min. BR was analyzed both as a dichotomous (bronchial hyperreactivity, BHR, at least 15% decline in FEV(1)) and as a continuous variable (time response slope, BR slope, individual decline in FEV(1) per log(min)). Results: Prevalence of wheeze last year ranged from 4.4% in Tirana (Albania) to 21.9% in Hawkes Bay (New Zealand) and of BHR from 2.1% in Tirana to 48% in Mumbai (India). The geometric mean BR slope varied between 3.4%/log(min) in Tirana and 12.8%/log(min) in Mumbai and Rome (Italy). At the individual level, BHR was positively associated with wheeze during the past 12 months both in affluent countries (OR = 3.6; 95% CI: 2.7-5.0) and non-affluent countries (OR = 3.0; 1.6-5.5). This association was more pronounced in atopic children. There was a correlation (rho = 0.64, P=0.002) between center-specific mean BR slope and wheeze prevalence in atopic, but not in non-atopic children. Conclusions: BR to saline in children varied considerably between countries. High rates of BR were not confined to affluent countries nor to centers with high prevalences of asthma symptoms. The association between wheeze and BHR at the individual level differed across centers and this heterogeneity can be largely explained by effect modification by atopy. Pediatr Pulmonol. 2010; 45:796-806. (C) 2010 Wiley-Liss, Inc.</dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>8755-6863</dc:source><dc:title>International Variations in Bronchial Responsiveness in Children: Findings From ISAAC Phase Two</dc:title><rioxxterms:author>Buchele, G</rioxxterms:author><rioxxterms:author>Genuneit, J</rioxxterms:author><rioxxterms:author>Weinmayr, G</rioxxterms:author><rioxxterms:author>Bjorksten, B</rioxxterms:author><rioxxterms:author>Gehring, U</rioxxterms:author><rioxxterms:author>von Mutius, E</rioxxterms:author><rioxxterms:author>Priftanji, A</rioxxterms:author><rioxxterms:author>Stein, RT</rioxxterms:author><rioxxterms:author>Addo-Yobo, EO</rioxxterms:author><rioxxterms:author>Priftis, KN</rioxxterms:author><rioxxterms:author>Shah, JR</rioxxterms:author><rioxxterms:author>Forastiere, F</rioxxterms:author><rioxxterms:author>Svabe, V</rioxxterms:author><rioxxterms:author>Crane, J</rioxxterms:author><rioxxterms:author>Nystad, W</rioxxterms:author><rioxxterms:author>Garcia-Marcos, L</rioxxterms:author><rioxxterms:author>Saraclar, Y</rioxxterms:author><rioxxterms:author>el-Sharif, N</rioxxterms:author><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Isaac Phase Two Study Grp [Inc Pearce, N]</rioxxterms:author><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1002/ppul.21259</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:33
Date: 2017-10-01

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:33</identifier>
      <datestamp>2017-10-01T06:39:15Z</datestamp>
      <setSpec>7374617475733D707562</setSpec>
      <setSpec>74797065733D61727469636C65</setSpec></header>
    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>P&gt;Background: Circulating allergen-specific IgE (sIgE) and skin prick tests (SPT) are used to define atopy. Downregulation of local inflammatory responsiveness has been proposed to explain a low prevalence of positive SPTs in less affluent countries. We analysed the association between SPTs, total and allergen-specific IgE and their relationships to allergic symptoms in centres with diverse living conditions. Methods: Cross-sectional studies of stratified random samples of 8 to 12-year-old children (n = 7461) used the standardized methodology of Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC). Symptoms of asthma, rhinitis and eczema were ascertained by parental questionnaires. Skin examination, hypertonic saline bronchial challenge, six aeroallergen SPTs and measurements of serum total IgE and sIgE were performed. Results: In nonaffluent countries, a higher proportion of children with positive SPT had no detectable sIgE (range 37-61%) than in affluent countries (0-37%). Total serum IgE was associated with all disease outcomes among children with both positive SPT and sIgE (P &lt; 0.001), but only with self-reported eczema in children with negative SPTs and negative sIgE. Conclusions: The international pattern of discordance between SPT and sIgE results did not support the downregulation hypothesis. Among children with no evidence of sensitization to common aeroallergens, increased total IgE contributes little to the risk of wheeze and rhinitis in the general population but may play a role in eczema.</dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>0105-4538</dc:source><dc:title>International variations in associations of allergic markers and diseases in children: ISAAC Phase Two</dc:title><rioxxterms:author>Weinmayr, G</rioxxterms:author><rioxxterms:author>Genuneit, J</rioxxterms:author><rioxxterms:author>Nagel, G</rioxxterms:author><rioxxterms:author>Bjorksten, B</rioxxterms:author><rioxxterms:author>van Hage, M</rioxxterms:author><rioxxterms:author>Priftanji, A</rioxxterms:author><rioxxterms:author>Cooper, P</rioxxterms:author><rioxxterms:author>Rijkjarv, MA</rioxxterms:author><rioxxterms:author>von Mutius, E</rioxxterms:author><rioxxterms:author>Tsanakas, J</rioxxterms:author><rioxxterms:author>Forastiere, F</rioxxterms:author><rioxxterms:author>Doekes, G</rioxxterms:author><rioxxterms:author>Garrido, JB</rioxxterms:author><rioxxterms:author>Suarez-Varela, MM</rioxxterms:author><rioxxterms:author>Braback, L</rioxxterms:author><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Isaac Phase Two Study Grp  [Inc Pearce, N]</rioxxterms:author><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1111/j.1398-9995.2009.02283.x</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:32
Date: 2017-09-30

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      <datestamp>2017-09-30T03:53:42Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Objectives To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema. Methods Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM(10) obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies. Results Annual concentrations of PM(10) at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM(10) and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 mu g/m(3) increase in PM(10) was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 mu g/m(3) increase in PM(10) was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies. Conclusions Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM10 has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries.</dc:description><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>1351-0711</dc:source><dc:title>Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)</dc:title><rioxxterms:author>Anderson, HR</rioxxterms:author><rioxxterms:author>Ruggles, R</rioxxterms:author><rioxxterms:author>Pandey, KD</rioxxterms:author><rioxxterms:author>Kapetanakis, V</rioxxterms:author><rioxxterms:author>Brunekreef, B</rioxxterms:author><rioxxterms:author>Lai, CKW</rioxxterms:author><rioxxterms:author>Strachan, DP</rioxxterms:author><rioxxterms:author>Weiland, SK</rioxxterms:author><rioxxterms:author>Isaac Phase One Study Grp  [Inc Pearce, N]</rioxxterms:author><rioxxterms:publication_date>2010</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/oem.2009.048785</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:31
Date: 2017-09-30

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ID: oai:researchonline.lshtm.ac.uk:30
Date: 2017-10-01

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      <identifier>oai:researchonline.lshtm.ac.uk:30</identifier>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Oxford University Press (OUP)</dc:publisher><dc:source>0002-9262</dc:source><dc:title>PATTERNS OF AGE OF PUBERTY IN RELATION TO EXPOSURE TO PERFLUOROOCTANOIC ACID (PFOA) AND PERFLUOROOCTANE SULFONATE (PFOS) AMONG CHILDREN LIVING IN AN AREA WITH PFOA-CONTAMINATED DRINKING WATER</dc:title><rioxxterms:author>Fletcher, T</rioxxterms:author><rioxxterms:author>Lopez-Espinosa, MJ</rioxxterms:author><rioxxterms:author>Armstrong, B</rioxxterms:author><rioxxterms:author>Fitz-Simon, N</rioxxterms:author><rioxxterms:author>Genser, B</rioxxterms:author><rioxxterms:author>Mondal, D</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:29
Date: 2017-09-30

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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>WHAT FACTORS ACCOUNT FOR THE ETHNIC DISPARITIES IN STAGE AT DIAGNOSIS AND CERVICAL CANCER SURVIVAL IN NEW ZEALAND?</dc:title><rioxxterms:author>Brewer, N</rioxxterms:author><rioxxterms:author>Richiardi, L</rioxxterms:author><rioxxterms:author>Borman, B</rioxxterms:author><rioxxterms:author>Pearce, N</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976b.72</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:28
Date: 2017-09-30

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:28</identifier>
      <datestamp>2017-09-30T02:41:20Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>TESTOSTERONE, CORTISOL: TESTOSTERONE RATIO AND PHYSICAL PERFORMANCE IN LATER LIFE: RESULTS FROM THE CAERPHILLY PROSPECTIVE STUDY (CAPS)</dc:title><rioxxterms:author>Gardner, M</rioxxterms:author><rioxxterms:author>Smith, GD</rioxxterms:author><rioxxterms:author>Lightman, S</rioxxterms:author><rioxxterms:author>Gallacher, J</rioxxterms:author><rioxxterms:author>Kuh, D</rioxxterms:author><rioxxterms:author>Ebrahim, S</rioxxterms:author><rioxxterms:author>Bayer, T</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976g.19</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:27
Date: 2017-09-30

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      <identifier>oai:researchonline.lshtm.ac.uk:27</identifier>
      <datestamp>2017-09-30T17:36:33Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>DETERMINANTS OF BED NET USAGE IN CHILDREN UNDER 5 AND HOUSEHOLD BED NET OWNERSHIP IN BIOKO ISLAND, EQUATORIAL GUINEA</dc:title><rioxxterms:author>Garcia-Basteiro, AL</rioxxterms:author><rioxxterms:author>Schwabe, C</rioxxterms:author><rioxxterms:author>Aragon, C</rioxxterms:author><rioxxterms:author>Baltazar, G</rioxxterms:author><rioxxterms:author>Rehman, AM</rioxxterms:author><rioxxterms:author>Matias, A</rioxxterms:author><rioxxterms:author>Nchama, GN</rioxxterms:author><rioxxterms:author>Kleinschmidt, I</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976l.33</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:26
Date: 2017-10-01

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:26</identifier>
      <datestamp>2017-10-01T10:00:53Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>Background: In line with the Global trend to improve malaria control efforts a major campaign of insecticide treated net distribution was initiated in 1999 and indoor residual spraying with DDT or pyrethroids was reintroduced in 2000 in Zambia. In 2006, these efforts were strengthened by the President's Malaria Initiative. This manuscript reports on the monitoring and evaluation of these activities and the potential impact of emerging insecticide resistance on disease transmission. Methods: Mosquitoes were captured daily through a series of 108 window exit traps located at 18 sentinel sites. Specimens were identified to species and analyzed for sporozoites. Adult Anopheles mosquitoes were collected resting indoors and larva collected in breeding sites were reared to F1 and F0 generations in the lab and tested for insecticide resistance following the standard WHO susceptibility assay protocol. Annual cross sectional household parasite surveys were carried out to monitor the impact of the control programme on prevalence of Plasmodium falciparum in children aged 1 to 14 years. Results: A total of 619 Anopheles gambiae s.l. and 228 Anopheles funestus s.l. were captured from window exit traps throughout the period, of which 203 were An. gambiae malaria vectors and 14 An. funestus s.s.. In 2010 resistance to DDT and the pyrethroids deltamethrin, lambda-cyhalothrin and permethrin was detected in both An. gambiae s.s. and An. funestus s.s.. No sporozoites were detected in either species. Prevalence of P. falciparum in the sentinel sites remained below 10% throughout the study period. Conclusion: Both An. gambiae s.s. and An. funestus s.s. were controlled effectively with the ITN and IRS programme in Zambia, maintaining a reduced disease transmission and burden. However, the discovery of DDT and pyrethroid resistance in the country threatens the sustainability of the vector control programme.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/26/1/pone.0024336.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1932-6203</dc:source><dc:title>Insecticide Resistance and the Future of Malaria Control in Zambia</dc:title><rioxxterms:author>Chanda, E</rioxxterms:author><rioxxterms:author>Hemingway, J</rioxxterms:author><rioxxterms:author>Kleinschmidt, I</rioxxterms:author><rioxxterms:author>Rehman, AM</rioxxterms:author><rioxxterms:author>Ramdeen, V</rioxxterms:author><rioxxterms:author>Phiri, FN</rioxxterms:author><rioxxterms:author>Coetzer, S</rioxxterms:author><rioxxterms:author>Mthembu, D</rioxxterms:author><rioxxterms:author>Shinondo, CJ</rioxxterms:author><rioxxterms:author>Chizema-Kawesha, E</rioxxterms:author><rioxxterms:author>Kamuliwo, M</rioxxterms:author><rioxxterms:author>Mukonka, V</rioxxterms:author><rioxxterms:author>Baboo, KS</rioxxterms:author><rioxxterms:author>Coleman, M</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pone.0024336</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:25
Date: 2017-09-30

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ID: oai:researchonline.lshtm.ac.uk:24
Date: 2017-10-01

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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>IDENTIFYING ADVERSE EVENTS OF VACCINES USING A BAYESIAN METHOD OF MEDICALLY GUIDED INFORMATION SHARING</dc:title><rioxxterms:author>Crooks, C</rioxxterms:author><rioxxterms:author>Prieto-Merino, D</rioxxterms:author><rioxxterms:author>Evans, S</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976c.8</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:23
Date: 2017-10-01

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:23</identifier>
      <datestamp>2017-10-01T00:08:18Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>PURPOSE. To estimate prevalence and describe causes of functional low vision (FLV) among a nationally representative sample of Nigerian adults, assess socioeconomic risk factors, and estimate the number of adults in Nigeria who might benefit from low vision assessment or rehabilitation services. METHODS. Multistage, stratified, cluster random sampling with probability proportional to size procedures were used to identify a nationally representative sample of 15,027 persons aged 40 years or older. Distance vision was measured using a reduced logMAR tumbling E-chart. All participants with presenting acuity of &lt; 6/12 in one or both eyes had their corrected acuity measured and underwent detailed clinical examination to determine the cause. FLV was defined as best corrected vision &lt; 6/18 in the better eye, after excluding those with no light perception in both eyes and those with treatable causes. Analysis took account of the clustered design. RESULTS. In all, 13,591 individuals were examined in 305 clusters (response rate, 89.9%). The crude prevalence of FLV was 3.5% (95% confidence interval, 3.1-3.9%). This was lower than the prevalence of blindness, which was 4.2%. Glaucoma was the most common cause and age the most important risk factor. There are estimated to be approximately 5000 adults with FLV per million population and 340 who are totally blind. Only 9.3% of those with FLV were of working age and literate. CONCLUSIONS. These are the first data on the prevalence, causes, and risk factors for FLV from Africa. Results support studies from Asia that the prevalence of FLV is lower than previously thought. Because the majority of adults with FLV in Nigeria live in rural areas and are elderly and not literate, further research is required to assess the nature of the interventions required and who might best deliver them. (Invest Ophthalmol Vis Sci. 2011; 52: 6714-6719) DOI: 10.1167/iovs.11-7293</dc:description><dc:language>en</dc:language><dc:publisher>Association for Research in Vision and Ophthalmology</dc:publisher><dc:source>0146-0404</dc:source><dc:title>Prevalence, Causes, and Risk Factors for Functional Low Vision in Nigeria: Results from the National Survey of Blindness and Visual Impairment</dc:title><rioxxterms:author>Entekume, G</rioxxterms:author><rioxxterms:author>Patel, J</rioxxterms:author><rioxxterms:author>Sivasubramaniam, S</rioxxterms:author><rioxxterms:author>Gilbert, CE</rioxxterms:author><rioxxterms:author>Ezelum, CC</rioxxterms:author><rioxxterms:author>Murthy, GVS</rioxxterms:author><rioxxterms:author>Rabiu, MM</rioxxterms:author><rioxxterms:author>Nigeria Natl Blindness, V</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1167/iovs.11-7293</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:22
Date: 2017-10-01

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      <identifier>oai:researchonline.lshtm.ac.uk:22</identifier>
      <datestamp>2017-10-01T04:38:13Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>INVESTIGATING VICTORIA'S INVERSE EQUITY HYPOTHESIS: THE CHANGING SOCIAL EPIDEMIOLOGY OF HIV INFECTION IN TANZANIA</dc:title><rioxxterms:author>Hargreaves, J</rioxxterms:author><rioxxterms:author>Howe, L</rioxxterms:author><rioxxterms:author>Slaymaker, E</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976m.42</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:21
Date: 2017-10-01

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:21</identifier>
      <datestamp>2017-10-01T13:59:42Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>BIRTH OUTCOMES AND EARLY-LIFE SOCIAL CHARACTERISTICS PREDICT UNEQUAL EDUCATIONAL OUTCOMES ACROSS THE LIFECOURSE AND ACROSS GENERATIONS. DATA FROM A SWEDISH COHORT BORN 1915-1929 AND THEIR GRANDCHILDREN BORN 1973-1980</dc:title><rioxxterms:author>Goodman, A</rioxxterms:author><rioxxterms:author>Gisselmann, M</rioxxterms:author><rioxxterms:author>Koupil, I</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976g.25</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:20
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:20</identifier>
      <datestamp>2017-09-30T05:41:30Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Multivariate meta-analysis represents a promising statistical tool in several research areas. Here, we provide a brief overview of the application of this methodology to combining complex multi-parameterized relationships, such as non-linear or delayed associations, in multi-site studies. The discussion focuses on the advantages over simpler univariate methods, estimation and computational issues and directions for further research. Copyright (C) 2011 John Wiley &amp; Sons, Ltd.</dc:description><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>0277-6715</dc:source><dc:title>Multivariate meta-analysis: A method to summarize non-linear associations</dc:title><rioxxterms:author>Gasparrini, A</rioxxterms:author><rioxxterms:author>Armstrong, B</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1002/sim.4226</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:19
Date: 2017-09-30

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RCUK RIOXX scheme for reporting of open access publications funded through UK Research Council grants
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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:19</identifier>
      <datestamp>2017-09-30T21:19:37Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Background Social background and birth characteristics are generally found to be independently associated with school achievements but the underlying mechanisms are not fully understood. This study aimed to explore how parental education and shorter gestational age jointly influence school performance in a cohort of Swedish children. Methods 10 835 children born between 1973 and 1981 were studied, the third generation of the register-based Uppsala Multigenerational Birth Cohort. Ordinal logistic regression models were fitted to estimate OR of achieving middle and high grades in Swedish language at age 16 years, relative to low grade, by parental education and own gestational age, adjusting for potential confounders. Results In children from families with lower parental education, the adjusted OR of receiving a higher grade was 0.54 (95% CI 0.41 to 0.71) for preterm (&lt;37 completed weeks) compared with full-term births. This estimate did not change when adjusted for several potential confounders (0.59; CI 0.44 to 0.79). When different cut-points were selected to define preterm birth, the estimated OR for those with low parental education decreased linearly from 0.83 (CI 0.72 to 0.96) using less than 39 weeks as the cut-point, to 0.52 (CI 0.30 to 0.90) using less than 35 weeks. There was no evidence of significant effects of shorter gestational age for children with parents from other educational groups. Conclusions The disadvantage of shorter gestational age on the chance of achieving higher grades in Swedish language was confined to children from families in which none of the parents had higher education. This suggests that the detrimental influence of shorter gestational age on school performance in language may be avoidable.</dc:description><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>The combined influence of parental education and preterm birth on school performance</dc:title><rioxxterms:author>Gisselmann, M</rioxxterms:author><rioxxterms:author>Koupil, I</rioxxterms:author><rioxxterms:author>de Stavola, BL</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2009.105569</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:18
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:18</identifier>
      <datestamp>2017-09-30T18:06:43Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><ali:free_to_read/><ali:license_ref start_date="2011">http://creativecommons.org/licenses/by/4.0</ali:license_ref><dc:description>Background: Recent attempts by large tobacco companies to represent themselves as socially responsible have been widely dismissed as image management. Existing research supports such claims by pointing to the failings and misleading nature of corporate social responsibility (CSR) initiatives. However, few studies have focused in depth on what tobacco companies hoped to achieve through CSR or reflected on the extent to which these ambitions have been realised. Methods and Findings: Iterative searching relating to CSR strategies was undertaken of internal British American Tobacco (BAT) documents, released through litigation in the US. Relevant documents (764) were indexed and qualitatively analysed. In the past decade, BAT has actively developed a wide-ranging CSR programme. Company documents indicate that one of the key aims of this programme was to help the company secure access to policymakers and, thereby, increase the company's chances of influencing policy decisions. Taking the UK as a case study, this paper demonstrates the way in which CSR can be used to renew and maintain dialogue with policymakers, even in ostensibly unreceptive political contexts. In practice, the impact of this political use of CSR is likely to be context specific; depending on factors such as policy 'elites' understanding of the credibility of companies as a reliable source of information. Conclusions: The findings suggest that tobacco company CSR strategies can enable access to and dialogue with policymakers and provide opportunities for issue definition. CSR should therefore be seen as a form of corporate political activity. This underlines the need for broad implementation of Article 5.3 of the Framework Convention on Tobacco Control. Measures are needed to ensure transparency of interactions between all parts of government and the tobacco industry and for policy makers to be made more aware of what companies hope to achieve through CSR.</dc:description><dc:format>application/pdf</dc:format><dc:identifier>http://researchonline.lshtm.ac.uk/18/1/pmed.1001076.pdf</dc:identifier><dc:language>en</dc:language><dc:publisher>Public Library of Science</dc:publisher><dc:source>1549-1277</dc:source><dc:title>Corporate Social Responsibility and Access to Policy Elites: An Analysis of Tobacco Industry Documents</dc:title><rioxxterms:author>Fooks, GJ</rioxxterms:author><rioxxterms:author>Gilmore, AB</rioxxterms:author><rioxxterms:author>Smith, KE</rioxxterms:author><rioxxterms:author>Collin, J</rioxxterms:author><rioxxterms:author>Holden, C</rioxxterms:author><rioxxterms:author>Lee, K</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>VoR</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1371/journal.pmed.1001076</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:17
Date: 2017-09-30

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      <identifier>oai:researchonline.lshtm.ac.uk:17</identifier>
      <datestamp>2017-09-30T02:47:18Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>0143-005X</dc:source><dc:title>ALLERGIES AND DIABETES AS RISK FACTORS FOR DENGUE HEMORRHAGIC FEVER: RESULTS OF A CASE CONTROL STUDY</dc:title><rioxxterms:author>Figueiredo, M</rioxxterms:author><rioxxterms:author>Rodrigues, L</rioxxterms:author><rioxxterms:author>Barreto, M</rioxxterms:author><rioxxterms:author>Lima, W</rioxxterms:author><rioxxterms:author>Costa, C</rioxxterms:author><rioxxterms:author>Morato, V</rioxxterms:author><rioxxterms:author>Blanton, R</rioxxterms:author><rioxxterms:author>Vasconcelos, P</rioxxterms:author><rioxxterms:author>Nunes, M</rioxxterms:author><rioxxterms:author>Teixeira, G</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/jech.2011.142976d.43</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:16
Date: 2017-09-30

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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>1053-8569</dc:source><dc:title>Using the Self Controlled Case Series Method To Assess the Risk of Myocardial Infarction in GPRD-Registered Users of Antipsychotic Agents</dc:title><rioxxterms:author>Brauer, R</rioxxterms:author><rioxxterms:author>Douglas, I</rioxxterms:author><rioxxterms:author>Smeeth, L</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:5
Date: 2017-09-30

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      <identifier>oai:researchonline.lshtm.ac.uk:5</identifier>
      <datestamp>2017-09-30T21:50:03Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>1053-8569</dc:source><dc:title>The Risk of Cancer Associated with Angiotensin-II Receptor Blockers</dc:title><rioxxterms:author>Bhaskaran, K</rioxxterms:author><rioxxterms:author>Douglas, I</rioxxterms:author><rioxxterms:author>Evans, S</rioxxterms:author><rioxxterms:author>van Staa, T</rioxxterms:author><rioxxterms:author>Smeeth, L</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:4
Date: 2017-10-01

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    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:4</identifier>
      <datestamp>2017-10-01T05:43:36Z</datestamp>
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      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:language>en</dc:language><dc:publisher>Wiley</dc:publisher><dc:source>1053-8569</dc:source><dc:title>Multiple Imputation for Missing Data in Electronic Health Databases: Practical Issues and Some Solutions</dc:title><rioxxterms:author>Carpenter, J</rioxxterms:author><rioxxterms:author>Petersen, I</rioxxterms:author><rioxxterms:author>Welch, C</rioxxterms:author><rioxxterms:author>Bartlett, J</rioxxterms:author><rioxxterms:author>Walters, K</rioxxterms:author><rioxxterms:author>Morris, R</rioxxterms:author><rioxxterms:author>White, I</rioxxterms:author><rioxxterms:author>Marston, L</rioxxterms:author><rioxxterms:author>Nazareth, I</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Conference Paper/Proceeding/Abstract</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:3
Date: 2017-09-30

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<record>
    <header>
      <identifier>oai:researchonline.lshtm.ac.uk:3</identifier>
      <datestamp>2017-09-30T08:36:51Z</datestamp>
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    <metadata>
      <rioxx xmlns="http://www.rioxx.net/schema/v2.0/rioxx/" xmlns:ali="http://ali.niso.org/2014/ali/1.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rioxxterms="http://docs.rioxx.net/schema/v2.0/rioxxterms/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.rioxx.net/schema/v2.0/rioxx/ http://www.rioxx.net/schema/v2.0/rioxx/rioxx.xsd"><dc:description>Objectives Recent publications suggest that fishing populations may be highly affected by the HIV epidemic. However, accurate data are scarce. The authors determined HIV and syphilis prevalence and associated risk factors in a fishing population of Lake Victoria in Uganda. Methods 10 188 volunteers aged &gt;= 13 years from a census carried out in five fishing communities between February and August 2009 were invited to attend central study clinics established in each community. After informed consent, 2005 randomly selected volunteers responded to socio-demographic and risk assessment questions, provided blood for HIV testing and 1618 volunteers were also tested for syphilis. Risk factors were analysed using logistic regression. Results HIV and active syphilis (rapid plasma reagin titre &gt;= 1:8) prevalences were 28.8% (95% CI 26.8 to 30.8) and 4.3% (95% CI 3.3 to 5.4), respectively, and high risk sexual behaviour was frequently reported. HIV prevalence was independently associated with female sex, increasing age, occupation (highest in fishermen), relationship to household head, self-reported genital sores and knowledge of an HIV infected partner. Alcohol consumption, syphilis and sexually transmitted infections (STIs) reported by health workers were associated with HIV in women, and genital discharge and inconsistent condom use in men. Syphilis prevalence was independently associated with age and alcohol consumption in women, and recent genital sores and sex under the influence of drugs in men. Conclusion This fishing population characterised by a very high HIV prevalence, high syphilis prevalence and frequently reported sexual risk behaviours, urgently needs improved STI services and targeted behavioural interventions.</dc:description><dc:language>en</dc:language><dc:publisher>BMJ Publishing Group</dc:publisher><dc:source>1368-4973</dc:source><dc:title>HIV and syphilis prevalence and associated risk factors among fishing communities of Lake Victoria, Uganda</dc:title><rioxxterms:author>Asiki, G</rioxxterms:author><rioxxterms:author>Mpendo, J</rioxxterms:author><rioxxterms:author>Abaasa, A</rioxxterms:author><rioxxterms:author>Agaba, C</rioxxterms:author><rioxxterms:author>Nanvubya, A</rioxxterms:author><rioxxterms:author>Nielsen, L</rioxxterms:author><rioxxterms:author>Seeley, J</rioxxterms:author><rioxxterms:author>Kaleebu, P</rioxxterms:author><rioxxterms:author>Grosskurth, H</rioxxterms:author><rioxxterms:author>Kamali, A</rioxxterms:author><rioxxterms:publication_date>2011</rioxxterms:publication_date><rioxxterms:type>Journal Article/Review</rioxxterms:type><rioxxterms:version>NA</rioxxterms:version><rioxxterms:version_of_record>http://dx.doi.org/10.1136/sti.2010.046805</rioxxterms:version_of_record></rioxx></metadata></record>
ID: oai:researchonline.lshtm.ac.uk:2
Date: 2017-10-01

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ID: oai:researchonline.lshtm.ac.uk:1
Date: 2017-09-30

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